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New Nuclear Medicine Imaging Radiotracer 64Cu(II) for diagnosing Hypoxia Conditions Based on the Cellular Copper Cycle

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The Advantages of EPR Spectroscopy in Exploring Diamagnetic Metal Ion Binding and Transfer Mechanisms in Biological Systems

Autores: Shelly Meron; Yulia Shenberger; Sharon Ruthstein
Publicado en: Crossref, Edición 3, 2022, ISSN 2312-7481
Editor: MDPI
DOI: 10.3390/magnetochemistry8010003

Disrupting Cu trafficking as a potential therapy for cancer

Autores: Sharon Ruthstein
Publicado en: Frontiers in Molecular Biosciences, Edición 2296889X, 2022, ISSN 2296-889X
Editor: Frontiers
DOI: 10.3389/fmolb.2022.1011294

Dynamical interplay between the human high-affinity copper transporter hCtr1 and its cognate metal ion

Autores: Sharon Ruthstein
Publicado en: Biophysical Journal, Edición 2, 2022, ISSN 0006-3495
Editor: Biophysical Society
DOI: 10.1016/j.bpj.2022.02.033

EPR Spectroscopy Provides New Insights into Complex Biological Reaction Mechanisms

Autores: Sharon Ruthstein
Publicado en: J. Phys. Chem. B., Edición 15206106, 2022, ISSN 1520-6106
Editor: American Chemical Society
DOI: 10.1021/acs.jpcb.2c05235

Insights into the N-terminal Cu(II) and Cu(I) binding sites of the human copper transporter CTR1

Autores: Yulia Shenberger, Ortal Marciano, Hugo E. Gottlieb, Sharon Ruthstein
Publicado en: Journal of Coordination Chemistry, Edición 71/11-13, 2018, Página(s) 1985-2002, ISSN 0095-8972
Editor: Gordon and Breach Science Publishers
DOI: 10.1080/00958972.2018.1492717

The pivotal role of MBD4–ATP7B in the human Cu( i ) excretion path as revealed by EPR experiments and all-atom simulations

Autores: Zena Qasem, Matic Pavlin, Ida Ritacco, Lada Gevorkyan-Airapetov, Alessandra Magistrato, Sharon Ruthstein
Publicado en: Metallomics, Edición 11/7, 2019, Página(s) 1288-1297, ISSN 1756-5901
Editor: Royal Society of Chemistry
DOI: 10.1039/C9MT00067D

Does the ATSM-Cu(II) Biomarker Integrate into the Human Cellular Copper Cycle?

Autores: Gulshan R. Walke, Sharon Ruthstein
Publicado en: ACS Omega, Edición 4/7, 2019, Página(s) 12278-12285, ISSN 2470-1343
Editor: ACS
DOI: 10.1021/acsomega.9b01748

Copper trafficking in eukaryotic systems: current knowledge from experimental and computational efforts

Autores: Alessandra Magistrato, Matic Pavlin, Zena Qasem, Sharon Ruthstein
Publicado en: Current Opinion in Structural Biology, Edición 58, 2019, Página(s) 26-33, ISSN 0959-440X
Editor: Elsevier BV
DOI: 10.1016/

Unraveling the Impact of Cysteine-to-Serine Mutations on the Structural and Functional Properties of Cu(I)-Binding Proteins

Autores: Pavlin, Qasem, Sameach, Gevorkyan-Airapetov, Ritacco, Ruthstein, Magistrato
Publicado en: International Journal of Molecular Sciences, Edición 20/14, 2019, Página(s) 3462, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20143462

An EPR Study on the Interaction between the Cu(I) Metal Binding Domains of ATP7B and the Atox1 Metallochaperone

Autores: Michael Zaccak, Zena Qasem, Lada Gevorkyan-Airapetov, Sharon Ruthstein
Publicado en: International Journal of Molecular Sciences, Edición 21/15, 2020, Página(s) 5536, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21155536

Cu(I) Controls Conformational States in Human Atox1 Metallochaperone: An EPR and Multiscale Simulation Study

Autores: Ortal Perkal, Zena Qasem, Meital Turgeman, Renana Schwartz, Lada Gevorkyan-Airapetov, Matic Pavlin, Alessandra Magistrato, Dan Thomas Major, Sharon Ruthstein
Publicado en: The Journal of Physical Chemistry B, Edición 124/22, 2020, Página(s) 4399-4411, ISSN 1520-6106
Editor: American Chemical Society
DOI: 10.1021/acs.jpcb.0c01744

Cellular Uptake of the ATSM

Autores: Sharon Ruthstein
Publicado en: ChemistryOpen, Edición 4, 2021, ISSN 2191-1363
Editor: Wiley
DOI: 10.1002/open.202100044


Autores: Ruthstein, Sharon; Shenberger, Yulia
Publicado en: PCT-IL, Edición 2, 2018
Editor: patentscope
DOI: 10.5281/zenodo.3244872

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