PREvention of STroke in Intracerebral haemorrhaGE survivors with Atrial Fibrillation

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PRESTIGE-AF “Dissemination Package”
Physician education materials for antithrombotic consultations with ICH survivors

Reports prepared following on from each consortium meeting, focusing on progress on major deliverables and milestones.Updated after every annual meeting. (M25, M37, M49)

First study subject approvals package

First study subject approvals package submitted

Dissemination & Communication Plan

Launch of website and social media accounts
Educational video on“Sample Collection Methods for Biomarker Studies”

Educational video on“Sample Collection Methods for Biomarker Studies at PRESTIGE-AF trial”

Publications

Stroke genetics informs drug discovery and risk prediction across ancestries

Auteurs: Aniket Mishra, Rainer Malik, Tsuyoshi Hachiya, Tuuli Jürgenson, Shinichi Namba, Daniel C. Posner, Frederick K. Kamanu, Masaru Koido, Quentin Le Grand, Mingyang Shi, Yunye He, Marios K. Georgakis, Ilana Caro, Kristi Krebs, Yi-Ching Liaw, Felix C. Vaura, Kuang Lin, Bendik Slagsvold Winsvold, Vinodh Srinivasasainagendra, Livia Parodi, Hee-Joon Bae, Ganesh Chauhan, Michael R. Chong, Liisa Tomppo, Ruf
Publié dans: Nature, 2022, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-022-05165-3

ESO Guideline on covert cerebral small vessel disease

Auteurs: Joanna M Wardlaw, Stephanie Debette, Hanna Jokinen, Frank-Erik De Leeuw, Leonardo Pantoni, Hugues Chabriat, Julie Staals, Fergus Doubal, Salvatore Rudilosso, Sebastian Eppinger, Sabrina Schilling, Raffaele Ornello, Christian Enzinger, Charlotte Cordonnier, Martin Taylor-Rowan, Arne G Lindgren
Publié dans: European Stroke Journal, 2021, ISSN 2396-9881
Éditeur: SAGE Publications
DOI: 10.1177/23969873211012132

Extent of routine diagnostic cardiac work-up at certified German stroke units participating in the prospective MonDAFIS study

Auteurs: Manuel C. Olma, Serdar Tütüncü, Ulrike Grittner, Claudia Kunze, Muhammad Jawad-Ul-Qamar, Paulus Kirchhof, Joachim Röther, Götz Thomalla, Roland Veltkamp, Ulrich Laufs, Darius G. Nabavi, Peter U. Heuschmann, Matthias Endres & Karl Georg Haeusler
Publié dans: Neurological Research and Practice, 2023, ISSN 2524-3489
Éditeur: BioMed Central Ltd
DOI: 10.1186/s42466-023-00246-8

Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate

Auteurs: Aniket Mishra, Cécile Duplaà, Dina Vojinovic, Hideaki Suzuki, Muralidharan Sargurupremraj, Nuno R Zilhão, Shuo Li, Traci M Bartz, Xueqiu Jian, Wei Zhao, Edith Hofer, Katharina Wittfeld, Sarah E Harris, Sandra van der Auwera-Palitschka, Michelle Luciano, Joshua C Bis, Hieab H H Adams, Claudia L Satizabal, Rebecca F Gottesman, Piyush G Gampawar, Robin Bülow, Stefan Weiss, Miao Yu, Mark E Bastin,
Publié dans: Brain, 2022, ISSN 1460-2156
Éditeur: Oxford University Press
DOI: 10.1093/brain/awab432

Natalizumab in acute ischemic stroke (ACTION II)

Auteurs: Mitchell S.V. Elkind, Roland Veltkamp, Joan Montaner, S. Claiborne Johnston, Aneesh B. Singhal, Kyra Becker, Maarten G. Lansberg, Weihua Tang, Rachna Kasliwal, Jacob Elkins
Publié dans: Neurology, Numéro 95/8, 2020, Page(s) e1091-e1104, ISSN 0028-3878
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000010038

Cerebral small vessel disease genomics and its implications across the lifespan

Auteurs: Muralidharan Sargurupremraj, Hideaki Suzuki, Xueqiu Jian, Chloé Sarnowski, Tavia E. Evans, Joshua C. Bis, Gudny Eiriksdottir, Saori Sakaue, Natalie Terzikhan, Mohamad Habes, Wei Zhao, Nicola J. Armstrong, Edith Hofer, Lisa R. Yanek, Saskia P. Hagenaars, Rajan B. Kumar, Erik B. van den Akker, Rebekah E. McWhirter, Stella Trompet, Aniket Mishra, Yasaman Saba, Claudia L. Satizabal, Gregory Beaudet,
Publié dans: Nature Communications, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-19111-2

Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised trials

Auteurs: Prof Rustam Al-Shahi Salman PhD, Jacqueline Stephen PhD, Prof Jayne F Tierney PhD, Prof Steff C Lewis PhD , Prof David E Newby MD, Adrian R Parry-Jones PhD, Prof Philip M White MD, Prof Stuart J Connolly MD, Prof Oscar R Benavente MD, Dar Dowlatshahi PhD, Prof Charlotte Cordonnier PhD, Catherine M Viscoli MD, Prof Kevin N Sheth MD, Prof Hooman Kamel MD, Prof Roland Veltkamp MD, Kristin T Larsen MD
Publié dans: The Lancet Neurology, 2023, ISSN 1474-4422
Éditeur: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(23)00315-0

Effectiveness and Safety of Antithrombotic Medication in Patients With Atrial Fibrillation and Intracranial Hemorrhage: Systematic Review and Meta-Analysis

Auteurs: Elena Ivany, Leona A. Ritchie, Gregory Y.H. Lip, Robyn R. Lotto, David J. Werring and Deirdre A. Lane
Publié dans: Stroke, 2022, ISSN 1524-4628
Éditeur: AHA Journals
DOI: 10.1161/strokeaha.122.038752

Time course of neuroinflammation after human stroke – a pilot study using co-registered PET and MRI

Auteurs: Lucio D’Anna, Graham Searle, Kirsten Harvey, Paul M. Matthews & Roland Veltkamp
Publié dans: BMC Neurology, 2023, ISSN 1471-2377
Éditeur: BioMed Central
DOI: 10.1186/s12883-023-03178-7

Burden of Stroke in Europe

Auteurs: Hatem A. Wafa, Charles D.A. Wolfe, Eva Emmett, Gregory A. Roth, Catherine O. Johnson, Yanzhong Wang
Publié dans: Stroke, Numéro 51/8, 2020, Page(s) 2418-2427, ISSN 0039-2499
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.120.029606

In‐Hospital ECG Findings, Changes in Medical Management, and Cardiovascular Outcomes in Patients With Acute Stroke or Transient Ischemic Attack

Auteurs: Manuel C. Olma, Serdar Tütüncü, Cornelia Fiessler, Claudia Kunze, Michael Krämer, Lena Steindorf‐Sabath, Muhammad Jawad‐Ul‐Qamar, Paulus Kirchhof, Ulrich Laufs, Johannes Schurig, Peter Kraft, Joachim Röther, Albrecht Günther, Götz Thomalla, Boris Dimitrijeski, Darius G. Nabavi, Roland Veltkamp, Peter U. Heuschmann, Karl Georg Haeusler and Matthias Endres
Publié dans: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023, ISSN 2047-9980
Éditeur: Wiley-Blackwell
DOI: 10.1161/jaha.122.027149

Managing Uncertainty: Physicians' Decision Making for Stroke Prevention for Patients with Atrial Fibrillation and Intracerebral Hemorrhage

Auteurs: Elena Ivany, Robyn R Lotto, Gregory Y H Lip, Deirdre A Lane
Publié dans: Thrombosis and Haemostasis, 2022, ISSN 0340-6245
Éditeur: Schattauer
DOI: 10.1055/a-1789-4824

Association of stroke lesion shape with newly detected atrial fibrillation – Results from the MonDAFIS study

Auteurs: Bernardo Crespo Pimentel, Thies Ingwersen, Karl Georg Haeusler, Eckhard Schlemm, Nils D Forkert, Deepthi Rajashekar, Pauline Mouches, Alina Königsberg, Paulus Kirchhof, Claudia Kunze, Serdar Tütüncü, Manuel C Olma, Michael Krämer, Dominik Michalski, Andrea Kraft, Timolaos Rizos, Torsten Helberg, Sven Ehrlich, Darius G Nabavi, Joachim Röther, Ulrich Laufs, Roland Veltkamp, Peter U Heuschmann,
Publié dans: European Stroke Journal, 2022, ISSN 2396-9873
Éditeur: European Stroke Organisation
DOI: 10.1177/23969873221100895

Drug–Drug Interactions with Direct Oral Anticoagulants

Auteurs: Kathrin I. Foerster, Simon Hermann, Gerd Mikus, Walter E. Haefeli
Publié dans: Clinical Pharmacokinetics, Numéro 59/8, 2020, Page(s) 967-980, ISSN 0312-5963
Éditeur: Adis International Ltd.
DOI: 10.1007/s40262-020-00879-x

Extent of white matter lesion is associated with early hemorrhagic transformation in acute ischemic stroke related to atrial fibrillation

Auteurs: Lucio D'Anna, Filippos T. Filippidis, Kirsten Harvey, Marilena Marinescu, Paul Bentley, Eleni Korompoki, Roland Veltkamp
Publié dans: Brain and Behaviour, 2021, ISSN 2162-3279
Éditeur: Wiley Open Access
DOI: 10.1002/brb3.2250

Stroke Genetics: Discovery, Insight Into Mechanisms, and Clinical Perspectives

Auteurs: Stéphanie Debette and Hugh S. Markus
Publié dans: Circulation Research, 2022, ISSN 0009-7330
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.122.319950

Early initiation of direct anticoagulation after stroke in patients with atrial fibrillation

Auteurs: L. D'Anna, F. T. Filippidis, S. Antony, Z. Brown, H. Wyatt, A. Malik, P. Sivakumaran, K. Harvey, M. Marinescu, P. Bentley, E. Korompoki, R. Veltkamp
Publié dans: European Journal of Neurology, Numéro 27/11, 2020, Page(s) 2168-2175, ISSN 1351-5101
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/ene.14396

Risk of Cerebrovascular Events in Intracerebral Hemorrhage Survivors With Atrial Fibrillation: A Nationwide Cohort Study

Auteurs: Peter Brønnum Nielsen, Line Melgaard, Thure Filskov Overvad, Martin Jensen, Torben Bjerregaard Larsen, Gregory Y.H. Lip
Publié dans: Stroke, 2022, ISSN 1524-4628
Éditeur: American Heart Association
DOI: 10.1161/strokeaha.121.038331

Independent external validation of a stroke recurrence score in patients with embolic stroke of undetermined source

Auteurs: Thies Ingwersen, Manuel C. Olma, Eckhard Schlemm, Carola Mayer, Bastian Cheng, Serdar Tütüncü, Paulus Kirchhof, Roland Veltkamp, Joachim Röther, Ulrich Laufs, Darius G. Nabavi, George Ntaios, Matthias Endres, Karl Georg Haeusler & Götz Thomalla
Publié dans: Neurological Research and Practice, 2023, ISSN 2524-3489
Éditeur: BioMed Central Limited
DOI: 10.1186/s42466-023-00279-z

Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease

Auteurs: Marie-Gabrielle Duperron, Maria J. Knol, Quentin Le Grand, Tavia E. Evans, Aniket Mishra, Ami Tsuchida, Gennady Roshchupkin, Takahiro Konuma, David-Alexandre Trégouët, Jose Rafael Romero, Stefan Frenzel, Michelle Luciano, Edith Hofer, Mathieu Bourgey, Nicole D. Dueker, Pilar Delgado, Saima Hilal, Rick M. Tankard, Florian Dubost, Jean Shin, Yasaman Saba, Nicola J. Armstrong, Constance Bordes, Mar
Publié dans: Nature Medicine, 2023, ISSN 1078-8956
Éditeur: Nature Publishing Group
DOI: 10.1038/s41591-023-02268-w

Genetics of common cerebral small vessel disease

Auteurs: Constance Bordes, Muralidharan Sargurupremraj, Aniket Mishra, Stéphanie Debette
Publié dans: Nature reviews neurology, 2022, ISSN 1759-4766
Éditeur: Springer Nature
DOI: 10.1038/s41582-021-00592-8

Genomic Studies Across the Lifespan Point to Early Mechanisms Determining Subcortical Volumes

Auteurs: Quentin Le Grand, Claudia L. Satizabal, Muralidharan Sargurupremraj, Aniket Mishra, Aicha Soumaré, Alexandre Laurent, Fabrice Crivello, Ami Tsuchida, Jean Shin, Mélissa Macalli, Baljeet Singh, Alexa S. Beiser, Charles DeCarli, Evan Fletcher, Tomas Paus, Mark Lathrop, Hieab H.H. Adams, Joshua C. Bis, Sudha Seshadri, Christophe Tzourio, Bernard Mazoyer, Stéphanie Debette
Publié dans: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2021, ISSN 2451-9022
Éditeur: Elsevier Ltd
DOI: 10.1016/j.bpsc.2021.10.011

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