Optimizing response to Li treatment through personalized evaluation of individuals with bipolar I disorder: the R-LiNK initiative

Project Information

R-LiNK

Grant agreement ID: 754907

DOI 10.3030/754907

Project closed

EC signature date 21 November 2017

Start date 1 January 2018

End date 30 June 2024

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 7 913 612,25

EU contribution € 7 702 532,25

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (6)

7Li MRI and primary outcome

7Li MRI and primary outcome : Manuscripts suitable for dissemination and presentation outlining the relationship between brain Li distribution and treatment response.

Report on status of posting results

Report on the status of posting results in the study registry/ies (including timelines when final posting of results is scheduled after end of funding period).

7Li MRI descriptive analysis

7Li MRI descriptive analysis : Manuscripts suitable for dissemination and presentation outlining the relationship between brain Li and baseline subject characteristics.

"Report on the ""enhanced adherence program"""

Report on (i) the feasibility and acceptability (patients view and clinicians view) of the “enhanced adherence program”, (ii) the global adherence of the recruited sample to be prepared once the follow-up evaluations are completed

Cost-effectiveness report

Based on the different predictive values of the different tests (biological (WP6), neuroimaging (WP4, WP5), multimodal (WP7)), KCL (P12) will simulate the added values in terms of cost-effectiveness of the implementation of these tests in the clinical practice.

Qualitative report Studies on acceptability-feasibility of the Lithium self-monitoring device (ALCYM, P10) and its potential to be transferred to bedside

P10 (Alcym) will report on the main characteristics of the Lithium self-monitoring device, its acceptability-feasibility and exploitation plan

Publications

Peer reviewed articles (13)

Anxiety and depression played a central role in the COVID-19 mental distress: A network analysis

Author(s): Fico G
Published in: Journal Of Affective Disorders, 2019, Page(s) 384-392, ISSN 0165-0327
Publisher: Elsevier BV
DOI: 10.1016/j.jad.2023.06.034

Can an Integrated Science Approach to Precision Medicine Research Improve Lithium Treatment in Bipolar Disorders?

Author(s): Jan Scott, Bruno Etain, Frank Bellivier
Published in: Frontiers in Psychiatry, Issue 9, 2018, ISSN 1664-0640
Publisher: Frontiers Research Foundation
DOI: 10.3389/fpsyt.2018.00360

Duration of untreated illness and bipolar disorder: time for a new definition? Results from a cross-sectional study

Author(s): Fico G
Published in: Journal Of Affective Disorders, 2017, Page(s) 513-520, ISSN 0165-0327
Publisher: Elsevier BV
DOI: 10.1016/j.jad.2021.07.062

Accumulation of Lithium in the Hippocampus of Patients With Bipolar Disorder: A Lithium-7 Magnetic Resonance Imaging Study at 7 Tesla

Author(s): Jacques Stout, Franz Hozer, Arthur Coste, Franck Mauconduit, Nouzha Djebrani-Oussedik, Samuel Sarrazin, Joel Poupon, Manon Meyrel, Sandro Romanzetti, Bruno Etain, Cécile Rabrait-Lerman, Josselin Houenou, Frank Bellivier, Edouard Duchesnay, Fawzi Boumezbeur
Published in: Biological Psychiatry, Issue 88/5, 2020, Page(s) 426-433, ISSN 0006-3223
Publisher: Elsevier BV
DOI: 10.1016/j.biopsych.2020.02.1181

Patterns of pharmacotherapy for bipolar disorder: A GBC survey

Author(s): Singh B
Published in: Bipolar Disorders, Issue 22-32, 2019, ISSN 1398-5647
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/bdi.13366

Long‐term treatment of bipolar disorder type I: A systematic and critical review of clinical guidelines with derived practice algorithms

Author(s): Norma Verdolini, Diego Hidalgo‐Mazzei, Laura Del Matto, Michele Muscas, Isabella Pacchiarotti, Andrea Murru, Ludovic Samalin, Alberto Aedo, Mauricio Tohen, Heinz Grunze, Allan H. Young, André F. Carvalho, Eduard Vieta
Published in: Bipolar Disorders, 2020, ISSN 1398-5647
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/bdi.13040

Exploring the potential of representation and transfer learning for anatomical neuroimaging: Application to psychiatry

Author(s): Dufumier, B.
Published in: NeuroImage, 2023, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2024.120665

Correlation between emotion dysregulation and mood symptoms of bipolar disorder: A systematic review and meta-analysis

Author(s): Oliva V
Published in: Acta Psychiatrica Scandinavica, 2019, Page(s) 472-490, ISSN 0001-690X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/acps.13618

Make lithium great again – Precisely!

Author(s): Frank Bellivier, Allan H. Young, Jan Scott, Bruno Etain, David A. Cousins
Published in: Bipolar Disorders, Issue 23/2, 2021, Page(s) 209-210, ISSN 1398-5647
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/bdi.13023

Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative

Author(s): Jan Scott, Diego Hidalgo-Mazzei, Rebecca Strawbridge, Allan Young, Matthieu Resche-Rigon, Bruno Etain, Ole A. Andreassen, Michael Bauer, Djamila Bennabi, Andrew M. Blamire, Fawzi Boumezbeur, Paolo Brambilla, Nadia Cattane, Annamaria Cattaneo, Marie Chupin, Klara Coello, Yann Cointepas, Francesc Colom, David A. Cousins, Caroline Dubertret, Edouard Duchesnay, Adele Ferro, Aitana Garcia-Estela, Jose
Published in: International Journal of Bipolar Disorders, Issue 7/1, 2019, ISSN 2194-7511
Publisher: SpringerOpen
DOI: 10.1186/s40345-019-0156-x

Separating common from salient patterns with Contrastive Representation Learning

Author(s): Robin Louiset
Published in: HAL Telecom Paris, 2024, ISSN 2374-3468
Publisher: HAL Telecom Paris
DOI: 10.48550/arXiv.2402.11928

An evidence map of actigraphy studies exploring longitudinal associations between rest-activity rhythms and course and outcome of bipolar disorders

Author(s): Jan Scott, Francesc Colom, Allan Young, Frank Bellivier, Bruno Etain
Published in: International Journal of Bipolar Disorders, Issue 8/1, 2020, ISSN 2194-7511
Publisher: SpringerOpen
DOI: 10.1186/s40345-020-00200-6

Is Usability Engineering Anticipation Possible during the Initial Research Actions? An Example with the R-Link in Vitro Self-monitoring Device

Author(s): K. Charrière, C. Azzopardi, S. Pelayo, M. Nicolier, T. Lihoreau, F. Bellivier, E. Haffen and B. Wacogne
Published in: Proceedings of the 15th International Joint Conference on Biomedical Engineering Systems and Technologies - ClinMed, 2022, ISSN 2184-4356
Publisher: SCITEPRESS - Science and Technology Publications
DOI: 10.5220/0010971600003123

Conference proceedings (2)

Functional Analysis to Drive Research and Identify Regulation Requirements: An Example with a Lithium Monitoring Device

Author(s): K. Charrière, C. Azzopardi, M. Nicolier, T. Lihoreau, F. Bellivier, E. Haffen, B. Wacogne
Published in: Proceedings of the 14th International Joint Conference on Biomedical Engineering Systems and Technologies, 2021, Page(s) 300-307, ISBN 978-989-758-490-9
Publisher: SCITEPRESS - Science and Technology Publications
DOI: 10.5220/0010382503000307

Calibration Free and Fluorescein Based Fiber Optic pH Sensor for Clinical Applications

Author(s): Bernard Gauthier-Manuel, Rutjaphan Kateklum, Bruno Wacogne
Published in: 2018 IEEE SENSORS, 2018, Page(s) 1-4, ISBN 978-1-5386-4707-3
Publisher: IEEE
DOI: 10.1109/icsens.2018.8630296

Non-peer reviewed articles (1)

Lithium: past, present, and future

Author(s): David A Cousins, Letizia Squarcina, Fawzi Boumezbeur, Allan H Young, Frank Bellivier
Published in: The Lancet Psychiatry, Issue 7/3, 2020, Page(s) 222-224, ISSN 2215-0366
Publisher: Elsevier Limited
DOI: 10.1016/s2215-0366(19)30365-7