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A rapid, non-invasive, cost-effective, analytical device for bacterial or viral infection diagnosis through ultra-high sensitivity breath analysis.

Objective

The world faces a growing epidemic of antimicrobial resistance (AMR); however, only two new classes of antibiotics have been brought to the market in the last 30 years. The discovery and development of new antibiotics is essential to maintain medical advances but poses significant scientific, clinical, and financial challenges, particularly for antibiotics active against Gram-negative bacteria (such as E. coli). Such bacteria have effective barriers against drugs, making treatment difficult, resistance likely and development costs and risks high. In addition, any new antibiotics brought to the market would likely be used cautiously to delay the development of resistance, adding an additional financial challenge in recouping the development costs. The O’Neill Report on AMR identifies diagnostics as critical to the battle against antibiotic resistance.

This innovation action, BreathSpec, proposes a viable solution to the global problem of AMR through the final developmental stages of an existing diagnostic device, which will allow a rapid, binary decision to be made on the need for antibiotic treatment, and which with suitable optimisation will allow further differentiation and stratification to take place. The Innovation Action includes technical developments to optimise its function, data acquisition for the development of the decision making analytical function and clinical validation.

It addresses these issues by producing reliable identification and quantification of key signature volatiles present in exhaled breath. It provides a non-invasive method for monitoring the volatile organic compounds present in an individual’s exhaled breath (and subsequently the blood) and has long been recognised as having significant utility as a clinical test that can be used for early disease detection and monitoring, and potentially to diagnose specific bacterial infections for better, more targeted use of existing antibiotics.

Call for proposal

H2020-FTIPilot-2016

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Sub call

H2020-FTIPilot-2016-1

Coordinator

IMSPEX DIAGNOSTICS LIMITED
Net EU contribution
€ 1 141 700,00
Address
Ty Menter, Navigation Park, Rct
CF45 4SN Abercynon
United Kingdom

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Region
Wales West Wales and The Valleys Central Valleys
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 489 800,00

Participants (4)

G.A.S. GESELLSCHAFT FUR ANALYTISCHESENSORSYSTEME M.B.H.
Germany
Net EU contribution
€ 507 150,00
Address
Otto Hahn Strasse 15
44227 Dortmund

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nordrhein-Westfalen Arnsberg Dortmund, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 217 350,00
STATISTICAMEDICA LIMITED
Ireland
Net EU contribution
€ 462 087,50
Address
26 Belarmine Court Enniskerry Road Stepaside
D18 Dublin

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ireland Eastern and Midland Dublin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 198 537,50
REDKNIGHT CONSULTANCY LTD
United Kingdom
Net EU contribution
€ 116 287,50
Address
21 The Dairy
CF728TT Pontyclun

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Wales West Wales and The Valleys Central Valleys
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 49 837,50
THE UNIVERSITY OF WARWICK
United Kingdom
Net EU contribution
€ 140 422,50
Address
Kirby Corner Road - University House
CV4 8UW Coventry

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Region
West Midlands (England) West Midlands Coventry
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00