Armoring multifunctional T cells for cancer therapy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Therapeutic Strategies for Targeting IL-1 in Cancer.

Author(s): Adrian Gottschlich; Stefan Endres; Sebastian Kobold
Published in: Cancers, Issue 6, 2021, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13030477

In vivo dynamics and anti-tumor effects of EpCAM-directed CAR T-cells against brain metastases from lung cancer

Author(s): Xu T, Karschnia P, Cadilha BL, Dede S, Lorenz M, Seewaldt N, Nikolaishvili E, Müller K, Blobner J, Teske N, Herold JJ, Rejeski K, Langer S, Obeck H, Lorenzini T, Mulazzani M, Zhang W, Ishikawa-Ankerhold H, Buchholz VR, Subklewe M, Thon N, Straube A, Tonn JC, Kobold S, von Baumgarten L.
Published in: Oncoimmunology, 2023, ISSN 2162-4011
Publisher: Landes Bioscience
DOI: 10.1080/2162402x.2022.2163781

9th Immunotherapy of Cancer conference (ITOC): A meeting report

Author(s): Dalloul I, Strzalkowski TJC, von Bergwelt-Baildon M, Nüssler V, Zielinski C, Kobold S.
Published in: Human Vaccines & Immunotherapeutics, 2022, ISSN 2164-5515
Publisher: Landes Bioscience
DOI: 10.1080/21645515.2022.2159706

Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors.

Author(s): Bruno L. Cadilha; M. Benmebarek; Klara Dorman; A Öner; Theo Lorenzini; Hannah Obeck; Mira Vänttinen; Mauro Di Pilato; Mauro Di Pilato; Jasper N. Pruessmann; Jasper N. Pruessmann; S Stoiber; Duc Huynh; Florian Märkl; Matthias Seifert; Katrin Manske; Javier Suarez-Gosalvez; Yi Zeng; Stefanie Lesch; C. Karches; Constanze Heise; Adrian Gottschlich; Moritz Thomas; Carsten Marr; Jin Zhang; Dharmendra
Published in: Science Advances, Issue 10, 2021, ISSN 2375-2548
Publisher: American Association for the Advancement of Science's
DOI: 10.1126/sciadv.abi5781

Augmenting anti-CD19 and anti-CD22 CAR T-cell function using PD-1-CD28 checkpoint fusion proteins

Author(s): Franziska Blaeschke,1 Dana Stenger,1,2 Antonia Apfelbeck,1 Bruno L. Cadilha,3 Mohamed-Reda Benmebarek,3 Jasmin Mahdawi,1 Eva Ortner,1 Mareike Lepenies,1 Nicola Habjan,1 Felicitas Rataj,3 Semjon Willier,1 Theresa Kaeuferle,1,4 Robbie G. Majzner,5,6 Dirk H. Busch,4,7,8 Sebastian Kobold,2,3 and Tobias Feuchtinger
Published in: Blood Cancer Journal, 2021, ISSN 2044-5385
Publisher: Nature Publishing Group
DOI: 10.1038/s41408-021-00499-z

Chimeric Antigen Receptor–Modified T Cells and T Cell–Engaging Bispecific Antibodies: Different Tools for the Same Job

Author(s): Melanie Schwerdtfeger,1,2 Mohamed-Reda Benmebarek,1 Stefan Endres,1,3,4 Marion Subklewe,5 Vincenzo Desiderio,2 and Sebastian Koboldcorresponding author1,3,4
Published in: Current Hematological Malignancy Reports, 2021, ISSN 1558-8211
Publisher: Springer Verlag
DOI: 10.1007/s11899-021-00628-2

Bispecific antibodies redirect synthetic agonistic receptor modified T cells against melanoma.

Author(s): Märkl F, Benmebarek MR, Keyl J, Cadilha BL, Geiger M, Karches C, Obeck H, Schwerdtfeger M, Michaelides S, Briukhovetska D, Stock S, Jobst J, Müller PJ, Majed L, Seifert M, Klüver AK, Lorenzini T, Grünmeier R, Thomas M, Gottschlich A, Klaus R, Marr C, von Bergwelt-Baildon M, Rothenfusser S, Levesque MP, Heppt MV, Endres S, Klein C, Kobold S.
Published in: Journal for ImmunoTherapy of Cancer, 2023, ISSN 2051-1426
Publisher: BMJ publishes JITC on behalf of the Society for Immunotherapy of Cancer
DOI: 10.1136/jitc-2022-006436

PD-1-CD28 fusion protein strengthens mesothelin-specific TRuC T cells in preclinical solid tumor models.

Author(s): Lesch S, Nottebrock A, Rataj F, Heise C, Endres S, Kobold S.
Published in: Cell Oncol, 2023, ISSN 2211-3428
Publisher: Springer Verlag
DOI: 10.1007/s13402-022-00747-9

Beyond direct killing-novel cellular immunotherapeutic strategies to reshape the tumor microenvironment.

Author(s): Huynh D, Winter P, Märkl F, Endres S, Kobold S.
Published in: Seminars in Immunopathology, 2023, ISSN 1863-2297
Publisher: Springer Verlag
DOI: 10.1007/s00281-022-00962-4

High-affinity CD16-polymorphism and Fc-engineered antibodies enable activity of CD16-chimeric antigen receptor-modified T cells for cancer therapy

Author(s): Felicitas Rataj, Severin J. Jacobi, Stefan Stoiber, Florian Asang, Justyna Ogonek, Nicholas Tokarew, Bruno L. Cadilha, Erwin van Puijenbroek, Constanze Heise, Peter Duewell, Stefan Endres, Christian Klein, Sebastian Kobold
Published in: British Journal of Cancer, Issue 120/1, 2019, Page(s) 79-87, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-018-0341-1

Migratory Engineering of T Cells for Cancer Therapy

Author(s): Stefanos Michaelides, Hannah Obeck, Daryna Kechur, Stefan Endres and Sebastian Kobold
Published in: Vaccines, 2022, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines10111845

Functional enhancement of mesothelin-targeted TRuC-T cells by a PD1-CD28 chimeric switch receptor

Author(s): McCarthy D, Lofgren M, Watt A, Horton H, Kieffer-Kwon P, Ding J, Kobold S, Baeuerle PA, Hofmeister R, Gutierrez DA, Tighe R.
Published in: Cancer Immunology, Immunotherapy, 2023, ISSN 1432-0851
Publisher: Springer
DOI: 10.1007/s00262-023-03556-7

Programmable multispecific DNA-origami-based T-cell engagers

Author(s): Wagenbauer KF, Pham N, Gottschlich A, Kick B, Kozina V, Frank C, Trninic D, Stömmer P, Grünmeier R, Carlini E, Tsiverioti CA, Kobold S, Funke JJ, Dietz H.
Published in: Nature Nanotechnology, 2023, ISSN 1748-3387
Publisher: Nature Publishing Group
DOI: 10.1038/s41565-023-01471-7

Design and Evaluation of TIM-3-CD28 Checkpoint Fusion Proteins to Improve Anti-CD19 CAR T-Cell Function

Author(s): Franziska Blaeschke, 1 Eva Ortner, 1 Dana Stenger, 1 , 2 Jasmin Mahdawi, 1 Antonia Apfelbeck, 1 Nicola Habjan, 1 Tanja Weißer, 1 Theresa Kaeuferle, 1 , 3 Semjon Willier, 1 Sebastian Kobold, 2 , 4 and Tobias Feuchtinger
Published in: Frontiers in Immunology, 2022, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2022.845499

Enhanced Chimeric Antigen Receptor T Cell Therapy through Co-Application of Synergistic Combination Partners

Author(s): Sophia Stock,1,2,* Anna-Kristina Kluever,1 Stefan Endres,1,3,4 and Sebastian Kobold
Published in: Biomedicines, 2022, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines10020307

NK Cells Armed with Chimeric Antigen Receptors (CAR): Roadblocks to Successful Development

Author(s): Ali Bashiri Dezfouli; Mina Yazdi; Alan Graham Pockley; Mohammad Khosravi; Sebastian Kobold; Ernst Wagner; Gabriele Multhoff
Published in: Cells, Issue 1, 2021, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10123390

Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody

Author(s): Martina Geiger, Kay-Gunnar Stubenrauch, Johannes Sam, Wolfgang F. Richter, Gregor Jordan, Jan Eckmann, Carina Hage, Valeria Nicolini, Anne Freimoser-Grundschober, Mirko Ritter, Matthias E. Lauer, Henning Stahlberg, Philippe Ringler, Jigar Patel, Eric Sullivan, Sandra Grau-Richards, Stefan Endres, Sebastian Kobold, Pablo Umaña, Peter Brünker, Christian Klein
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-16838-w

ESCRT machinery: role of membrane repair mechanisms in escaping cell death

Author(s): "Lisa Gregor,#1 Sophia Stock,#1,2,3 and Sebastian Koboldcorresponding author"
Published in: Signal Transduction and Targeted Therapy, 2022, ISSN 2059-3635
Publisher: Springer Nature
DOI: 10.1038/s41392-022-01108-6

An In Vivo Inflammatory Loop Potentiates KRAS Blockade

Author(s): Kristina A. M. Arendt,1,2,† Giannoula Ntaliarda,3,† Vasileios Armenis,3 Danai Kati,3 Christin Henning,1,2 Georgia A. Giotopoulou,1,2,3 Mario A. A. Pepe,1,2 Laura V. Klotz,1,2 Anne-Sophie Lamort,1,2 Rudolf A. Hatz,2,4,5 Sebastian Kobold,2,6 Andrea C. Schamberger,1,2,*‡ and Georgios T. Stathopoulos
Published in: Biomedicines, 2022, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines10030592

Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia

Author(s): Gottschlich A, Thomas M, Grünmeier R, Lesch S, Rohrbacher L, Igl V, Briukhovetska D, Benmebarek MR, Vick B, Dede S, Müller K, Xu T, Dhoqina D, Märkl F, Robinson S, Sendelhofert A, Schulz H, Umut Ö, Kavaka V, Tsiverioti CA, Carlini E, Nandi S, Strzalkowski T, Lorenzini T, Stock S, Müller PJ, Dörr J, Seifert M, Cadilha BL, Brabenec R, Röder N, Rataj F, Nüesch M, Modemann F, Wellbrock J, Fied
Published in: Nature Biotechnology, 2023, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/s41587-023-01684-0

Broad T Cell Targeting of Structural Proteins After SARS-CoV-2 Infection: High Throughput Assessment of T Cell Reactivity Using an Automated Interferon Gamma Release Assay

Author(s): Isabel Brand, 1 , 2 , † Leonard Gilberg, 1 , 3 , † Jan Bruger, 1 , † Mercè Garí, 4 Andreas Wieser, 1 , 5 Tabea M. Eser, 1 , 5 Jonathan Frese, 1 Mohamed I. M. Ahmed, 1 , 5 Raquel Rubio-Acero, 1 Jessica M. Guggenbuehl Noller, 1 Noemi Castelletti, 1 Jana Diekmannshemke, 4 , 6 Sophie Thiesbrummel, 4 , 6 Duc Huynh, 2 Simon Winter, 1 Inge Kroidl, 1 , 5 Christiane Fuchs, 4 , 6 , 7 Michael Hoelsch
Published in: Frontiers in Immunology, 2021, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2021.688436

T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis

Author(s): Briukhovetska D, Suarez-Gosalvez J, Voigt C, Markota A, Giannou AD, Schübel M, Jobst J, Zhang T, Dörr J, Märkl F, Majed L, Müller PJ, May P, Gottschlich A, Tokarew N, Lücke J, Oner A, Schwerdtfeger M, Andreu-Sanz D, Grünmeier R, Seifert M, Michaelides S, Hristov M, König LM, Cadilha BL, Mikhaylov O, Anders HJ, Rothenfusser S, Flavell RA, Cerezo-Wallis D, Tejedo C, Soengas MS, Bald T, Huber
Published in: Immunity, 2023, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2022.12.010

Dual TLR9 and PD-L1 targeting unleashes dendritic cells to induce durable antitumor immunity.

Author(s): Fernandez-Rodriguez L, Cianciaruso C, Bill R, Trefny MP, Klar R, Kirchhammer N, Buchi M, Festag J, Michel S, Kohler RH, Jones E, Maaske A, Vom Berg J, Kobold S, Kashyap AS, Jaschinski F, Dixon KO, Pittet MJ, Zippelius A.
Published in: Journal for the Immunotherapy of Cancer, 2023, ISSN 2051-1426
Publisher: BMJ
DOI: 10.1136/jitc-2023-006714

Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer

Author(s): Uta M. Demel,1,2,3 Marlitt Böger,1,2 Schayan Yousefian,1,4,5 Corinna Grunert,1,2 Le Zhang,1,2 Paul W. Hotz,6 Adrian Gottschlich,7 Hazal Köse,1,2 Konstandina Isaakidis,1,2 Dominik Vonficht,8,9,10 Florian Grünschläger,8,9,10 Elena Rohleder,1,2 Kristina Wagner,6 Judith Dönig,6 Veronika Igl,7 Bernadette Brzezicha,11 Francis Baumgartner,1,2,3 Stefan Habringer,1,2,3 Jens Löber,12 Björn Chapuy,1,4
Published in: The Journal of Clinical Investigations, 2022, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci152383

Sixth Immunotherapy of Cancer conference (ITOC): advances and perspectives—a meeting report

Author(s): Catarina Pinto, Michael Bergmann, Daria Briukhovetska, Volkmar Nuessler, Mario Sznol, Michael von Bergwelt-Baildon, Sebastian Kobold
Published in: Journal for ImmunoTherapy of Cancer, Issue 8/1, 2019, Page(s) e000268, ISSN 2051-1426
Publisher: BMJ
DOI: 10.1136/jitc-2019-000268

Prognosis and tumor biology of pancreatic cancer patients with isolated lung metastases: translational results from the German multicenter AIO-YMO-PAK-0515 study

Author(s): S.F. Kruger,1,∗ A. Lohneis,2,3 A. Abendroth,4 A.W. Berger,5 T.J. Ettrich,5 O. Waidmann,6,7 M. Kapp,8 B. Steiner,9 J. Kumbrink,10 A. Reischer,1 M. Haas,1 C.B. Westphalen,1,11 D. Zhang,1 L. Miller-Phillips,1 P.J. Burger,1 S. Kobold,11,12 J. Werner,13 M. Subklewe,1,11 M. von Bergwelt-Baildon,1,11 V. Kunzmann,8 T. Seufferlein,5 J.T. Siveke,4 M. Sinn,2,14 V. Heinemann,1,11 S. Ormanns,10,11,† and S.
Published in: ESMO Open, 2022, ISSN 2059-7029
Publisher: ESMO
DOI: 10.1016/j.esmoop.2022.100388

Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming.

Author(s): Wu H, Zhao X, Hochrein SM, Eckstein M, Gubert GF, Knöpper K, Mansilla AM, Öner A, Doucet-Ladevèze R, Schmitz W, Ghesquière B, Theurich S, Dudek J, Gasteiger G, Zernecke A, Kobold S, Kastenmüller W, Vaeth M.
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-42634-3

Immunostimulatory RNA leads to functional reprogramming of myeloid-derived suppressor cells in pancreatic cancer

Author(s): Philipp Metzger, Sabrina V. Kirchleitner, Michael Kluge, Lars M. Koenig, Christine Hörth, Carlotta A. Rambuscheck, Daniel Böhmer, Julia Ahlfeld, Sebastian Kobold, Caroline C. Friedel, Stefan Endres, Max Schnurr, Peter Duewell
Published in: Journal for ImmunoTherapy of Cancer, Issue 7/1, 2019, ISSN 2051-1426
Publisher: BMJ
DOI: 10.1186/s40425-019-0778-7

Skin dendritic cells in melanoma are key for successful checkpoint blockade therapy

Author(s): Anastasia Prokopi,1 Christoph H Tripp,1 Bart Tummers,2 Florian Hornsteiner,1 Sarah Spoeck,1 Jeremy Chase Crawford,2 Derek R Clements,3 Mirjana Efremova,4 Katharina Hutter,1 Lydia Bellmann,1 Giuseppe Cappellano,1 Bruno L Cadilha,5,6 Sebastian Kobold,5,6,7 Louis Boon,8 Daniela Ortner,1 Zlatko Trajanoski,4 Suzie Chen,9 Tanja D de Gruijl,10 Juliana Idoyaga,3 Douglas R Green,2 and Patrizia Stoitzner
Published in: Journal for the Immunotherapy of Cancer, 2021, ISSN 2051-1426
Publisher: BMJ
DOI: 10.1136/jitc-2020-000832

Interleukin-37 Inhibits Colon Carcinogensis During Chronic Colitis

Author(s): Steffeni Mountford, Andrea Ringleb, Rahel Schwaiger, Doris Mayr, Sebastian Kobold, Charles A. Dinarello, Philip Bufler
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2019.02632

Mutation-specific CAR T cells as precision therapy for IGLV3-21R110 expressing high-risk chronic lymphocytic leukemia

Author(s): Märkl F, Schultheiß C, Ali M, Chen SS, Zintchenko M, Egli L, Mietz J, Chijioke O, Paschold L, Spajic S, Holtermann A, Dörr J, Stock S, Zingg A, Läubli H, Piseddu I, Anz D, Minden MD, Zhang T, Nerreter T, Hudecek M, Minguet S, Chiorazzi N, Kobold S, Binder M.
Published in: Nature Communications, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-45378-w

T cells armed with the C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours

Author(s): "Stefanie Lesch,#1 Viktoria Blumenberg,#1,2 Stefan Stoiber,1 Adrian Gottschlich,1 Justyna Ogonek,1 Bruno L. Cadilha,1 Zahra Dantes,3 Felicitas Rataj,1 Klara Dorman,1 Johannes Lutz,1 Clara H. Karches,1 Constanze Heise,1 Mathias Kurzay,1 Benjamin M. Larimer,4 Simon Grassmann,1 Moritz Rapp,1 Alessia Nottebrock,1 Stephan Kruger,1,2 Nicholas Tokarew,1 Philipp Metzger,1 Christine Hoerth,1 Mohamed-Reda Be"
Published in: Nature Biomedical Engineering, 2021, ISSN 2157-846X
Publisher: Springer-Nature
DOI: 10.1038/s41551-021-00737-6

Utility and Drawbacks of Chimeric Antigen Receptor T Cell (CAR-T) Therapy in Lung Cancer

Author(s): Prameela Kandra, 1 , † Rajender Nandigama, 2 , † Bastian Eul, 3 Magdalena Huber, 4 Sebastian Kobold, 5 , 6 Werner Seeger, 2 , 3 , 7 Friedrich Grimminger, 3 , 7 and Rajkumar Savaicorresponding author
Published in: Frontiers in Immunolgoy, 2022, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2022.903562

Role and Potential of Different T Helper Cell Subsets in Adoptive Cell Therapy

Author(s): Andreu-Sanz D, Kobold S.
Published in: Cancers (Basel), 2023, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15061650

Correction to: CD33 BiTE® molecule-mediated immune synapse formation and subsequent T-cell activation is determined by the expression profile of activating and inhibitory checkpoint molecules on AML cells.

Author(s): Marcinek A, Brauchle B, Rohrbacher L, Hänel G, Philipp N, Märkl F, Strzalkowski T, Lacher SM, Udiljak D, Spiekermann K, Theurich S, Kobold S, Kischel R, James JR, Bücklein VL, Subklewe M.
Published in: Cancer Immunology, Immunotherapy, 2023, ISSN 1432-0851
Publisher: Springer
DOI: 10.1007/s00262-023-03457-9

CXCR6 Positions Cytotoxic T Cells to Receive Critical Survival Signals in the Tumor Microenvironment

Author(s): Mauro Di Pilato,1,2,3,12 Raphael Kfuri-Rubens,1,4,12 Jasper N. Pruessmann,1,2,12 Aleksandra J. Ozga,1,2,12 Marius Messemaker,5 Bruno L. Cadilha,4 Ramya Sivakumar,6 Chiara Cianciaruso,2,5 Ross D. Warner,1 Francesco Marangoni,1,2 Esteban Carrizosa,1,2 Stefanie Lesch,4 James Billingsley,7 Daniel Perez-Ramos,8 Fidel Zavala,8 Esther Rheinbay,9 Andrew D. Luster,1,2 Michael Y. Gerner,6 Sebastian Kobold,4
Published in: Cell, 2021, ISSN 1097-4172
Publisher: Cell Press
DOI: 10.1016/j.cell.2021.07.015

Defective Interfering Genomes and the Full-Length Viral Genome Trigger RIG-I After Infection With Vesicular Stomatitis Virus in a Replication Dependent Manner

Author(s): Andreas Linder, 1 , 2 Viktoria Bothe, 1 Nicolas Linder, 1 Paul Schwarzlmueller, 1 Frank Dahlström, 1 Christoph Bartenhagen, 3 Martin Dugas, 3 Dharmendra Pandey, 1 Julia Thorn-Seshold, 1 , 4 Daniel F. R. Boehmer, 1 Lars M. Koenig, 1 Sebastian Kobold, 1 , 5 Max Schnurr, 1 Johannes Raedler, 1 Giulia Spielmann, 1 Hadi Karimzadeh, 1 , 4 Andreas Schmidt, 1 Stefan Endres, 1 , 4 and Simon Rothenfusser
Published in: Frontiers in Immunology, 2021, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2021.595390

Microphthalmia-Associated Transcription Factor (MITF) Regulates Immune Cell Migration into Melanoma

Author(s): Gabriela M Wiedemann, Celina Aithal, Angelina Kraechan, Constanze Heise, Bruno L Cadilha, Jin Zhang, Peter Duewell, Robert Ballotti, Stefan Endres, Corine Bertolotto, Sebastian Kobold
Published in: Translational Oncology, Issue 12/2, 2019, Page(s) 350-360, ISSN 1936-5233
Publisher: Neoplasia Press
DOI: 10.1016/j.tranon.2018.10.014

Innate and adaptive immunity combined for cancer treatment

Author(s): Sebastian Kobold
Published in: Proceedings of the National Academy of Sciences, Issue 116/4, 2019, Page(s) 1087-1088, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1820166116

Cancer cells induce interleukin-22 production from memory CD4 + T cells via interleukin-1 to promote tumor growth

Author(s): Cornelia Voigt, Peter May, Adrian Gottschlich, Anamarija Markota, Daniel Wenk, Inga Gerlach, Sebastian Voigt, Georgios T. Stathopoulos, Kristina A. M. Arendt, Constanze Heise, Felicitas Rataj, Klaus-Peter Janssen, Melanie Königshoff, Hauke Winter, Isabelle Himsl, Wolfgang E. Thasler, Max Schnurr, Simon Rothenfußer, Stefan Endres, Sebastian Kobold
Published in: Proceedings of the National Academy of Sciences, Issue 114/49, 2017, Page(s) 12994-12999, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1705165114

Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells

Author(s): Mohamed-Reda Benmebarek, Clara Karches, Bruno Cadilha, Stefanie Lesch, Stefan Endres, Sebastian Kobold
Published in: International Journal of Molecular Sciences, Issue 20/6, 2019, Page(s) 1283, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20061283

Targeting interleukin-22 for cancer therapy

Author(s): Anamarija Markota, Stefan Endres, Sebastian Kobold
Published in: Human Vaccines & Immunotherapeutics, Issue 14/8, 2018, Page(s) 2012-2015, ISSN 2164-5515
Publisher: Landes Bioscience
DOI: 10.1080/21645515.2018.1461300

PD1-CD28 Fusion Protein Enables CD4+ T Cell Help for Adoptive T Cell Therapy in Models of Pancreatic Cancer and Non-hodgkin Lymphoma

Author(s): Felicitas Rataj, Fabian B. T. Kraus, Michael Chaloupka, Simon Grassmann, Constanze Heise, Bruno L. Cadilha, Peter Duewell, Stefan Endres, Sebastian Kobold
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2018.01955

Limitations in the Design of Chimeric Antigen Receptors for Cancer Therapy

Author(s): Stefan Stoiber, Bruno L. Cadilha, Mohamed-Reda Benmebarek, Stefanie Lesch, Stefan Endres, Sebastian Kobold
Published in: Cells, Issue 8/5, 2019, Page(s) 472, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells8050472

Bispecific Antibodies Enable Synthetic Agonistic Receptor-Transduced T Cells for Tumor Immunotherapy

Author(s): Clara H. Karches, Mohamed-Reda Benmebarek, Moritz L. Schmidbauer, Mathias Kurzay, Richard Klaus, Martina Geiger, Felicitas Rataj, Bruno L. Cadilha, Stefanie Lesch, Constanze Heise, Ramona Murr, Johannes vom Berg, Martin Jastroch, Daniel Lamp, Jian Ding, Peter Duewell, Gerhard Niederfellner, Claudio Sustmann, Stefan Endres, Christian Klein, Sebastian Kobold
Published in: Clinical Cancer Research, Issue 25/19, 2019, Page(s) 5890-5900, ISSN 1078-0432
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-18-3927

Advances in cancer immunotherapy 2019 – latest trends

Author(s): Stephan Kruger, Matthias Ilmer, Sebastian Kobold, Bruno L. Cadilha, Stefan Endres, Steffen Ormanns, Gesa Schuebbe, Bernhard W. Renz, Jan G. D’Haese, Hans Schloesser, Volker Heinemann, Marion Subklewe, Stefan Boeck, Jens Werner, Michael von Bergwelt-Baildon
Published in: Journal of Experimental & Clinical Cancer Research, Issue 38/1, 2019, ISSN 1756-9966
Publisher: MDPI
DOI: 10.1186/s13046-019-1266-0

Epithelial-type systemic breast carcinoma cells with a restricted mesenchymal transition are a major source of metastasis

Author(s): Xiao Liu, Junjian Li, Bruno Loureiro Cadilha, Anamarija Markota, Cornelia Voigt, Zhe Huang, Peter P. Lin, Daisy D. Wang, Juncheng Dai, Gisela Kranz, Anna Krandick, Darko Libl, Horst Zitzelsberger, Isabella Zagorski, Herbert Braselmann, Min Pan, Sibo Zhu, Yuanchi Huang, Sebastian Niedermeyer, Christoph A. Reichel, Bernd Uhl, Daria Briukhovetska, Javier Suárez, Sebastian Kobold, Olivier Gires, Hong
Published in: Science Advances, Issue 5/6, 2019, Page(s) eaav4275, ISSN 2375-2548
Publisher: Science
DOI: 10.1126/sciadv.aav4275

Combining the best of two worlds: highly flexible chimeric antigen receptor adaptor molecules (CAR-adaptors) for the recruitment of chimeric antigen receptor T cells

Author(s): Diana Darowski, Sebastian Kobold, Christian Jost, Christian Klein
Published in: mAbs, Issue 11/4, 2019, Page(s) 621-631, ISSN 1942-0870
Publisher: Landes Bioscience
DOI: 10.1080/19420862.2019.1596511

A modular and controllable T cell therapy platform for acute myeloid leukemia

Author(s): "Mohamed-Reda Benmebarek,#1 Bruno L. Cadilha,#1 Monika Herrmann,2 Stefanie Lesch,1 Saskia Schmitt,2 Stefan Stoiber,1 Abbass Darwich,3 Christian Augsberger,2 Bettina Brauchle,2,4 Lisa Rohrbacher,2,4 Arman Oner,1 Matthias Seifert,1 Melanie Schwerdtfeger,1 Adrian Gottschlich,1 Felicitas Rataj,1 Nadja C. Fenn,2 Christian Klein,5 Marion Subklewe,2,4,6 Stefan Endres,1,6,7 Karl-Peter Hopfner,8 and Sebasti"
Published in: Leukemia, 2021, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-020-01109-w

Chimeric antigen receptor T cells engineered to recognize the P329G-mutated Fc part of effector-silenced tumor antigen-targeting human IgG1 antibodies enable modular targeting of solid tumors

Author(s): "Sophia Stock,corresponding author#1,2,3 Mohamed-Reda Benmebarek,#1,4 Anna-Kristina Kluever,1 Diana Darowski,5,6 Christian Jost,5,7 Kay-Gunnar Stubenrauch,8 Joerg Benz,9 Anne Freimoser-Grundschober,5 Ekkehard Moessner,5 Pablo Umana,5 Marion Subklewe,2,3 Stefan Endres,1,3,10 Christian Klein,corresponding author5 and Sebastian Koboldcorresponding author"
Published in: Journal for the Immunotherapy of Cancer, 2022, ISSN 2051-1426
Publisher: BMJ
DOI: 10.1136/jitc-2022-005054

Rationale for Combining Bispecific T Cell Activating Antibodies With Checkpoint Blockade for Cancer Therapy

Author(s): Sebastian Kobold, Stanislav Pantelyushin, Felicitas Rataj, Johannes vom Berg
Published in: Frontiers in Oncology, Issue 8, 2018, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2018.00285

CD33 BiTE® molecule-mediated immune synapse formation and subsequent T-cell activation is determined by the expression profile of activating and inhibitory checkpoint molecules on AML cells.

CAR T Cells Targeting Membrane-Bound Hsp70 on Tumor Cells Mimic Hsp70-Primed NK Cells

Author(s): Ali Bashiri Dezfouli,corresponding author 1 , * Mina Yazdi, 2 , † Mohamed-Reda Benmebarek, 3 , † Melissa Schwab, 1 , † Stefanos Michaelides, 3 Arianna Miccichè, 4 Dirk Geerts, 4 Stefan Stangl, 1 , 5 Sarah Klapproth, 6 Ernst Wagner, 2 Sebastian Kobold, 3 , 7 and Gabriele Multhoff 1
Published in: Frontiers in Immunology, 2022, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2022.883694

Transwell migration assay to interrogate human CAR-T cell chemotaxis

Author(s): Arman Oner, Sebastian Kobold
Published in: Star Protocols, 2022, ISSN 2666-1667
Publisher: Cell Press
DOI: 10.1016/j.xpro.2022.101708

History and current status of clinical studies using human pluripotent stem cells.

Author(s): Kobold S, Bultjer N, Stacey G, Mueller SC, Kurtz A, Mah N.
Published in: Stem Cell Reports, 2023, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2023.03.005

Major immunophenotypic abnormalities in patients with primary adrenal insufficiency of different etiology.

Author(s): Nowotny HF, Marchant Seiter T, Ju J, Gottschlich A, Schneider H, Zopp S, Vogel F, Tschaidse L, Auer MK, Lottspeich C, Kobold S, Rothenfusser S, Beuschlein F, Reincke M, Braun L, Reisch N.
Published in: Frontiers in Immunology, 2023, ISSN 1664-3224
Publisher: Lausanne Frontiers Media S.A. 2010-
DOI: 10.3389/fimmu.2023.1275828

The Neurokinin-1 Receptor Is a Target in Pediatric Rhabdoid Tumors

Author(s): Julian Kolorz,1,† Salih Demir,1,† Adrian Gottschlich,2 Iris Beirith,3 Matthias Ilmer,3,4 Daniel Lüthy,1 Christoph Walz,5 Mario M. Dorostkar,6 Thomas Magg,7 Fabian Hauck,7 Dietrich von Schweinitz,1 Sebastian Kobold,2,4,8 Roland Kappler,1 and Michael Berger
Published in: Current Oncology, 2021, ISSN 1718-7729
Publisher: MDPI
DOI: 10.3390/curroncol29010008

Impact of the selective A2AR and A2BR dual antagonist AB928/etrumadenant on CAR T cell function.

Author(s): Seifert M, Benmebarek MR, Briukhovetska D, Märkl F, Dörr J, Cadilha BL, Jobst J, Stock S, Andreu-Sanz D, Lorenzini T, Grünmeier R, Oner A, Obeck H, Majed L, Dhoqina D, Feinendegen M, Gottschlich A, Zhang J, Schindler U, Endres S, Kobold S.
Published in: Br J Cancer., 2022, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-022-02013-z

HDR-based CRISPR/Cas9-mediated Knockout of PD-L1 in C57BL/6 Mice.

Author(s): Heeb LV, Taskoparan B, Katsoulas A, Beffinger M, Clavien PA, Kobold S, Gupta A, Berg JV.
Published in: Bio Protocol, 2023, ISSN 2331-8325
Publisher: Bio-protocol LLC
DOI: 10.21769/bioprotoc.4724

Prodrug-Activating Chain Exchange (PACE) converts targeted prodrug derivatives to functional bi- or multispecific antibodies

Author(s): Steffen Dickopf, Can Buldun, Vedran Vasic, Guy Georges, Carina Hage, Klaus Mayer, Matthias Forster, Uwe Wessels, Kay-Gunnar Stubenrauch, Jörg Benz, Andreas Ehler, Matthias E. Lauer, Philippe Ringler, Sebastian Kobold, Stefan Endres, Christian Klein, and Ulrich Brinkmanncorresponding author
Published in: Biological Chemistry, 2022, ISSN 1431-6730
Publisher: Walter de Gruyter GmbH & Co. KG
DOI: 10.1515/hsz-2021-0401

Teaching an old dog new tricks: next-generation CAR T cells

Author(s): Nicholas Tokarew, Justyna Ogonek, Stefan Endres, Michael von Bergwelt-Baildon, Sebastian Kobold
Published in: British Journal of Cancer, Issue 120/1, 2019, Page(s) 26-37, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-018-0325-1

Interleukins in cancer: from biology to therapy

Author(s): "Daria Briukhovetska,#1 Janina Dörr,#1 Stefan Endres,1,2,3 Peter Libby,4 Charles A. Dinarello,5 and Sebastian Koboldcorresponding author"
Published in: Nature Reviews in Cancer, 2021, ISSN 1474-175X
Publisher: Nature Publishing Group
DOI: 10.1038/s41568-021-00363-z

Paralysis of the cytotoxic granule machinery is a new cancer immune evasion mechanism mediated by chitinase 3-like-1

Author(s): Abbass Darwich,1 Alessandra Silvestri,2 Mohamed-Reda Benmebarek,3 Juliette Mouriès,1 Bruno Cadilha,4 Alessia Melacarne,2 Lapo Morelli,5 Domenico Supino,1 Alexandre Taleb,6 Hannah Obeck,3 Claudio Sustmann,6 Agnese Losurdo,2 Giovanna Masci,2 Giuseppe Curigliano,5,7 Sebastian Kobold,8 Giuseppe Penna,2 and Maria Rescigno
Published in: Journal for the Immunotherapy of Cancer, 2021, ISSN 2051-1426
Publisher: BMJ
DOI: 10.1136/jitc-2021-003224

Long non-coding RNAs in cancer stem cells

Author(s): Melanie Schwerdtfeger,a,b Vincenzo Desiderio,a Sebastian Kobold,b,c Tarik Regad,d Silvia Zappavigna,d and Michele Caraglia
Published in: Translational Oncology, Issue 19365233, 2021, ISSN 1936-5233
Publisher: Neoplasia Press
DOI: 10.1016/j.tranon.2021.101134

Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22.

Author(s): Giannou AD, Kempski J, Shiri AM, Lücke J, Zhang T, Zhao L, Zazara DE, Cortesi F, Riecken K, Amezcua Vesely MC, Low JS, Xu H, Kaffe E, Garcia-Perez L, Agalioti T, Yamada Y, Jungraithmayr W, Zigmond E, Karstens KF, Steglich B, Wagner J, Konczalla L, Carambia A, Schulze K, von Felden J, May P, Briukhovetska D, Bedke T, Brockmann L, Starzonek S, Lange T, Koch C, Riethdorf S, Pelczar P, Böttcher M, S
Published in: Immunity, 2023, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2022.12.014

CXCR6 expressing T cells: Functions and role in the control of tumors

Author(s): Mabrouk N, Tran T, Sam I, Pourmir I, Gruel N, Granier C, Pineau J, Gey A, Kobold S, Fabre E, Tartour E.
Published in: Frontiers in Immunology, 2022, ISSN 1664-3224
Publisher: Lausanne Frontiers Media S.A. 2010-
DOI: 10.3389/fimmu.2022.1022136

Rational design of PD-1-CD28 immunostimulatory fusion proteins for CAR T cell therapy

Author(s): Lorenzini T, Cadilha BL, Obeck H, Benmebarek MR, Märkl F, Michaelides S, Strzalkowski T, Briukhovetska D, Müller PJ, Nandi S, Winter P, Majed L, Grünmeier R, Seifert M, Rausch S, Feuchtinger T, Endres S, Kobold S.
Published in: British Journal of Cancer, 2023, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-023-02332-9

Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice

Author(s): Barbara Spix,1 Elisabeth S. Butz,2,3 Cheng-Chang Chen,2,4 Anna Scotto Rosato,1 Rachel Tang,1 Aicha Jeridi,5 Veronika Kudrina,1 Eva Plesch,2 Philipp Wartenberg,6 Elisabeth Arlt,1 Daria Briukhovetska,7 Meshal Ansari,5 Gizem Günes Günsel,5 Thomas M. Conlon,5 Amanda Wyatt,6 Sandra Wetzel,8 Daniel Teupser,9 Lesca M. Holdt,9 Fabien Ectors,10 Ingrid Boekhoff,1 Ulrich Boehm,6 Jaime García-Añoveros,11
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-27860-x

Alterations in regulatory T cells and immune checkpoint molecules in pancreatic cancer patients receiving FOLFIRINOX or gemcitabine plus nab-paclitaxel

Author(s): "L. Sams,#1 S. Kruger,#1 V. Heinemann,1,2 D. Bararia,3 S. Haebe,1,3 S. Alig,1,3 M. Haas,1 D. Zhang,1 C. B. Westphalen,1 S. Ormanns,4 P. Metzger,5 J. Werner,6 O. Weigert,1,2,3 M. von Bergwelt-Baildon,1,2 F. Rataj,5 S. Kobold,2,5 and S. Boeck"
Published in: Clinical and Translational Oncology, 2021, ISSN 1699-048X
Publisher: Doyma
DOI: 10.1007/s12094-021-02620-x

CAR T cell therapy in solid tumors: a short review.

Author(s): Öykü Umut; Adrian Gottschlich; Stefan Endres; Sebastian Kobold
Published in: Memo, Issue 7, 2021, ISSN 1865-5041
Publisher: Springer Verlag
DOI: 10.1007/s12254-021-00703-7

Challenges in Clinical Trial Design for T Cell‐Based Cancer Immunotherapy

Author(s): Stephan F. Kruger, Bruno L. Cadilha, Michael Bergwelt‐Baildon, Stefan Endres, Sebastian Kobold
Published in: Clinical Pharmacology & Therapeutics, Issue 107/1, 2019, Page(s) 47-49, ISSN 0009-9236
Publisher: Nature Publishing Group
DOI: 10.1002/cpt.1659

CXCR6 deficiency impairs cancer vaccine efficacy and CD8+ resident memory T-cell recruitment in head and neck and lung tumors

Author(s): Karaki, Soumaya; Blanc, Charlotte; Tran, Thi; Galy-Fauroux, Isabelle; Mougel, Alice; Dransart, Estelle; Anson, Marie; Tanchot, Corinne; Paolini, Lea; Gruel, Nadege; Gibault, Laure; Lepimpec-Barhes, Francoise; Fabre, Elizabeth; Benhamouda, Nadine; Badoual, Cecile; Damotte, Diane; Donnadieu, Emmanuel; Kobold, Sebastian; Mami-Chouaib, Fathia; Golub, Rachel; Johannes, Ludger; Tartour, Eric
Published in: "Journal for Immunotherapy of Cancer, BMJ Publishing Group 2021, 9 (3), pp.e001948. ⟨10.1136/jitc-2020-001948⟩", Issue 1, 2021, ISSN 2051-1426
Publisher: BMJ
DOI: 10.1136/jitc-2020-001948

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