Publications Peer reviewed articles (48) Therapeutic Strategies for Targeting IL-1 in Cancer. Author(s): Adrian Gottschlich; Stefan Endres; Sebastian Kobold Published in: Cancers, Issue 6, 2021, ISSN 2072-6694 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers13030477 Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors. Author(s): Bruno L. Cadilha; M. Benmebarek; Klara Dorman; A Öner; Theo Lorenzini; Hannah Obeck; Mira Vänttinen; Mauro Di Pilato; Mauro Di Pilato; Jasper N. Pruessmann; Jasper N. Pruessmann; S Stoiber; Duc Huynh; Florian Märkl; Matthias Seifert; Katrin Manske; Javier Suarez-Gosalvez; Yi Zeng; Stefanie Lesch; C. Karches; Constanze Heise; Adrian Gottschlich; Moritz Thomas; Carsten Marr; Jin Zhang; Dharmendra Published in: Science Advances, Issue 10, 2021, ISSN 2375-2548 Publisher: American Association for the Advancement of Science's DOI: 10.1126/sciadv.abi5781 Augmenting anti-CD19 and anti-CD22 CAR T-cell function using PD-1-CD28 checkpoint fusion proteins Author(s): Franziska Blaeschke,1 Dana Stenger,1,2 Antonia Apfelbeck,1 Bruno L. Cadilha,3 Mohamed-Reda Benmebarek,3 Jasmin Mahdawi,1 Eva Ortner,1 Mareike Lepenies,1 Nicola Habjan,1 Felicitas Rataj,3 Semjon Willier,1 Theresa Kaeuferle,1,4 Robbie G. Majzner,5,6 Dirk H. Busch,4,7,8 Sebastian Kobold,2,3 and Tobias Feuchtinger Published in: Blood Cancer Journal, 2021, ISSN 2044-5385 Publisher: Nature Publishing Group DOI: 10.1038/s41408-021-00499-z Chimeric Antigen Receptor–Modified T Cells and T Cell–Engaging Bispecific Antibodies: Different Tools for the Same Job Author(s): Melanie Schwerdtfeger,1,2 Mohamed-Reda Benmebarek,1 Stefan Endres,1,3,4 Marion Subklewe,5 Vincenzo Desiderio,2 and Sebastian Koboldcorresponding author1,3,4 Published in: Current Hematological Malignancy Reports, 2021, ISSN 1558-8211 Publisher: Springer Verlag DOI: 10.1007/s11899-021-00628-2 High-affinity CD16-polymorphism and Fc-engineered antibodies enable activity of CD16-chimeric antigen receptor-modified T cells for cancer therapy Author(s): Felicitas Rataj, Severin J. Jacobi, Stefan Stoiber, Florian Asang, Justyna Ogonek, Nicholas Tokarew, Bruno L. Cadilha, Erwin van Puijenbroek, Constanze Heise, Peter Duewell, Stefan Endres, Christian Klein, Sebastian Kobold Published in: British Journal of Cancer, Issue 120/1, 2019, Page(s) 79-87, ISSN 0007-0920 Publisher: Nature Publishing Group DOI: 10.1038/s41416-018-0341-1 Design and Evaluation of TIM-3-CD28 Checkpoint Fusion Proteins to Improve Anti-CD19 CAR T-Cell Function Author(s): Franziska Blaeschke, 1 Eva Ortner, 1 Dana Stenger, 1 , 2 Jasmin Mahdawi, 1 Antonia Apfelbeck, 1 Nicola Habjan, 1 Tanja Weißer, 1 Theresa Kaeuferle, 1 , 3 Semjon Willier, 1 Sebastian Kobold, 2 , 4 and Tobias Feuchtinger Published in: Frontiers in Immunology, 2022, ISSN 1664-3224 Publisher: Frontiers DOI: 10.3389/fimmu.2022.845499 Enhanced Chimeric Antigen Receptor T Cell Therapy through Co-Application of Synergistic Combination Partners Author(s): Sophia Stock,1,2,* Anna-Kristina Kluever,1 Stefan Endres,1,3,4 and Sebastian Kobold Published in: Biomedicines, 2022, ISSN 2227-9059 Publisher: MDPI DOI: 10.3390/biomedicines10020307 NK Cells Armed with Chimeric Antigen Receptors (CAR): Roadblocks to Successful Development Author(s): Ali Bashiri Dezfouli; Mina Yazdi; Alan Graham Pockley; Mohammad Khosravi; Sebastian Kobold; Ernst Wagner; Gabriele Multhoff Published in: Cells, Issue 1, 2021, ISSN 2073-4409 Publisher: MDPI DOI: 10.3390/cells10123390 Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody Author(s): Martina Geiger, Kay-Gunnar Stubenrauch, Johannes Sam, Wolfgang F. Richter, Gregor Jordan, Jan Eckmann, Carina Hage, Valeria Nicolini, Anne Freimoser-Grundschober, Mirko Ritter, Matthias E. Lauer, Henning Stahlberg, Philippe Ringler, Jigar Patel, Eric Sullivan, Sandra Grau-Richards, Stefan Endres, Sebastian Kobold, Pablo Umaña, Peter Brünker, Christian Klein Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-020-16838-w ESCRT machinery: role of membrane repair mechanisms in escaping cell death Author(s): "Lisa Gregor,#1 Sophia Stock,#1,2,3 and Sebastian Koboldcorresponding author" Published in: Signal Transduction and Targeted Therapy, 2022, ISSN 2059-3635 Publisher: Springer Nature DOI: 10.1038/s41392-022-01108-6 An In Vivo Inflammatory Loop Potentiates KRAS Blockade Author(s): Kristina A. M. Arendt,1,2,† Giannoula Ntaliarda,3,† Vasileios Armenis,3 Danai Kati,3 Christin Henning,1,2 Georgia A. Giotopoulou,1,2,3 Mario A. A. Pepe,1,2 Laura V. Klotz,1,2 Anne-Sophie Lamort,1,2 Rudolf A. Hatz,2,4,5 Sebastian Kobold,2,6 Andrea C. Schamberger,1,2,*‡ and Georgios T. Stathopoulos Published in: Biomedicines, 2022, ISSN 2227-9059 Publisher: MDPI DOI: 10.3390/biomedicines10030592 Broad T Cell Targeting of Structural Proteins After SARS-CoV-2 Infection: High Throughput Assessment of T Cell Reactivity Using an Automated Interferon Gamma Release Assay Author(s): Isabel Brand, 1 , 2 , † Leonard Gilberg, 1 , 3 , † Jan Bruger, 1 , † Mercè Garí, 4 Andreas Wieser, 1 , 5 Tabea M. Eser, 1 , 5 Jonathan Frese, 1 Mohamed I. M. Ahmed, 1 , 5 Raquel Rubio-Acero, 1 Jessica M. Guggenbuehl Noller, 1 Noemi Castelletti, 1 Jana Diekmannshemke, 4 , 6 Sophie Thiesbrummel, 4 , 6 Duc Huynh, 2 Simon Winter, 1 Inge Kroidl, 1 , 5 Christiane Fuchs, 4 , 6 , 7 Michael Hoelsch Published in: Frontiers in Immunology, 2021, ISSN 1664-3224 Publisher: Frontiers DOI: 10.3389/fimmu.2021.688436 Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer Author(s): Uta M. Demel,1,2,3 Marlitt Böger,1,2 Schayan Yousefian,1,4,5 Corinna Grunert,1,2 Le Zhang,1,2 Paul W. Hotz,6 Adrian Gottschlich,7 Hazal Köse,1,2 Konstandina Isaakidis,1,2 Dominik Vonficht,8,9,10 Florian Grünschläger,8,9,10 Elena Rohleder,1,2 Kristina Wagner,6 Judith Dönig,6 Veronika Igl,7 Bernadette Brzezicha,11 Francis Baumgartner,1,2,3 Stefan Habringer,1,2,3 Jens Löber,12 Björn Chapuy,1,4 Published in: The Journal of Clinical Investigations, 2022, ISSN 0021-9738 Publisher: American Society for Clinical Investigation DOI: 10.1172/jci152383 Sixth Immunotherapy of Cancer conference (ITOC): advances and perspectives—a meeting report Author(s): Catarina Pinto, Michael Bergmann, Daria Briukhovetska, Volkmar Nuessler, Mario Sznol, Michael von Bergwelt-Baildon, Sebastian Kobold Published in: Journal for ImmunoTherapy of Cancer, Issue 8/1, 2019, Page(s) e000268, ISSN 2051-1426 Publisher: BMJ DOI: 10.1136/jitc-2019-000268 Prognosis and tumor biology of pancreatic cancer patients with isolated lung metastases: translational results from the German multicenter AIO-YMO-PAK-0515 study Author(s): S.F. Kruger,1,∗ A. Lohneis,2,3 A. Abendroth,4 A.W. Berger,5 T.J. Ettrich,5 O. Waidmann,6,7 M. Kapp,8 B. Steiner,9 J. Kumbrink,10 A. Reischer,1 M. Haas,1 C.B. Westphalen,1,11 D. Zhang,1 L. Miller-Phillips,1 P.J. Burger,1 S. Kobold,11,12 J. Werner,13 M. Subklewe,1,11 M. von Bergwelt-Baildon,1,11 V. Kunzmann,8 T. Seufferlein,5 J.T. Siveke,4 M. Sinn,2,14 V. Heinemann,1,11 S. Ormanns,10,11,† and S. Published in: ESMO Open, 2022, ISSN 2059-7029 Publisher: ESMO DOI: 10.1016/j.esmoop.2022.100388 Immunostimulatory RNA leads to functional reprogramming of myeloid-derived suppressor cells in pancreatic cancer Author(s): Philipp Metzger, Sabrina V. Kirchleitner, Michael Kluge, Lars M. Koenig, Christine Hörth, Carlotta A. Rambuscheck, Daniel Böhmer, Julia Ahlfeld, Sebastian Kobold, Caroline C. Friedel, Stefan Endres, Max Schnurr, Peter Duewell Published in: Journal for ImmunoTherapy of Cancer, Issue 7/1, 2019, ISSN 2051-1426 Publisher: BMJ DOI: 10.1186/s40425-019-0778-7 Skin dendritic cells in melanoma are key for successful checkpoint blockade therapy Author(s): Anastasia Prokopi,1 Christoph H Tripp,1 Bart Tummers,2 Florian Hornsteiner,1 Sarah Spoeck,1 Jeremy Chase Crawford,2 Derek R Clements,3 Mirjana Efremova,4 Katharina Hutter,1 Lydia Bellmann,1 Giuseppe Cappellano,1 Bruno L Cadilha,5,6 Sebastian Kobold,5,6,7 Louis Boon,8 Daniela Ortner,1 Zlatko Trajanoski,4 Suzie Chen,9 Tanja D de Gruijl,10 Juliana Idoyaga,3 Douglas R Green,2 and Patrizia Stoitzner Published in: Journal for the Immunotherapy of Cancer, 2021, ISSN 2051-1426 Publisher: BMJ DOI: 10.1136/jitc-2020-000832 Interleukin-37 Inhibits Colon Carcinogensis During Chronic Colitis Author(s): Steffeni Mountford, Andrea Ringleb, Rahel Schwaiger, Doris Mayr, Sebastian Kobold, Charles A. Dinarello, Philip Bufler Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224 Publisher: Frontiers DOI: 10.3389/fimmu.2019.02632 T cells armed with the C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours Author(s): "Stefanie Lesch,#1 Viktoria Blumenberg,#1,2 Stefan Stoiber,1 Adrian Gottschlich,1 Justyna Ogonek,1 Bruno L. Cadilha,1 Zahra Dantes,3 Felicitas Rataj,1 Klara Dorman,1 Johannes Lutz,1 Clara H. Karches,1 Constanze Heise,1 Mathias Kurzay,1 Benjamin M. Larimer,4 Simon Grassmann,1 Moritz Rapp,1 Alessia Nottebrock,1 Stephan Kruger,1,2 Nicholas Tokarew,1 Philipp Metzger,1 Christine Hoerth,1 Mohamed-Reda Be" Published in: Nature Biomedical Engineering, 2021, ISSN 2157-846X Publisher: Springer-Nature DOI: 10.1038/s41551-021-00737-6 Utility and Drawbacks of Chimeric Antigen Receptor T Cell (CAR-T) Therapy in Lung Cancer Author(s): Prameela Kandra, 1 , † Rajender Nandigama, 2 , † Bastian Eul, 3 Magdalena Huber, 4 Sebastian Kobold, 5 , 6 Werner Seeger, 2 , 3 , 7 Friedrich Grimminger, 3 , 7 and Rajkumar Savaicorresponding author Published in: Frontiers in Immunolgoy, 2022, ISSN 1664-3224 Publisher: Frontiers DOI: 10.3389/fimmu.2022.903562 CXCR6 Positions Cytotoxic T Cells to Receive Critical Survival Signals in the Tumor Microenvironment Author(s): Mauro Di Pilato,1,2,3,12 Raphael Kfuri-Rubens,1,4,12 Jasper N. Pruessmann,1,2,12 Aleksandra J. Ozga,1,2,12 Marius Messemaker,5 Bruno L. Cadilha,4 Ramya Sivakumar,6 Chiara Cianciaruso,2,5 Ross D. Warner,1 Francesco Marangoni,1,2 Esteban Carrizosa,1,2 Stefanie Lesch,4 James Billingsley,7 Daniel Perez-Ramos,8 Fidel Zavala,8 Esther Rheinbay,9 Andrew D. Luster,1,2 Michael Y. Gerner,6 Sebastian Kobold,4 Published in: Cell, 2021, ISSN 1097-4172 Publisher: Cell Press DOI: 10.1016/j.cell.2021.07.015 Defective Interfering Genomes and the Full-Length Viral Genome Trigger RIG-I After Infection With Vesicular Stomatitis Virus in a Replication Dependent Manner Author(s): Andreas Linder, 1 , 2 Viktoria Bothe, 1 Nicolas Linder, 1 Paul Schwarzlmueller, 1 Frank Dahlström, 1 Christoph Bartenhagen, 3 Martin Dugas, 3 Dharmendra Pandey, 1 Julia Thorn-Seshold, 1 , 4 Daniel F. R. Boehmer, 1 Lars M. Koenig, 1 Sebastian Kobold, 1 , 5 Max Schnurr, 1 Johannes Raedler, 1 Giulia Spielmann, 1 Hadi Karimzadeh, 1 , 4 Andreas Schmidt, 1 Stefan Endres, 1 , 4 and Simon Rothenfusser Published in: Frontiers in Immunology, 2021, ISSN 1664-3224 Publisher: Frontiers DOI: 10.3389/fimmu.2021.595390 Microphthalmia-Associated Transcription Factor (MITF) Regulates Immune Cell Migration into Melanoma Author(s): Gabriela M Wiedemann, Celina Aithal, Angelina Kraechan, Constanze Heise, Bruno L Cadilha, Jin Zhang, Peter Duewell, Robert Ballotti, Stefan Endres, Corine Bertolotto, Sebastian Kobold Published in: Translational Oncology, Issue 12/2, 2019, Page(s) 350-360, ISSN 1936-5233 Publisher: Neoplasia Press DOI: 10.1016/j.tranon.2018.10.014 Innate and adaptive immunity combined for cancer treatment Author(s): Sebastian Kobold Published in: Proceedings of the National Academy of Sciences, Issue 116/4, 2019, Page(s) 1087-1088, ISSN 0027-8424 Publisher: National Academy of Sciences DOI: 10.1073/pnas.1820166116 Cancer cells induce interleukin-22 production from memory CD4 + T cells via interleukin-1 to promote tumor growth Author(s): Cornelia Voigt, Peter May, Adrian Gottschlich, Anamarija Markota, Daniel Wenk, Inga Gerlach, Sebastian Voigt, Georgios T. Stathopoulos, Kristina A. M. Arendt, Constanze Heise, Felicitas Rataj, Klaus-Peter Janssen, Melanie Königshoff, Hauke Winter, Isabelle Himsl, Wolfgang E. Thasler, Max Schnurr, Simon Rothenfußer, Stefan Endres, Sebastian Kobold Published in: Proceedings of the National Academy of Sciences, Issue 114/49, 2017, Page(s) 12994-12999, ISSN 0027-8424 Publisher: National Academy of Sciences DOI: 10.1073/pnas.1705165114 Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells Author(s): Mohamed-Reda Benmebarek, Clara Karches, Bruno Cadilha, Stefanie Lesch, Stefan Endres, Sebastian Kobold Published in: International Journal of Molecular Sciences, Issue 20/6, 2019, Page(s) 1283, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms20061283 Targeting interleukin-22 for cancer therapy Author(s): Anamarija Markota, Stefan Endres, Sebastian Kobold Published in: Human Vaccines & Immunotherapeutics, Issue 14/8, 2018, Page(s) 2012-2015, ISSN 2164-5515 Publisher: Landes Bioscience DOI: 10.1080/21645515.2018.1461300 PD1-CD28 Fusion Protein Enables CD4+ T Cell Help for Adoptive T Cell Therapy in Models of Pancreatic Cancer and Non-hodgkin Lymphoma Author(s): Felicitas Rataj, Fabian B. T. Kraus, Michael Chaloupka, Simon Grassmann, Constanze Heise, Bruno L. Cadilha, Peter Duewell, Stefan Endres, Sebastian Kobold Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224 Publisher: Frontiers DOI: 10.3389/fimmu.2018.01955 Limitations in the Design of Chimeric Antigen Receptors for Cancer Therapy Author(s): Stefan Stoiber, Bruno L. Cadilha, Mohamed-Reda Benmebarek, Stefanie Lesch, Stefan Endres, Sebastian Kobold Published in: Cells, Issue 8/5, 2019, Page(s) 472, ISSN 2073-4409 Publisher: MDPI DOI: 10.3390/cells8050472 Bispecific Antibodies Enable Synthetic Agonistic Receptor-Transduced T Cells for Tumor Immunotherapy Author(s): Clara H. Karches, Mohamed-Reda Benmebarek, Moritz L. Schmidbauer, Mathias Kurzay, Richard Klaus, Martina Geiger, Felicitas Rataj, Bruno L. Cadilha, Stefanie Lesch, Constanze Heise, Ramona Murr, Johannes vom Berg, Martin Jastroch, Daniel Lamp, Jian Ding, Peter Duewell, Gerhard Niederfellner, Claudio Sustmann, Stefan Endres, Christian Klein, Sebastian Kobold Published in: Clinical Cancer Research, Issue 25/19, 2019, Page(s) 5890-5900, ISSN 1078-0432 Publisher: American Association for Cancer Research DOI: 10.1158/1078-0432.ccr-18-3927 Advances in cancer immunotherapy 2019 – latest trends Author(s): Stephan Kruger, Matthias Ilmer, Sebastian Kobold, Bruno L. Cadilha, Stefan Endres, Steffen Ormanns, Gesa Schuebbe, Bernhard W. Renz, Jan G. D’Haese, Hans Schloesser, Volker Heinemann, Marion Subklewe, Stefan Boeck, Jens Werner, Michael von Bergwelt-Baildon Published in: Journal of Experimental & Clinical Cancer Research, Issue 38/1, 2019, ISSN 1756-9966 Publisher: MDPI DOI: 10.1186/s13046-019-1266-0 Epithelial-type systemic breast carcinoma cells with a restricted mesenchymal transition are a major source of metastasis Author(s): Xiao Liu, Junjian Li, Bruno Loureiro Cadilha, Anamarija Markota, Cornelia Voigt, Zhe Huang, Peter P. Lin, Daisy D. Wang, Juncheng Dai, Gisela Kranz, Anna Krandick, Darko Libl, Horst Zitzelsberger, Isabella Zagorski, Herbert Braselmann, Min Pan, Sibo Zhu, Yuanchi Huang, Sebastian Niedermeyer, Christoph A. Reichel, Bernd Uhl, Daria Briukhovetska, Javier Suárez, Sebastian Kobold, Olivier Gires, Hong Published in: Science Advances, Issue 5/6, 2019, Page(s) eaav4275, ISSN 2375-2548 Publisher: Science DOI: 10.1126/sciadv.aav4275 Combining the best of two worlds: highly flexible chimeric antigen receptor adaptor molecules (CAR-adaptors) for the recruitment of chimeric antigen receptor T cells Author(s): Diana Darowski, Sebastian Kobold, Christian Jost, Christian Klein Published in: mAbs, Issue 11/4, 2019, Page(s) 621-631, ISSN 1942-0870 Publisher: Landes Bioscience DOI: 10.1080/19420862.2019.1596511 A modular and controllable T cell therapy platform for acute myeloid leukemia Author(s): "Mohamed-Reda Benmebarek,#1 Bruno L. Cadilha,#1 Monika Herrmann,2 Stefanie Lesch,1 Saskia Schmitt,2 Stefan Stoiber,1 Abbass Darwich,3 Christian Augsberger,2 Bettina Brauchle,2,4 Lisa Rohrbacher,2,4 Arman Oner,1 Matthias Seifert,1 Melanie Schwerdtfeger,1 Adrian Gottschlich,1 Felicitas Rataj,1 Nadja C. Fenn,2 Christian Klein,5 Marion Subklewe,2,4,6 Stefan Endres,1,6,7 Karl-Peter Hopfner,8 and Sebasti" Published in: Leukemia, 2021, ISSN 0887-6924 Publisher: Nature Publishing Group DOI: 10.1038/s41375-020-01109-w Chimeric antigen receptor T cells engineered to recognize the P329G-mutated Fc part of effector-silenced tumor antigen-targeting human IgG1 antibodies enable modular targeting of solid tumors Author(s): "Sophia Stock,corresponding author#1,2,3 Mohamed-Reda Benmebarek,#1,4 Anna-Kristina Kluever,1 Diana Darowski,5,6 Christian Jost,5,7 Kay-Gunnar Stubenrauch,8 Joerg Benz,9 Anne Freimoser-Grundschober,5 Ekkehard Moessner,5 Pablo Umana,5 Marion Subklewe,2,3 Stefan Endres,1,3,10 Christian Klein,corresponding author5 and Sebastian Koboldcorresponding author" Published in: Journal for the Immunotherapy of Cancer, 2022, ISSN 2051-1426 Publisher: BMJ DOI: 10.1136/jitc-2022-005054 Rationale for Combining Bispecific T Cell Activating Antibodies With Checkpoint Blockade for Cancer Therapy Author(s): Sebastian Kobold, Stanislav Pantelyushin, Felicitas Rataj, Johannes vom Berg Published in: Frontiers in Oncology, Issue 8, 2018, ISSN 2234-943X Publisher: Frontiers Media S. A. DOI: 10.3389/fonc.2018.00285 CAR T Cells Targeting Membrane-Bound Hsp70 on Tumor Cells Mimic Hsp70-Primed NK Cells Author(s): Ali Bashiri Dezfouli,corresponding author 1 , * Mina Yazdi, 2 , † Mohamed-Reda Benmebarek, 3 , † Melissa Schwab, 1 , † Stefanos Michaelides, 3 Arianna Miccichè, 4 Dirk Geerts, 4 Stefan Stangl, 1 , 5 Sarah Klapproth, 6 Ernst Wagner, 2 Sebastian Kobold, 3 , 7 and Gabriele Multhoff 1 Published in: Frontiers in Immunology, 2022, ISSN 1664-3224 Publisher: Frontiers DOI: 10.3389/fimmu.2022.883694 The Neurokinin-1 Receptor Is a Target in Pediatric Rhabdoid Tumors Author(s): Julian Kolorz,1,† Salih Demir,1,† Adrian Gottschlich,2 Iris Beirith,3 Matthias Ilmer,3,4 Daniel Lüthy,1 Christoph Walz,5 Mario M. Dorostkar,6 Thomas Magg,7 Fabian Hauck,7 Dietrich von Schweinitz,1 Sebastian Kobold,2,4,8 Roland Kappler,1 and Michael Berger Published in: Current Oncology, 2021, ISSN 1718-7729 Publisher: MDPI DOI: 10.3390/curroncol29010008 Prodrug-Activating Chain Exchange (PACE) converts targeted prodrug derivatives to functional bi- or multispecific antibodies Author(s): Steffen Dickopf, Can Buldun, Vedran Vasic, Guy Georges, Carina Hage, Klaus Mayer, Matthias Forster, Uwe Wessels, Kay-Gunnar Stubenrauch, Jörg Benz, Andreas Ehler, Matthias E. Lauer, Philippe Ringler, Sebastian Kobold, Stefan Endres, Christian Klein, and Ulrich Brinkmanncorresponding author Published in: Biological Chemistry, 2022, ISSN 1431-6730 Publisher: Walter de Gruyter GmbH & Co. KG DOI: 10.1515/hsz-2021-0401 Teaching an old dog new tricks: next-generation CAR T cells Author(s): Nicholas Tokarew, Justyna Ogonek, Stefan Endres, Michael von Bergwelt-Baildon, Sebastian Kobold Published in: British Journal of Cancer, Issue 120/1, 2019, Page(s) 26-37, ISSN 0007-0920 Publisher: Nature Publishing Group DOI: 10.1038/s41416-018-0325-1 Interleukins in cancer: from biology to therapy Author(s): "Daria Briukhovetska,#1 Janina Dörr,#1 Stefan Endres,1,2,3 Peter Libby,4 Charles A. Dinarello,5 and Sebastian Koboldcorresponding author" Published in: Nature Reviews in Cancer, 2021, ISSN 1474-175X Publisher: Nature Publishing Group DOI: 10.1038/s41568-021-00363-z Paralysis of the cytotoxic granule machinery is a new cancer immune evasion mechanism mediated by chitinase 3-like-1 Author(s): Abbass Darwich,1 Alessandra Silvestri,2 Mohamed-Reda Benmebarek,3 Juliette Mouriès,1 Bruno Cadilha,4 Alessia Melacarne,2 Lapo Morelli,5 Domenico Supino,1 Alexandre Taleb,6 Hannah Obeck,3 Claudio Sustmann,6 Agnese Losurdo,2 Giovanna Masci,2 Giuseppe Curigliano,5,7 Sebastian Kobold,8 Giuseppe Penna,2 and Maria Rescigno Published in: Journal for the Immunotherapy of Cancer, 2021, ISSN 2051-1426 Publisher: BMJ DOI: 10.1136/jitc-2021-003224 Long non-coding RNAs in cancer stem cells Author(s): Melanie Schwerdtfeger,a,b Vincenzo Desiderio,a Sebastian Kobold,b,c Tarik Regad,d Silvia Zappavigna,d and Michele Caraglia Published in: Translational Oncology, Issue 19365233, 2021, ISSN 1936-5233 Publisher: Neoplasia Press DOI: 10.1016/j.tranon.2021.101134 Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice Author(s): Barbara Spix,1 Elisabeth S. Butz,2,3 Cheng-Chang Chen,2,4 Anna Scotto Rosato,1 Rachel Tang,1 Aicha Jeridi,5 Veronika Kudrina,1 Eva Plesch,2 Philipp Wartenberg,6 Elisabeth Arlt,1 Daria Briukhovetska,7 Meshal Ansari,5 Gizem Günes Günsel,5 Thomas M. Conlon,5 Amanda Wyatt,6 Sandra Wetzel,8 Daniel Teupser,9 Lesca M. Holdt,9 Fabien Ectors,10 Ingrid Boekhoff,1 Ulrich Boehm,6 Jaime García-Añoveros,11 Published in: Nature Communications, 2022, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-021-27860-x Alterations in regulatory T cells and immune checkpoint molecules in pancreatic cancer patients receiving FOLFIRINOX or gemcitabine plus nab-paclitaxel Author(s): "L. Sams,#1 S. Kruger,#1 V. Heinemann,1,2 D. Bararia,3 S. Haebe,1,3 S. Alig,1,3 M. Haas,1 D. Zhang,1 C. B. Westphalen,1 S. Ormanns,4 P. Metzger,5 J. Werner,6 O. Weigert,1,2,3 M. von Bergwelt-Baildon,1,2 F. Rataj,5 S. Kobold,2,5 and S. Boeck" Published in: Clinical and Translational Oncology, 2021, ISSN 1699-048X Publisher: Doyma DOI: 10.1007/s12094-021-02620-x CAR T cell therapy in solid tumors: a short review. Author(s): Öykü Umut; Adrian Gottschlich; Stefan Endres; Sebastian Kobold Published in: Memo, Issue 7, 2021, ISSN 1865-5041 Publisher: Springer Verlag DOI: 10.1007/s12254-021-00703-7 Challenges in Clinical Trial Design for T Cell‐Based Cancer Immunotherapy Author(s): Stephan F. Kruger, Bruno L. Cadilha, Michael Bergwelt‐Baildon, Stefan Endres, Sebastian Kobold Published in: Clinical Pharmacology & Therapeutics, Issue 107/1, 2019, Page(s) 47-49, ISSN 0009-9236 Publisher: Nature Publishing Group DOI: 10.1002/cpt.1659 CXCR6 deficiency impairs cancer vaccine efficacy and CD8+ resident memory T-cell recruitment in head and neck and lung tumors Author(s): Karaki, Soumaya; Blanc, Charlotte; Tran, Thi; Galy-Fauroux, Isabelle; Mougel, Alice; Dransart, Estelle; Anson, Marie; Tanchot, Corinne; Paolini, Lea; Gruel, Nadege; Gibault, Laure; Lepimpec-Barhes, Francoise; Fabre, Elizabeth; Benhamouda, Nadine; Badoual, Cecile; Damotte, Diane; Donnadieu, Emmanuel; Kobold, Sebastian; Mami-Chouaib, Fathia; Golub, Rachel; Johannes, Ludger; Tartour, Eric Published in: "Journal for Immunotherapy of Cancer, BMJ Publishing Group 2021, 9 (3), pp.e001948. ⟨10.1136/jitc-2020-001948⟩", Issue 1, 2021, ISSN 2051-1426 Publisher: BMJ DOI: 10.1136/jitc-2020-001948 Searching for OpenAIRE data... 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