Armoring multifunctional T cells for cancer therapy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Therapeutic Strategies for Targeting IL-1 in Cancer.

Autores: Adrian Gottschlich; Stefan Endres; Sebastian Kobold
Publicado en: Cancers, Edición 6, 2021, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13030477

In vivo dynamics and anti-tumor effects of EpCAM-directed CAR T-cells against brain metastases from lung cancer

Autores: Xu T, Karschnia P, Cadilha BL, Dede S, Lorenz M, Seewaldt N, Nikolaishvili E, Müller K, Blobner J, Teske N, Herold JJ, Rejeski K, Langer S, Obeck H, Lorenzini T, Mulazzani M, Zhang W, Ishikawa-Ankerhold H, Buchholz VR, Subklewe M, Thon N, Straube A, Tonn JC, Kobold S, von Baumgarten L.
Publicado en: Oncoimmunology, 2023, ISSN 2162-4011
Editor: Landes Bioscience
DOI: 10.1080/2162402x.2022.2163781

9th Immunotherapy of Cancer conference (ITOC): A meeting report

Autores: Dalloul I, Strzalkowski TJC, von Bergwelt-Baildon M, Nüssler V, Zielinski C, Kobold S.
Publicado en: Human Vaccines & Immunotherapeutics, 2022, ISSN 2164-5515
Editor: Landes Bioscience
DOI: 10.1080/21645515.2022.2159706

Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors.

Autores: Bruno L. Cadilha; M. Benmebarek; Klara Dorman; A Öner; Theo Lorenzini; Hannah Obeck; Mira Vänttinen; Mauro Di Pilato; Mauro Di Pilato; Jasper N. Pruessmann; Jasper N. Pruessmann; S Stoiber; Duc Huynh; Florian Märkl; Matthias Seifert; Katrin Manske; Javier Suarez-Gosalvez; Yi Zeng; Stefanie Lesch; C. Karches; Constanze Heise; Adrian Gottschlich; Moritz Thomas; Carsten Marr; Jin Zhang; Dharmendra
Publicado en: Science Advances, Edición 10, 2021, ISSN 2375-2548
Editor: American Association for the Advancement of Science's
DOI: 10.1126/sciadv.abi5781

Augmenting anti-CD19 and anti-CD22 CAR T-cell function using PD-1-CD28 checkpoint fusion proteins

Autores: Franziska Blaeschke,1 Dana Stenger,1,2 Antonia Apfelbeck,1 Bruno L. Cadilha,3 Mohamed-Reda Benmebarek,3 Jasmin Mahdawi,1 Eva Ortner,1 Mareike Lepenies,1 Nicola Habjan,1 Felicitas Rataj,3 Semjon Willier,1 Theresa Kaeuferle,1,4 Robbie G. Majzner,5,6 Dirk H. Busch,4,7,8 Sebastian Kobold,2,3 and Tobias Feuchtinger
Publicado en: Blood Cancer Journal, 2021, ISSN 2044-5385
Editor: Nature Publishing Group
DOI: 10.1038/s41408-021-00499-z

Chimeric Antigen Receptor–Modified T Cells and T Cell–Engaging Bispecific Antibodies: Different Tools for the Same Job

Autores: Melanie Schwerdtfeger,1,2 Mohamed-Reda Benmebarek,1 Stefan Endres,1,3,4 Marion Subklewe,5 Vincenzo Desiderio,2 and Sebastian Koboldcorresponding author1,3,4
Publicado en: Current Hematological Malignancy Reports, 2021, ISSN 1558-8211
Editor: Springer Verlag
DOI: 10.1007/s11899-021-00628-2

Bispecific antibodies redirect synthetic agonistic receptor modified T cells against melanoma.

Autores: Märkl F, Benmebarek MR, Keyl J, Cadilha BL, Geiger M, Karches C, Obeck H, Schwerdtfeger M, Michaelides S, Briukhovetska D, Stock S, Jobst J, Müller PJ, Majed L, Seifert M, Klüver AK, Lorenzini T, Grünmeier R, Thomas M, Gottschlich A, Klaus R, Marr C, von Bergwelt-Baildon M, Rothenfusser S, Levesque MP, Heppt MV, Endres S, Klein C, Kobold S.
Publicado en: Journal for ImmunoTherapy of Cancer, 2023, ISSN 2051-1426
Editor: BMJ publishes JITC on behalf of the Society for Immunotherapy of Cancer
DOI: 10.1136/jitc-2022-006436

PD-1-CD28 fusion protein strengthens mesothelin-specific TRuC T cells in preclinical solid tumor models.

Autores: Lesch S, Nottebrock A, Rataj F, Heise C, Endres S, Kobold S.
Publicado en: Cell Oncol, 2023, ISSN 2211-3428
Editor: Springer Verlag
DOI: 10.1007/s13402-022-00747-9

Beyond direct killing-novel cellular immunotherapeutic strategies to reshape the tumor microenvironment.

Autores: Huynh D, Winter P, Märkl F, Endres S, Kobold S.
Publicado en: Seminars in Immunopathology, 2023, ISSN 1863-2297
Editor: Springer Verlag
DOI: 10.1007/s00281-022-00962-4

High-affinity CD16-polymorphism and Fc-engineered antibodies enable activity of CD16-chimeric antigen receptor-modified T cells for cancer therapy

Autores: Felicitas Rataj, Severin J. Jacobi, Stefan Stoiber, Florian Asang, Justyna Ogonek, Nicholas Tokarew, Bruno L. Cadilha, Erwin van Puijenbroek, Constanze Heise, Peter Duewell, Stefan Endres, Christian Klein, Sebastian Kobold
Publicado en: British Journal of Cancer, Edición 120/1, 2019, Página(s) 79-87, ISSN 0007-0920
Editor: Nature Publishing Group
DOI: 10.1038/s41416-018-0341-1

Migratory Engineering of T Cells for Cancer Therapy

Autores: Stefanos Michaelides, Hannah Obeck, Daryna Kechur, Stefan Endres and Sebastian Kobold
Publicado en: Vaccines, 2022, ISSN 2076-393X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines10111845

Functional enhancement of mesothelin-targeted TRuC-T cells by a PD1-CD28 chimeric switch receptor

Autores: McCarthy D, Lofgren M, Watt A, Horton H, Kieffer-Kwon P, Ding J, Kobold S, Baeuerle PA, Hofmeister R, Gutierrez DA, Tighe R.
Publicado en: Cancer Immunology, Immunotherapy, 2023, ISSN 1432-0851
Editor: Springer
DOI: 10.1007/s00262-023-03556-7

Programmable multispecific DNA-origami-based T-cell engagers

Autores: Wagenbauer KF, Pham N, Gottschlich A, Kick B, Kozina V, Frank C, Trninic D, Stömmer P, Grünmeier R, Carlini E, Tsiverioti CA, Kobold S, Funke JJ, Dietz H.
Publicado en: Nature Nanotechnology, 2023, ISSN 1748-3387
Editor: Nature Publishing Group
DOI: 10.1038/s41565-023-01471-7

Design and Evaluation of TIM-3-CD28 Checkpoint Fusion Proteins to Improve Anti-CD19 CAR T-Cell Function

Autores: Franziska Blaeschke, 1 Eva Ortner, 1 Dana Stenger, 1 , 2 Jasmin Mahdawi, 1 Antonia Apfelbeck, 1 Nicola Habjan, 1 Tanja Weißer, 1 Theresa Kaeuferle, 1 , 3 Semjon Willier, 1 Sebastian Kobold, 2 , 4 and Tobias Feuchtinger
Publicado en: Frontiers in Immunology, 2022, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2022.845499

Enhanced Chimeric Antigen Receptor T Cell Therapy through Co-Application of Synergistic Combination Partners

Autores: Sophia Stock,1,2,* Anna-Kristina Kluever,1 Stefan Endres,1,3,4 and Sebastian Kobold
Publicado en: Biomedicines, 2022, ISSN 2227-9059
Editor: MDPI
DOI: 10.3390/biomedicines10020307

NK Cells Armed with Chimeric Antigen Receptors (CAR): Roadblocks to Successful Development

Autores: Ali Bashiri Dezfouli; Mina Yazdi; Alan Graham Pockley; Mohammad Khosravi; Sebastian Kobold; Ernst Wagner; Gabriele Multhoff
Publicado en: Cells, Edición 1, 2021, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells10123390

Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody

Autores: Martina Geiger, Kay-Gunnar Stubenrauch, Johannes Sam, Wolfgang F. Richter, Gregor Jordan, Jan Eckmann, Carina Hage, Valeria Nicolini, Anne Freimoser-Grundschober, Mirko Ritter, Matthias E. Lauer, Henning Stahlberg, Philippe Ringler, Jigar Patel, Eric Sullivan, Sandra Grau-Richards, Stefan Endres, Sebastian Kobold, Pablo Umaña, Peter Brünker, Christian Klein
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-16838-w

ESCRT machinery: role of membrane repair mechanisms in escaping cell death

Autores: "Lisa Gregor,#1 Sophia Stock,#1,2,3 and Sebastian Koboldcorresponding author"
Publicado en: Signal Transduction and Targeted Therapy, 2022, ISSN 2059-3635
Editor: Springer Nature
DOI: 10.1038/s41392-022-01108-6

An In Vivo Inflammatory Loop Potentiates KRAS Blockade

Autores: Kristina A. M. Arendt,1,2,† Giannoula Ntaliarda,3,† Vasileios Armenis,3 Danai Kati,3 Christin Henning,1,2 Georgia A. Giotopoulou,1,2,3 Mario A. A. Pepe,1,2 Laura V. Klotz,1,2 Anne-Sophie Lamort,1,2 Rudolf A. Hatz,2,4,5 Sebastian Kobold,2,6 Andrea C. Schamberger,1,2,*‡ and Georgios T. Stathopoulos
Publicado en: Biomedicines, 2022, ISSN 2227-9059
Editor: MDPI
DOI: 10.3390/biomedicines10030592

Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia

Autores: Gottschlich A, Thomas M, Grünmeier R, Lesch S, Rohrbacher L, Igl V, Briukhovetska D, Benmebarek MR, Vick B, Dede S, Müller K, Xu T, Dhoqina D, Märkl F, Robinson S, Sendelhofert A, Schulz H, Umut Ö, Kavaka V, Tsiverioti CA, Carlini E, Nandi S, Strzalkowski T, Lorenzini T, Stock S, Müller PJ, Dörr J, Seifert M, Cadilha BL, Brabenec R, Röder N, Rataj F, Nüesch M, Modemann F, Wellbrock J, Fied
Publicado en: Nature Biotechnology, 2023, ISSN 1087-0156
Editor: Nature Publishing Group
DOI: 10.1038/s41587-023-01684-0

Broad T Cell Targeting of Structural Proteins After SARS-CoV-2 Infection: High Throughput Assessment of T Cell Reactivity Using an Automated Interferon Gamma Release Assay

Autores: Isabel Brand, 1 , 2 , † Leonard Gilberg, 1 , 3 , † Jan Bruger, 1 , † Mercè Garí, 4 Andreas Wieser, 1 , 5 Tabea M. Eser, 1 , 5 Jonathan Frese, 1 Mohamed I. M. Ahmed, 1 , 5 Raquel Rubio-Acero, 1 Jessica M. Guggenbuehl Noller, 1 Noemi Castelletti, 1 Jana Diekmannshemke, 4 , 6 Sophie Thiesbrummel, 4 , 6 Duc Huynh, 2 Simon Winter, 1 Inge Kroidl, 1 , 5 Christiane Fuchs, 4 , 6 , 7 Michael Hoelsch
Publicado en: Frontiers in Immunology, 2021, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2021.688436

T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis

Autores: Briukhovetska D, Suarez-Gosalvez J, Voigt C, Markota A, Giannou AD, Schübel M, Jobst J, Zhang T, Dörr J, Märkl F, Majed L, Müller PJ, May P, Gottschlich A, Tokarew N, Lücke J, Oner A, Schwerdtfeger M, Andreu-Sanz D, Grünmeier R, Seifert M, Michaelides S, Hristov M, König LM, Cadilha BL, Mikhaylov O, Anders HJ, Rothenfusser S, Flavell RA, Cerezo-Wallis D, Tejedo C, Soengas MS, Bald T, Huber
Publicado en: Immunity, 2023, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2022.12.010

Dual TLR9 and PD-L1 targeting unleashes dendritic cells to induce durable antitumor immunity.

Autores: Fernandez-Rodriguez L, Cianciaruso C, Bill R, Trefny MP, Klar R, Kirchhammer N, Buchi M, Festag J, Michel S, Kohler RH, Jones E, Maaske A, Vom Berg J, Kobold S, Kashyap AS, Jaschinski F, Dixon KO, Pittet MJ, Zippelius A.
Publicado en: Journal for the Immunotherapy of Cancer, 2023, ISSN 2051-1426
Editor: BMJ
DOI: 10.1136/jitc-2023-006714

Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer

Autores: Uta M. Demel,1,2,3 Marlitt Böger,1,2 Schayan Yousefian,1,4,5 Corinna Grunert,1,2 Le Zhang,1,2 Paul W. Hotz,6 Adrian Gottschlich,7 Hazal Köse,1,2 Konstandina Isaakidis,1,2 Dominik Vonficht,8,9,10 Florian Grünschläger,8,9,10 Elena Rohleder,1,2 Kristina Wagner,6 Judith Dönig,6 Veronika Igl,7 Bernadette Brzezicha,11 Francis Baumgartner,1,2,3 Stefan Habringer,1,2,3 Jens Löber,12 Björn Chapuy,1,4
Publicado en: The Journal of Clinical Investigations, 2022, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci152383

Sixth Immunotherapy of Cancer conference (ITOC): advances and perspectives—a meeting report

Autores: Catarina Pinto, Michael Bergmann, Daria Briukhovetska, Volkmar Nuessler, Mario Sznol, Michael von Bergwelt-Baildon, Sebastian Kobold
Publicado en: Journal for ImmunoTherapy of Cancer, Edición 8/1, 2019, Página(s) e000268, ISSN 2051-1426
Editor: BMJ
DOI: 10.1136/jitc-2019-000268

Prognosis and tumor biology of pancreatic cancer patients with isolated lung metastases: translational results from the German multicenter AIO-YMO-PAK-0515 study

Autores: S.F. Kruger,1,∗ A. Lohneis,2,3 A. Abendroth,4 A.W. Berger,5 T.J. Ettrich,5 O. Waidmann,6,7 M. Kapp,8 B. Steiner,9 J. Kumbrink,10 A. Reischer,1 M. Haas,1 C.B. Westphalen,1,11 D. Zhang,1 L. Miller-Phillips,1 P.J. Burger,1 S. Kobold,11,12 J. Werner,13 M. Subklewe,1,11 M. von Bergwelt-Baildon,1,11 V. Kunzmann,8 T. Seufferlein,5 J.T. Siveke,4 M. Sinn,2,14 V. Heinemann,1,11 S. Ormanns,10,11,† and S.
Publicado en: ESMO Open, 2022, ISSN 2059-7029
Editor: ESMO
DOI: 10.1016/j.esmoop.2022.100388

Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming.

Autores: Wu H, Zhao X, Hochrein SM, Eckstein M, Gubert GF, Knöpper K, Mansilla AM, Öner A, Doucet-Ladevèze R, Schmitz W, Ghesquière B, Theurich S, Dudek J, Gasteiger G, Zernecke A, Kobold S, Kastenmüller W, Vaeth M.
Publicado en: Nature Communications, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-42634-3

Immunostimulatory RNA leads to functional reprogramming of myeloid-derived suppressor cells in pancreatic cancer

Autores: Philipp Metzger, Sabrina V. Kirchleitner, Michael Kluge, Lars M. Koenig, Christine Hörth, Carlotta A. Rambuscheck, Daniel Böhmer, Julia Ahlfeld, Sebastian Kobold, Caroline C. Friedel, Stefan Endres, Max Schnurr, Peter Duewell
Publicado en: Journal for ImmunoTherapy of Cancer, Edición 7/1, 2019, ISSN 2051-1426
Editor: BMJ
DOI: 10.1186/s40425-019-0778-7

Skin dendritic cells in melanoma are key for successful checkpoint blockade therapy

Autores: Anastasia Prokopi,1 Christoph H Tripp,1 Bart Tummers,2 Florian Hornsteiner,1 Sarah Spoeck,1 Jeremy Chase Crawford,2 Derek R Clements,3 Mirjana Efremova,4 Katharina Hutter,1 Lydia Bellmann,1 Giuseppe Cappellano,1 Bruno L Cadilha,5,6 Sebastian Kobold,5,6,7 Louis Boon,8 Daniela Ortner,1 Zlatko Trajanoski,4 Suzie Chen,9 Tanja D de Gruijl,10 Juliana Idoyaga,3 Douglas R Green,2 and Patrizia Stoitzner
Publicado en: Journal for the Immunotherapy of Cancer, 2021, ISSN 2051-1426
Editor: BMJ
DOI: 10.1136/jitc-2020-000832

Interleukin-37 Inhibits Colon Carcinogensis During Chronic Colitis

Autores: Steffeni Mountford, Andrea Ringleb, Rahel Schwaiger, Doris Mayr, Sebastian Kobold, Charles A. Dinarello, Philip Bufler
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2019.02632

Mutation-specific CAR T cells as precision therapy for IGLV3-21R110 expressing high-risk chronic lymphocytic leukemia

Autores: Märkl F, Schultheiß C, Ali M, Chen SS, Zintchenko M, Egli L, Mietz J, Chijioke O, Paschold L, Spajic S, Holtermann A, Dörr J, Stock S, Zingg A, Läubli H, Piseddu I, Anz D, Minden MD, Zhang T, Nerreter T, Hudecek M, Minguet S, Chiorazzi N, Kobold S, Binder M.
Publicado en: Nature Communications, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-45378-w

T cells armed with the C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours

Autores: "Stefanie Lesch,#1 Viktoria Blumenberg,#1,2 Stefan Stoiber,1 Adrian Gottschlich,1 Justyna Ogonek,1 Bruno L. Cadilha,1 Zahra Dantes,3 Felicitas Rataj,1 Klara Dorman,1 Johannes Lutz,1 Clara H. Karches,1 Constanze Heise,1 Mathias Kurzay,1 Benjamin M. Larimer,4 Simon Grassmann,1 Moritz Rapp,1 Alessia Nottebrock,1 Stephan Kruger,1,2 Nicholas Tokarew,1 Philipp Metzger,1 Christine Hoerth,1 Mohamed-Reda Be"
Publicado en: Nature Biomedical Engineering, 2021, ISSN 2157-846X
Editor: Springer-Nature
DOI: 10.1038/s41551-021-00737-6

Utility and Drawbacks of Chimeric Antigen Receptor T Cell (CAR-T) Therapy in Lung Cancer

Autores: Prameela Kandra, 1 , † Rajender Nandigama, 2 , † Bastian Eul, 3 Magdalena Huber, 4 Sebastian Kobold, 5 , 6 Werner Seeger, 2 , 3 , 7 Friedrich Grimminger, 3 , 7 and Rajkumar Savaicorresponding author
Publicado en: Frontiers in Immunolgoy, 2022, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2022.903562

Role and Potential of Different T Helper Cell Subsets in Adoptive Cell Therapy

Autores: Andreu-Sanz D, Kobold S.
Publicado en: Cancers (Basel), 2023, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15061650

Correction to: CD33 BiTE® molecule-mediated immune synapse formation and subsequent T-cell activation is determined by the expression profile of activating and inhibitory checkpoint molecules on AML cells.

Autores: Marcinek A, Brauchle B, Rohrbacher L, Hänel G, Philipp N, Märkl F, Strzalkowski T, Lacher SM, Udiljak D, Spiekermann K, Theurich S, Kobold S, Kischel R, James JR, Bücklein VL, Subklewe M.
Publicado en: Cancer Immunology, Immunotherapy, 2023, ISSN 1432-0851
Editor: Springer
DOI: 10.1007/s00262-023-03457-9

CXCR6 Positions Cytotoxic T Cells to Receive Critical Survival Signals in the Tumor Microenvironment

Autores: Mauro Di Pilato,1,2,3,12 Raphael Kfuri-Rubens,1,4,12 Jasper N. Pruessmann,1,2,12 Aleksandra J. Ozga,1,2,12 Marius Messemaker,5 Bruno L. Cadilha,4 Ramya Sivakumar,6 Chiara Cianciaruso,2,5 Ross D. Warner,1 Francesco Marangoni,1,2 Esteban Carrizosa,1,2 Stefanie Lesch,4 James Billingsley,7 Daniel Perez-Ramos,8 Fidel Zavala,8 Esther Rheinbay,9 Andrew D. Luster,1,2 Michael Y. Gerner,6 Sebastian Kobold,4
Publicado en: Cell, 2021, ISSN 1097-4172
Editor: Cell Press
DOI: 10.1016/j.cell.2021.07.015

Defective Interfering Genomes and the Full-Length Viral Genome Trigger RIG-I After Infection With Vesicular Stomatitis Virus in a Replication Dependent Manner

Autores: Andreas Linder, 1 , 2 Viktoria Bothe, 1 Nicolas Linder, 1 Paul Schwarzlmueller, 1 Frank Dahlström, 1 Christoph Bartenhagen, 3 Martin Dugas, 3 Dharmendra Pandey, 1 Julia Thorn-Seshold, 1 , 4 Daniel F. R. Boehmer, 1 Lars M. Koenig, 1 Sebastian Kobold, 1 , 5 Max Schnurr, 1 Johannes Raedler, 1 Giulia Spielmann, 1 Hadi Karimzadeh, 1 , 4 Andreas Schmidt, 1 Stefan Endres, 1 , 4 and Simon Rothenfusser
Publicado en: Frontiers in Immunology, 2021, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2021.595390

Microphthalmia-Associated Transcription Factor (MITF) Regulates Immune Cell Migration into Melanoma

Autores: Gabriela M Wiedemann, Celina Aithal, Angelina Kraechan, Constanze Heise, Bruno L Cadilha, Jin Zhang, Peter Duewell, Robert Ballotti, Stefan Endres, Corine Bertolotto, Sebastian Kobold
Publicado en: Translational Oncology, Edición 12/2, 2019, Página(s) 350-360, ISSN 1936-5233
Editor: Neoplasia Press
DOI: 10.1016/j.tranon.2018.10.014

Innate and adaptive immunity combined for cancer treatment

Autores: Sebastian Kobold
Publicado en: Proceedings of the National Academy of Sciences, Edición 116/4, 2019, Página(s) 1087-1088, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1820166116

Cancer cells induce interleukin-22 production from memory CD4 + T cells via interleukin-1 to promote tumor growth

Autores: Cornelia Voigt, Peter May, Adrian Gottschlich, Anamarija Markota, Daniel Wenk, Inga Gerlach, Sebastian Voigt, Georgios T. Stathopoulos, Kristina A. M. Arendt, Constanze Heise, Felicitas Rataj, Klaus-Peter Janssen, Melanie Königshoff, Hauke Winter, Isabelle Himsl, Wolfgang E. Thasler, Max Schnurr, Simon Rothenfußer, Stefan Endres, Sebastian Kobold
Publicado en: Proceedings of the National Academy of Sciences, Edición 114/49, 2017, Página(s) 12994-12999, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.1705165114

Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells

Autores: Mohamed-Reda Benmebarek, Clara Karches, Bruno Cadilha, Stefanie Lesch, Stefan Endres, Sebastian Kobold
Publicado en: International Journal of Molecular Sciences, Edición 20/6, 2019, Página(s) 1283, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20061283

Targeting interleukin-22 for cancer therapy

Autores: Anamarija Markota, Stefan Endres, Sebastian Kobold
Publicado en: Human Vaccines & Immunotherapeutics, Edición 14/8, 2018, Página(s) 2012-2015, ISSN 2164-5515
Editor: Landes Bioscience
DOI: 10.1080/21645515.2018.1461300

PD1-CD28 Fusion Protein Enables CD4+ T Cell Help for Adoptive T Cell Therapy in Models of Pancreatic Cancer and Non-hodgkin Lymphoma

Autores: Felicitas Rataj, Fabian B. T. Kraus, Michael Chaloupka, Simon Grassmann, Constanze Heise, Bruno L. Cadilha, Peter Duewell, Stefan Endres, Sebastian Kobold
Publicado en: Frontiers in Immunology, Edición 9, 2018, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2018.01955

Limitations in the Design of Chimeric Antigen Receptors for Cancer Therapy

Autores: Stefan Stoiber, Bruno L. Cadilha, Mohamed-Reda Benmebarek, Stefanie Lesch, Stefan Endres, Sebastian Kobold
Publicado en: Cells, Edición 8/5, 2019, Página(s) 472, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells8050472

Bispecific Antibodies Enable Synthetic Agonistic Receptor-Transduced T Cells for Tumor Immunotherapy

Autores: Clara H. Karches, Mohamed-Reda Benmebarek, Moritz L. Schmidbauer, Mathias Kurzay, Richard Klaus, Martina Geiger, Felicitas Rataj, Bruno L. Cadilha, Stefanie Lesch, Constanze Heise, Ramona Murr, Johannes vom Berg, Martin Jastroch, Daniel Lamp, Jian Ding, Peter Duewell, Gerhard Niederfellner, Claudio Sustmann, Stefan Endres, Christian Klein, Sebastian Kobold
Publicado en: Clinical Cancer Research, Edición 25/19, 2019, Página(s) 5890-5900, ISSN 1078-0432
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-18-3927

Advances in cancer immunotherapy 2019 – latest trends

Autores: Stephan Kruger, Matthias Ilmer, Sebastian Kobold, Bruno L. Cadilha, Stefan Endres, Steffen Ormanns, Gesa Schuebbe, Bernhard W. Renz, Jan G. D’Haese, Hans Schloesser, Volker Heinemann, Marion Subklewe, Stefan Boeck, Jens Werner, Michael von Bergwelt-Baildon
Publicado en: Journal of Experimental & Clinical Cancer Research, Edición 38/1, 2019, ISSN 1756-9966
Editor: MDPI
DOI: 10.1186/s13046-019-1266-0

Epithelial-type systemic breast carcinoma cells with a restricted mesenchymal transition are a major source of metastasis

Autores: Xiao Liu, Junjian Li, Bruno Loureiro Cadilha, Anamarija Markota, Cornelia Voigt, Zhe Huang, Peter P. Lin, Daisy D. Wang, Juncheng Dai, Gisela Kranz, Anna Krandick, Darko Libl, Horst Zitzelsberger, Isabella Zagorski, Herbert Braselmann, Min Pan, Sibo Zhu, Yuanchi Huang, Sebastian Niedermeyer, Christoph A. Reichel, Bernd Uhl, Daria Briukhovetska, Javier Suárez, Sebastian Kobold, Olivier Gires, Hong
Publicado en: Science Advances, Edición 5/6, 2019, Página(s) eaav4275, ISSN 2375-2548
Editor: Science
DOI: 10.1126/sciadv.aav4275

Combining the best of two worlds: highly flexible chimeric antigen receptor adaptor molecules (CAR-adaptors) for the recruitment of chimeric antigen receptor T cells

Autores: Diana Darowski, Sebastian Kobold, Christian Jost, Christian Klein
Publicado en: mAbs, Edición 11/4, 2019, Página(s) 621-631, ISSN 1942-0870
Editor: Landes Bioscience
DOI: 10.1080/19420862.2019.1596511

A modular and controllable T cell therapy platform for acute myeloid leukemia

Autores: "Mohamed-Reda Benmebarek,#1 Bruno L. Cadilha,#1 Monika Herrmann,2 Stefanie Lesch,1 Saskia Schmitt,2 Stefan Stoiber,1 Abbass Darwich,3 Christian Augsberger,2 Bettina Brauchle,2,4 Lisa Rohrbacher,2,4 Arman Oner,1 Matthias Seifert,1 Melanie Schwerdtfeger,1 Adrian Gottschlich,1 Felicitas Rataj,1 Nadja C. Fenn,2 Christian Klein,5 Marion Subklewe,2,4,6 Stefan Endres,1,6,7 Karl-Peter Hopfner,8 and Sebasti"
Publicado en: Leukemia, 2021, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/s41375-020-01109-w

Chimeric antigen receptor T cells engineered to recognize the P329G-mutated Fc part of effector-silenced tumor antigen-targeting human IgG1 antibodies enable modular targeting of solid tumors

Autores: "Sophia Stock,corresponding author#1,2,3 Mohamed-Reda Benmebarek,#1,4 Anna-Kristina Kluever,1 Diana Darowski,5,6 Christian Jost,5,7 Kay-Gunnar Stubenrauch,8 Joerg Benz,9 Anne Freimoser-Grundschober,5 Ekkehard Moessner,5 Pablo Umana,5 Marion Subklewe,2,3 Stefan Endres,1,3,10 Christian Klein,corresponding author5 and Sebastian Koboldcorresponding author"
Publicado en: Journal for the Immunotherapy of Cancer, 2022, ISSN 2051-1426
Editor: BMJ
DOI: 10.1136/jitc-2022-005054

Rationale for Combining Bispecific T Cell Activating Antibodies With Checkpoint Blockade for Cancer Therapy

Autores: Sebastian Kobold, Stanislav Pantelyushin, Felicitas Rataj, Johannes vom Berg
Publicado en: Frontiers in Oncology, Edición 8, 2018, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/fonc.2018.00285

CD33 BiTE® molecule-mediated immune synapse formation and subsequent T-cell activation is determined by the expression profile of activating and inhibitory checkpoint molecules on AML cells.

CAR T Cells Targeting Membrane-Bound Hsp70 on Tumor Cells Mimic Hsp70-Primed NK Cells

Autores: Ali Bashiri Dezfouli,corresponding author 1 , * Mina Yazdi, 2 , † Mohamed-Reda Benmebarek, 3 , † Melissa Schwab, 1 , † Stefanos Michaelides, 3 Arianna Miccichè, 4 Dirk Geerts, 4 Stefan Stangl, 1 , 5 Sarah Klapproth, 6 Ernst Wagner, 2 Sebastian Kobold, 3 , 7 and Gabriele Multhoff 1
Publicado en: Frontiers in Immunology, 2022, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2022.883694

Transwell migration assay to interrogate human CAR-T cell chemotaxis

Autores: Arman Oner, Sebastian Kobold
Publicado en: Star Protocols, 2022, ISSN 2666-1667
Editor: Cell Press
DOI: 10.1016/j.xpro.2022.101708

History and current status of clinical studies using human pluripotent stem cells.

Autores: Kobold S, Bultjer N, Stacey G, Mueller SC, Kurtz A, Mah N.
Publicado en: Stem Cell Reports, 2023, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2023.03.005

Major immunophenotypic abnormalities in patients with primary adrenal insufficiency of different etiology.

Autores: Nowotny HF, Marchant Seiter T, Ju J, Gottschlich A, Schneider H, Zopp S, Vogel F, Tschaidse L, Auer MK, Lottspeich C, Kobold S, Rothenfusser S, Beuschlein F, Reincke M, Braun L, Reisch N.
Publicado en: Frontiers in Immunology, 2023, ISSN 1664-3224
Editor: Lausanne Frontiers Media S.A. 2010-
DOI: 10.3389/fimmu.2023.1275828

The Neurokinin-1 Receptor Is a Target in Pediatric Rhabdoid Tumors

Autores: Julian Kolorz,1,† Salih Demir,1,† Adrian Gottschlich,2 Iris Beirith,3 Matthias Ilmer,3,4 Daniel Lüthy,1 Christoph Walz,5 Mario M. Dorostkar,6 Thomas Magg,7 Fabian Hauck,7 Dietrich von Schweinitz,1 Sebastian Kobold,2,4,8 Roland Kappler,1 and Michael Berger
Publicado en: Current Oncology, 2021, ISSN 1718-7729
Editor: MDPI
DOI: 10.3390/curroncol29010008

Impact of the selective A2AR and A2BR dual antagonist AB928/etrumadenant on CAR T cell function.

Autores: Seifert M, Benmebarek MR, Briukhovetska D, Märkl F, Dörr J, Cadilha BL, Jobst J, Stock S, Andreu-Sanz D, Lorenzini T, Grünmeier R, Oner A, Obeck H, Majed L, Dhoqina D, Feinendegen M, Gottschlich A, Zhang J, Schindler U, Endres S, Kobold S.
Publicado en: Br J Cancer., 2022, ISSN 0007-0920
Editor: Nature Publishing Group
DOI: 10.1038/s41416-022-02013-z

HDR-based CRISPR/Cas9-mediated Knockout of PD-L1 in C57BL/6 Mice.

Autores: Heeb LV, Taskoparan B, Katsoulas A, Beffinger M, Clavien PA, Kobold S, Gupta A, Berg JV.
Publicado en: Bio Protocol, 2023, ISSN 2331-8325
Editor: Bio-protocol LLC
DOI: 10.21769/bioprotoc.4724

Prodrug-Activating Chain Exchange (PACE) converts targeted prodrug derivatives to functional bi- or multispecific antibodies

Autores: Steffen Dickopf, Can Buldun, Vedran Vasic, Guy Georges, Carina Hage, Klaus Mayer, Matthias Forster, Uwe Wessels, Kay-Gunnar Stubenrauch, Jörg Benz, Andreas Ehler, Matthias E. Lauer, Philippe Ringler, Sebastian Kobold, Stefan Endres, Christian Klein, and Ulrich Brinkmanncorresponding author
Publicado en: Biological Chemistry, 2022, ISSN 1431-6730
Editor: Walter de Gruyter GmbH & Co. KG
DOI: 10.1515/hsz-2021-0401

Teaching an old dog new tricks: next-generation CAR T cells

Autores: Nicholas Tokarew, Justyna Ogonek, Stefan Endres, Michael von Bergwelt-Baildon, Sebastian Kobold
Publicado en: British Journal of Cancer, Edición 120/1, 2019, Página(s) 26-37, ISSN 0007-0920
Editor: Nature Publishing Group
DOI: 10.1038/s41416-018-0325-1

Interleukins in cancer: from biology to therapy

Autores: "Daria Briukhovetska,#1 Janina Dörr,#1 Stefan Endres,1,2,3 Peter Libby,4 Charles A. Dinarello,5 and Sebastian Koboldcorresponding author"
Publicado en: Nature Reviews in Cancer, 2021, ISSN 1474-175X
Editor: Nature Publishing Group
DOI: 10.1038/s41568-021-00363-z

Paralysis of the cytotoxic granule machinery is a new cancer immune evasion mechanism mediated by chitinase 3-like-1

Autores: Abbass Darwich,1 Alessandra Silvestri,2 Mohamed-Reda Benmebarek,3 Juliette Mouriès,1 Bruno Cadilha,4 Alessia Melacarne,2 Lapo Morelli,5 Domenico Supino,1 Alexandre Taleb,6 Hannah Obeck,3 Claudio Sustmann,6 Agnese Losurdo,2 Giovanna Masci,2 Giuseppe Curigliano,5,7 Sebastian Kobold,8 Giuseppe Penna,2 and Maria Rescigno
Publicado en: Journal for the Immunotherapy of Cancer, 2021, ISSN 2051-1426
Editor: BMJ
DOI: 10.1136/jitc-2021-003224

Long non-coding RNAs in cancer stem cells

Autores: Melanie Schwerdtfeger,a,b Vincenzo Desiderio,a Sebastian Kobold,b,c Tarik Regad,d Silvia Zappavigna,d and Michele Caraglia
Publicado en: Translational Oncology, Edición 19365233, 2021, ISSN 1936-5233
Editor: Neoplasia Press
DOI: 10.1016/j.tranon.2021.101134

Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22.

Autores: Giannou AD, Kempski J, Shiri AM, Lücke J, Zhang T, Zhao L, Zazara DE, Cortesi F, Riecken K, Amezcua Vesely MC, Low JS, Xu H, Kaffe E, Garcia-Perez L, Agalioti T, Yamada Y, Jungraithmayr W, Zigmond E, Karstens KF, Steglich B, Wagner J, Konczalla L, Carambia A, Schulze K, von Felden J, May P, Briukhovetska D, Bedke T, Brockmann L, Starzonek S, Lange T, Koch C, Riethdorf S, Pelczar P, Böttcher M, S
Publicado en: Immunity, 2023, ISSN 1074-7613
Editor: Cell Press
DOI: 10.1016/j.immuni.2022.12.014

CXCR6 expressing T cells: Functions and role in the control of tumors

Autores: Mabrouk N, Tran T, Sam I, Pourmir I, Gruel N, Granier C, Pineau J, Gey A, Kobold S, Fabre E, Tartour E.
Publicado en: Frontiers in Immunology, 2022, ISSN 1664-3224
Editor: Lausanne Frontiers Media S.A. 2010-
DOI: 10.3389/fimmu.2022.1022136

Rational design of PD-1-CD28 immunostimulatory fusion proteins for CAR T cell therapy

Autores: Lorenzini T, Cadilha BL, Obeck H, Benmebarek MR, Märkl F, Michaelides S, Strzalkowski T, Briukhovetska D, Müller PJ, Nandi S, Winter P, Majed L, Grünmeier R, Seifert M, Rausch S, Feuchtinger T, Endres S, Kobold S.
Publicado en: British Journal of Cancer, 2023, ISSN 0007-0920
Editor: Nature Publishing Group
DOI: 10.1038/s41416-023-02332-9

Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice

Autores: Barbara Spix,1 Elisabeth S. Butz,2,3 Cheng-Chang Chen,2,4 Anna Scotto Rosato,1 Rachel Tang,1 Aicha Jeridi,5 Veronika Kudrina,1 Eva Plesch,2 Philipp Wartenberg,6 Elisabeth Arlt,1 Daria Briukhovetska,7 Meshal Ansari,5 Gizem Günes Günsel,5 Thomas M. Conlon,5 Amanda Wyatt,6 Sandra Wetzel,8 Daniel Teupser,9 Lesca M. Holdt,9 Fabien Ectors,10 Ingrid Boekhoff,1 Ulrich Boehm,6 Jaime García-Añoveros,11
Publicado en: Nature Communications, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-27860-x

Alterations in regulatory T cells and immune checkpoint molecules in pancreatic cancer patients receiving FOLFIRINOX or gemcitabine plus nab-paclitaxel

Autores: "L. Sams,#1 S. Kruger,#1 V. Heinemann,1,2 D. Bararia,3 S. Haebe,1,3 S. Alig,1,3 M. Haas,1 D. Zhang,1 C. B. Westphalen,1 S. Ormanns,4 P. Metzger,5 J. Werner,6 O. Weigert,1,2,3 M. von Bergwelt-Baildon,1,2 F. Rataj,5 S. Kobold,2,5 and S. Boeck"
Publicado en: Clinical and Translational Oncology, 2021, ISSN 1699-048X
Editor: Doyma
DOI: 10.1007/s12094-021-02620-x

CAR T cell therapy in solid tumors: a short review.

Autores: Öykü Umut; Adrian Gottschlich; Stefan Endres; Sebastian Kobold
Publicado en: Memo, Edición 7, 2021, ISSN 1865-5041
Editor: Springer Verlag
DOI: 10.1007/s12254-021-00703-7

Challenges in Clinical Trial Design for T Cell‐Based Cancer Immunotherapy

Autores: Stephan F. Kruger, Bruno L. Cadilha, Michael Bergwelt‐Baildon, Stefan Endres, Sebastian Kobold
Publicado en: Clinical Pharmacology & Therapeutics, Edición 107/1, 2019, Página(s) 47-49, ISSN 0009-9236
Editor: Nature Publishing Group
DOI: 10.1002/cpt.1659

CXCR6 deficiency impairs cancer vaccine efficacy and CD8+ resident memory T-cell recruitment in head and neck and lung tumors

Autores: Karaki, Soumaya; Blanc, Charlotte; Tran, Thi; Galy-Fauroux, Isabelle; Mougel, Alice; Dransart, Estelle; Anson, Marie; Tanchot, Corinne; Paolini, Lea; Gruel, Nadege; Gibault, Laure; Lepimpec-Barhes, Francoise; Fabre, Elizabeth; Benhamouda, Nadine; Badoual, Cecile; Damotte, Diane; Donnadieu, Emmanuel; Kobold, Sebastian; Mami-Chouaib, Fathia; Golub, Rachel; Johannes, Ludger; Tartour, Eric
Publicado en: "Journal for Immunotherapy of Cancer, BMJ Publishing Group 2021, 9 (3), pp.e001948. ⟨10.1136/jitc-2020-001948⟩", Edición 1, 2021, ISSN 2051-1426
Editor: BMJ
DOI: 10.1136/jitc-2020-001948

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