What is Tuberculosis? Challenging the Current Paradigm of Tuberculosis Natural History using Mathematical Modelling Techniques

Project Information

TBornotTB

Grant agreement ID: 757699

DOI

10.3030/757699

Project closed

EC signature date 12 January 2018

Start date 1 March 2018

End date 30 November 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 818,75

EU contribution

€ 1 499 818,75

Coordinated by

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (23)

Asymptomatic but infectious – The silent driver of pathogen transmission. A pragmatic review

Author(s): Nabila Shaikh; Pooja Swali; Rein M.G.J. Houben
Published in: Epidemics, 2023, ISSN 1755-4365
Publisher: Elsevier BV
DOI: 10.1016/j.epidem.2023.100704

Subclinical tuberculosis disease - a review and analysis of prevalence surveys to inform definitions, burden, associations and screening methodology

Author(s): Beatrice Frascella, Alexandra S Richards, Bianca Sossen, Jon C Emery, Anna Odone, Irwin Law, Ikushi Onozaki, Hanif Esmail, Rein M G J Houben
Published in: Clinical Infectious Diseases, 2020, ISSN 1058-4838
Publisher: University of Chicago Press
DOI: 10.1093/cid/ciaa1402

Quantifying progression and regression across the spectrum of pulmonary tuberculosis: a data synthesis study

Author(s): Alexandra S Richards, Bianca Sossen, Jon C Emery, Katherine C Horton, Torben Heinsohn, Beatrice Frascella, Federica Balzarini, Aurea Oradini-Alacreu, Brit Häcker, Anna Odone, Nicky McCreesh, Alison D Grant, Katharina Kranzer, Frank Cobelens, Hanif Esmail, Rein M G J Houben
Published in: The Lancet Global Health, 2023, ISSN 2214-109X
Publisher: Elsevier BV
DOI: 10.1016/s2214-109x(23)00082-7

Classification of early tuberculosis states to guide research for improved care and prevention: an international Delphi consensus exercise

Author(s): Anna K Coussens, Syed MA Zaidi, Brian A Allwood, Puneet K Dewan, Prof Glenda Gray, Mikashmi Kohli , Tamara Kredo, Prof Ben J Marais, Prof Guy Marks, Leo Martinez, Morten Ruhwald, Prof Thomas J Scriba, Prof James A Seddon, Phumeza Tisile, Prof Digby F Warner, Prof Robert J Wilkinson (PhD), Hanif Esmail (PhD), Rein MGJ Houben
Published in: The Lancet Respiratory Medicine, 2024, ISSN 2213-2600
Publisher: Elsevier Limited
DOI: 10.1016/s2213-2600(24)00028-6

Adolescent tuberculosis

Author(s): Kathryn J Snow, Andrea T Cruz, James A Seddon, Rashida A Ferrand, Silvia S Chiang, Jennifer A Hughes, Beate Kampmann, Steve M Graham, Peter J Dodd, Rein M Houben, Justin T Denholm, Susan M Sawyer, Katharina Kranzer
Published in: The Lancet Child & Adolescent Health, Issue 4/1, 2020, Page(s) 68-79, ISSN 2352-4642
Publisher: Elsevier
DOI: 10.1016/s2352-4642(19)30337-2

The natural history of untreated pulmonary tuberculosis in adults: a systematic review and meta-analysis

Author(s): Bianca Sossen, Alexandra S Richards, Torben Heinsohn, Beatrice Frascella, Federica Balzarini, Aurea Oradini-Alacreu, Anna Odone, Ewelina Rogozinska, Brit Häcker, Frank Cobelens, Katharina Kranzer, Rein M G J Houben, Hanif Esmail
Published in: Lancet Respiratory Medicine, 2023, ISSN 2213-2600
Publisher: Elsevier Limited
DOI: 10.1016/s2213-2600(23)00097-8

Reevaluating progression and pathways following <i>Mycobacterium tuberculosis</i> infection within the spectrum of tuberculosis

Author(s): Katherine C. Horton; Alexandra S. Richards; Jon C. Emery; Hanif Esmail; Rein M. G. J. Houben
Published in: Proceedings of the National Academy of Sciences, 2023, ISSN 1091-6490
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2221186120

Social determinants of the changing tuberculosis prevalence in Việt Nam: Analysis of population-level cross-sectional studies

Author(s): Foster Nicola, Hai V. Nguyen, Nhung V. Nguyen, Hoa B. Nguyen, Edine W. Tiemersma, Frank G. J. Cobelens, Matthew Quaife, and Rein M. G. J. Houben.
Published in: PLOS Medicine, 2022, ISSN 1549-1676
Publisher: PLOS
DOI: 10.1371/journal.pmed.1003935

Estimating the contribution of subclinical tuberculosis disease to transmission – an individual patient data analysis from prevalence surveys

Author(s): Jon C. Emery; Peter J. Dodd; Sayera Banu; Beatrice Frascella; Frances L. Garden; Katherine C. Horton; Shahed Hossain; Irwin Law; Frank van Leth; Guy B. Marks; Hoa Binh Nguyen; Hai Viet Nguyen; Ikushi Onozaki; Maria Imelda D. Quelapio; Alexandra S Richards; Nabila Shaikh; Edine W. Tiemersma; Richard G White; Khalequ Zaman; Frank Cobelens; Rein MGJ Houben
Published in: Elife, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.1101/2022.06.09.22276188

Treatment for radiographically active, sputum culture-negative pulmonary tuberculosis: a systematic review and meta-analysis

Author(s): Adam Thorburn Gray; Liana Macpherson; Ffion Carlin; Bianca Sossen; Alexandra S. Richards; Sandra V. Kik; Rein M. G. J. Houben; Peter MacPherson; Matteo Quartagno; Ewelina Rogozińska; Hanif Esmail
Published in: PLOS ONE, 2023, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1101/2023.01.27.23285085

The contribution of asymptomatic SARS-CoV-2 infections to transmission - a model-based analysis of the Diamond Princess outbreak

Author(s): Emery, Jon C; Russel, Timothy W; Liu, Yang; Hellewell, Joel; Pearson, Carl AB; Knight, Gwen M; Eggo, Rosalind M; Kucharski, Adam J; Funk, Sebastian; Flasche, Stefan; Houben, Rein M G J
Published in: Elife, Issue 4, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.1101/2020.05.07.20093849

Self-clearance of Mycobacterium tuberculosis infection: implications for lifetime risk and population at-risk of tuberculosis disease.

Author(s): Jon C Emery; Alexandra S Richards; Katie D Dale; C. Finn McQuaid; Richard G. White; Justin T Denholm; Rein M G J Houben
Published in: Proceedings. Biological Sciences, Issue 2, 2021, ISSN 1471-2946
Publisher: The Royal Society Publishing
DOI: 10.1098/rspb.2020.1635

Beyond latent and active – a scoping review of conceptual frameworks and diagnostic criteria for tuberculosis

Author(s): Syed MA Zaidi; Anna K Coussens; James A Seddon; Tamara Kredo; Digby Warner; Rein M G J Houben; Hanif Esmail
Published in: eClinicalMedicine, Issue 2, 2023, ISSN 2589-5370
Publisher: Elsevier
DOI: 10.1101/2023.07.05.23292171

Contribution of remote M.tuberculosis infection to tuberculosis disease: A 30-year population study

Author(s): Judith R. Glynn; Palwasha Khan; Themba Mzembe; Lifted Sichali; Paul E. M. Fine; Amelia C. Crampin; Rein M. G. J. Houben
Published in: PLOS ONE, 2023, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0278136

Mind the gap – Managing tuberculosis across the disease spectrum

Author(s): Hanif Esmail; Liana Macpherson; Anna K. Coussens; Rein M.G.J. Houben
Published in: eBioMedicine, Issue 2, 2022, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2022.103928

Tuberculosis prevalence: beyond the tip of the iceberg

Author(s): Houben, Rein M G J, Hanif Esmail, Frank Cobelens, Caroline M L Williams, and Anna K Coussens.
Published in: The Lancet Respiratory Medicine, 2022, ISSN 2213-2600
Publisher: Elsevier Limited
DOI: 10.1016/s2213-2600(22)00184-9

The impact of social protection and poverty elimination on global tuberculosis incidence: a statistical modelling analysis of Sustainable Development Goal 1

Author(s): Daniel J Carter; Philippe Glaziou; Knut Lönnroth; Andrew M. Siroka; Katherine Floyd; Diana Weil; Mario C. Raviglione; Mario C. Raviglione; Rein M G J Houben; Delia Boccia
Published in: The Lancet Global Health, Issue 2, 2018, ISSN 2214-109X
Publisher: Elsevier BV
DOI: 10.1016/s2214-109x(18)30195-5

Estimating Long-term Tuberculosis Reactivation Rates in Australian Migrants

Author(s): Katie D Dale, James M Trauer, Peter J Dodd, Rein M G J Houben, Justin T Denholm
Published in: Clinical Infectious Diseases, 2019, ISSN 1058-4838
Publisher: University of Chicago Press
DOI: 10.1093/cid/ciz569

What if They Don’t Have Tuberculosis? The Consequences and Trade-offs Involved in False-positive Diagnoses of Tuberculosis

Author(s): Rein M G J Houben, Marek Lalli, Katharina Kranzer, Nick A Menzies, Samuel G Schumacher, David W Dowdy
Published in: Clinical Infectious Diseases, 2018, Page(s) 150-6, ISSN 1058-4838
Publisher: University of Chicago Press
DOI: 10.1093/cid/ciy544

Systematic neglect of men as a key population in tuberculosis

Author(s): Katherine C. Horton, Richard G. White, Rein M.G.J. Houben
Published in: Tuberculosis, Issue 113, 2018, Page(s) 249-253, ISSN 1472-9792
Publisher: Churchill Livingstone
DOI: 10.1016/j.tube.2018.09.006

Global burden of latent multidrug-resistant tuberculosis: trends and estimates based on mathematical modelling

Author(s): Gwenan M Knight, C Finn McQuaid, Peter J Dodd, Rein M G J Houben
Published in: The Lancet Infectious Diseases, Issue 19/8, 2019, Page(s) 903-912, ISSN 1473-3099
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(19)30307-x

The Importance of Heterogeneity to the Epidemiology of Tuberculosis

Author(s): James M Trauer, Peter J Dodd, M Gabriela M Gomes, Gabriela B Gomez, Rein M G J Houben, Emma S McBryde, Yayehirad A Melsew, Nicolas A Menzies, Nimalan Arinaminpathy, Sourya Shrestha, David W Dowdy
Published in: Clinical Infectious Diseases, Issue 69/1, 2018, Page(s) 159-166, ISSN 1058-4838
Publisher: University of Chicago Press
DOI: 10.1093/cid/ciy938

Use of chest radiography screening for TB: a re-evaluation of the Kolín study

Author(s): Schwalb Calderon, Alvaro; Emery, J C; Houben, R M G J
Published in: The International Journal of Tuberculosis and Lung Disease, Issue 2, 2022, ISSN 1027-3719
Publisher: International Union Against Tuberculosis And Lung Disease/Union Internationale Contre la Tuberculose et les Maladies Respiratories
DOI: 10.5588/ijtld.22.0216

Non-peer reviewed articles (3)

Post-tuberculosis mortality and morbidity: valuing the hidden epidemic

Author(s): Matthew Quaife, Rein M G J Houben, Brian Allwood, Ted Cohen, Anna K Coussens, Anthony D Harries, Sanne van Kampen, Florian M Marx, Sedona Sweeney, Robert S Wallis, Nicolas A Menzies
Published in: The Lancet Respiratory Medicine, Issue 8/4, 2020, Page(s) 332-333, ISSN 2213-2600
Publisher: Elsevier Limited
DOI: 10.1016/s2213-2600(20)30039-4

Tuberculosis transmission during the subclinical period: could unrelated cough play a part?

Author(s): Hanif Esmail, Peter J Dodd, Rein M G J Houben
Published in: The Lancet Respiratory Medicine, Issue 6/4, 2018, Page(s) 244-246, ISSN 2213-2600
Publisher: Elsevier Limited
DOI: 10.1016/s2213-2600(18)30105-x

Spotting the old foe—revisiting the case definition for TB

Author(s): Rein M G J Houben, Hanif Esmail, Jon C Emery, Louis R Joslyn, C Finn McQuaid, Nicolas A Menzies, Joaquín Sanz, Sourya Shrestha, Richard G White, Chongguang Yang, Frank Cobelens
Published in: The Lancet Respiratory Medicine, Issue 7/3, 2019, Page(s) 199-201, ISSN 2213-2600
Publisher: Elsevier Limited
DOI: 10.1016/s2213-2600(19)30038-4