Malaria Parasite Networking: Discovering Modes of Cell-Cell Communication

Project Information

MalPar.NET

Grant agreement ID: 757743

DOI 10.3030/757743

Project closed

EC signature date 13 September 2017

Start date 1 October 2017

End date 30 September 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 500 000,00

EU contribution € 1 500 000,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

Publications

Peer reviewed articles (14)

Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration

Author(s): Ofir-Birin Y, Ben Ami Pilo H, Cruz Camacho A, Rudik A, Rivkin A, Revach OY, Nir N, Block Tamin T, Abou Karam P, Kiper E, Peleg Y, Nevo R, Solomon A, Havkin-Solomon T, Rojas A, Rotkopf R, Porat Z, Avni D, Schwartz E, Zillinger T, Hartmann G, Di Pizio A, Quashie NB, Dikstein R, Gerlic M, Torrecilhas AC, Levy C, Nolte-'t Hoen ENM, Bowie AG, Regev-Rudzki N
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24997-7

Transforming parasites into their own foes: parasitic extracellular vesicles as a vaccine platform

Author(s): Daniel Alfandari, Sharon Cadury, Mattia I. Morandi, Neta Regev-Rudzki
Published in: Transforming parasites into their own foes: parasitic extracellular vesicles as a vaccine platform, 2023, ISSN 1471-5007
Publisher: CellPress
DOI: 10.1016/j.pt.2023.08.009

Extracellular vesicle fusion visualized by cryo-electron microscopy

Author(s): Mattia I Morandi, Petro Busko, Efrat Ozer-Partuk, Suman Khan, Giulia Zarfati, Yael Elbaz-Alon, Paula Abou Karam, Tina Napso Shogan, Lana Ginini, Ziv Gil, Neta Regev-Rudzki, Ori Avinoam
Published in: PNAS Nexus, 2022, ISSN 2752-6542
Publisher: OXFORDAcademics
DOI: 10.1093/pnasnexus/pgac156

Sialylated N-glycans mediate monocyte uptake of extracellular vesicles secreted from Plasmodium falciparum-infected red blood cells

Author(s): Hila Ben Ami Pilo,Sana Khan Khilji,Jost Lühle,Karina Biskup,Bar Levy Gal,Irit Rosenhek Goldian,Daniel Alfandari,Or-Yam Revach,Edo Kiper,Mattia I. Morandi,Ron Rotkopf,Ziv Porat,Véronique Blanchard,Peter H. Seeberger,Neta Regev-Rudzki,Oren Moscovitz
Published in: Journal of Extracellular Biology, 2022, ISSN 2768-2811
Publisher: Wiley Online Report
DOI: 10.1002/jex2.33

20S proteasomes secreted by the malaria parasite promote its growth

Author(s): Dekel E, Yaffe D, Rosenhek-Goldian I, Ben-Nissan G, Ofir-Birin Y, Morandi MI, Ziv T, Sisquella X, Pimentel MA, Nebl T, Kapp E, Ohana Daniel Y, Karam PA, Alfandari D, Rotkopf R, Malihi S, Temin TB, Mullick D, Revach OY, Rudik A, Gov NS, Azuri I, Porat Z, Bergamaschi G, Sorkin R, Wuite GJL, Avinoam O, Carvalho TG, Cohen SR, Sharon M, Regev-Rudzki N
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-21344-8

High-throughput analysis of the transcriptional patterns of sexual genes in malaria

Author(s): Abel Cruz Camacho, Edo Kiper, Sonia Oren , Nir Zaharoni , Netta Nir, Noam Soffer , Yael Noy, Bar Ben David, Anna Rivkin, Ron Rotkopf, Dan Michael, Teresa G Carvalho, Neta Regev-Rudzki
Published in: Parasite Vectors, 2023, ISSN 1756-3305
Publisher: BioMed Central
DOI: 10.1186/s13071-022-05624-w

Histamine releasing factor and elongation factor 1 alpha secreted via malaria parasites extracellular vesicles promote immune evasion by inhibiting specific T cell responses

Author(s): Demarta‐Gatsi, Claudia; Rivkin, Anna; Di Bartolo, Vincenzo; Peronet, Roger; Ding, Shuai; Commere, Pierre‐Henri; Guillonneau, François; Bellalou, Jacques; Brûlé, Sébastien; Abou Karam, Paula; Cohen, Sidney R.; Lagache, Thibault; Janse, Chris J.; Regev‐Rudzki, Neta; Mécheri, Salaheddine
Published in: "Cellular Microbiology, Wiley, 2019, 21 (7), ⟨10.1111/cmi.13021⟩", Issue 1, 2019, ISSN 1462-5822
Publisher: Wiley Online Library
DOI: 10.1111/cmi.13021

Monitoring Extracellular Vesicle Cargo Active Uptake by Imaging Flow Cytometry

Author(s): Yifat Ofir-Birin, Paula Abou karam, Ariel Rudik, Tal Giladi, Ziv Porat, Neta Regev-Rudzki
Published in: Frontiers in Immunology, Issue 9, 2018, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2018.01011

Antibody-Free Labeling of Malaria-Derived Extracellular Vesicles Using Flow Cytometry

Author(s): Elya Dekel, Paula Abou Karam, Yael Ohana-Daniel, Mirit Biton, Neta Regev-Rudzki, Ziv Porat
Published in: Biomedicines, Issue 8/5, 2020, Page(s) 98, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines8050098

Cell communication and protein degradation: All in one parasitic package

Author(s): Sharon M, Regev-Rudzki N
Published in: Journal of Extracellular Vesicles, 2021, ISSN 2001-3078
Publisher: Wiley Online Library
DOI: 10.1002/jev2.12116

Biogenesis of extracellular vesicles in protozoan parasites: The ESCRT complex in the trafficking fast lane?

Author(s): Abel Cruz Camacho, Daniel Alfandari, Ewa Kozela, Neta Regev-Rudzki
Published in: PLOS Pathogens, 2023, ISSN 1553-7366
Publisher: Public Library of Science
DOI: 10.1371/journal.ppat.1011140

Mitochondrial-derived vesicles retain membrane potential and contain a functional ATP synthase

Author(s): Reut Hazan Ben-Menachem, Dvora Lintzer, Tamar Ziv, Koyeli Das, Irit Rosenhek-Goldian, Ziv Porat, Hila Ben Ami Pilo, Sharon Karniely, Ann Saada, Neta Regev-Rudzki, Ophry Pines
Published in: EMBO Reports, 2023, ISSN 1469-3178
Publisher: EMBOpress
DOI: 10.15252/embr.202256114

Monitoring Distribution Dynamics of EV RNA Cargo Within Recipient Monocytes and Macrophages

Author(s): Alfandari D, Ben Ami Pilo H, Abou Karam P, Dagan O, Joubran C, Rotkopf R, Regev-Rudzki N, Porat Z
Published in: Frontiers in cellular and infection microbiology, 2022, ISSN 2235-2988
Publisher: Frontiers Media S. A.
DOI: 10.3389/fcimb.2021.739628

Malaria parasites release vesicle subpopulations with signatures of different destinations

Author(s): Paula Abou Karam, Irit Rosenhek-Goldian, Tamar Ziv, Hila Ben Ami Pilo, Ido Azuri, Anna Rivkin, Edo Kiper, Ron Rotkopf, Sidney R Cohen, Ana Claudia Torrecilhas, Ori Avinoam, Alicia Rojas, Mattia I Morandi, Neta Regev-Rudzki
Published in: EMBO Rep., 2022, ISSN 1469-3178
Publisher: EMBOPRESS
DOI: 10.15252/embr.202254755

Non-peer reviewed articles (1)

Schistosomal extracellular vesicle‐enclosed miRNAs modulate host T helper cell differentiation

Author(s): Tal Meningher, Yiftah Barsheshet, Yifat Ofir‐Birin, Daniel Gold, Boris Brant, Elya Dekel, Yechezkel Sidi, Eli Schwartz, Neta Regev‐Rudzki, Orly Avni, Dror Avni
Published in: EMBO reports, Issue 21/1, 2019, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201947882