Novel Blueprints for the Visible-Light-Mediated Assembly of C–N Bonds via Nitrogen Radicals

Project Information

NEBULAR

Grant agreement ID: 758427

DOI

10.3030/758427

Project closed

EC signature date 17 October 2017

Start date 1 January 2018

End date 31 October 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 494 777,00

EU contribution

€ 1 494 777,00

Coordinated by

RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN
Germany

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (22)

Divergent Nickel-Catalysed Ring-Opening–Functionalisation of Cyclobutanone Oximes with Organozincs

Author(s): Lucrezia Angelini; Laia Malet Sanz; Daniele Leonori
Published in: Synlett, Issue 31, 2019, Page(s) 37-40, ISSN 0936-5214
Publisher: Georg Thieme Verlag
DOI: 10.1055/s-0039-1690690

A case of chain propagation: α-aminoalkyl radicals as initiators for aryl radical chemistry

Author(s): Timothée Constantin; Fabio Juliá; Nadeem S. Sheikh; Daniele Leonori
Published in: Chemical Science, Issue 11, 2021, Page(s) 12822-12828, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sc04387g

Minimization of Back-Electron Transfer Enables the Elusive sp3 C−H Functionalization of Secondary Anilines

Author(s): Daniele Leonori; Huaibo Zhao
Published in: Angewandte Chemie International Edition, Issue 60, 2021, Page(s) 7669-7674, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202100051

Practical and Selective sp3 C–H Bond Chlorination via Aminium Radicals

Author(s): Alastair J. McMillan; Martyna Sieńkowska; Piero Di Lorenzo; Gemma K. Gransbury; Nicholas F. Chilton; Michela Salamone; Alessandro Ruffoni; Massimo Bietti; Daniele Leonori
Published in: Angewandte Chemie International Edition, Issue 60, 2021, Page(s) 7132-7139, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ange.202100030

Halogen-atom and group transfer reactivity enabled by hydrogen tunneling

Author(s): Timothée Constantin, Bartosz Górski, Michael J. Tilby, Saloua Chelli, Fabio Juliá, Josep Llaveria, Kevin J. Gillen, Hendrik Zipse, Sami Lakhdar, and Daniele Leonori
Published in: Science, 2022, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abq8663

A Desaturative Approach for Aromatic Aldehyde Synthesis via Synergistic Enamine, Photoredox and Cobalt Triple Catalysis

Author(s): Huaibo Zhao; Henry P. Caldora; Oliver Turner; James J. Douglas; Daniele Leonori
Published in: Angewandte Chemie International Edition, Issue 61, 2022, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202201870

The interplay of polar effects in controlling the selectivity of radical reactions

Author(s): Alessandro Ruffoni, Rory C. Mykura, Massimo Bietti & Daniele Leonori
Published in: Nature Synthesis, 2022, ISSN 2731-0582
Publisher: Nature Portfolio
DOI: 10.1038/s44160-022-00108-2

Applications of Halogen-Atom Transfer (XAT) for the Generation of Carbon Radicals in Synthetic Photochemistry and Photocatalysis

Author(s): Fabio Juliá; Timothée Constantin; Daniele Leonori
Published in: Chemical Reviews, Issue 122, 2022, Page(s) 2292-2352, ISSN 0009-2665
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrev.1c00558

Practical and regioselective amination of arenes using alkyl amines

Author(s): Alessandro Ruffoni, Fabio Juliá, Thomas D. Svejstrup, Alastair J. McMillan, James J. Douglas, Daniele Leonori
Published in: Nature Chemistry, Issue 11/5, 2019, Page(s) 426-433, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-019-0254-5

Photoinduced Remote Functionalization of Amides and Amines Using Electrophilic Nitrogen Radicals

Author(s): Sara P. Morcillo, Elizabeth M. Dauncey, Ji Hye Kim, James J. Douglas, Nadeem S. Sheikh, Daniele Leonori
Published in: Angewandte Chemie International Edition, Issue 57/39, 2018, Page(s) 12945-12949, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201807941

Reaction of Nitrogen-Radicals with Organometallics Under Ni-Catalysis: N-Arylations and Amino-Functionalization Cascades

Author(s): Lucrezia Angelini, Jacob Davies, Marco Simonetti, Laia Malet Sanz, Nadeem S. Sheikh, Daniele Leonori
Published in: Angewandte Chemie International Edition, Issue 58/15, 2019, Page(s) 5003-5007, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201900510

Photoinduced decarboxylative azidation of cyclic amino acids

Author(s): David C. Marcote, Rosie Street-Jeakings, Elizabeth Dauncey, James J. Douglas, Alessandro Ruffoni, Daniele Leonori
Published in: Organic & Biomolecular Chemistry, Issue 17/7, 2019, Page(s) 1839-1842, ISSN 1477-0520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8ob02702a

Aminoalkyl radicals as halogen-atom transfer agents for activation of alkyl and aryl halides

Author(s): Timothée Constantin, Margherita Zanini, Alessio Regni, Nadeem S. Sheikh, Fabio Juliá, Daniele Leonori
Published in: Science, Issue 367/6481, 2020, Page(s) 1021-1026, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aba2419

A photochemical dehydrogenative strategy for aniline synthesis

Author(s): Shashikant U. Dighe, Fabio Juliá, Alberto Luridiana, James J. Douglas, Daniele Leonori
Published in: Nature, Issue 584/7819, 2020, Page(s) 75-81, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2539-7

A dual photoredox-nickel strategy for remote functionalization via iminyl radicals: radical ring-opening-arylation, -vinylation and -alkylation cascades

Author(s): Elizabeth M. Dauncey, Shashikant U. Dighe, James J. Douglas, Daniele Leonori
Published in: Chemical Science, Issue 10/33, 2019, Page(s) 7728-7733, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9sc02616a

Photoinduced Olefin Diamination with Alkylamines

Author(s): Sebastian Govaerts, Lucrezia Angelini, Charlotte Hampton, Laia Malet‐Sanz, Alessandro Ruffoni, Daniele Leonori
Published in: Angewandte Chemie International Edition, 2020, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202005652

Divergent Strain‐Release Amino‐Functionalization of [1.1.1]Propellane with Electrophilic Nitrogen‐Radicals

Author(s): Ji Hye Kim, Alessandro Ruffoni, Yasair S. S. Al‐Faiyz, Nadeem S. Sheikh, Daniele Leonori
Published in: Angewandte Chemie International Edition, Issue 59/21, 2020, Page(s) 8225-8231, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202000140

Photoexcited nitroarenes for the oxidative cleavage of alkenes

Author(s): Alessandro Ruffoni, Charlotte Hampton, Marco Simonetti & Daniele Leonori
Published in: Nature, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05211-0

Merging Halogen-Atom Transfer (XAT) and Cobalt Catalysis to Override E2-Selectivity in the Elimination of Alkyl Halides: A Mild Route toward contra-Thermodynamic Olefins.

Author(s): Huaibo Zhao; Alastair J. McMillan; Timothée Constantin; Rory C. Mykura; Fabio Juliá; Daniele Leonori
Published in: Journal of the Americal Chemical Society, Issue 143, 2021, Page(s) 14806-14813, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c06768

Radical hydroxymethylation of alkyl iodides using formaldehyde as a C1 synthon

Author(s): Lewis Caiger; Conar Sinton; Timothée Constantin; James Douglas; Nadeem S. Sheikh; Fabio Juliá; Daniele Leonori
Published in: Chemical Science, Issue 12, 2021, Page(s) 10448-10454, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1sc03083c

A radical approach for the selective C–H borylation of azines

Author(s): Ji Hye Kim, Timothée Constantin, Marco Simonetti, Josep Llaveria, Nadeem S. Sheikh & Daniele Leonori
Published in: Nature, 2021, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-03637-6

Merging Halogen-Atom Transfer (XAT) and Copper Catalysis for the Modular Suzuki–Miyaura-Type Cross-Coupling of Alkyl Iodides and Organoborons

Author(s): Zhenhua Zhang; Bartosz Górski; Daniele Leonori
Published in: Journal of the American Chemical Society, Issue 144, 2022, Page(s) 1986-1992, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c12649