In vivo functional screens to decipher mechanisms of stochastically- and mutationally-induced chemoresistance in Acute Myeloid Leukemia

Project Information

AltCheM

Grant agreement ID: 758848

DOI

10.3030/758848

Project closed

EC signature date 5 December 2017

Start date 1 March 2018

End date 29 February 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (19)

Screening of ETO2-GLIS2–induced Super Enhancers identifies targetable cooperative dependencies in acute megakaryoblastic leukemia

Author(s): Salima Benbarche, Cécile K Lopez, Eralda Salataj, Zakia Aid, Cécile Thirant, Marie-Charlotte Laiguillon, Séverine Lecourt, Yannis Belloucif, Camille Vaganay, Marion Antonini, Jiang Hu, Alexandra da Silva Babinet, Delphine Ndiaye-Lobry, Bryann Pardieu, Arnaud Petit, Alexandre Puissant, Julie Chaumeil, Thomas Mercher, Camille Lobry
Published in: Science Adv, 2022, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abg9455

Cystine uptake inhibition potentiates front-line therapies in acute myeloid leukemia

Author(s): Pardieu, Bryann; Pasanisi, Justine; Ling, Frank; Dal Bello, Reinaldo; Penneroux, Justine; Su, Angela; Joudinaud, Romane; Chat, Laureen; Wu, Hsin Chieh; Duchmann, Matthieu; Sodaro, Gaetano; Chauvel, Clémentine; Castelli, Florence A; Vasseur, Loic; Pacchiardi, Kim; Belloucif, Yannis; Laiguillon, Marie-Charlotte; Meduri, Eshwar; Vaganay, Camille; Alexe, Gabriela; Berrou, Jeannig; Benaksas, Chaima; F
Published in: EISSN: 1476-5551, Issue 1, 2022, ISSN 1476-5551
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-022-01573-6

Walking the Tightrope: Balancing Delicate Inflammation Response to Eradicate Acute Myeloid Leukemia

Author(s): Alexandre Puissant, Hind Medyouf
Published in: Cancer Discov, 2022, ISSN 2159-8290
Publisher: AACR
DOI: 10.1158/2159-8290.cd-22-0473

The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Author(s): Angela Su, Frank Ling, Camille Vaganay, Gaetano Sodaro, Chaïma Benaksas, Reinaldo Dal Bello, Antoine Forget, Bryann Pardieu, Kevin H. Lin, Justine C. Rutter, Christopher F. Bassil, Gael Fortin, Justine Pasanisi, Iléana Antony-Debré, Gabriela Alexe, Jean-François Benoist, Alain Pruvost, Yana Pikman, Jun Qi, Marie-Hélène Schlageter, Jean-Baptiste Micol, Giovanni Roti, Thomas Cluzeau, Hervé Do
Published in: Cancer Discovery, 2020, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-19-0970

Hematopoietic differentiation at single-cell resolution in NPM1-mutated AML

Author(s): Matthieu Duchmann, Romane Joudinaud, Augustin Boudry, Justine Pasanisi, Giuseppe Di Feo, Rathana Kim, Maxime Bucci, Clémentine Chauvel, Laureen Chat, Lise Larcher, Kim Pacchiardi, Stéphanie Mathis, Emmanuel Raffoux, Lionel Adès, Céline Berthon, Emmanuelle Clappier, Christophe Roumier, Alexandre Puissant, Claude Preudhomme, Nicolas Duployez, Raphaël Itzykson
Published in: Blood Cancer J, 2022, ISSN 2044-5385
Publisher: Nature Publishing Group
DOI: 10.1038/s41408-022-00734-1

HER2 Signaling Hijacks the Creatine Shuttle to Fuel Breast Cancer Cell Growth

Author(s): Issam Ben-Sahra, Alexandre Puissant
Published in: Cell Metabolism, Issue 28/6, 2018, Page(s) 805-807, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2018.11.009

A multiparametric niche-like drug screening platform in acute myeloid leukemia

Author(s): Reinaldo Dal Bello, Justine Pasanisi, Romane Joudinaud, Matthieu Duchmann, Bryann Pardieu, Paolo Ayaka, Giuseppe Di Feo, Gaetano Sodaro, Clémentine Chauvel, Rathana Kim, Loic Vasseur, Laureen Chat, Frank Ling, Kim Pacchiardi, Camille Vaganay, Jeannig Berrou, Chaima Benaksas, Nicolas Boissel, Thorsten Braun, Claude Preudhomme, Hervé Dombret, Emmanuel Raffoux, Nina Fenouille, Emmanuelle Clappier,
Published in: Blood Cancer J, 2022, ISSN 2044-5385
Publisher: Nature Publishing Group
DOI: 10.1038/s41408-022-00689-3

Favorable pharmacokinetic and pharmacodynamic properties of gilteritinib in cerebrospinal fluid: a potential effective treatment in relapsing meningeal acute myeloid leukemia FLT3-ITD patients

Author(s): Nicolas Vignal, Loïs Kelly, Etienne Lengline, Aurélie Cabannes-Hamy, Justine Siavellis, David Ghez, Hélène Sauvageon, Thorsten Braun, Evelyne Jacqz-Aigrain, Milena Kohn, Philippe Rousselot, Alexandre Puissant, Emmanuel Raffoux, Samia Mourah, Lauriane Goldwirt
Published in: Haematologica, 2023, ISSN 1592-8721
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2022.282596

Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor

Author(s): Blandine Roux; Camille Vaganay; Jesse D. Vargas; Gabriela Alexe; Gabriela Alexe; Chaïma Benaksas; Bryann Pardieu; Nina Fenouille; Jana M. Ellegast; Jana M. Ellegast; Edyta Malolepsza; Frank Ling; Gaetano Sodaro; Linda Ross; Linda Ross; Yana Pikman; Yana Pikman; Amy Saur Conway; Amy Saur Conway; Yangzhong Tang; Tony Wu; Daniel Anderson; Ronan Le Moigne; Han-Jie Zhou; Frederic Luciano; Christina R.
Published in: "Science Translational Medicine, American Association for the Advancement of Science, 2021, 13 (587), ⟨10.1126/scitranslmed.abg1168⟩", Issue 1, 2021, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abg1168

Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory or High-risk Leukemias: A Report from the LEAP Consortium

Author(s): Yana Pikman; Sarah K. Tasian; Maria Luisa Sulis; Maria Luisa Sulis; Kristen E. Stevenson; Traci M. Blonquist; Beth Apsel Winger; Todd M. Cooper; Melinda Pauly; Kelly W. Maloney; Michael J. Burke; Patrick A. Brown; Nathan Gossai; Jennifer L. McNeer; Neerav Shukla; Peter D. Cole; Peter D. Cole; Justine M. Kahn; Jing Chen; Matthew J. Barth; Jeffrey A. Magee; Lisa M. Gennarini; Asmani A. Adhav; Cather
Published in: Cancer Discov, Issue 1, 2021, ISSN 2159-8290
Publisher: American Association for Cancer Research
DOI: 10.1158/2159-8290.cd-20-0564

Targeting a lineage-specific PI3Kɣ-Akt signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule

Author(s): Lois M Kelly, Justine C Rutter, Kevin H Lin, Frank Ling , Matthieu Duchmann, Emmanuelle Latour, Nadia Arang, Hélène Pasquer, Duong Ho Nhat, Juliette Charles, Shane T Killarney, Hazel X Ang, Federica Namor, Cécile Culeux, Bérangère Lombard, Damarys Loew, Danielle L Swaney, Nevan J Krogan, Luc Brunel, Élodie Carretero, Pascal Verdié, Muriel Amblard, Sofiane Fodil, Tony Huynh, Marie Sebert, Li
Published in: Nat Cancer, 2024, ISSN 2662-1347
Publisher: Nature Publishing Group
DOI: 10.1038/s43018-024-00782-5

Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy

Author(s): Amanda L. Robichaud; Gabriela Alexe; Gabriela Alexe; Gabriela Alexe; Amy Saur Conway; Frances F. Diehl; Kimberly Stegmaier; Kimberly Stegmaier; Jun Qi; Nicole Ocasio-Martinez; Alexandre Puissant; Yana Pikman; Angela Su; Giovanni Roti; Samuel Kitara; Caroline A. Lewis; Matthew G. Vander Heiden; Matthew G. Vander Heiden
Published in: Leukemia, Issue 1, 2022, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1101/2020.02.06.936286

Relative Mitochondrial Priming Predicts Survival in Older AML Patients Treated Intensively

Author(s): Reinaldo Dal Bello, Kim Pacchiardi, Clémentine Chauvel, Lionel Adès, Thorsten Braun, Justine Pasanisi, Elise Fournier, Céline Berthon, Emmanuelle Clappier, Emmanuel Raffoux, Delphine Lebon, Thomas Cluzeau, Christophe Roumier, Adriana Plesa, Karine Celli-Lebras, Hervé Dombret, Claude Preudhomme, Stéphanie Mathis, Alexandre Puissant, Claude Gardin, Raphael Itzykson
Published in: Hemasphere, 2022, ISSN 2572-9241
Publisher: Wiley
DOI: 10.1097/hs9.0000000000000819

Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia

Author(s): Florence F. Wagner, Lina Benajiba, Arthur J. Campbell, Michel Weïwer, Joshua R. Sacher, Jennifer P. Gale, Linda Ross, Alexandre Puissant, Gabriela Alexe, Amy Conway, Morgan Back, Yana Pikman, Ilene Galinsky, Daniel J. DeAngelo, Richard M. Stone, Taner Kaya, Xi Shi, Matthew B. Robers, Thomas Machleidt, Jennifer Wilkinson, Olivier Hermine, Andrew Kung, Adam J. Stein, Damodharan Lakshminarasimhan, M
Published in: Science Translational Medicine, Issue 10/431, 2018, Page(s) eaam8460, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aam8460

Phosphoproteomics of primary AML patient samples reveals rationale for AKT combination therapy and p53 context to overcome selinexor resistance

Author(s): Kristina B Emdal, Nicolàs Palacio-Escat, Caroline Wigerup, Akihiro Eguchi, Helén Nilsson, Dorte B Bekker-Jensen, Lars Rönnstrand, Julhash U Kazi, Alexandre Puissant, Raphaël Itzykson, Julio Saez-Rodriguez, Kristina Masson, Peter Blume-Jensen, Jesper V Olsen
Published in: Cell Rep, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.111177

PitViper: a software for comparative meta-analysis and annotation of functional screening data

Author(s): Paul-Arthur Meslin, Lois M Kelly, Salima Benbarche, Séverine Lecourt, Kevin H Lin, Justine C Rutter, Christopher F Bassil, Raphael Itzykson, Kris C Wood, Alexandre Puissant, Camille Lobry
Published in: NAR Genom Bioinform, 2024, ISSN 2631-9268
Publisher: Oxford Academic
DOI: 10.1093/nargab/lqae059

CDK6 is an essential direct target of NUP98 fusion proteins in acute myeloid leukemia

Author(s): Johannes Schmoellerl, Inês Amorim Monteiro Barbosa, Thomas Eder, Tania Brandstoetter, Luisa Schmidt, Barbara Maurer, Selina Troester, Ha Thi Thanh Pham, Mohanty Sagarajit, Jessica Ebner, Gabriele Manhart, Ezgi Aslan, Stefan Terlecki-Zaniewicz, Christa Van der Veen, Gregor Hoermann, Nicolas Duployez, Arnaud Petit, Helene Lapillonne, Alexandre Puissant, Raphael Itzykson, Richard Moriggl, Michael He
Published in: Blood, Issue 136/4, 2020, Page(s) 387-400, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2019003267

P2RY2-AKT activation is a therapeutically actionable consequence of XPO1 inhibition in acute myeloid leukemia

Author(s): Kevin H. Lin; Justine C. Rutter; Abigail Xie; Shane T. Killarney; Camille Vaganay; Chaima Benaksas; Frank Ling; Gaetano Sodaro; Paul-Arthur Meslin; Christopher F. Bassil; Nina Fenouille; Jacob Hoj; Rachel Washart; Hazel X. Ang; Christian Cerda-Smith; Paul Chaintreuil; Arnaud Jacquel; Patrick Auberger; Antoine Forget; Raphael Itzykson; Min Lu; Jiaxing Lin; Mariaelena Pierobon; Zhecheng Sheng; Xingh
Published in: Nat Cancer, Issue 1, 2022, ISSN 2662-1347
Publisher: Nature Publishing Group
DOI: 10.1038/s43018-022-00394-x

Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer

Author(s): Kevin H. Lin, Justine C. Rutter, Abigail Xie, Bryann Pardieu, Emily T. Winn, Reinaldo Dal Bello, Antoine Forget, Raphael Itzykson, Yeong-Ran Ahn, Ziwei Dai, Raiyan T. Sobhan, Grace R. Anderson, Katherine R. Singleton, Amy E. Decker, Peter S. Winter, Jason W. Locasale, Lorin Crawford, Alexandre Puissant, Kris C. Wood
Published in: Nature Genetics, Issue 52/4, 2020, Page(s) 408-417, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-020-0590-9

Non-peer reviewed articles (1)

Creatine kinase pathway inhibition alters GSK3 and WNT signaling in EVI1-positive AML

Author(s): Lina Benajiba, Gabriela Alexe, Angela Su, Emmanuel Raffoux, Jean Soulier, Michael T. Hemann, Olivier Hermine, Raphael Itzykson, Kimberly Stegmaier, Alexandre Puissant
Published in: Leukemia, Issue 33/3, 2019, Page(s) 800-804, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-018-0291-x