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In vivo functional screens to decipher mechanisms of stochastically- and mutationally-induced chemoresistance in Acute Myeloid Leukemia


The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Author(s): Angela Su, Frank Ling, Camille Vaganay, Gaetano Sodaro, Chaïma Benaksas, Reinaldo Dal Bello, Antoine Forget, Bryann Pardieu, Kevin H. Lin, Justine C. Rutter, Christopher F. Bassil, Gael Fortin, Justine Pasanisi, Iléana Antony-Debré, Gabriela Alexe, Jean-François Benoist, Alain Pruvost, Yana Pikman, Jun Qi, Marie-Hélène Schlageter, Jean-Baptiste Micol, Giovanni Roti, Thomas Cluzeau, Hervé Do
Published in: Cancer Discovery, 2020, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/

HER2 Signaling Hijacks the Creatine Shuttle to Fuel Breast Cancer Cell Growth

Author(s): Issam Ben-Sahra, Alexandre Puissant
Published in: Cell Metabolism, 28/6, 2018, Page(s) 805-807, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2018.11.009

Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor

Author(s): Blandine Roux; Camille Vaganay; Jesse D. Vargas; Gabriela Alexe; Gabriela Alexe; Chaïma Benaksas; Bryann Pardieu; Nina Fenouille; Jana M. Ellegast; Jana M. Ellegast; Edyta Malolepsza; Frank Ling; Gaetano Sodaro; Linda Ross; Linda Ross; Yana Pikman; Yana Pikman; Amy Saur Conway; Amy Saur Conway; Yangzhong Tang; Tony Wu; Daniel Anderson; Ronan Le Moigne; Han-Jie Zhou; Frederic Luciano; Christina R.
Published in: "Science Translational Medicine, American Association for the Advancement of Science, 2021, 13 (587), ⟨10.1126/scitranslmed.abg1168⟩", 19466234, 2021, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abg1168

Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia

Author(s): Florence F. Wagner, Lina Benajiba, Arthur J. Campbell, Michel Weïwer, Joshua R. Sacher, Jennifer P. Gale, Linda Ross, Alexandre Puissant, Gabriela Alexe, Amy Conway, Morgan Back, Yana Pikman, Ilene Galinsky, Daniel J. DeAngelo, Richard M. Stone, Taner Kaya, Xi Shi, Matthew B. Robers, Thomas Machleidt, Jennifer Wilkinson, Olivier Hermine, Andrew Kung, Adam J. Stein, Damodharan Lakshminarasimhan, M
Published in: Science Translational Medicine, 10/431, 2018, Page(s) eaam8460, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aam8460

CDK6 is an essential direct target of NUP98 fusion proteins in acute myeloid leukemia

Author(s): Johannes Schmoellerl, Inês Amorim Monteiro Barbosa, Thomas Eder, Tania Brandstoetter, Luisa Schmidt, Barbara Maurer, Selina Troester, Ha Thi Thanh Pham, Mohanty Sagarajit, Jessica Ebner, Gabriele Manhart, Ezgi Aslan, Stefan Terlecki-Zaniewicz, Christa Van der Veen, Gregor Hoermann, Nicolas Duployez, Arnaud Petit, Helene Lapillonne, Alexandre Puissant, Raphael Itzykson, Richard Moriggl, Michael He
Published in: Blood, 136/4, 2020, Page(s) 387-400, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2019003267

Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer

Author(s): Kevin H. Lin, Justine C. Rutter, Abigail Xie, Bryann Pardieu, Emily T. Winn, Reinaldo Dal Bello, Antoine Forget, Raphael Itzykson, Yeong-Ran Ahn, Ziwei Dai, Raiyan T. Sobhan, Grace R. Anderson, Katherine R. Singleton, Amy E. Decker, Peter S. Winter, Jason W. Locasale, Lorin Crawford, Alexandre Puissant, Kris C. Wood
Published in: Nature Genetics, 52/4, 2020, Page(s) 408-417, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-020-0590-9

Creatine kinase pathway inhibition alters GSK3 and WNT signaling in EVI1-positive AML

Author(s): Lina Benajiba, Gabriela Alexe, Angela Su, Emmanuel Raffoux, Jean Soulier, Michael T. Hemann, Olivier Hermine, Raphael Itzykson, Kimberly Stegmaier, Alexandre Puissant
Published in: Leukemia, 33/3, 2019, Page(s) 800-804, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-018-0291-x