In vivo functional screens to decipher mechanisms of stochastically- and mutationally-induced chemoresistance in Acute Myeloid Leukemia

Project Information

AltCheM

Grant agreement ID: 758848

DOI 10.3030/758848

Project closed

EC signature date 5 December 2017

Start date 1 March 2018

End date 29 February 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 500 000,00

EU contribution € 1 500 000,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Publications

Peer reviewed articles (9)

Cystine uptake inhibition potentiates front-line therapies in acute myeloid leukemia

Author(s): Pardieu, Bryann; Pasanisi, Justine; Ling, Frank; Dal Bello, Reinaldo; Penneroux, Justine; Su, Angela; Joudinaud, Romane; Chat, Laureen; Wu, Hsin Chieh; Duchmann, Matthieu; Sodaro, Gaetano; Chauvel, Clémentine; Castelli, Florence A; Vasseur, Loic; Pacchiardi, Kim; Belloucif, Yannis; Laiguillon, Marie-Charlotte; Meduri, Eshwar; Vaganay, Camille; Alexe, Gabriela; Berrou, Jeannig; Benaksas, Chaima; F
Published in: EISSN: 1476-5551, Issue 1, 2022, ISSN 1476-5551
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-022-01573-6

The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Author(s): Angela Su, Frank Ling, Camille Vaganay, Gaetano Sodaro, Chaïma Benaksas, Reinaldo Dal Bello, Antoine Forget, Bryann Pardieu, Kevin H. Lin, Justine C. Rutter, Christopher F. Bassil, Gael Fortin, Justine Pasanisi, Iléana Antony-Debré, Gabriela Alexe, Jean-François Benoist, Alain Pruvost, Yana Pikman, Jun Qi, Marie-Hélène Schlageter, Jean-Baptiste Micol, Giovanni Roti, Thomas Cluzeau, Hervé Do
Published in: Cancer Discovery, 2020, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-19-0970

HER2 Signaling Hijacks the Creatine Shuttle to Fuel Breast Cancer Cell Growth

Author(s): Issam Ben-Sahra, Alexandre Puissant
Published in: Cell Metabolism, Issue 28/6, 2018, Page(s) 805-807, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2018.11.009

Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor

Author(s): Blandine Roux; Camille Vaganay; Jesse D. Vargas; Gabriela Alexe; Gabriela Alexe; Chaïma Benaksas; Bryann Pardieu; Nina Fenouille; Jana M. Ellegast; Jana M. Ellegast; Edyta Malolepsza; Frank Ling; Gaetano Sodaro; Linda Ross; Linda Ross; Yana Pikman; Yana Pikman; Amy Saur Conway; Amy Saur Conway; Yangzhong Tang; Tony Wu; Daniel Anderson; Ronan Le Moigne; Han-Jie Zhou; Frederic Luciano; Christina R.
Published in: "Science Translational Medicine, American Association for the Advancement of Science, 2021, 13 (587), ⟨10.1126/scitranslmed.abg1168⟩", Issue 19466234, 2021, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abg1168

Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory or High-risk Leukemias: A Report from the LEAP Consortium

Author(s): Yana Pikman; Sarah K. Tasian; Maria Luisa Sulis; Maria Luisa Sulis; Kristen E. Stevenson; Traci M. Blonquist; Beth Apsel Winger; Todd M. Cooper; Melinda Pauly; Kelly W. Maloney; Michael J. Burke; Patrick A. Brown; Nathan Gossai; Jennifer L. McNeer; Neerav Shukla; Peter D. Cole; Peter D. Cole; Justine M. Kahn; Jing Chen; Matthew J. Barth; Jeffrey A. Magee; Lisa M. Gennarini; Asmani A. Adhav; Cather
Published in: Cancer Discov, Issue 1, 2021, ISSN 2159-8290
Publisher: American Association for Cancer Research
DOI: 10.1158/2159-8290.cd-20-0564

Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia

Author(s): Florence F. Wagner, Lina Benajiba, Arthur J. Campbell, Michel Weïwer, Joshua R. Sacher, Jennifer P. Gale, Linda Ross, Alexandre Puissant, Gabriela Alexe, Amy Conway, Morgan Back, Yana Pikman, Ilene Galinsky, Daniel J. DeAngelo, Richard M. Stone, Taner Kaya, Xi Shi, Matthew B. Robers, Thomas Machleidt, Jennifer Wilkinson, Olivier Hermine, Andrew Kung, Adam J. Stein, Damodharan Lakshminarasimhan, M
Published in: Science Translational Medicine, Issue 10/431, 2018, Page(s) eaam8460, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aam8460

CDK6 is an essential direct target of NUP98 fusion proteins in acute myeloid leukemia

Author(s): Johannes Schmoellerl, Inês Amorim Monteiro Barbosa, Thomas Eder, Tania Brandstoetter, Luisa Schmidt, Barbara Maurer, Selina Troester, Ha Thi Thanh Pham, Mohanty Sagarajit, Jessica Ebner, Gabriele Manhart, Ezgi Aslan, Stefan Terlecki-Zaniewicz, Christa Van der Veen, Gregor Hoermann, Nicolas Duployez, Arnaud Petit, Helene Lapillonne, Alexandre Puissant, Raphael Itzykson, Richard Moriggl, Michael He
Published in: Blood, Issue 136/4, 2020, Page(s) 387-400, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2019003267

P2RY2-AKT activation is a therapeutically actionable consequence of XPO1 inhibition in acute myeloid leukemia

Author(s): Kevin H. Lin; Justine C. Rutter; Abigail Xie; Shane T. Killarney; Camille Vaganay; Chaima Benaksas; Frank Ling; Gaetano Sodaro; Paul-Arthur Meslin; Christopher F. Bassil; Nina Fenouille; Jacob Hoj; Rachel Washart; Hazel X. Ang; Christian Cerda-Smith; Paul Chaintreuil; Arnaud Jacquel; Patrick Auberger; Antoine Forget; Raphael Itzykson; Min Lu; Jiaxing Lin; Mariaelena Pierobon; Zhecheng Sheng; Xingh
Published in: Nat Cancer, Issue 1, 2022, ISSN 2662-1347
Publisher: Nature Publishing Group
DOI: 10.1038/s43018-022-00394-x

Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer

Author(s): Kevin H. Lin, Justine C. Rutter, Abigail Xie, Bryann Pardieu, Emily T. Winn, Reinaldo Dal Bello, Antoine Forget, Raphael Itzykson, Yeong-Ran Ahn, Ziwei Dai, Raiyan T. Sobhan, Grace R. Anderson, Katherine R. Singleton, Amy E. Decker, Peter S. Winter, Jason W. Locasale, Lorin Crawford, Alexandre Puissant, Kris C. Wood
Published in: Nature Genetics, Issue 52/4, 2020, Page(s) 408-417, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-020-0590-9

Non-peer reviewed articles (1)

Creatine kinase pathway inhibition alters GSK3 and WNT signaling in EVI1-positive AML

Author(s): Lina Benajiba, Gabriela Alexe, Angela Su, Emmanuel Raffoux, Jean Soulier, Michael T. Hemann, Olivier Hermine, Raphael Itzykson, Kimberly Stegmaier, Alexandre Puissant
Published in: Leukemia, Issue 33/3, 2019, Page(s) 800-804, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-018-0291-x