In vivo functional screens to decipher mechanisms of stochastically- and mutationally-induced chemoresistance in Acute Myeloid Leukemia

Informacje na temat projektu

AltCheM

Identyfikator umowy o grant: 758848

DOI

10.3030/758848

Projekt został zamknięty

Data podpisania przez KE 5 Grudnia 2017

Data rozpoczęcia 1 Marca 2018

Data zakończenia 29 Lutego 2024

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 1 500 000,00

Wkład UE

€ 1 500 000,00

Koordynowany przez

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (19)

Screening of ETO2-GLIS2–induced Super Enhancers identifies targetable cooperative dependencies in acute megakaryoblastic leukemia

Autorzy: Salima Benbarche, Cécile K Lopez, Eralda Salataj, Zakia Aid, Cécile Thirant, Marie-Charlotte Laiguillon, Séverine Lecourt, Yannis Belloucif, Camille Vaganay, Marion Antonini, Jiang Hu, Alexandra da Silva Babinet, Delphine Ndiaye-Lobry, Bryann Pardieu, Arnaud Petit, Alexandre Puissant, Julie Chaumeil, Thomas Mercher, Camille Lobry
Opublikowane w: Science Adv, 2022, ISSN 2375-2548
Wydawca: AAAS
DOI: 10.1126/sciadv.abg9455

Cystine uptake inhibition potentiates front-line therapies in acute myeloid leukemia

Autorzy: Pardieu, Bryann; Pasanisi, Justine; Ling, Frank; Dal Bello, Reinaldo; Penneroux, Justine; Su, Angela; Joudinaud, Romane; Chat, Laureen; Wu, Hsin Chieh; Duchmann, Matthieu; Sodaro, Gaetano; Chauvel, Clémentine; Castelli, Florence A; Vasseur, Loic; Pacchiardi, Kim; Belloucif, Yannis; Laiguillon, Marie-Charlotte; Meduri, Eshwar; Vaganay, Camille; Alexe, Gabriela; Berrou, Jeannig; Benaksas, Chaima; F
Opublikowane w: EISSN: 1476-5551, Numer 1, 2022, ISSN 1476-5551
Wydawca: Nature Publishing Group
DOI: 10.1038/s41375-022-01573-6

Walking the Tightrope: Balancing Delicate Inflammation Response to Eradicate Acute Myeloid Leukemia

Autorzy: Alexandre Puissant, Hind Medyouf
Opublikowane w: Cancer Discov, 2022, ISSN 2159-8290
Wydawca: AACR
DOI: 10.1158/2159-8290.cd-22-0473

The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

Autorzy: Angela Su, Frank Ling, Camille Vaganay, Gaetano Sodaro, Chaïma Benaksas, Reinaldo Dal Bello, Antoine Forget, Bryann Pardieu, Kevin H. Lin, Justine C. Rutter, Christopher F. Bassil, Gael Fortin, Justine Pasanisi, Iléana Antony-Debré, Gabriela Alexe, Jean-François Benoist, Alain Pruvost, Yana Pikman, Jun Qi, Marie-Hélène Schlageter, Jean-Baptiste Micol, Giovanni Roti, Thomas Cluzeau, Hervé Do
Opublikowane w: Cancer Discovery, 2020, ISSN 2159-8274
Wydawca: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-19-0970

Hematopoietic differentiation at single-cell resolution in NPM1-mutated AML

Autorzy: Matthieu Duchmann, Romane Joudinaud, Augustin Boudry, Justine Pasanisi, Giuseppe Di Feo, Rathana Kim, Maxime Bucci, Clémentine Chauvel, Laureen Chat, Lise Larcher, Kim Pacchiardi, Stéphanie Mathis, Emmanuel Raffoux, Lionel Adès, Céline Berthon, Emmanuelle Clappier, Christophe Roumier, Alexandre Puissant, Claude Preudhomme, Nicolas Duployez, Raphaël Itzykson
Opublikowane w: Blood Cancer J, 2022, ISSN 2044-5385
Wydawca: Nature Publishing Group
DOI: 10.1038/s41408-022-00734-1

HER2 Signaling Hijacks the Creatine Shuttle to Fuel Breast Cancer Cell Growth

Autorzy: Issam Ben-Sahra, Alexandre Puissant
Opublikowane w: Cell Metabolism, Numer 28/6, 2018, Strona(/y) 805-807, ISSN 1550-4131
Wydawca: Cell Press
DOI: 10.1016/j.cmet.2018.11.009

A multiparametric niche-like drug screening platform in acute myeloid leukemia

Autorzy: Reinaldo Dal Bello, Justine Pasanisi, Romane Joudinaud, Matthieu Duchmann, Bryann Pardieu, Paolo Ayaka, Giuseppe Di Feo, Gaetano Sodaro, Clémentine Chauvel, Rathana Kim, Loic Vasseur, Laureen Chat, Frank Ling, Kim Pacchiardi, Camille Vaganay, Jeannig Berrou, Chaima Benaksas, Nicolas Boissel, Thorsten Braun, Claude Preudhomme, Hervé Dombret, Emmanuel Raffoux, Nina Fenouille, Emmanuelle Clappier,
Opublikowane w: Blood Cancer J, 2022, ISSN 2044-5385
Wydawca: Nature Publishing Group
DOI: 10.1038/s41408-022-00689-3

Favorable pharmacokinetic and pharmacodynamic properties of gilteritinib in cerebrospinal fluid: a potential effective treatment in relapsing meningeal acute myeloid leukemia FLT3-ITD patients

Autorzy: Nicolas Vignal, Loïs Kelly, Etienne Lengline, Aurélie Cabannes-Hamy, Justine Siavellis, David Ghez, Hélène Sauvageon, Thorsten Braun, Evelyne Jacqz-Aigrain, Milena Kohn, Philippe Rousselot, Alexandre Puissant, Emmanuel Raffoux, Samia Mourah, Lauriane Goldwirt
Opublikowane w: Haematologica, 2023, ISSN 1592-8721
Wydawca: Ferrata Storti Foundation
DOI: 10.3324/haematol.2022.282596

Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor

Autorzy: Blandine Roux; Camille Vaganay; Jesse D. Vargas; Gabriela Alexe; Gabriela Alexe; Chaïma Benaksas; Bryann Pardieu; Nina Fenouille; Jana M. Ellegast; Jana M. Ellegast; Edyta Malolepsza; Frank Ling; Gaetano Sodaro; Linda Ross; Linda Ross; Yana Pikman; Yana Pikman; Amy Saur Conway; Amy Saur Conway; Yangzhong Tang; Tony Wu; Daniel Anderson; Ronan Le Moigne; Han-Jie Zhou; Frederic Luciano; Christina R.
Opublikowane w: "Science Translational Medicine, American Association for the Advancement of Science, 2021, 13 (587), ⟨10.1126/scitranslmed.abg1168⟩", Numer 1, 2021, ISSN 1946-6234
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abg1168

Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory or High-risk Leukemias: A Report from the LEAP Consortium

Autorzy: Yana Pikman; Sarah K. Tasian; Maria Luisa Sulis; Maria Luisa Sulis; Kristen E. Stevenson; Traci M. Blonquist; Beth Apsel Winger; Todd M. Cooper; Melinda Pauly; Kelly W. Maloney; Michael J. Burke; Patrick A. Brown; Nathan Gossai; Jennifer L. McNeer; Neerav Shukla; Peter D. Cole; Peter D. Cole; Justine M. Kahn; Jing Chen; Matthew J. Barth; Jeffrey A. Magee; Lisa M. Gennarini; Asmani A. Adhav; Cather
Opublikowane w: Cancer Discov, Numer 1, 2021, ISSN 2159-8290
Wydawca: American Association for Cancer Research
DOI: 10.1158/2159-8290.cd-20-0564

Targeting a lineage-specific PI3Kɣ-Akt signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule

Autorzy: Lois M Kelly, Justine C Rutter, Kevin H Lin, Frank Ling , Matthieu Duchmann, Emmanuelle Latour, Nadia Arang, Hélène Pasquer, Duong Ho Nhat, Juliette Charles, Shane T Killarney, Hazel X Ang, Federica Namor, Cécile Culeux, Bérangère Lombard, Damarys Loew, Danielle L Swaney, Nevan J Krogan, Luc Brunel, Élodie Carretero, Pascal Verdié, Muriel Amblard, Sofiane Fodil, Tony Huynh, Marie Sebert, Li
Opublikowane w: Nat Cancer, 2024, ISSN 2662-1347
Wydawca: Nature Publishing Group
DOI: 10.1038/s43018-024-00782-5

Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy

Autorzy: Amanda L. Robichaud; Gabriela Alexe; Gabriela Alexe; Gabriela Alexe; Amy Saur Conway; Frances F. Diehl; Kimberly Stegmaier; Kimberly Stegmaier; Jun Qi; Nicole Ocasio-Martinez; Alexandre Puissant; Yana Pikman; Angela Su; Giovanni Roti; Samuel Kitara; Caroline A. Lewis; Matthew G. Vander Heiden; Matthew G. Vander Heiden
Opublikowane w: Leukemia, Numer 1, 2022, ISSN 0887-6924
Wydawca: Nature Publishing Group
DOI: 10.1101/2020.02.06.936286

Relative Mitochondrial Priming Predicts Survival in Older AML Patients Treated Intensively

Autorzy: Reinaldo Dal Bello, Kim Pacchiardi, Clémentine Chauvel, Lionel Adès, Thorsten Braun, Justine Pasanisi, Elise Fournier, Céline Berthon, Emmanuelle Clappier, Emmanuel Raffoux, Delphine Lebon, Thomas Cluzeau, Christophe Roumier, Adriana Plesa, Karine Celli-Lebras, Hervé Dombret, Claude Preudhomme, Stéphanie Mathis, Alexandre Puissant, Claude Gardin, Raphael Itzykson
Opublikowane w: Hemasphere, 2022, ISSN 2572-9241
Wydawca: Wiley
DOI: 10.1097/hs9.0000000000000819

Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia

Autorzy: Florence F. Wagner, Lina Benajiba, Arthur J. Campbell, Michel Weïwer, Joshua R. Sacher, Jennifer P. Gale, Linda Ross, Alexandre Puissant, Gabriela Alexe, Amy Conway, Morgan Back, Yana Pikman, Ilene Galinsky, Daniel J. DeAngelo, Richard M. Stone, Taner Kaya, Xi Shi, Matthew B. Robers, Thomas Machleidt, Jennifer Wilkinson, Olivier Hermine, Andrew Kung, Adam J. Stein, Damodharan Lakshminarasimhan, M
Opublikowane w: Science Translational Medicine, Numer 10/431, 2018, Strona(/y) eaam8460, ISSN 1946-6234
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aam8460

Phosphoproteomics of primary AML patient samples reveals rationale for AKT combination therapy and p53 context to overcome selinexor resistance

Autorzy: Kristina B Emdal, Nicolàs Palacio-Escat, Caroline Wigerup, Akihiro Eguchi, Helén Nilsson, Dorte B Bekker-Jensen, Lars Rönnstrand, Julhash U Kazi, Alexandre Puissant, Raphaël Itzykson, Julio Saez-Rodriguez, Kristina Masson, Peter Blume-Jensen, Jesper V Olsen
Opublikowane w: Cell Rep, 2022, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2022.111177

PitViper: a software for comparative meta-analysis and annotation of functional screening data

Autorzy: Paul-Arthur Meslin, Lois M Kelly, Salima Benbarche, Séverine Lecourt, Kevin H Lin, Justine C Rutter, Christopher F Bassil, Raphael Itzykson, Kris C Wood, Alexandre Puissant, Camille Lobry
Opublikowane w: NAR Genom Bioinform, 2024, ISSN 2631-9268
Wydawca: Oxford Academic
DOI: 10.1093/nargab/lqae059

CDK6 is an essential direct target of NUP98 fusion proteins in acute myeloid leukemia

Autorzy: Johannes Schmoellerl, Inês Amorim Monteiro Barbosa, Thomas Eder, Tania Brandstoetter, Luisa Schmidt, Barbara Maurer, Selina Troester, Ha Thi Thanh Pham, Mohanty Sagarajit, Jessica Ebner, Gabriele Manhart, Ezgi Aslan, Stefan Terlecki-Zaniewicz, Christa Van der Veen, Gregor Hoermann, Nicolas Duployez, Arnaud Petit, Helene Lapillonne, Alexandre Puissant, Raphael Itzykson, Richard Moriggl, Michael He
Opublikowane w: Blood, Numer 136/4, 2020, Strona(/y) 387-400, ISSN 0006-4971
Wydawca: American Society of Hematology
DOI: 10.1182/blood.2019003267

P2RY2-AKT activation is a therapeutically actionable consequence of XPO1 inhibition in acute myeloid leukemia

Autorzy: Kevin H. Lin; Justine C. Rutter; Abigail Xie; Shane T. Killarney; Camille Vaganay; Chaima Benaksas; Frank Ling; Gaetano Sodaro; Paul-Arthur Meslin; Christopher F. Bassil; Nina Fenouille; Jacob Hoj; Rachel Washart; Hazel X. Ang; Christian Cerda-Smith; Paul Chaintreuil; Arnaud Jacquel; Patrick Auberger; Antoine Forget; Raphael Itzykson; Min Lu; Jiaxing Lin; Mariaelena Pierobon; Zhecheng Sheng; Xingh
Opublikowane w: Nat Cancer, Numer 1, 2022, ISSN 2662-1347
Wydawca: Nature Publishing Group
DOI: 10.1038/s43018-022-00394-x

Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer

Autorzy: Kevin H. Lin, Justine C. Rutter, Abigail Xie, Bryann Pardieu, Emily T. Winn, Reinaldo Dal Bello, Antoine Forget, Raphael Itzykson, Yeong-Ran Ahn, Ziwei Dai, Raiyan T. Sobhan, Grace R. Anderson, Katherine R. Singleton, Amy E. Decker, Peter S. Winter, Jason W. Locasale, Lorin Crawford, Alexandre Puissant, Kris C. Wood
Opublikowane w: Nature Genetics, Numer 52/4, 2020, Strona(/y) 408-417, ISSN 1061-4036
Wydawca: Nature Publishing Group
DOI: 10.1038/s41588-020-0590-9

Non-peer reviewed articles (1)

Creatine kinase pathway inhibition alters GSK3 and WNT signaling in EVI1-positive AML

Autorzy: Lina Benajiba, Gabriela Alexe, Angela Su, Emmanuel Raffoux, Jean Soulier, Michael T. Hemann, Olivier Hermine, Raphael Itzykson, Kimberly Stegmaier, Alexandre Puissant
Opublikowane w: Leukemia, Numer 33/3, 2019, Strona(/y) 800-804, ISSN 0887-6924
Wydawca: Nature Publishing Group
DOI: 10.1038/s41375-018-0291-x