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Laser Ablation: SElectivity and monitoRing for OPTImal tuMor removAL

Objective

Laser Ablation (LA) was extensively investigated for its benefits as minimally invasive thermal therapy for tumor. Despite the LA pros as potential alternative to surgical resection (e.g., use of small fiber optics, echo-endoscope procedures and image-guidance without artifact), the lack of tools for safe and patient-specific treatment restrained its clinical use. LASER OPTIMAL offers a renaissance to LA for the practical management of challenging tumors (e.g., pancreatic cancer): it investigates and develops integrated solutions to achieve an effective and selective LA, that thermally destroys the whole tumor mass, while spearing the normal tissue around. The excellent ambition of LASER OPTIMAL is to achieve and merge: a) biocompatible nanoparticles (BNPs) injected in the tumor, to enhance the selective absorption of laser light; b) patient-specific anatomy of tumor and its surrounding, extracted from clinical images, to retrieve the optimal laser settings; c) accurate, fast and real-time heat-transfer model to simulate laser-tissue-BNPs interaction, predict and visualize the treatment dynamics; d) real-time temperature measurement system to monitor LA effects, account for unpredictable physiological events and tune the settings (closed-loop). The design of ex vivo and in vivo animal tests allows assessing the system performances and driving the possible workflow re-design. Finally, human trials are envisaged to prove the significant impact of the LASER OPTIMAL paradigm. The collaboration of researchers, engineers and clinicians will drive the use of this innovative strategy in clinical routine. The research on the patient-specific system for the mini-invasive tumors removal, and the ground-breaking insights on clinical use of BNPs will strongly impact on EU healthcare system and society, by creating a novel product. This paradigm is also embeddable in existing system of industrial partner, extendable to other procedures, thus able to encourage a dedicated market.

Call for proposal

ERC-2017-STG
See other projects for this call

Funding Scheme

ERC-STG - Starting Grant

Host institution

POLITECNICO DI MILANO
Address
Piazza Leonardo Da Vinci 32
20133 Milano
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 134 822,74

Beneficiaries (4)

POLITECNICO DI MILANO
Italy
EU contribution
€ 1 134 822,74
Address
Piazza Leonardo Da Vinci 32
20133 Milano
Activity type
Higher or Secondary Education Establishments
BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE

Participation ended

United States
EU contribution
€ 105 462,26
Address
1450 E Duarte Rd
91010 3000 Duarte Ca
Activity type
Other
FONDATION DE COOPERATION SCIENTIFIQUE
France
EU contribution
€ 184 290
Address
1 Place De L'hopital
67000 Strasbourg
Activity type
Other
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
EU contribution
€ 75 000
Address
Via Mario Negri 2
20156 Milano
Activity type
Research Organisations