Engineering T cells and B cells for Immunotherapy using V(D)J recombination

Project Information

VDJtargeting

Grant agreement ID: 759296

DOI

10.3030/759296

Project closed

EC signature date 8 September 2017

Start date 1 October 2017

End date 30 September 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 496 875,00

EU contribution

€ 1 496 875,00

Coordinated by

TEL AVIV UNIVERSITY
Israel

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (3)

Frequent aneuploidy in primary human T cells after CRISPR-Cas9 cleavage

Author(s): "Alessio David Nahmad # 1 2, Eli Reuveni # 3, Ella Goldschmidt # 4, Tamar Tenne 5, Meytal Liberman 5, Miriam Horovitz-Fried 1 2, Rami Khosravi 6, Hila Kobo 7, Eyal Reinstein 5 8, Asaf Madi 9, Uri Ben-David 10, Adi Barzel"
Published in: Nature Biotechnology, 2022, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/s41587-022-01377-0

Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion

Author(s): Alessio D. Nahmad, Yuval Raviv, Miriam Horovitz-Fried, Ilan Sofer, Tal Akriv, Daniel Nataf, Iris Dotan, Yaron Carmi, David Burstein, Yariv Wine, Itai Benhar, Adi Barzel
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19649-1

In vivo engineered B cells retain memory and secrete high titers of anti-HIV antibodies in mice

Author(s): Alessio D Nahmad , Cicera R Lazzarotto , Natalie Zelikson , Talia Kustin , Mary Tenuta , Deli Huang , Inbal Reuveni , Daniel Nataf , Yuval Raviv , Miriam Horovitz-Fried , Iris Dotan , Yaron Carmi , Rina Rosin-Arbesfeld 5, David Nemazee , James E Voss , Adi Stern , Shengdar Q Tsai , Adi Barzel
Published in: Nature Biotechnology, 2022, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/s41587-022-01328-9