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Holistic digital-to-physical prototyping and production pilot for microfluidic MEMS

Livrables

Prototype of environmental analysis platform and report on demonstration

A device with following success criteriaEvaluation of new manufactured chips vs the current lab produced chipsEvaluation of the the microfluidic devices against current state of the artEvaluation of the microfluidic devices against current validated laboratory techniques

Prototype for cancer diagnosis and report on demonstration

a A device for CTC typing by at mechanical behaviour and at leat two different biomarkers in series allowing high resolution imaging at least 40X imaging and b A device for collection of high purity ctDNANA from blood enrichmnent factor at least 100x

Prototype of organ-on-chip platform and report on demonstration

A device allowing the growth differenciation and organization of cells in predefined geometries down to 20m scales and cells survival of at least one week with an optimal target of 3 weeks Demonstration for the reconstruction of guts bone and brain models

Conference presentations, dedicated workshops and cooperation report with EPPN

At least 10 presentations of the project during conferences2 oneday workshops organized in the premise of the partners Report of the cooperation realised with the EPPN network

Marketing brochures, video and roll-up

One brochure printed in 1000 copies one video 3 to 5 minutes describing the project and the opportunities 2 roll ups describing the project

Website for the project

A website describing the project and showing news

Publications

In vitro bone metastasis dwelling in a 3D bioengineered niche

Auteurs: Weijing Han, Rania El Botty, Elodie Montaudon, Laurent Malaquin, Frederic Deschaseaux, Nicolas Espagnolle, Elisabetta Marangoni, Paul Cottu, Gérard Zalcman, Maria Carla Parrini, Franck Assayag, Luc Sensebe, Pascal Silberzan, Anne Vincent-Salomon, Guillaume Dutertre, Sergio Roman-Roman, Stephanie Descroix, Jacques Camonis
Publié dans: Biomaterials, 269, 2021, Page(s) 120624, ISSN 0142-9612
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120624

3D deterministic lateral displacement (3D-DLD) cartridge system for high throughput particle sorting

Auteurs: Petra Jusková, Lionel Matthys, Jean-Louis Viovy, Laurent Malaquin
Publié dans: Chemical Communications, 56/38, 2020, Page(s) 5190-5193, ISSN 1359-7345
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c9cc05858c

3D printing of a biocompatible low molecular weight supramolecular hydrogel by dimethylsulfoxide water solvent exchange

Auteurs: Anaïs Chalard, Morgane Mauduit, Sandrine Souleille, Pierre Joseph, Laurent Malaquin, Juliette Fitremann
Publié dans: Additive Manufacturing, 33, 2020, Page(s) 101162, ISSN 2214-8604
Éditeur: Elsevier BV
DOI: 10.1016/j.addma.2020.101162

Colon Fibroblasts and Inflammation: Sparring Partners in Colorectal Cancer Initiation?

Auteurs: Lauriane Onfroy-Roy, Dimitri Hamel, Laurent Malaquin, Audrey Ferrand
Publié dans: Cancers, 13/8, 2021, Page(s) 1749, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13081749

Miniaturized capillary ion chromatograph with UV light-emitting diode based indirect absorbance detection for anion analysis in potable and environmental waters

Auteurs: Eoin Murray, Yan Li, Sinead A. Currivan, Breda Moore, Aoife Morrin, Dermot Diamond, Mirek Macka, Brett Paull
Publié dans: Journal of Separation Science, 41/16, 2018, Page(s) 3224-3231, ISSN 1615-9306
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/jssc.201800495

Development of a Cost-Effective Sensing Platform for Monitoring Phosphate in Natural Waters

Auteurs: Andrew Donohoe, Gareth Lacour, Peter McCluskey, Dermot Diamond, Margaret McCaul
Publié dans: Chemosensors, 6/4, 2018, Page(s) 57, ISSN 2227-9040
Éditeur: -
DOI: 10.3390/chemosensors6040057

Direct laser fabrication of free-standing PEGDA-hydrogel scaffolds for neuronal cell growth

Auteurs: Angelo Accardo, Marie-Charline Blatché, Rémi Courson, Isabelle Loubinoux, Christophe Vieu, Laurent Malaquin
Publié dans: Materials Today, 21/3, 2018, Page(s) 315-316, ISSN 1369-7021
Éditeur: Elsevier BV
DOI: 10.1016/j.mattod.2018.02.004

Direct laser fabrication of meso-scale 2D and 3D architectures with micrometric feature resolution

Auteurs: Angelo Accardo, Rémi Courson, Roberto Riesco, Vincent Raimbault, Laurent Malaquin
Publié dans: Additive Manufacturing, 22, 2018, Page(s) 440-446, ISSN 2214-8604
Éditeur: Elsevier BV
DOI: 10.1016/j.addma.2018.04.027

Water-in-PDMS emulsion templating of highly interconnected porous architectures for 3D cell culture

Auteurs: Roberto Riesco, Louisa Boyer, Sarah Blosse, Pauline M. Lefebvre, Pauline Assemat, Thierry Leichlé, Angelo Accardo, Laurent Malaquin
Publié dans: ACS Applied Materials & Interfaces, 2019, ISSN 1944-8244
Éditeur: American Chemical Society
DOI: 10.1021/acsami.9b07564

Two-photon lithography and microscopy of 3D hydrogel scaffolds for neuronal cell growth

Auteurs: Angelo Accardo, Marie-Charline Blatché, Rémi Courson, Isabelle Loubinoux, Christophe Vieu, Laurent Malaquin
Publié dans: Biomedical Physics & Engineering Express, 4/2, 2018, Page(s) 027009, ISSN 2057-1976
Éditeur: IOP Publishing Ltd.
DOI: 10.1088/2057-1976/aaab93

Resolution improvement of 3D stereo-lithography through the direct laser trajectory programming: Application to microfluidic deterministic lateral displacement device

Auteurs: Petra Juskova, Alexis Ollitrault, Marco Serra, Jean-Louis Viovy, Laurent Malaquin
Publié dans: Analytica Chimica Acta, 1000, 2018, Page(s) 239-247, ISSN 0003-2670
Éditeur: Elsevier BV
DOI: 10.1016/j.aca.2017.11.062

Fabrication of 3D scaffolds reproducing intestinal epithelium topography by high-resolution 3D stereolithography

Auteurs: Justine Creff, Rémi Courson, Thomas Mangeat, Julie Foncy, Sandrine Souleille, C. Thibault, Arnaud Besson, Laurent Malaquin
Publié dans: Biomaterials, 221, 2019, Page(s) 119404, ISSN 0142-9612
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2019.119404

Fluidic Platforms Incorporating Photo-Responsive Soft-Polymers Based on Spiropyran: From Green Synthesis to Precision Flow Control

Auteurs: Komala Pandurangan, Ruairi Barrett, Dermot Diamond, Margaret McCaul
Publié dans: Frontiers in Materials, 7, 2021, ISSN 2296-8016
Éditeur: Frontiers Media SA
DOI: 10.3389/fmats.2020.615021

4D printing with spin-crossover polymer composites

Auteurs: Mario Piedrahita-Bello, José Elias Angulo-Cervera, Rémi Courson, Gábor Molnár, Laurent Malaquin, Christophe Thibault, Bertrand Tondu, Lionel Salmon, Azzedine Bousseksou
Publié dans: Journal of Materials Chemistry C, 8/18, 2020, Page(s) 6001-6005, ISSN 2050-7534
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d0tc01532f

In vitro models of intestinal epithelium: Toward bioengineered systems

Auteurs: Justine Creff, Laurent Malaquin, Arnaud Besson
Publié dans: Journal of Tissue Engineering, 12, 2021, Page(s) 204173142098520, ISSN 2041-7314
Éditeur: Journal of Tissue Engineering
DOI: 10.1177/2041731420985202