Risultati finali Demonstrators, pilots, prototypes (3) Prototype of environmental analysis platform and report on demonstration A device with following success criteriaEvaluation of new manufactured chips vs the current lab produced chipsEvaluation of the the microfluidic devices against current state of the artEvaluation of the microfluidic devices against current validated laboratory techniques Prototype for cancer diagnosis and report on demonstration a A device for CTC typing by at mechanical behaviour and at leat two different biomarkers in series allowing high resolution imaging at least 40X imaging and b A device for collection of high purity ctDNANA from blood enrichmnent factor at least 100x Prototype of organ-on-chip platform and report on demonstration A device allowing the growth differenciation and organization of cells in predefined geometries down to 20m scales and cells survival of at least one week with an optimal target of 3 weeks Demonstration for the reconstruction of guts bone and brain models Websites, patent fillings, videos etc. (3) Conference presentations, dedicated workshops and cooperation report with EPPN At least 10 presentations of the project during conferences2 oneday workshops organized in the premise of the partners Report of the cooperation realised with the EPPN network Marketing brochures, video and roll-up One brochure printed in 1000 copies one video 3 to 5 minutes describing the project and the opportunities 2 roll ups describing the project Website for the project A website describing the project and showing news Pubblicazioni Peer reviewed articles (15) In vitro bone metastasis dwelling in a 3D bioengineered niche Autori: Weijing Han, Rania El Botty, Elodie Montaudon, Laurent Malaquin, Frederic Deschaseaux, Nicolas Espagnolle, Elisabetta Marangoni, Paul Cottu, Gérard Zalcman, Maria Carla Parrini, Franck Assayag, Luc Sensebe, Pascal Silberzan, Anne Vincent-Salomon, Guillaume Dutertre, Sergio Roman-Roman, Stephanie Descroix, Jacques Camonis Pubblicato in: Biomaterials, Numero 269, 2021, Pagina/e 120624, ISSN 0142-9612 Editore: Pergamon Press Ltd. DOI: 10.1016/j.biomaterials.2020.120624 3D deterministic lateral displacement (3D-DLD) cartridge system for high throughput particle sorting Autori: Petra Jusková, Lionel Matthys, Jean-Louis Viovy, Laurent Malaquin Pubblicato in: Chemical Communications, Numero 56/38, 2020, Pagina/e 5190-5193, ISSN 1359-7345 Editore: Royal Society of Chemistry DOI: 10.1039/c9cc05858c 3D printing of a biocompatible low molecular weight supramolecular hydrogel by dimethylsulfoxide water solvent exchange Autori: Anaïs Chalard, Morgane Mauduit, Sandrine Souleille, Pierre Joseph, Laurent Malaquin, Juliette Fitremann Pubblicato in: Additive Manufacturing, Numero 33, 2020, Pagina/e 101162, ISSN 2214-8604 Editore: Elsevier BV DOI: 10.1016/j.addma.2020.101162 Colon Fibroblasts and Inflammation: Sparring Partners in Colorectal Cancer Initiation? Autori: Lauriane Onfroy-Roy, Dimitri Hamel, Laurent Malaquin, Audrey Ferrand Pubblicato in: Cancers, Numero 13/8, 2021, Pagina/e 1749, ISSN 2072-6694 Editore: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers13081749 Miniaturized capillary ion chromatograph with UV light-emitting diode based indirect absorbance detection for anion analysis in potable and environmental waters Autori: Eoin Murray, Yan Li, Sinead A. Currivan, Breda Moore, Aoife Morrin, Dermot Diamond, Mirek Macka, Brett Paull Pubblicato in: Journal of Separation Science, Numero 41/16, 2018, Pagina/e 3224-3231, ISSN 1615-9306 Editore: John Wiley & Sons Ltd. DOI: 10.1002/jssc.201800495 Development of a Cost-Effective Sensing Platform for Monitoring Phosphate in Natural Waters Autori: Andrew Donohoe, Gareth Lacour, Peter McCluskey, Dermot Diamond, Margaret McCaul Pubblicato in: Chemosensors, Numero 6/4, 2018, Pagina/e 57, ISSN 2227-9040 Editore: - DOI: 10.3390/chemosensors6040057 Direct laser fabrication of free-standing PEGDA-hydrogel scaffolds for neuronal cell growth Autori: Angelo Accardo, Marie-Charline Blatché, Rémi Courson, Isabelle Loubinoux, Christophe Vieu, Laurent Malaquin Pubblicato in: Materials Today, Numero 21/3, 2018, Pagina/e 315-316, ISSN 1369-7021 Editore: Elsevier BV DOI: 10.1016/j.mattod.2018.02.004 Direct laser fabrication of meso-scale 2D and 3D architectures with micrometric feature resolution Autori: Angelo Accardo, Rémi Courson, Roberto Riesco, Vincent Raimbault, Laurent Malaquin Pubblicato in: Additive Manufacturing, Numero 22, 2018, Pagina/e 440-446, ISSN 2214-8604 Editore: Elsevier BV DOI: 10.1016/j.addma.2018.04.027 Water-in-PDMS emulsion templating of highly interconnected porous architectures for 3D cell culture Autori: Roberto Riesco, Louisa Boyer, Sarah Blosse, Pauline M. Lefebvre, Pauline Assemat, Thierry Leichlé, Angelo Accardo, Laurent Malaquin Pubblicato in: ACS Applied Materials & Interfaces, 2019, ISSN 1944-8244 Editore: American Chemical Society DOI: 10.1021/acsami.9b07564 Two-photon lithography and microscopy of 3D hydrogel scaffolds for neuronal cell growth Autori: Angelo Accardo, Marie-Charline Blatché, Rémi Courson, Isabelle Loubinoux, Christophe Vieu, Laurent Malaquin Pubblicato in: Biomedical Physics & Engineering Express, Numero 4/2, 2018, Pagina/e 027009, ISSN 2057-1976 Editore: IOP Publishing Ltd. DOI: 10.1088/2057-1976/aaab93 Resolution improvement of 3D stereo-lithography through the direct laser trajectory programming: Application to microfluidic deterministic lateral displacement device Autori: Petra Juskova, Alexis Ollitrault, Marco Serra, Jean-Louis Viovy, Laurent Malaquin Pubblicato in: Analytica Chimica Acta, Numero 1000, 2018, Pagina/e 239-247, ISSN 0003-2670 Editore: Elsevier BV DOI: 10.1016/j.aca.2017.11.062 Fabrication of 3D scaffolds reproducing intestinal epithelium topography by high-resolution 3D stereolithography Autori: Justine Creff, Rémi Courson, Thomas Mangeat, Julie Foncy, Sandrine Souleille, C. Thibault, Arnaud Besson, Laurent Malaquin Pubblicato in: Biomaterials, Numero 221, 2019, Pagina/e 119404, ISSN 0142-9612 Editore: Pergamon Press Ltd. DOI: 10.1016/j.biomaterials.2019.119404 Fluidic Platforms Incorporating Photo-Responsive Soft-Polymers Based on Spiropyran: From Green Synthesis to Precision Flow Control Autori: Komala Pandurangan, Ruairi Barrett, Dermot Diamond, Margaret McCaul Pubblicato in: Frontiers in Materials, Numero 7, 2021, ISSN 2296-8016 Editore: Frontiers Media SA DOI: 10.3389/fmats.2020.615021 4D printing with spin-crossover polymer composites Autori: Mario Piedrahita-Bello, José Elias Angulo-Cervera, Rémi Courson, Gábor Molnár, Laurent Malaquin, Christophe Thibault, Bertrand Tondu, Lionel Salmon, Azzedine Bousseksou Pubblicato in: Journal of Materials Chemistry C, Numero 8/18, 2020, Pagina/e 6001-6005, ISSN 2050-7534 Editore: Royal Society of Chemistry DOI: 10.1039/d0tc01532f In vitro models of intestinal epithelium: Toward bioengineered systems Autori: Justine Creff, Laurent Malaquin, Arnaud Besson Pubblicato in: Journal of Tissue Engineering, Numero 12, 2021, Pagina/e 204173142098520, ISSN 2041-7314 Editore: Journal of Tissue Engineering DOI: 10.1177/2041731420985202 È in corso la ricerca di dati su OpenAIRE... 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