Periodic Reporting for period 1 - THERACAT (Bio-orthogonal catalysis for cancer therapy)
Reporting period: 2018-03-01 to 2020-02-29
At the training level, three Training Events have been organized, including lectures from supervisors as well as from external invited experts: (1) How to plan and start a PhD (M12); (2) Chemical synthesis and catalysis (M18); (3) Drug delivery and microscopy (M24). All ESRs prepared their Personal Career Development Plan which is being updated yearly. Moreover, assessment of ESRs is performed every 6 months by the corresponding Assessment Commissions formed by supervisors from the Network having different profiles (academia/industry). The first secondments have also been implemented but, unfortunately, they have been finished earlier than planned due to COVID-19 outbreak.
At the scientific level, the initial work performed allowed to obtain key tools necessary that are now available or almost complete, including: microscopy methods (IBEC-TUE), pro-dyes and pro-drugs (TUE, EDI), catalysts (BAS, GRO, TEVA), catalytic nanoparticles (TAU, TUE) and in vitro (BGX) and in vivo (TAG, TAU) methods. In the last period the combination of such elements starts to give relevant results for the consortium. The imaging techniques developed have been applied to the study of the synthesized nanoparticles providing information about their behavior in vitro and in cells. Moreover, the catalysts screening led to the first hits and the selected catalysts are now under implementation on the nanoparticles developed in the different nodes. ESRs have presented these results in international conferences and seminars/workshops, being also actively involved in communication and outreach activities open to students at different levels and to the general public.