Bio-orthogonal catalysis for cancer therapy

Project Information

THERACAT

Grant agreement ID: 765497

DOI

10.3030/765497

Project closed

EC signature date 4 April 2018

Start date 1 March 2018

End date 31 August 2022

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 3 380 767,25

EU contribution

€ 3 380 767,25

Coordinated by

FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (5)

General press articles submitted to EU magazines (M48)

General press articles submitted to EU magazines M48

THERACAT conference
THERACAT video
Website completion
General press articles submitted to EU magazines (M30)

General press articles submitted to EU magazines M30

Documents, reports (5)

Training events minutes (Training event 5)

Training events minutes Training event 5

Training events minutes (Training event 1)
Training events minutes (Training event 2)
Training events minutes (Training event 4)

Training events minutes Training event 4

Training events minutes (Training event 3)

Training events minutes Training event 3

Publications

Peer reviewed articles (12)

En Route to Stabilized Compact Conformations of Single-Chain Polymeric Nanoparticles in Complex Media

Author(s): Stefan Wijker, Linlin Deng, Fabian Eisenreich, Ilja K. Voets, and Anja R. A. Palmans
Published in: Macromolecules, Issue 00249297, 2021, Page(s) 6220-6230, ISSN 0024-9297
Publisher: American Chemical Society
DOI: 10.1021/acs.macromol.2c00930

Developing Pd(II) based amphiphilic polymeric nanoparticles for pro-drug activation in complex media

Author(s): Anjana Sathyan, Stephen Croke, Ana M. Perez-Lopez, Bas F.M. de Waal, Asier Unciti-Broceta, Anja R. A. Palmans
Published in: Molecular Systems Design & Engineering, Issue 20589689, 2022, ISSN 2058-9689
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2me00173j

Elucidating the Stability of Single-Chain Polymeric Nanoparticles in Biological Media and Living Cells

Author(s): Linlin Deng, Lorenzo Albertazzi, and Anja R. A. Palmans
Published in: Biomacromolecules, Issue 15257797, 2022, Page(s) 326-338, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.1c01291

Bioorthogonal Strategies for the in Vivo Synthesis or Release of Drugs

Author(s): Lozhkin, B.; Ward, T. R.
Published in: Bioorganic & Medicinal Chemistry, Issue 09680896, 2021, Page(s) 116310, ISSN 0968-0896
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2021.116310

Tuning the Reactivity of Micellar Nanoreactors by Precise Adjustments of the Amphiphile and Substrate Hydrophobicity

Author(s): Roey Amir; Shreyas Wagle; Gadi Slor; Shahar Tevet
Published in: Macromolecules, Issue 00249297, 2021, ISSN 0024-9297
Publisher: American Chemical Society
DOI: 10.1021/acs.macromol.1c01755

Small Molecule Kinase Inhibitor Drugs (1995-2021): Medical Indication, Pharmacology, and Synthesis

Author(s): Cecilia C Ayala-Aguilera; Teresa Valero; Álvaro Lorente-Macías; Daniel J. Baillache; Stephen Croke; Asier Unciti-Broceta
Published in: Journal of Medicinal Chemistry, Issue 65, 2022, Page(s) 1047-1131, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00963

A Close-to-Aromatize Approach for the Late-Stage Functionalization through Ring Closing Metathesis

Author(s): Lozhkin, Boris; Ward, Thomas R
Published in: Helvetica Chimica Acta, Issue 15222675, 2021, Page(s) e2100024, ISSN 1522-2675
Publisher: John Wiley & Sons
DOI: 10.1002/hlca.202100024

Judging Enzyme-Responsive Micelles by Their Covers: Direct Comparison of Dendritic Amphiphiles with Different Hydrophilic Blocks.

Author(s): Gadi Slor, Alis R. Olea, Sílvia Pujals, Ali Tigrine, Victor R. De La Rosa, Richard Hoogenboom, Lorenzo Albertazzi, Roey J. Amir
Published in: Biomacromolecules, Issue 22(3), 2021, Page(s) 1197-1210, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.0c01708

Design and Evolution of Chimeric Streptavidin for Protein-Enabled Dual Gold Catalysis

Author(s): Christoffel, F., Igareta, N., Pellizzoni, M. M., Tiessler-Sala, L., Lozhkin, B., Spiess, D. C., Lledos, A., Marechal, J.-D., Peterson, R. L., Ward, T. R.
Published in: Nature Catalysis, Issue 25201158, 2022, Page(s) 643-653, ISSN 2520-1158
Publisher: Nautre Research
DOI: 10.1038/s41929-021-00651-9

Transition metal catalysts for the bioorthogonal synthesis of bioactive agents.

Author(s): Melissa O.N. van de L'Isle; Mari Carmen Ortega-Liebana; Asier Unciti-Broceta
Published in: Current Opinion in Chemical Biology, Issue 13675931, 2021, Page(s) 32-42, ISSN 1367-5931
Publisher: Elsevier BV
DOI: 10.1016/j.cbpa.2020.10.001

Architectural Change of the Shell-Forming Block from Linear to V-Shaped Accelerates Micellar Disassembly, but Slows the Complete Enzymatic Degradation of the Amphiphiles

Author(s): Merav Segal, Lihi Ozery, Gadi Slor, Shreyas Wagle, Tamara Ehm, Roy Beck, Roey J. Amir
Published in: Biomacromolecules, Issue 15257797, 2020, Page(s) 4076-4086, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.0c00882

Mapping the relationship between total and functional antibodies conjugated to nanoparticles with spectrally-resolved direct stochastic optical reconstruction microscopy (SR-dSTORM)

Author(s): Emmanouil Archontakis, Laura Woythe, Bas van Hoof and Lorenzo Albertazzi
Published in: Nanoscale Advances, Issue 25160230, 2022, Page(s) 4402-4409, ISSN 2516-0230
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2na00435f