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Multidisciplinary European Joint Doctorate in the Design and Development of Glyco Drugs

Deliverables

Communication and public engagement report

The PhD4GlycoDrug network will assure that its research activities are made known to society at large in such a way that they can be understood by a layperson. Outreach activities will be conducted with the possibility to harvest feedback information from the targeted population, and will include: i) active participation in the Researchers’ Nights for each ESR; ii) communication via consortium website with links to Beneficiaries’ homepages and vice-versa, and link to Glycopedia; iii) social media communication (e.g. Twitter and Facebook); iv) project brochures and flyers distributed at public events (e.g. Information Days for high school students)and visits to high schools; v) Press releases, interviews and popular newspaper articles. To do so, we have made a Communication Plan and will report on its implementation. This deliverable will be updated at month 48.

Report on Dissemination of the results to scientific audience

Results will be published in quality international scientific journals, granting open access to all peer-reviewed scientific publications. The research work is expected to lead to 2-4 scientific publications per ESR, as 2 publications is a minimum requirement for a PhD thesis in some beneficiaries. High impact international journals will be targeted. To support the availability of scientific data and broad scientific community the results will be disseminated via the Network web-site, institutional repositories and networks, like ResearchGate. This deliverable will be updated at month 48.

Webpage with social media linking options

To support the availability of scientific data and broad scientific community the results will be disseminated via the Network web-site. This will be designed and will be operative shortly after beginning of the project.

Publications

Recombinant Lectin from Tepary Bean (Phaseolus acutifolius) with Specific Recognition for Cancer-Associated Glycans: Production, Structural Characterization, and Target Identification

Author(s): Dania Martínez-Alarcón, Annabelle Varrot, Elaine Fitches, John A. Gatehouse, Min Cao, Prashant Pyati, Alejandro Blanco-Labra, Teresa Garcia-Gasca
Published in: Biomolecules, Issue 10/4, 2020, Page(s) 654, ISSN 2218-273X
DOI: 10.3390/biom10040654

BC2L-C N-Terminal Lectin Domain Complexed with Histo Blood Group Oligosaccharides Provides New Structural Information

Author(s): Rafael Bermeo, Anna Bernardi, Annabelle Varrot
Published in: Molecules, Issue 25/2, 2020, Page(s) 248, ISSN 1420-3049
DOI: 10.3390/molecules25020248

A Potent Mimetic of the Siglec‐8 Ligand 6’‐Sulfo‐Sialyl Lewisx

Author(s): Blijke Kroezen, Gabriele Conti, Benedetta Girardi, Jonathan Cramer, Xiaohua Jiang, Said Rabbani, Jennifer Müller, Maja Kokot, Enrico Luisoni, Daniel Ricklin, Oliver Schwardt, Beat Ernst
Published in: ChemMedChem, 2020, ISSN 1860-7179
DOI: 10.1002/cmdc.202000417

Intracellular Hydrolysis of Small-Molecule O-Linked N-Acetylglucosamine Transferase Inhibitors Differs among Cells and Is Not Required for Its Inhibition

Author(s): Elena Maria Loi, Matjaž Weiss, Stane Pajk, Martina Gobec, Tihomir Tomašič, Roland J. Pieters, Marko Anderluh
Published in: Molecules, Issue 25/15, 2020, Page(s) 3381, ISSN 1420-3049
DOI: 10.3390/molecules25153381

Computational tools for drawing, building and displaying carbohydrates: a visual guide

Author(s): Kanhaya Lal, Rafael Bermeo, Serge Perez
Published in: Beilstein Journal of Organic Chemistry, Issue 16, 2020, Page(s) 2448-2468, ISSN 1860-5397
DOI: 10.3762/bjoc.16.199

Biochemical and structural studies of target lectin SapL1 from the emerging opportunistic microfungus Scedosporium apiospermum

Author(s): Dania Martínez-Alarcón, Viviane Balloy, Jean-Philippe Bouchara, Roland J. Pieters, Annabelle Varrot
Published in: Scientific Reports, Issue 11/1, 2021, ISSN 2045-2322
DOI: 10.1038/s41598-021-95008-4

One pot synthesis of thio -glycosides via aziridine opening reactions

Author(s): Nives Hribernik, Alice Tamburrini, Ermelinda Falletta, Anna Bernardi
Published in: Organic & Biomolecular Chemistry, Issue 19/1, 2021, Page(s) 233-247, ISSN 1477-0520
DOI: 10.1039/d0ob01956a

Overview of the Assays to Probe O-Linked β-N-Acetylglucosamine Transferase Binding and Activity

Author(s): Cyril Balsollier, Roland J. Pieters, Marko Anderluh
Published in: Molecules, Issue 26/4, 2021, Page(s) 1037, ISSN 1420-3049
DOI: 10.3390/molecules26041037

Measuring Carbohydrate-Lectin Interactions : A Guide for Beginners

Author(s): Margherita Duca
Published in: GlycoPedia, Issue e-chapter, 2020