Deliverables Documents, reports (2) Communication and public engagement report The PhD4GlycoDrug network will assure that its research activities are made known to society at large in such a way that they can be understood by a layperson. Outreach activities will be conducted with the possibility to harvest feedback information from the targeted population, and will include: i) active participation in the Researchers’ Nights for each ESR; ii) communication via consortium website with links to Beneficiaries’ homepages and vice-versa, and link to Glycopedia; iii) social media communication (e.g. Twitter and Facebook); iv) project brochures and flyers distributed at public events (e.g. Information Days for high school students)and visits to high schools; v) Press releases, interviews and popular newspaper articles. To do so, we have made a Communication Plan and will report on its implementation. This deliverable will be updated at month 48. Report on Dissemination of the results to scientific audience Results will be published in quality international scientific journals, granting open access to all peer-reviewed scientific publications. The research work is expected to lead to 2-4 scientific publications per ESR, as 2 publications is a minimum requirement for a PhD thesis in some beneficiaries. High impact international journals will be targeted. To support the availability of scientific data and broad scientific community the results will be disseminated via the Network web-site, institutional repositories and networks, like ResearchGate. This deliverable will be updated at month 48. Websites, patent fillings, videos etc. (1) Webpage with social media linking options To support the availability of scientific data and broad scientific community the results will be disseminated via the Network web-site. This will be designed and will be operative shortly after beginning of the project. Publications Peer reviewed articles (19) Benzimidazole–galactosides bind selectively to the Galectin-8 N-Terminal domain: Structure-based design and optimisation Author(s): Mujtaba Hassan, Sjors van Klaveren, Maria Håkansson, Carl Diehl, Rebeka Kovačič, Floriane Baussière, Anders P. Sundin, Jaka Dernovšek, Björn Walse, Fredrik Zetterberg, Hakon Leffler, Marko Anderluh, Tihomir Tomašič, Žiga Jakopin, Ulf J. Nilsson Published in: European Journal of Medicinal Chemistry, 2021, ISSN 0223-5234 Publisher: Elsevier BV DOI: 10.1016/j.ejmech.2021.113664 Selective Galectin-8N Ligands: The Design and Synthesis of Phthalazinone-d-Galactals Author(s): Sjors van Klaveren, Anders P. Sundin, Žiga Jakopin, Marko Anderluh, Hakon Leffler, Ulf J. Nilsson, Tihomir Tomašič Published in: ChemMedChem, 2022, Page(s) 1-8, ISSN 1860-7187 Publisher: Wiley DOI: 10.1002/cmdc.202100575 Direct sialic acid 4-OAc substitution by nitrogen, sulfur and carbon nucleophiles with retention ofstereochemistry Author(s): Tiago Bozzola, Ulf J. Nilsson and Ulf Ellervik Published in: RSC Advances, Issue 19, 2022, Page(s) 11992–11995, ISSN 2046-2069 Publisher: Royal Society of Chemistry DOI: 10.1039/d2ra01576e Prediction and Validation of a Druggable Site on Virulence Factor of Drug Resistant Burkholderia Cenocepacia Author(s): Kanhaya Lal; Kanhaya Lal; Rafael Bermeo; Rafael Bermeo; Jonathan Cramer; Francesca Vasile; Beat Ernst; Anne Imberty; Anna Bernardi; Annabelle Varrot; Laura Belvisi Published in: "Chemistry - A European Journal, Wiley-VCH Verlag, 2021, ⟨10.1002/chem.202100252⟩", Issue 1, 2021, ISSN 1521-3765 Publisher: Wiley-VCH GmbH DOI: 10.1002/chem.202100252 Recombinant Lectin from Tepary Bean (Phaseolus acutifolius) with Specific Recognition for Cancer-Associated Glycans: Production, Structural Characterization, and Target Identification Author(s): Dania Martínez-Alarcón, Annabelle Varrot, Elaine Fitches, John A. Gatehouse, Min Cao, Prashant Pyati, Alejandro Blanco-Labra, Teresa Garcia-Gasca Published in: Biomolecules, Issue 10/4, 2020, Page(s) 654, ISSN 2218-273X Publisher: MDPI DOI: 10.3390/biom10040654 New Quinolinone O-GlcNAc Transferase Inhibitors Based on Fragment Growth Author(s): Weiss Matjaž, Loi Elena M., Sterle Maša, Balsollier Cyril, Tomašič Tihomir, Pieters Roland J., Gobec Martina, Anderluh Marko Published in: Frontiers in Chemistry, 2021, ISSN 2296-2646 Publisher: Frontiers Media S.A. DOI: 10.3389/fchem.2021.666122 Rhamnose-based glycomimetic for recruitment of endogenous anti-rhamnose antibodies Author(s): Nives Hribernik, Fabrizio Chiodo, Roland J. Pieters, Anna Bernardi Published in: Tetrahedron Letters, 2022, ISSN 0040-4039 Publisher: Elsevier BV DOI: 10.1016/j.tetlet.2022.153843 BC2L-C N-Terminal Lectin Domain Complexed with Histo Blood Group Oligosaccharides Provides New Structural Information Author(s): Rafael Bermeo, Anna Bernardi, Annabelle Varrot Published in: Molecules, Issue 25/2, 2020, Page(s) 248, ISSN 1420-3049 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/molecules25020248 A Potent Mimetic of the Siglec‐8 Ligand 6’‐Sulfo‐Sialyl Lewisx Author(s): Blijke Kroezen, Gabriele Conti, Benedetta Girardi, Jonathan Cramer, Xiaohua Jiang, Said Rabbani, Jennifer Müller, Maja Kokot, Enrico Luisoni, Daniel Ricklin, Oliver Schwardt, Beat Ernst Published in: ChemMedChem, 2020, ISSN 1860-7179 Publisher: Wiley - V C H Verlag GmbbH & Co. DOI: 10.1002/cmdc.202000417 Intracellular Hydrolysis of Small-Molecule O-Linked N-Acetylglucosamine Transferase Inhibitors Differs among Cells and Is Not Required for Its Inhibition Author(s): Elena Maria Loi, Matjaž Weiss, Stane Pajk, Martina Gobec, Tihomir Tomašič, Roland J. Pieters, Marko Anderluh Published in: Molecules, Issue 25/15, 2020, Page(s) 3381, ISSN 1420-3049 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/molecules25153381 Computational tools for drawing, building and displaying carbohydrates: a visual guide Author(s): Kanhaya Lal, Rafael Bermeo, Serge Perez Published in: Beilstein Journal of Organic Chemistry, Issue 16, 2020, Page(s) 2448-2468, ISSN 1860-5397 Publisher: Beilstein-Institut DOI: 10.3762/bjoc.16.199 Biochemical and structural studies of target lectin SapL1 from the emerging opportunistic microfungus Scedosporium apiospermum Author(s): Dania Martínez-Alarcón, Viviane Balloy, Jean-Philippe Bouchara, Roland J. Pieters, Annabelle Varrot Published in: Scientific Reports, Issue 11/1, 2021, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-021-95008-4 Structure-Guided Design of d-Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain. Author(s): Mujtaba Hassan; Mujtaba Hassan; Floriane Baussière; Samo Guzelj; Anders Sundin; Maria Håkansson; Rebeka Kovačič; Hakon Leffler; Tihomir Tomašič; Marko Anderluh; Žiga Jakopin; Ulf J. Nilsson Published in: ACS Medicinal Chemistry Letters, Issue 1, 2021, Page(s) 1745–1752, ISSN 1948-5875 Publisher: American Chemical Society DOI: 10.1021/acsmedchemlett.1c00371 One pot synthesis of thio -glycosides via aziridine opening reactions Author(s): Nives Hribernik, Alice Tamburrini, Ermelinda Falletta, Anna Bernardi Published in: Organic & Biomolecular Chemistry, Issue 19/1, 2021, Page(s) 233-247, ISSN 1477-0520 Publisher: Royal Society of Chemistry DOI: 10.1039/d0ob01956a Selective Monovalent Galectin-8 Ligands Based on 3-Lactoylgalactoside Author(s): Benedetta Girardi, Martina Manna, Sjors Van Klaveren, Tihomir Tomašič, Žiga Jakopin, Hakon Leffler, Ulf J. Nilsson, Daniel Ricklin, Janez Mravljak, Oliver Schwardt, Marko Anderluh Published in: ChemMedChem, 2021, ISSN 1860-7179 Publisher: Wiley - V C H Verlag GmbbH & Co. DOI: 10.1002/cmdc.202100514 Discovery of a New Drug-like Series of OGT Inhibitors by Virtual Screening Author(s): Loi, Elena M., Tihomir Tomašič, Cyril Balsollier, Kevin van Eekelen, Matjaž Weiss, Martina Gobec, Matthew G. Alteen, David J. Vocadlo, Roland J. Pieters, and Marko Anderluh Published in: Molecules, 2022, Page(s) 1-21, ISSN 1420-3049 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/molecules27061996 Prediction and Validation of a Druggable Site on Virulence Factor of Drug Resistant Burkholderia cenocepacia Author(s): Kanhaya Lal, Rafael Bermeo, Jonathan Cramer, Francesca Vasile, Beat Ernst, Anne Imberty, Anna Bernardi, Annabelle Varrot, Laura Belvisi Published in: Chemistry - A European Journal, 2021, Page(s) 10341-10348, ISSN 1521-3765 Publisher: Wiley-VCH Verlag DOI: 10.1002/chem.202100252 Druggable Allosteric Sites in β-Propeller Lectins Author(s): Shanina E, Kuhaudomlarp S, Lal K, Seeberger PH, Imberty A, Rademacher C Published in: Angewandte Chemie International Edition, Issue 52, 2022, Page(s) 1-9, ISSN 1433-7851 Publisher: John Wiley & Sons Ltd. DOI: 10.1002/anie.202109339 Overview of the Assays to Probe O-Linked β-N-Acetylglucosamine Transferase Binding and Activity Author(s): Cyril Balsollier, Roland J. Pieters, Marko Anderluh Published in: Molecules, Issue 26/4, 2021, Page(s) 1037, ISSN 1420-3049 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/molecules26041037 Thesis and dissertations (3) DECOYS FOR DISRUPTING CARBOHYDRATE-LECTIN INTERACTIONS Author(s): Nives Hribernik Published in: 2021 Publisher: Universita' degli Studi di Milano DESIGN, SYNTHESIS AND EVALUATION OF ANTAGONISTS TOWARDS BC2L-C Author(s): Rafael Bermeo Malo Published in: 2021 Publisher: Universita' degli Studi di Milano DOI: 10.13130/bermeo-malo-rafael_phd2021-06-18 STRUCTURE-BASED DESIGN OF GLYCOMIMETIC LIGANDS FOR THE N-TERMINAL DOMAIN OF BC2L-C LECTIN Author(s): Kanhaya Lal Published in: 2021 Publisher: Universita' degli Studi di Milano DOI: 10.13130/lal-kanhaya_phd2021-12-15 Other (2) Measuring Carbohydrate-Lectin Interactions : A Guide for Beginners Author(s): Margherita Duca Published in: GlycoPedia, Issue e-chapter, 2020 Publisher: GlycoPedia (https://www.glycopedia.eu/) The Fascinating World of SigLec Proteins: A Primer Author(s): Benedetta Girardi, Serge Perez Published in: GlycoPedia, Issue e-chapter, 2022 Publisher: GlvcoPedia (https://www.glvcopedia.eu/) Searching for OpenAIRE data... 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