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Impact of air pollutants on cutaneous responses in both healthy and compromised skin barrier, and innovative solutions to protect skin against urban pollution

Deliverables

Awarding of doctoral degree - ESR2

The research assignment is intended to result in a scientific thesis either at UNIFE (ESR2) or UNIFR (ESR1 & ESR3). A copy of the PhD thesis will be made available to the PO.

Impact of cigarette smoke in combination with UV radiation on SC biomechanical properties in both healthy and atopic skin models

Report on research activities performed by ESR2 to understand the impact of cigarette smoke on skin biomechanical properties

Awarding of doctoral degree - ESR1

The research assignment is intended to result in a scientific thesis either at UNIFE (ESR2) or UNIFR (ESR1 & ESR3). A copy of the PhD thesis will be made available to the PO.

Awarding of doctoral degree - ESR3

The research assignment is intended to result in a scientific thesis either at UNIFE (ESR2) or UNIFR (ESR1 & ESR3). A copy of the PhD thesis will be made available to the PO.

Impact of diesel/gasoline exhaust in combination with UV radiation on SC biomechanical properties in both healthy and atopic skin models

Report on research activities performed by ESR3 to understand the impact of diesel/gasoline exhaust on skin biomechanical properties

Impact of ozone in combination with UV radiation on SC biomechanical properties in both healthy and atopic skin models

Report on research activities performed by ESR1 to understand the impact of ozone on skin biomechanical properties

Workshop on Effects of Pollution on Healthy and Damaged Skin

Three specific 2-day workshops will be organised during the project. The workshops will consist in plenary lessons as well as poster/podium sessions specifically dedicated to young researchers (PhD students) beyond the 3 ESRs involved in this project. Although the two workshops related to molecular biology will be led by the two academic beneficiaries (UoF & UNIFR), DCE will host the workshop related to polymer chemistry

"Scientific publication ESR3 #2"

Data dissemination in international peer-reviewed journals (at least 2 publications per ESR)

"Scientific publication ESR1 #2"

Data dissemination in international peer-reviewed journals (at least 2 publications per ESR)

"Scientific publication ESR1 #1"

Data dissemination in international peer-reviewed journals (at least 2 publications per ESR)

Advertisement of ESR position (including EURAXESS)

Advertisements with broad description of knowledge and competencies will be published widely and internationally (via electronic job postings) including on the European portal EURAXESS. Working conditions and entitlements, including career development prospects, will be part of the advertisements. The recruitment strategy will be based on open, efficient and transparent procedures, in line with “The Code of Conduct for the Recruitment of Researcher”. All applications fulfilling the position description will be taken into consideration independently of the gender, age, and nationality of the applicant.

"Scientific publication ESR3 #1"

Data dissemination in international peer-reviewed journals (at least 2 publications per ESR)

"Scientific publication ESR2 #2"

Data dissemination in international peer-reviewed journals (at least 2 publications per ESR)

"Scientific publication ESR2 #1"

Data dissemination in international peer-reviewed journals (at least 2 publications per ESR)

Workshop on Cell Culture & Molecular Biology

Three specific 2-day workshops will be organised during the project. The workshops will consist in plenary lessons as well as poster/podium sessions specifically dedicated to young researchers (PhD students) beyond the 3 ESRs involved in this project. Although the two workshops related to molecular biology will be led by the two academic beneficiaries (UoF & UNIFR), DCE will host the workshop related to polymer chemistry

Workshop on Polymer Chemistry & Silicone Technologies

Three specific 2-day workshops will be organised during the project. The workshops will consist in plenary lessons as well as poster/podium sessions specifically dedicated to young researchers (PhD students) beyond the 3 ESRs involved in this project. Although the two workshops related to molecular biology will be led by the two academic beneficiaries (UoF & UNIFR), DCE will host the workshop related to polymer chemistry

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Publications

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Author(s): Irini M. Dijkhoff, Benedetta Petracca, Roxane Prieux, Giuseppe Valacchi, Barbara Rothen-Rutishauser, Marc Eeman
Published in: Journal of Visualized Experiments, 171, 2021, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/61802

Bench approaches to study the detrimental cutaneous impact of tropospheric ozone

Author(s): Petracca, Benedetta; Rothen-Rutishauser, Barbara; Valacchi, Giuseppe; Eeman, Marc
Published in: Journal of Exposure Science & Environmental Epidemiology, 6 issues per year, 2020, ISSN 1559-0631
Publisher: Nature Publishing Group
DOI: 10.5281/zenodo.4279176

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Author(s): Irini M. Dijkhoff, Barbara Drasler, Bedia Begum Karakocak, Alke Petri-Fink, Giuseppe Valacchi, Marc Eeman, Barbara Rothen-Rutishauser
Published in: Particle and Fibre Toxicology, 17/1, 2020, ISSN 1743-8977
Publisher: BioMed Central
DOI: 10.1186/s12989-020-00366-y

Inflammasome Activation in Pollution-Induced Skin Conditions

Author(s): Francesca Ferrara, Roxane Prieux, Brittany Woodby, Giuseppe Valacchi
Published in: Plastic & Reconstructive Surgery, 147/1S-2, 2021, Page(s) 15S-24S, ISSN 0032-1052
Publisher: Williams & Wilkins Co.
DOI: 10.1097/PRS.0000000000007617

Involvement of 4‐hydroxy‐2‐nonenal in pollution‐induced skin damage

Author(s): Alessandra Pecorelli, Brittany Woodby, Roxane Prieux, Giuseppe Valacchi
Published in: BioFactors, 2019, ISSN 0951-6433
Publisher: International Union of Biochemistry by IRL Press
DOI: 10.1002/biof.1513

Mimicking cigarette smoke exposure to assess cutaneous toxicity

Author(s): Roxane Prieux, Marc Eeman, Barbara Rothen-Rutishauser, Giuseppe Valacchi
Published in: Toxicology in Vitro, 2019, Page(s) 104664, ISSN 0887-2333
Publisher: Elsevier BV
DOI: 10.1016/j.tiv.2019.104664

Ethosomes for Coenzyme Q10 Cutaneous Administration: From Design to 3D Skin Tissue Evaluation

Author(s): Sguizzato, Maddalena; Mariani, Paolo; Spinozzi Francesco; Benedusi, Mascia; Cervellati, Franco; Cortesi, Rita; Drechsler, Markus; Prieux, Roxane; Valacchi, Giuseppe; Esposito, Elisabetta
Published in: Antioxidants, 2020, ISSN 2076-3921
Publisher: MDPI
DOI: 10.3390/antiox9060485

Effects of ozone on stratum corneum lipid integrity and assembly

Author(s): Benedetta Petracca, Andreea Nădăban, Marc Eeman, Gert S. Gooris, Joke A. Bouwstra
Published in: Chemistry and Physics of Lipids, 240, 2021, Page(s) 105121, ISSN 0009-3084
Publisher: Elsevier BV
DOI: 10.1016/j.chemphyslip.2021.105121

Biological responses in reconstructed skin upon ozone and solar radiation

Author(s): Benedetta Petracca, Barbara Rothen-Rutishauser, Agnes Tessier, Yuka Kamidoi, Marc Eeman
Published in: The 31st IFSCC Congress 2020 Yokohama, 2020, Page(s) 250-258
Publisher: The Society of Cosmetic Chemists of Japan (SCCJ)
DOI: 10.5281/zenodo.5599561