Deliverables Documents, reports (39) Silkworm strain sensitivity to infections in different LD determined Silkworm strain sensitivity to infections in different LD determined Effects of clock mutations on diapause (morph morphology) in aphids Report on effects of clock mutations on diapause in aphids Entrainment profile of flies with only the ocelli-expressed Rh2 rhodopsin Entrainment profile of flies with only the ocelliexpressed Rh2 rhodopsin Entrainment profile of flies with only Rh2 and no Hiscl1 or flies with only Rh2 and no ort Entrainment profile of flies with only Rh2 and no Hiscl1 or flies with only Rh2 and no ort Silkmoth Transcriptome analysis Silkmoth Transcriptome analysis reported Nasonia functional analysis of period knock-out Nasonia functional analysis of period knock-out described (M18). D3.13 Nasonia functional analysis of other candidate clock genes on behaviour described Nasonia functional analysis of other candidate clock genes on behaviour Nasonia functional analysis of other candidate clock genes on behaviour described Circadian neuronal network responding to different manipulations Report describing how circadian neuronal network responds to different genetic and environmental manipulations Circadian behaviour and clock gene expression in pea aphids Report on circadian behaviour and clock gene expression in pea aphids Effects of bumblebee clock mutants on circadian and other behaviour Report effects of bumblebee clock mutants on circadian rhythms in locomotor activity suncompass navigation and timing visits to flowers by bumblebee foragers Effects of Ucp4c knock-out on metabolic physiology of larvae and disruptions in other signalling pathways Report effects of Ucp4c knock-outs on metabolic physiology of larvae and disruptions in other signalling pathways Diapause, circadian rhythms and gene expression in D. ezoana clock mutants Report of diapause circadian rhythms and gene expression in D ezoana clock mutants Identification of regulatory elements in light responsive genes Identification of regulatory elements in light responsive genes Description of how stress affects behaviour, synaptic plasticity and longevity of flies in when ho is manipulated genetically Description of how stress affects behaviour synaptic plasticity and longevity of flies when ho is manipulated genetically Nasonia circannual clock gene fluctuations and expression patterns Nasonia circannual clock gene fluctuations and expression patterns described Role of antioxidants on ho, clock gene expression, cell death, in normal conditions and under environmental stress Role of antioxidants sulphorafan on ho clock gene expression cell death in normal conditions and under environmental stress Circadian clock gene expression and diapause in aphids Report of circadian clock gene expression and diapause in aphids Rescue of the phenotype using UAS-Rh5 Rescue of the phenotype using UAS-Rh5. Locomotor profile and sleep of flies with different combinations of Rhodopsins and histamine receptors (ort and HisCl1) in LD 12:12 as well as short and long photoperiods Locomotor profile and sleep of flies with different combinations of Rhodopsins and histamine receptors ort and HisCl1 in LD 1212 as well as short and long photoperiods Neuronal basis for temperature compensation Report describing neuronal basis for temperature compensation Effects of clock mutations on the health and performance of nurses Report effects of clock mutations on the health and performance of nurses which are typically active aroundtheclock with no or attenuated circadian rhythms Upc4c expression in pest species Report of Upc4c expression in pest species Analyse other Rhodopsin mutants in temperature entrainment Analyse other Rhodopsin mutants in temperature entrainment including a line lacking all Rhodopsins generated by the Rouyer lab Immunohistological and in situ expression patterns of clock and neuropeptide genes in pea aphids described Immunohistological and in situ expression patterns of pea aphids described Effects of mutagenesis on neuropeptide and clock genes on linden bug Effects of knockdown and CRISPRCas9 mutagenesis on neuropeptide and clock genes on linden bug behaviour and diapause reported ho expression pattern in the brain of Drosophila during 24 h cycle in LD 12:12 Description of ho expression pattern in the brain of Drosophila during 24 h cycle in LD 12:12 Effects of Ucp4c inhibitors on pest species Effects of Ucp4c inhibitors on pest species described Analyse the behaviour of Rh5 mutants Analyse the behaviour of Rh5 mutants. Characterization of the temporal expression profiles of UCP4C in laboratory and natural fruit fly lines sampled at different latitudes Characterization of the temporal expression profiles of UCP4C at different temperatures in laboratory and natural fruit fly lines sampled at different latitudes Identification of clock cells controlling cyclic expression of ho mRNA and protein Identification of clock cells controlling cyclic expression of ho mRNA and protein Candidate photoreceptor function in the circadian clock and their expression pattern in Bombus terrestris Report describing the candidate photoreceptor function in the circadian clock and their expression pattern in Bombus terrestris Effects of photoperiod on linden bug reproductive behaviour Report of effects of photoperiod on linden bug reproductive behaviour Identification of light-sensitive genes in Nasonia Identification of lightsensitive genes in Nasonia M20 D29 Identification of regulatory elements in light responsive genes Polymorphism and gene expression linked to latitudinal variation Report describing the linking of polymorphism and gene expression patterns to latitudinal variation in behavioural circadian light response Mapping protein interactions between clock proteins in Bombus terrestris Report describing mapping clock protein interactions in Bombus terrestris D. ezoana diapause and clock gene expression under different photoperiods Report of D. ezoana diapause and clock gene expression under different photoperiods. Molecular analysis of clock protein synchronisation Molecular analysis of clock protein synchronisation in clock neurons of Rhodopsin mutants that affect behavioural temperature entrainment Expression peptides of relevant neuropeptides in linden bug Expression peptides of relevant neuropeptides described in linden bugs Characterization of mutant silkworms for productivity and sensitivity to infections Characterization of mutant silkworms for productivity and sensitivity to infections Websites, patent fillings, videos etc. (1) Websites (external and internal for data sharing) Websites (external and internal for data sharing) Other (2) Exploitation plan draft Exploitation plan draft Overall dissemination strategy including Dissemination and Communication plan Overall dissemination strategy including Dissemination and Communication plan Publications Peer reviewed articles (16) Circadian rhythms and the liver Author(s): Rodolfo Costa, Chiara Mangini, Esther D. Domenie, Lisa Zarantonello, Sara Montagnese Published in: Liver international, 2022, ISSN 1478-3223 Publisher: Blackwell Publishing Inc. DOI: 10.1111/liv.15501 Mitochondrial Cytochrome c Oxidase Defects Alter Cellular Homeostasis of Transition Metals Author(s): Michele Brischigliaro, Denis Badocco, Rodolfo Costa, Carlo Viscomi, Massimo Zeviani, Paolo Pastore, Erika Fernandez-Vizarra Published in: Frontiers in Cell and Developmental Biology, Issue 2296634X, 2022, ISSN 2296-634X Publisher: Frontiers DOI: 10.3389/fcell.2022.892069 Regulation of heme oxygenase and its cross-talks with apoptosis and autophagy under different conditions in Drosophila Author(s): Terence Al L. Abaquita, MIlena Damulewicz, Debarati Bhattacharya, Elzbieta Pyza Published in: Antioxidants, 2021, ISSN 2076-3921 Publisher: MDPI DOI: 10.3390/antiox10111716 The Circadian Clock in Lepidoptera Author(s): Daniel Brady; Alessio Saviane; Silvia Cappellozza; Federica Sandrelli Published in: Frontiers in Physiology, Issue 3, 2021, ISSN 1664-042X Publisher: Frontiers Research Foundation DOI: 10.3389/fphys.2021.776826 The role of astrocytes in generating circadian rhythmicity in health and disease Author(s): Rodolfo Costa, Sara Montagnese Published in: Journal of Neurochemistry, Issue 14714159, 2021, ISSN 1471-4159 Publisher: Wiley DOI: 10.1111/jnc.15312 Antibodies Against the Clock Proteins Period and Cryptochrome Reveal the Neuronal Organization of the Circadian Clock in the Pea Aphid Author(s): Colizzi, Francesca Sara; Beer, Katharina; Cuti, Paolo; Deppisch, Peter; Martínez Torres, David; Yoshii, Taishi; Helfrich-Förster, Charlotte Published in: Frontiers in Physiology, Issue 3, 2021, ISSN 1664-042X Publisher: Frontiers Research Foundation DOI: 10.3389/fphys.2021.705048 Mesencephalic astrocyte-derived neurotrophic factor regulates morphology of pigment-dispersing factor-positive clock neurons and circadian neuronal plasticity in Drosophila melanogaster Author(s): Wojciech Krzeptowski, Lucyna Walkowicz, Ewelina Krzeptowska Edyta Motta, Kacper Witek, Joanna Szramel, Terence Al Abaquita, Published in: Frontiers in Physiology, 2021, ISSN 1664-042X Publisher: Frontiers Research Foundation DOI: 10.3389/fphys.2021.705183 Progress in the characterization of insulin-like peptides in aphids: Immunohistochemical mapping of ILP4 Author(s): Paolo Cuti, Miquel Barberà, Jan A. Veenstra, David Martínez-Torres Published in: Insect Biochemistry and Molecular Biology, Issue 136, 2021, Page(s) 103623, ISSN 0965-1748 Publisher: Pergamon Press Ltd. DOI: 10.1016/j.ibmb.2021.103623 Peripheral Sensory Organs Contribute to Temperature Synchronization of the Circadian Clock in Drosophila melanogaster Author(s): Rebekah George, Ralf Stanewsky Published in: Frontiers in Physiology, Issue 1664042X, 2021, ISSN 1664-042X Publisher: Frontiers Research Foundation DOI: 10.3389/fphys.2021.622545 Insect Cecropins, Antimicrobial Peptides with Potential Therapeutic Applications Author(s): Daniel Brady, Alessandro Grapputo, Ottavia Romoli, Federica Sandrelli Published in: International Journal of Molecular Sciences, Issue 20/23, 2019, Page(s) 5862, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms20235862 Temperature synchronization of the Drosophila circadian clock protein PERIOD is controlled by the TRPA channel PYREXIA Author(s): Sanne Roessingh, Mechthild Rosing, Martina Marunova, Maite Ogueta, Rebekah George, Angelique Lamaze, Ralf Stanewsky Published in: Communications Biology, Issue 2/1, 2019, ISSN 2399-3642 Publisher: Springer Nature group DOI: 10.1038/s42003-019-0497-0 Light and Temperature Synchronizes Locomotor Activity in the Linden Bug, Pyrrhocoris apterus Author(s): Magdalena Maria Kaniewska, Hana Vaněčková, David Doležel, Joanna Kotwica-Rolinska Published in: Frontiers in Physiology, Issue 11, 2020, ISSN 1664-042X Publisher: Frontiers Research Foundation DOI: 10.3389/fphys.2020.00242 An Efficient Workflow for Screening and Stabilizing CRISPR/Cas9-Mediated Mutant Lines in Bombyx mori Author(s): Daniel Brady, Alessio Saviane, Silvia Cappellozza, Federica Sandrelli Published in: Methods and Protocols, Issue 4/1, 2021, Page(s) 4, ISSN 2409-9279 Publisher: MDPI DOI: 10.3390/mps4010004 A natural timeless polymorphism allowing circadian clock synchronization in “white nights” Author(s): Angelique Lamaze, Chenghao Chen, Solene Leleux, Min Xu, Rebekah George & Ralf Stanewsky Published in: Nature communications, 2022, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-022-29293-6 Natural alleles of the clock gene timeless differentially affect life-history traits in Drosophila Author(s): Gabriele Andreatta, Sara Montagnese, Rodolfo Costa Published in: Frontiers in Physiology, 2022, ISSN 1664-042X Publisher: Frontiers Research Foundation DOI: 10.3389/fphys.2022.1092951 Toward a Molecular Approach to Chronotype Assessment Author(s): Alberto Biscontin, Lisa Zarantonello, Antonella Russo, Rodolfo Costa, Sara Montagnese Published in: Journal of Biological Rhythms, Issue 07487304, 2022, ISSN 0748-7304 Publisher: Sage Science Press DOI: 10.1177/07487304221099365 Other (1) The ticking of the biological clock Author(s): Valeria Zonato, Charalambos Kyriacou Published in: EU Research, Issue 27524736, 2022, ISSN 2752-4736 Publisher: Blazon Publishing and Media Ltd Searching for OpenAIRE data... 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