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Microbial deployment of new-to-nature chemistries for refactoring the barriers between living and non-living matter

Objective

This Project is about bringing a suite of chemical reactions (and its related non-biological compounds and elements) to the biological fold (i.e. their 'biologization') by going beyond the Central Dogma of Molecular Biology (DNA→ RNA→ proteins→ metabolism) through both tuning and overcoming the uni-directionality of the information flow. To reverse-engineer reactions into a biological code, the utility function of the chemical process of interest will be progressively coupled to the fitness function of a live carrier (e.g. an engineered, synthetic or cyborg-ized bacterial chassis), the intermediate steps being supported by automated chemo-robots. The new-to-nature reactions (NTN) pursued within the MADONNA lifetime as case studies will include CO2 capture and recruitment of elemental silicon to become part of essential organo-Si metabolites. Along with the development of the new reactions, the research agenda of the Project will also include the [i] modelling and prediction on the impact of the new biotransformations on the overall functioning of the Biosphere once/if adopted at a large scale by the industrial sector and [ii] design of environmental simulators for evaluating the performance and evolution of the new biological reactions under given physico-chemical settings. With such approaches, MADONNA aims to fill many of the gaps between the 3 types of global-scale processing of chemical elements operating in our planet: Geochemical, Biological and Industrial. The scale of applications of the foundational technologies developed herein (which spin themselves much beyond CO2 and silicon) is unprecedented and a large number of societal ramifications including ethical, security, safety, economic, governance and public perceptions aspects at stake will be included. If successful, MADONNA will enable an entirely new type of sustainable industry in which many types of waste become assets instead of liabilities.

Call for proposal

H2020-FETOPEN-2016-2017

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Sub call

H2020-FETOPEN-1-2016-2017

Coordinator

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Net EU contribution
€ 526 713,75
Address
Calle Serrano 117
28006 Madrid
Spain

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (7)

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
Net EU contribution
€ 439 327,50
Address
Raemistrasse 101
8092 Zuerich

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAT BASEL
Switzerland
Net EU contribution
€ 429 413,75
Address
Petersplatz 1
4051 Basel

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Isthmus

Participation ended

France
Net EU contribution
€ 225 624,25
Address
Rue Saint Amand 31
75015 Paris

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ile-de-France Ile-de-France Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
SORBONNE UNIVERSITE
France
Net EU contribution
€ 202 103,25
Address
21 Rue De L'ecole De Medecine
75006 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITY OF GLASGOW
United Kingdom
Net EU contribution
€ 421 875,00
Address
University Avenue
G12 8QQ Glasgow

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Region
West Central Scotland Glasgow City
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSIDAD POMPEU FABRA
Spain
Net EU contribution
€ 313 450,00
Address
Placa De La Merce, 10-12
08002 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
BIOFACTION KG
Austria
Net EU contribution
€ 410 310,00
Address
Kundmanngasse 39/12
1030 Wien

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Wien Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00