Objective
There is currently no high-throughput method to efficiently identify and optimize nanoparticle delivery of therapeutic relevant cargo such as drugs or mRNA before progression through costly clinical development. This is in stark contrast to the situation for small molecules and antibodies, where screening technologies such as high-throughput small molecule screening and phage display in the last decades have proven very successful to aid and drive drug discovery and development.
Our project ‘CodeSphere’ seeks to develop a method for DNA-tagging of nanoparticles to efficiently optimize nanoparticles on several parameters in parallel from libraries which - in time - will be at least 1.000-10.000 larger than the capability of current state-of-the-art screening methods. The project will initially work towards the generation of a library of > 1.000 different T cell targeted liposomal nanoparticles containing mRNA encoding anti-cancer proteins.
This library of DNA-tagged nanoparticles will be screened in “one-pot” in human blood to identify nanoparticles with optimal characteristics to efficiently deliver mRNA to specific cell populations.
Through such a technology, one could gain knowledge on which particle design is most optimal including stability in blood, ‘stealth’ evasion of the immune system, optimal systemic circulation time, efficiency in reaching the target tissue (e.g. cancer lesion) and efficiency in delivering the drug or other cargo. The technology can be applied to whole blood preparations, primary cells, cell lines, and even as in vivo screening in whole organisms.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences biological sciences microbiology virology
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine oncology
- engineering and technology nanotechnology nano-materials
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-POC - Proof of Concept Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2017-PoC
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2800 Kongens Lyngby
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.