Investigating nutrients as key determinants of DC-induced CD8 T cell responses

Project Information

DC_Nutrient

Grant agreement ID: 770769

DOI

10.3030/770769

Project closed

EC signature date 26 April 2018

Start date 1 May 2018

End date 30 April 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 995 861,00

EU contribution

€ 1 995 861,00

Coordinated by

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

Publications

Peer reviewed articles (13)

Competition for nutrients and its role in controlling immune responses

Author(s): Nidhi Kedia-Mehta, David K. Finlay
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-10015-4

The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing

Author(s): Mariana P. Cervantes-Silva, Richard G. Carroll, Mieszko M. Wilk, Diana Moreira, Cloe A. Payet, James R. O’Siorain, Shannon L. Cox, Lauren E. Fagan, Paula A. Klavina, Yan He, Tabea Drewinski, Alan McGinley, Sharleen M. Buel, George A. Timmons, James O. Early, Roger J. S. Preston, Jennifer M. Hurley, David K. Finlay, Ingmar Schoen, F. Javier Sánchez-García, Kingston H. G. Mills & Annie M. Curtis
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34897-z

Cytokine-induced natural killer cell training is dependent on cellular metabolism and is defective in obesity

Author(s): Nidhi Kedia-Mehta, Laura Tobin, Vanessa Zaiatz-Bittencourt, Marta M. Pisarska, Conor De Barra, Chloe Choi, Einas Elamin, Donal O’Shea, Clair M. Gardiner, David K. Finlay, Andrew E. Hogan
Published in: Blood Advances, 2021, ISSN 2473-9537
Publisher: American Society of Hematology
DOI: 10.1182/bloodadvances.2021005047

Metabolic requirements of NK cells during the acute response against retroviral infection

Author(s): Littwitz-Salomon, E; Moreira, D; Frost, JN; Choi, C; Liou, KT; Ahern, DK; O'Shaughnessy, S; Wagner, B; Biron, CA; Drakesmith, H; Dittmer, U; Finlay, DK
Published in: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021), Issue 3, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25715-z

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses

Author(s): Xavier Michelet, Lydia Dyck, Andrew Hogan, Roisin M. Loftus, Danielle Duquette, Kevin Wei, Semir Beyaz, Ali Tavakkoli, Cathriona Foley, Raymond Donnelly, Cliona O’Farrelly, Mathilde Raverdeau, Ashley Vernon, William Pettee, Donal O’Shea, Barbara S. Nikolajczyk, Kingston H. G. Mills, Michael B. Brenner, David Finlay & Lydia Lynch
Published in: Nature Immunology, 2018, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-018-0251-7

Metabolites: fuelling the immune response

Author(s): Mauro Corrado; Diana Moreira; Nicholas Jones
Published in: Clinical and Experimental Immunology, Issue 3, 2022, ISSN 2475-6296
Publisher: Oxford University Press
DOI: 10.1093/cei/uxac053

Natural Killer Cells Integrate Signals Received from Tumour Interactions and IL2 to Induce Robust and Prolonged Anti-Tumour and Metabolic Responses.

Author(s): Finlay, David; Kedia-Mehta, Nidhi; Choi, Chloe; McCrudden, Aisling; Littwitz-Salomon, Elisabeth; Fox, Proinnsias G.; Gardiner, Clair M.
Published in: Immunometabolism, Issue 3, 2019, ISSN 2633-0407
Publisher: Jane Mao, Wolters Kluwer
DOI: 10.20900/immunometab20190014

Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages

Author(s): Jennifer K Dowling , Remsha Afzal Linden J Gearing , Mariana P Cervantes-Silva , Stephanie Annett , Gavin M Davis , Chiara De Santi , Nadine Assmann , Katja Dettmer , Daniel J Gough, Glenn R Bantug Fidinny I Hamid , Frances K Nally , Conor P Duffy , Aoife L Gorman , Alex M Liddicoat , Ed C Lavelle , Christoph Hess , Peter J Oefner , David K Finlay , Gavin P Davey , Tracy Robson , Annie M Curtis
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-21617-2

Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans

Author(s): Barry Scott, Emily A. Day, Katie L. O’Brien, John Scanlan, Grace Cromwell, Aine Ni Scannail, Marie E. McDonnell, David K. Finlay & Lydia Lynch
Published in: Nature Metabolism, 2024, ISSN 2522-5812
Publisher: Nature
DOI: 10.1038/s42255-024-01018-7

Dendritic cells metabolism: a strategic path to improve antitumoral DC vaccination

Author(s): Emma Currivan; David Finlay; Diana Moreira
Published in: Clinical and Experimental Immunology, Issue 1, 2022, ISSN 2475-6296
Publisher: Oxford University Press
DOI: 10.1093/cei/uxac048

QUAS-R: An SLC1A5-mediated glutamine uptake assay with single-cell resolution reveals metabolic heterogeneity with immune populations

Author(s): Leonard R. Pelgrom; Gavin M. Davis; Simon O’Shaughnessy; Emilie J.M. Wezenberg; Sander I. Van Kasteren; David K. Finlay; Linda V. Sinclair
Published in: Cell Reports, Vol 42, Iss 8, Pp 112828- (2023), Issue 5, 2023, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.112828

Optimising NK cell metabolism to increase the efficacy of cancer immunotherapy

Author(s): Choi, Chloe; Finlay, David K.
Published in: Stem Cell Research & Therapy, Issue 3, 2021, ISSN 1757-6512
Publisher: BioMed Central
DOI: 10.1186/s13287-021-02377-8

Diverse Immunoregulatory Roles of Oxysterols-The Oxidized Cholesterol Metabolites.

Author(s): Chloe Choi; David K. Finlay
Published in: Metabolites, Issue 1, 2020, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo10100384