Investigating nutrients as key determinants of DC-induced CD8 T cell responses

Informazioni relative al progetto

DC_Nutrient

ID dell’accordo di sovvenzione: 770769

DOI

10.3030/770769

Progetto chiuso

Data della firma CE 26 Aprile 2018

Data di avvio 1 Maggio 2018

Data di completamento 30 Aprile 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 995 861,00

Contributo UE

€ 1 995 861,00

Coordinato da

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (1)

Data Management Plan

Pubblicazioni

Peer reviewed articles (13)

Competition for nutrients and its role in controlling immune responses

Autori: Nidhi Kedia-Mehta, David K. Finlay
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-10015-4

The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing

Autori: Mariana P. Cervantes-Silva, Richard G. Carroll, Mieszko M. Wilk, Diana Moreira, Cloe A. Payet, James R. O’Siorain, Shannon L. Cox, Lauren E. Fagan, Paula A. Klavina, Yan He, Tabea Drewinski, Alan McGinley, Sharleen M. Buel, George A. Timmons, James O. Early, Roger J. S. Preston, Jennifer M. Hurley, David K. Finlay, Ingmar Schoen, F. Javier Sánchez-García, Kingston H. G. Mills & Annie M. Curtis
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-34897-z

Cytokine-induced natural killer cell training is dependent on cellular metabolism and is defective in obesity

Autori: Nidhi Kedia-Mehta, Laura Tobin, Vanessa Zaiatz-Bittencourt, Marta M. Pisarska, Conor De Barra, Chloe Choi, Einas Elamin, Donal O’Shea, Clair M. Gardiner, David K. Finlay, Andrew E. Hogan
Pubblicato in: Blood Advances, 2021, ISSN 2473-9537
Editore: American Society of Hematology
DOI: 10.1182/bloodadvances.2021005047

Metabolic requirements of NK cells during the acute response against retroviral infection

Autori: Littwitz-Salomon, E; Moreira, D; Frost, JN; Choi, C; Liou, KT; Ahern, DK; O'Shaughnessy, S; Wagner, B; Biron, CA; Drakesmith, H; Dittmer, U; Finlay, DK
Pubblicato in: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021), Numero 3, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-25715-z

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses

Autori: Xavier Michelet, Lydia Dyck, Andrew Hogan, Roisin M. Loftus, Danielle Duquette, Kevin Wei, Semir Beyaz, Ali Tavakkoli, Cathriona Foley, Raymond Donnelly, Cliona O’Farrelly, Mathilde Raverdeau, Ashley Vernon, William Pettee, Donal O’Shea, Barbara S. Nikolajczyk, Kingston H. G. Mills, Michael B. Brenner, David Finlay & Lydia Lynch
Pubblicato in: Nature Immunology, 2018, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-018-0251-7

Metabolites: fuelling the immune response

Autori: Mauro Corrado; Diana Moreira; Nicholas Jones
Pubblicato in: Clinical and Experimental Immunology, Numero 3, 2022, ISSN 2475-6296
Editore: Oxford University Press
DOI: 10.1093/cei/uxac053

Natural Killer Cells Integrate Signals Received from Tumour Interactions and IL2 to Induce Robust and Prolonged Anti-Tumour and Metabolic Responses.

Autori: Finlay, David; Kedia-Mehta, Nidhi; Choi, Chloe; McCrudden, Aisling; Littwitz-Salomon, Elisabeth; Fox, Proinnsias G.; Gardiner, Clair M.
Pubblicato in: Immunometabolism, Numero 3, 2019, ISSN 2633-0407
Editore: Jane Mao, Wolters Kluwer
DOI: 10.20900/immunometab20190014

Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages

Autori: Jennifer K Dowling , Remsha Afzal Linden J Gearing , Mariana P Cervantes-Silva , Stephanie Annett , Gavin M Davis , Chiara De Santi , Nadine Assmann , Katja Dettmer , Daniel J Gough, Glenn R Bantug Fidinny I Hamid , Frances K Nally , Conor P Duffy , Aoife L Gorman , Alex M Liddicoat , Ed C Lavelle , Christoph Hess , Peter J Oefner , David K Finlay , Gavin P Davey , Tracy Robson , Annie M Curtis
Pubblicato in: Nature Communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-21617-2

Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans

Autori: Barry Scott, Emily A. Day, Katie L. O’Brien, John Scanlan, Grace Cromwell, Aine Ni Scannail, Marie E. McDonnell, David K. Finlay & Lydia Lynch
Pubblicato in: Nature Metabolism, 2024, ISSN 2522-5812
Editore: Nature
DOI: 10.1038/s42255-024-01018-7

Dendritic cells metabolism: a strategic path to improve antitumoral DC vaccination

Autori: Emma Currivan; David Finlay; Diana Moreira
Pubblicato in: Clinical and Experimental Immunology, Numero 1, 2022, ISSN 2475-6296
Editore: Oxford University Press
DOI: 10.1093/cei/uxac048

QUAS-R: An SLC1A5-mediated glutamine uptake assay with single-cell resolution reveals metabolic heterogeneity with immune populations

Autori: Leonard R. Pelgrom; Gavin M. Davis; Simon O’Shaughnessy; Emilie J.M. Wezenberg; Sander I. Van Kasteren; David K. Finlay; Linda V. Sinclair
Pubblicato in: Cell Reports, Vol 42, Iss 8, Pp 112828- (2023), Numero 5, 2023, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2023.112828

Optimising NK cell metabolism to increase the efficacy of cancer immunotherapy

Autori: Choi, Chloe; Finlay, David K.
Pubblicato in: Stem Cell Research & Therapy, Numero 3, 2021, ISSN 1757-6512
Editore: BioMed Central
DOI: 10.1186/s13287-021-02377-8

Diverse Immunoregulatory Roles of Oxysterols-The Oxidized Cholesterol Metabolites.

Autori: Chloe Choi; David K. Finlay
Pubblicato in: Metabolites, Numero 1, 2020, ISSN 2218-1989
Editore: MDPI
DOI: 10.3390/metabo10100384