Overcoming the Selectivity Challenge in Chemistry and Chemical Biology via Innovative Tethering Strategies

Project Information

SeleCHEM

Grant agreement ID: 771170

DOI

10.3030/771170

Project closed

EC signature date 15 January 2018

Start date 1 January 2019

End date 31 December 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

To create and submit a Data Management Plan

Publications

Peer reviewed articles (19)

One-pot synthesis of functionalized bis(trifluoromethylated)benziodoxoles from iodine(i) precursors

Author(s): Tobias Michael Milzarek; Nieves P. Ramirez; Xingyu Liu; Jerome Waser;
Published in: Chemical Communications, Issue 59, 2023, Page(s) 12637-12640, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3cc04525k

Peptide-Hypervalent Iodine Reagent Chimeras: Enabling Peptide Functionalization and Macrocyclization

Author(s): Xingyu Liu, Xinjian Ji, Christian Heinis, Jerome Waser
Published in: Angewandte Chemie International Edition, Issue 62/33, 2023, Page(s) e202306036, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202306036

Palladium-Catalyzed Functionalization of Olefins and Alkynes: From Oxyalkynylation to Tethered Dynamic Kinetic Asymmetric Transformations (DYKAT)

Author(s): Stefano Nicolai, Ugo Orcel, Bastian Muriel, Phillip D. G. Greenwood, Luca Buzzetti, Mikus Puriņš, Jerome Waser
Published in: Synlett, 2021, Page(s) 472-487, ISSN 0936-5214
Publisher: Georg Thieme Verlag
DOI: 10.1055/a-1308-0021

Cys–Cys and Cys–Lys Stapling of Unprotected Peptides Enabled by Hypervalent Iodine Reagents

Author(s): Javier Ceballos, Elija Grinhagena, Gontran Sangouard, Christian Heinis, Jerome Waser
Published in: Angewandte Chemie International Edition, Issue 60/16, 2021, Page(s) 9022-9031, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202014511

Synthesis of propargyl silanes from terminal alkynes via a migratory Sonogashira reaction

Author(s): Mikus Purins, Lucas Eichenberger, Jerome Waser
Published in: Chemical Communications, Issue 59, 2023, Page(s) 7931-7934, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3cc01847d

Palladium-Catalyzed trans-Hydroalkoxylation: Counterintuitive Use of an Aryl Iodide Additive to Promote C–H Bond Formation

Author(s): Ashis Das, Luca Buzzetti, Mikus Purins, Jerome Waser
Published in: ACS Catalysis, Issue 12, 13, 2022, Page(s) 7565–7570, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.2c01809

Enantioselective Carboetherification/Hydrogenation for the Synthesis of Amino Alcohols via a Catalytically Formed Chiral Auxiliary

Author(s): Luca Buzzetti, Mikus Puriņš, Phillip D. G. Greenwood, Jerome Waser
Published in: Journal of the American Chemical Society, Issue 142/41, 2020, Page(s) 17334-17339, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.0c09177

Palladium-Catalyzed Carboxy-Alkynylation of Propargylic Amines Using Carbonate Salts as Carbon Dioxide Source

Author(s): Phillip D. G. Greenwood, Jerome Waser
Published in: European Journal of Organic Chemistry, Issue 2019/31-32, 2019, Page(s) 5183-5186, ISSN 1434-193X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.201900500

“Doubly Orthogonal” Labeling of Peptides and Proteins

Author(s): Romain Tessier, Javier Ceballos, Nora Guidotti, Raphael Simonet-Davin, Beat Fierz, Jerome Waser
Published in: Chem, Issue 5/8, 2019, Page(s) 2243-2263, ISSN 2451-9294
Publisher: Cell Press Elsevier
DOI: 10.1016/j.chempr.2019.06.022

Ethynylation of Cysteine Residues: From Peptides to Proteins in Vitro and in Living Cells

Author(s): Romain Tessier, Raj Kumar Nandi, Brendan G. Dwyer, Daniel Abegg, Charlotte Sornay, Javier Ceballos, Stéphane Erb, Sarah Cianférani, Alain Wagner, Guilhem Chaubet, Alexander Adibekian, Jerome Waser
Published in: Angewandte Chemie International Edition, Issue 59/27, 2020, Page(s) 10961-10970, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202002626

Synthesis of Fluorescent Cyclic Peptides via Gold(I)-Catalyzed Macrocyclization

Author(s): Xingyu Liu; Wei Cai; Nathan Ronceray; Alksandra Radenovic; Beat Fierz; Jerome Waser
Published in: Journal of the American Chemical Society, Issue 145, 2023, Page(s) 26525-26531, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c09261

Asymmetric Cyclopropanation and Epoxidation via a Catalytically Formed Chiral Auxiliary

Author(s): Mikus Purins, Jerome Waser
Published in: Angewandte Chemie International Edition, Issue 61, 2022, Page(s) e202113925, ISSN 1521-3773
Publisher: Wiley VCH
DOI: 10.1002/anie.202113925

Pd(II)-Catalyzed Aminoacetoxylation of Alkenes Via Tether Formation

Author(s): Thomas Rossolini, Ashis Das, Stefano Nicolai, Jerome Waser
Published in: Organic Letters, Issue 24, 2022, Page(s) 5068-5072, ISSN 1523-7052
Publisher: ACS
DOI: 10.1021/acs.orglett.2c01838

Hypervalent Iodine-Mediated Late-Stage Peptide and Protein Functionalization

Author(s): Emmanuelle M. D. Allouche, Elija Grinhagena, Jerome Waser
Published in: Angewandte Chemie International Edition, 2021, ISSN 1521-3773
Publisher: Wiley
DOI: 10.1002/anie.202112287

Amphiphilic Iodine(III) Reagents for the Lipophilization of Peptides in Water

Author(s): Abhaya Kumar Mishra, Romain Tessier, Durga Prasad Hari, Jerome Waser
Published in: Angewandte Chemie International Edition, Issue 60/33, 2021, Page(s) 17963-17968, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202106458

Pd-catalyzed functionalization of alkenes and alkynes using removable tethers

Author(s): Das, Ashis; Waser, Jerome
Published in: Tetrahedron, Issue 128, 2022, Page(s) 133135, ISSN 0040-4020
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.tet.2022.133135

Synthesis of Trifluoromethylated Alkenes: Hypervalent Iodine Meets High-Valent Copper

Author(s): Tobias Michael Milzarek, Jerome Waser
Published in: Angewandte Chemie International Edition, Issue 62/33, 2023, Page(s) e202306128, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202306128

Cysteine‐Cysteine Cross‐Conjugation of both Peptides and Proteins with a Bifunctional Hypervalent Iodine‐Electrophilic Reagent

Author(s): Ilias Koutsopetras; Abhaya Kumar Mishra; Rania Benazza; Oscar Hernandez‐Alba; Sarah Cianférani; Guilhem Chaubet; Stefano Nicolai; Jérôme Waser
Published in: Chemistry A European Journal, Issue 29, 2023, Page(s) e202302689, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202302689

Inhibition of Thiol‐Mediated Uptake with Irreversible Covalent Inhibitors

Author(s): Bumhee Lim, Yangyang Cheng, Takehiro Kato, Anh‐Tuan Pham, Eliott Le Du, Abhaya Kumar Mishra, Elija Grinhagena, Dimitri Moreau, Naomi Sakai, Jerome Waser, Stefan Matile
Published in: Helvetica Chimica Acta, 2021, ISSN 0018-019X
Publisher: Verlag Helvetica Chimica Acta
DOI: 10.1002/hlca.202100085