Objective
Natural selection explains the appearance of design in the living world. But at what level is adaptive design expected to manifest (gene, organism or society) and what is its function? Adaptation may manifest at multiple levels, and indeed new levels of adaptive individuality may evolve over time – such as with the emergence of multicellularity and eusociality. However, understanding the forces that drive such “major transitions” remains a challenge: current theory, with its focus on single, simple traits, has been unable to engage with issues of complex, coordinated adaptation at the level of the group, and this has led to a striking mismatch between theory and data. In particular, there is currently very poor understanding of what drives conflicts within groups and how group-level adaptation can sometimes prevail despite these conflicts. My research team will develop new theoretical and in silico experimental paradigms for studying complex, group-level adaptation to resolve these problems. We will: (1) synthesize the theories of inclusive fitness and multilevel selection to allow direct engagement with complex adaptive design at multiple levels of biological organization; (2) take a geometric approach to social adaptation to determine how complex, multidimensional phenotypes evolve in the context of social conflicts; (3) develop a computational paradigm for group-level adaptation in which complexity may be quantified and tracked over evolutionary timescales; and (4) employ genomic imprinting as a tractable model of major transitions, to understand how conflicts of interest arise and how they resolve to maintain or disrupt the adaptive integrity of the organism, with applications to childhood cancers and growth, fertility and neurological disorders. This research will yield novel insights into the fundamental drivers of complex adaptation at the level of whole organisms and successful societies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography fertility
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-COG - Consolidator Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2017-COG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
KY16 9AJ ST ANDREWS
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.