Sympathetic and immune mechanisms underlying obesity

Project Information

SympatimmunObesity

Grant agreement ID: 771431

DOI 10.3030/771431

EC signature date 8 May 2018

Start date 1 January 2019

End date 31 December 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 029 175,00

EU contribution € 2 029 175,00

Coordinated by

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (14)

A Tale of Three Systems: Toward a Neuroimmunoendocrine Model of Obesity

Author(s): Conan J.O. O'Brien, Emma R. Haberman, Ana I. Domingos
Published in: Annual Review of Cell and Developmental Biology, Issue 37, 2021, Page(s) 549-573, ISSN 1081-0706
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-cellbio-120319-114106

MARCO in alveolar macrophages negatively regulates Ace expression and aldosterone production

Author(s): Conan J O O’Brien, Giorgio Ratti, Emma Haberman, Charles Sweeney, Siamon Gordon, Ana I Domingos
Published in: eLife, 2024, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.91318.1

Think (of science) globally, act locally

Author(s): Ana I. Domingos
Published in: American Journal Physiology Endocrinology and Metabolism, Issue 1, 2022, ISSN 0193-1849
Publisher: American Physiological Society
DOI: 10.1152/ajpendo.00203.2022

Macrophages Can Drive Sympathetic Excitability in the Early Stages of Hypertension.

Author(s): Oliver C. Neely; Ana I. Domingos; David J. Paterson
Published in: Frontiers in Cardiovascular Medicine, Vol 8 (2022), Issue 1, 2022, ISSN 2297-055X
Publisher: Frontiers
DOI: 10.3389/fcvm.2021.807904

Immunomodulatory Leptin Receptor⁺Sympathetic Perineurial Cells Protect Against Obesity by Facilitating Neuroendocrine-Mediated Brown Adipose Tissue Thermogenesis

Author(s): E R Haberman; G Sarker; B A Arús; S Yilmaz-Özcan; N Martínez-Sánchez; E Freibergerová; I Fernández-González; C Zentai; C J O O’Brien; D E Grainger; S Chakarov; A Raimondi; M Iannacone; M López; F Ginhoux; A I Domingos
Published in: Immunity, Issue 1, 2023, ISSN 1097-4180
Publisher: Cell Press
DOI: 10.1101/2023.05.09.539963

Sympathetic NPY protects from obesity by sustaining thermogenic fat

Author(s): Yitao Zhu, Lu Yao, Ana Luisa Gallo-Ferraz, Bruna Bombassaro, Marcela R. Simoes, Ichitaro Abe, Jing Chen, Gitalee Sarker, Alessandro Ciccarelli, Carl Lee, Noelia Martinez-Sanchez, Michael Dustin, View ORCID ProfileKurt Anderson, Cheng Zhan, Tamas Horvath, Licio A. Velloso, View ORCID ProfileShingo Kajimura, Ana I. Domingos
Published in: Nature, 2024, ISSN 1476-4687
Publisher: Nature Press
DOI: 10.1101/2024.05.18.594804

Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects

Author(s): Inês Mahú; Andreia Barateiro; Andreia Barateiro; Eva Rial-Pensado; Noelia Martínez-Sánchez; Sandra H. Vaz; Sandra H. Vaz; Pedro M. S. D. Cal; Benjamin Jenkins; Tiago Rodrigues; Carlos Cordeiro; Miguel F. Costa; Miguel F. Costa; Raquel Mendes; Elsa Seixas; Mafalda M.A. Pereira; Nadiya Kubasova; Vitka Gres; Imogen Morris; Carolina Temporão; Marta Olivares; Yolanda Sanz; Albert Koulman; Francisc
Published in: reponame:Repositório Científico de Acesso Aberto de Portugal, Issue 2, 2020, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2020.04.013

Leptin: a missing piece in the immunometabolism puzzle

Author(s): Ana I. Domingos
Published in: Nature Reviews Immunology, 2019, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/s41577-019-0251-3

Mediation of the Acute Stress Response by the Skeleton

Author(s): Julian Meyer Berger, Parminder Singh, Lori Khrimian, Donald A. Morgan, Subrata Chowdhury, Emilio Arteaga-Solis, Tamas L. Horvath, Ana I. Domingos, Anna L. Marsland, Vijay Kumar Yadav, Kamal Rahmouni, Xiao-Bing Gao, Gerard Karsenty
Published in: Cell Metabolism, Issue 30/5, 2019, Page(s) 890-902.e8, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2019.08.012

Central nicotine induces browning through hypothalamic κ opioid receptor

Author(s): Patricia Seoane-Collazo, Laura Liñares-Pose, Eva Rial-Pensado, Amparo Romero-Picó, José María Moreno-Navarrete, Noelia Martínez-Sánchez, Pablo Garrido-Gil, Ramón Iglesias-Rey, Donald A. Morgan, Naoki Tomasini, Samuel Andrew Malone, Ana Senra, Cintia Folgueira, Gema Medina-Gomez, Tomás Sobrino, José L. Labandeira-García, Rubén Nogueiras, Ana I. Domingos, José-Manuel Fernández-Real, Kam
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-12004-z

Obesity: a neuroimmunometabolic perspective

Author(s): Chelsea M. Larabee, Oliver C. Neely, Ana I. Domingos
Published in: Nature Reviews Endocrinology, Issue 16/1, 2020, Page(s) 30-43, ISSN 1759-5029
Publisher: Nature Publishing Group
DOI: 10.1038/s41574-019-0283-6

Neuro-mesenchymal units control ILC2 and obesity via a brain–adipose circuit

Author(s): Filipa Cardoso, Roel G. J. Klein Wolterink, Cristina Godinho-Silva, Rita G. Domingues, Hélder Ribeiro, Joaquim Alves da Silva, Inês Mahú, Ana I. Domingos, Henrique Veiga-Fernandes
Published in: Nature, Issue 597, 2021, Page(s) 410-414, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-03830-7

The perineurium integrates leptin with its sympathetic outflow to protect against obesity

Author(s): Gitalee Sarker, Emma Habermann, Anandhakumar Chandran, Thomas Monfeuga, Cyrielle Maroteau, Sofia Lundh, Andrea Raimondi, Noelia Martínez Sánchez, Bernardo Arús, View ORCID ProfileMatteo Iannacone, Enrique M. Toledo, Ana Domingos
Published in: Nature (under review), 2024, ISSN 1476-4687
Publisher: Nature Press
DOI: 10.1101/2024.07.04.602091

The sympathetic nervous system in the 21st century: Neuroimmune interactions in metabolic homeostasis and obesity

Author(s): Noelia Martinez-Sanchez, Owen Sweeney, Davi Sidarta-Oliveira, Alexandre Caron, Sarah A. Stanley, Ana I. Domingos
Published in: Neuron, Issue 110, 2024, Page(s) 3597-3626, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2022.10.017

Non-peer reviewed articles (3)

An anti-obesity immunotherapy?

Author(s): Conan J. O. O'Brien, Ana I. Domingos
Published in: Science, Issue 373, 2024, Page(s) 24-25, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abj5072

ILC3s gut rhythm

Author(s): Gitalee Sarker, Chelsea M. Larabee, Ana I. Domingos
Published in: Nature Immunology, Issue 21, 2023, Page(s) 106-108, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-019-0580-1

Illuminating Neuroimmunity: A Humoral Brain

Author(s): Emma R. Haberman, Ana I. Domingos
Published in: Immunity, Issue 52, 2021, Page(s) 900-902, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2020.05.011