Skip to main content
European Commission logo
français français
CORDIS - Résultats de la recherche de l’UE
CORDIS
CORDIS Web 30th anniversary CORDIS Web 30th anniversary

Novel Metabolic Pathways in Cancer

Objectif

Metabolic adaptations in central carbon metabolism play a key role in cancer. Yet, the success of therapeutic interventions in major pathways has been limited, although some of the changes have been known to exist for almost 100 years.

Biochemical textbooks present intermediary metabolism as something canonical, and the molecular identity of most enzymes required for the production of known intermediary metabolites is indeed known. Yet, the function of many putative enzymes is still unknown, indicating that novel metabolic pathways containing so far unknown metabolites exist.

We have recently discovered a novel metabolic pathway containing two metabolites that have never been described before. Preliminary data indicate that this pathway might play an important role in a group of cancers sharing specific mutations. Furthermore, genetic inactivation of a component of this pathway in mice is compatible with normal development, indicating that pharmacological inhibition should be well tolerated.

In the present project, we will use a multi-dimensional approach combining biochemical, genetic and pharmacological techniques, to identify missing components of this metabolic pathway and assess its role in cellular metabolism and cancer development. In the process of this, we will develop tools that will allow us to test whether this pathway can be targeted in vivo. Thus, our work will lead to the description of a novel metabolic pathway, should reveal novel regulatory circuits and might open novel therapeutic avenues in cancer and beyond.

Mots‑clés

Régime de financement

ERC-COG - Consolidator Grant

Institution d’accueil

UNIVERSITE CATHOLIQUE DE LOUVAIN
Contribution nette de l'UE
€ 1 989 103,00
Adresse
PLACE DE L UNIVERSITE 1
1348 Louvain La Neuve
Belgique

Voir sur la carte

Région
Région wallonne Prov. Brabant Wallon Arr. Nivelles
Type d’activité
Higher or Secondary Education Establishments
Liens
Coût total
€ 1 989 103,00

Bénéficiaires (1)