Novel Metabolic Pathways in Cancer

Project Information

NoMePaCa

Grant agreement ID: 771704

DOI 10.3030/771704

Project closed

EC signature date 27 April 2018

Start date 1 May 2018

End date 30 April 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 989 103,00

EU contribution € 1 989 103,00

Coordinated by

UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium

Publications

Peer reviewed articles (10)

The promiscuous binding pocket of SLC35A1 ensures redundant transport of CDP-ribitol to the Golgi

Author(s): Benoît Ury, Sven Potelle, Francesco Caligiore, Matthew R Whorton, Guido T Bommer
Published in: Journal of Biological Chemistry, Issue 296, 2021, Page(s) 100789, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100789

Parkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite

Author(s): Isaac P Heremans, Francesco Caligiore, Isabelle Gerin, Marina Bury, Marilena Lutz, Julie Graff, Vincent Stroobant, Didier Vertommen, Aurelio A Teleman, Emile Van Schaftingen, Guido T Bommer
Published in: Proceedings of the National Academy of Sciences USA, Issue 119 (4), 2022, Page(s) e2111338119, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2111338119

Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency

Author(s): Maria Veiga-da-Cunha, Nathalie Chevalier, Xavier Stephenne, Jean-Philippe Defour, Nicole Paczia, Alina Ferster, Younes Achouri, Joseph P. Dewulf, Carole L. Linster, Guido T. Bommer, Emile Van Schaftingen
Published in: Proceedings of the National Academy of Sciences, Issue 116/4, 2019, Page(s) 1241-1250, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1816143116

Pyridoxamine-phosphate oxidases and pyridoxamine-phosphate oxidase-related proteins catalyze the oxidation of 6-NAD(P)H to NAD(P)+

Author(s): Alexandre Y. Marbaix, Georges Chehade, Gaëtane Noël, Pierre Morsomme, Didier Vertommen, Guido T. Bommer, Emile Van Schaftingen
Published in: Biochemical Journal, Issue 476/20, 2019, Page(s) 3033-3052, ISSN 0264-6021
Publisher: Portland Press, Ltd.
DOI: 10.1042/bcj20190602

Inborn errors of metabolite repair

Author(s): Maria Veiga‐da‐Cunha, Emile Van Schaftingen, Guido T. Bommer
Published in: Journal of Inherited Metabolic Disease, 2019, ISSN 0141-8955
Publisher: Kluwer Academic Publishers
DOI: 10.1002/jimd.12187

The synthesis of branched-chain fatty acids is limited by enzymatic decarboxylation of ethyl- and methylmalonyl-CoA

Author(s): Joseph P. Dewulf, Isabelle Gerin, Mark H. Rider, Maria Veiga-da-Cunha, Emile Van Schaftingen, Guido T. Bommer
Published in: Biochemical Journal, Issue 476/16, 2019, Page(s) 2427-2447, ISSN 0264-6021
Publisher: Portland Press, Ltd.
DOI: 10.1042/bcj20190500

Metabolite Repair Enzymes Control Metabolic Damage in Glycolysis

Author(s): Guido T. Bommer, Emile Van Schaftingen, Maria Veiga-da-Cunha
Published in: Trends in Biochemical Sciences, 2019, ISSN 0968-0004
Publisher: Elsevier BV
DOI: 10.1016/j.tibs.2019.07.004

Phosphoglycolate has profound metabolic effects but most likely no role in a metabolic DNA response in cancer cell lines

Author(s): Isabelle Gerin, Marina Bury, Francesca Baldin, Julie Graff, Emile Van Schaftingen, Guido T. Bommer
Published in: Biochemical Journal, Issue 476/4, 2019, Page(s) 629-643, ISSN 0264-6021
Publisher: Portland Press, Ltd.
DOI: 10.1042/bcj20180435

Human cytosolic transaminases: side activities and patterns of discrimination towards physiologically available alternative substrates

Author(s): Francesco Caligiore; Erika Zangelmi; Carola Vetro; Takfarinas Kentache; Joseph P. Dewulf; Maria Veiga-da-Cunha; Emile Van Schaftingen; Guido Bommer; Alessio Peracchi
Published in: Cellular and Molecular Life Sciences, Issue 2, 2022, Page(s) 79(8):421., ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-022-04439-3

ECHDC1 knockout mice accumulate ethyl-branched lipids and excrete abnormal intermediates of branched-chain fatty acid metabolism

Author(s): Joseph P. Dewulf; Stéphanie Paquay; Etienne Marbaix; Younès Achouri; Emile Van Schaftingen; Guido T. Bommer
Published in: Journal of Biological Chemistry, Issue Volume 297, Issue 4, October 2021, 2021, Page(s) 101083, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.101083