Novel Metabolic Pathways in Cancer

Project Information

NoMePaCa

Grant agreement ID: 771704

DOI

10.3030/771704

Project closed

EC signature date 27 April 2018

Start date 1 May 2018

End date 30 April 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 989 103,00

EU contribution

€ 1 989 103,00

Coordinated by

UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

The promiscuous binding pocket of SLC35A1 ensures redundant transport of CDP-ribitol to the Golgi

Author(s): Benoît Ury, Sven Potelle, Francesco Caligiore, Matthew R Whorton, Guido T Bommer
Published in: Journal of Biological Chemistry, Issue 296, 2021, Page(s) 100789, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100789

Insights into energy balance dysregulation from a mouse model of methylmalonic aciduria

Author(s): Marie Lucienne, Raffaele Gerlini, Birgit Rathkolb, Julia Calzada-Wack, Patrick Forny, Stephan Wueest, Andres Kaech, Florian Traversi, Merima Forny, Céline Bürer, Antonio Aguilar-Pimentel, Martin Irmler, Johannes Beckers, Sven Sauer, Stefan Kölker, Joseph P Dewulf, Guido T Bommer, Daniel Hoces, Valerie Gailus-Durner, Helmut Fuchs, Jan Rozman, D Sean Froese, Matthias R Baumgartner, and Martin Hra
Published in: Human molecular genetics, Issue 32(17), 2023, Page(s) 2717–2734., ISSN 1460-2083
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddad100

A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis

Author(s): Matthew P. Wilson, Takfarinas Kentache, Charlotte R. Althoff, Céline Schulz, Geoffroy de Bettignies, Gisèle Mateu Cabrera, Loreta Cimbalistiene, Birute Burnyte, Grace Yoon, Gregory Costain, Sandrine Vuillaumier-Barrot, David Cheillan, Daisy Rymen, Lucie Rychtarova, Hana Hansikova, Marina Bury, Joseph P. Dewulf, Francesco Caligiore, Jaak Jaeken, Vincent Cantagrel, Emile Van Schaftingen, Gert Mat
Published in: Cell, Issue 187(14), 2024, Page(s) 3585-3601.e22, ISSN 1097-4172
Publisher: Cell Press Elsevier
DOI: 10.1016/j.cell.2024.04.041

Parkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite

Author(s): Isaac P Heremans, Francesco Caligiore, Isabelle Gerin, Marina Bury, Marilena Lutz, Julie Graff, Vincent Stroobant, Didier Vertommen, Aurelio A Teleman, Emile Van Schaftingen, Guido T Bommer
Published in: Proceedings of the National Academy of Sciences USA, Issue 119 (4), 2022, Page(s) e2111338119, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2111338119

Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency

Author(s): Maria Veiga-da-Cunha, Nathalie Chevalier, Xavier Stephenne, Jean-Philippe Defour, Nicole Paczia, Alina Ferster, Younes Achouri, Joseph P. Dewulf, Carole L. Linster, Guido T. Bommer, Emile Van Schaftingen
Published in: Proceedings of the National Academy of Sciences, Issue 116/4, 2019, Page(s) 1241-1250, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1816143116

Pyridoxamine-phosphate oxidases and pyridoxamine-phosphate oxidase-related proteins catalyze the oxidation of 6-NAD(P)H to NAD(P)+

Author(s): Alexandre Y. Marbaix, Georges Chehade, Gaëtane Noël, Pierre Morsomme, Didier Vertommen, Guido T. Bommer, Emile Van Schaftingen
Published in: Biochemical Journal, Issue 476/20, 2019, Page(s) 3033-3052, ISSN 0264-6021
Publisher: Portland Press, Ltd.
DOI: 10.1042/bcj20190602

Inborn errors of metabolite repair

Author(s): Maria Veiga‐da‐Cunha, Emile Van Schaftingen, Guido T. Bommer
Published in: Journal of Inherited Metabolic Disease, Issue 43(1), 2019, Page(s) 14-24, ISSN 0141-8955
Publisher: Kluwer Academic Publishers
DOI: 10.1002/jimd.12187

The synthesis of branched-chain fatty acids is limited by enzymatic decarboxylation of ethyl- and methylmalonyl-CoA

Author(s): Joseph P. Dewulf, Isabelle Gerin, Mark H. Rider, Maria Veiga-da-Cunha, Emile Van Schaftingen, Guido T. Bommer
Published in: Biochemical Journal, Issue 476/16, 2019, Page(s) 2427-2447, ISSN 0264-6021
Publisher: Portland Press, Ltd.
DOI: 10.1042/bcj20190500

Metabolite Repair Enzymes Control Metabolic Damage in Glycolysis

Author(s): Guido T. Bommer, Emile Van Schaftingen, Maria Veiga-da-Cunha
Published in: Trends in Biochemical Sciences, 2019, ISSN 0968-0004
Publisher: Elsevier BV
DOI: 10.1016/j.tibs.2019.07.004

Phosphoglycolate has profound metabolic effects but most likely no role in a metabolic DNA response in cancer cell lines

Author(s): Isabelle Gerin, Marina Bury, Francesca Baldin, Julie Graff, Emile Van Schaftingen, Guido T. Bommer
Published in: Biochemical Journal, Issue 476/4, 2019, Page(s) 629-643, ISSN 0264-6021
Publisher: Portland Press, Ltd.
DOI: 10.1042/bcj20180435

Human cytosolic transaminases: side activities and patterns of discrimination towards physiologically available alternative substrates

Author(s): Francesco Caligiore; Erika Zangelmi; Carola Vetro; Takfarinas Kentache; Joseph P. Dewulf; Maria Veiga-da-Cunha; Emile Van Schaftingen; Guido Bommer; Alessio Peracchi
Published in: Cellular and Molecular Life Sciences, Issue 2, 2022, Page(s) 79(8):421., ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-022-04439-3

ECHDC1 knockout mice accumulate ethyl-branched lipids and excrete abnormal intermediates of branched-chain fatty acid metabolism

Author(s): Joseph P. Dewulf; Stéphanie Paquay; Etienne Marbaix; Younès Achouri; Emile Van Schaftingen; Guido T. Bommer
Published in: Journal of Biological Chemistry, Issue Volume 297, Issue 4, October 2021, 2021, Page(s) 101083, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.101083