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Towards prevention of autoimmune diseases: the case of rheumatoid arthritis

Publications

Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis

Author(s): Christina Gerstner, Sara Turcinov, Aase H. Hensvold, Karine Chemin, Hannes Uchtenhagen, Tamara H. Ramwadhdoebe, Anatoly Dubnovitsky, Genadiy Kozhukh, Lars Rönnblom, William W. Kwok, Adnane Achour, Anca I. Catrina, Lisa G. M. van Baarsen, Vivianne Malmström
Published in: BMC Immunology, Issue 21/1, 2020, ISSN 1471-2172
DOI: 10.1186/s12865-020-00357-w

Triggering of a Dll4–Notch1 loop impairs wound healing in diabetes

Author(s): Xiaowei Zheng, Sampath Narayanan, Vivekananda Gupta Sunkari, Sofie Eliasson, Ileana Ruxandra Botusan, Jacob Grünler, Anca Irinel Catrina, Freddy Radtke, Cheng Xu, Allan Zhao, Neda Rajamand Ekberg, Urban Lendahl, Sergiu-Bogdan Catrina
Published in: Proceedings of the National Academy of Sciences, Issue 116/14, 2019, Page(s) 6985-6994, ISSN 0027-8424
DOI: 10.1073/pnas.1900351116

Association between number and type of different ACPA fine specificities with lung abnormalities in early, untreated rheumatoid arthritis

Author(s): Vijay Joshua, Aase Haj Hensvold, Gudrun Reynisdottir, Monica Hansson, Martin Cornillet, Leonor Nogueira, Guy Serre, Sven Nyren, Reza Karimi, Anders Eklund, Magnus Sköld, Johan Grunewald, Katerina Chatzidionysiou, Anca Catrina
Published in: RMD Open, Issue 6/2, 2020, Page(s) e001278, ISSN 2056-5933
DOI: 10.1136/rmdopen-2020-001278

Extracellular miR-574-5p Induces Osteoclast Differentiation via TLR 7/8 in Rheumatoid Arthritis

Author(s): Anett B. Hegewald, Kai Breitwieser, Sarah M. Ottinger, Fariborz Mobarrez, Marina Korotkova, Bence Rethi, Per-Johan Jakobsson, Anca I. Catrina, Heidi Wähämaa, Meike J. Saul
Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
DOI: 10.3389/fimmu.2020.585282

Rheumatoid arthritis patients display B-cell dysregulation already in the naïve repertoire consistent with defects in B-cell tolerance

Author(s): Yan Wang, Katy A. Lloyd, Ioannis Melas, Diana Zhou, Radha Thyagarajan, Joakim Lindqvist, Monika Hansson, Anna Svärd, Linda Mathsson-Alm, Alf Kastbom, Karin Lundberg, Lars Klareskog, Anca I. Catrina, Stephen Rapecki, Vivianne Malmström, Caroline Grönwall
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-56279-0

Different Hierarchies of Anti–Modified Protein Autoantibody Reactivities in Rheumatoid Arthritis

Author(s): Peter Sahlström, Monika Hansson, Johanna Steen, Khaled Amara, Philip J. Titcombe, Björn Forsström, Ragnhild Stålesen, Lena Israelsson, Luca Piccoli, Karin Lundberg, Lars Klareskog, Daniel L. Mueller, Anca I. Catrina, Karl Skriner, Vivianne Malmström, Caroline Grönwall
Published in: Arthritis & Rheumatology, Issue 72/10, 2020, Page(s) 1643-1657, ISSN 2326-5191
DOI: 10.1002/art.41385

Presence, function, and regulation of IL‐17F‐expressing human CD4 + T cells

Author(s): Lachrissa A. Burns, Ash Maroof, Diane Marshall, Kathryn J. A. Steel, Sylvine Lalnunhlimi, Suzanne Cole, Anca Catrina, Bruce Kirkham, Leonie S. Taams
Published in: European Journal of Immunology, Issue 50/4, 2020, Page(s) 568-580, ISSN 0014-2980
DOI: 10.1002/eji.201948138

Increased citrullination and expression of peptidylarginine deiminases independently of P. gingivalis and A. actinomycetemcomitans in gingival tissue of patients with periodontitis

Author(s): Marianne Engström, Kaja Eriksson, Linkiat Lee, Monika Hermansson, Anders Johansson, Anthony P. Nicholas, Natalija Gerasimcik, Karin Lundberg, Lars Klareskog, Anca Irinel Catrina, Tülay Yucel-Lindberg
Published in: Journal of Translational Medicine, Issue 16/1, 2018, ISSN 1479-5876
DOI: 10.1186/s12967-018-1588-2

Secretory anti-citrullinated protein antibodies in serum associate with lung involvement in early rheumatoid arthritis

Author(s): Karin Roos Ljungberg, Vijay Joshua, Thomas Skogh, Anders Eklund, C Magnus Sköld, Reza Karimi, Sven Nyrén, Anna Svärd, Anca I Catrina, Alf Kastbom
Published in: Rheumatology, 2019, ISSN 1462-0324
DOI: 10.1093/rheumatology/kez377

Citrullination Controls Dendritic Cell Transdifferentiation into Osteoclasts

Author(s): Akilan Krishnamurthy, A. Jimmy Ytterberg, Meng Sun, Koji Sakuraba, Johanna Steen, Vijay Joshua, Nataliya K. Tarasova, Vivianne Malmström, Heidi Wähämaa, Bence Réthi, Anca I. Catrina
Published in: The Journal of Immunology, Issue 202/11, 2019, Page(s) 3143-3150, ISSN 0022-1767
DOI: 10.4049/jimmunol.1800534

Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis

Author(s): Kaja Eriksson, Guozhong Fei, Anna Lundmark, Daniel Benchimol, Linkiat Lee, Yue O. O. Hu, Anna Kats, Saedis Saevarsdottir, Anca Irinel Catrina, Björn Klinge, Anders F. Andersson, Lars Klareskog, Karin Lundberg, Leif Jansson, Tülay Yucel-Lindberg
Published in: Journal of Clinical Medicine, Issue 8/5, 2019, Page(s) 630, ISSN 2077-0383
DOI: 10.3390/jcm8050630

Recognition of Amino Acid Motifs, Rather Than Specific Proteins, by Human Plasma Cell–Derived Monoclonal Antibodies to Posttranslationally Modified Proteins in Rheumatoid Arthritis

Author(s): Johanna Steen, Björn Forsström, Peter Sahlström, Victoria Odowd, Lena Israelsson, Akilan Krishnamurthy, Sara Badreh, Linda Mathsson Alm, Joanne Compson, Daniel Ramsköld, Welcome Ndlovu, Stephen Rapecki, Monika Hansson, Philip J. Titcombe, Holger Bang, Daniel L. Mueller, Anca I. Catrina, Caroline Grönwall, Karl Skriner, Peter Nilsson, Daniel Lightwood, Lars Klareskog, Vivianne Malmström
Published in: Arthritis & Rheumatology, Issue 71/2, 2019, Page(s) 196-209, ISSN 2326-5191
DOI: 10.1002/art.40699

The role of anti-citrullinated protein antibody reactivities in an inception cohort of patients with rheumatoid arthritis receiving treat-to-target therapy

Author(s): Maria Karolina Jonsson, Aase Haj Hensvold, Monika Hansson, Anna-Birgitte Aga, Joseph Sexton, Linda Mathsson-Alm, Martin Cornillet, Guy Serre, Siri Lillegraven, Bjørg-Tilde Svanes Fevang, Anca Irinel Catrina, Espen Andre Haavardsholm
Published in: Arthritis Research & Therapy, Issue 20/1, 2018, ISSN 1478-6362
DOI: 10.1186/s13075-018-1635-7

Initial validation and results of the Symptoms in Persons At Risk of Rheumatoid Arthritis (SPARRA) questionnaire: a EULAR project

Author(s): Marian H van Beers-Tas, Marieke M ter Wee, Lilian H van Tuyl, Bertha Maat, Wijnanda Hoogland, Aase H Hensvold, Anca I Catrina, Erika Mosor, Tanja A Stamm, Axel Finckh, Delphine S Courvoisier, Andrew Filer, Ilfita Sahbudin, Rebecca J Stack, Karim Raza, Dirkjan van Schaardenburg
Published in: RMD Open, Issue 4/1, 2018, Page(s) e000641, ISSN 2056-5933
DOI: 10.1136/rmdopen-2017-000641

Challenging judgement of a low-positive ACPA test in the context of individuals at risk of RA

Author(s): Aase Haj Hensvold, Anca I Catrina
Published in: Annals of the Rheumatic Diseases, 2018, Page(s) annrheumdis-2016-211062, ISSN 0003-4967
DOI: 10.1136/annrheumdis-2016-211062

Stabilized Cyclic Peptides as Scavengers of Autoantibodies: Neutralization of Anticitrullinated Protein/Peptide Antibodies in Rheumatoid Arthritis

Author(s): Sunithi Gunasekera, Cátia Fernandes-Cerqueira, Stefan Wennmalm, Heidi Wähämaa, Yngve Sommarin, Anca I. Catrina, Per-Johan Jakobsson, Ulf Göransson
Published in: ACS Chemical Biology, Issue 13/6, 2018, Page(s) 1525-1535, ISSN 1554-8929
DOI: 10.1021/acschembio.8b00118

EOMES-positive CD4 + T cells are increased in PTPN22 (1858T) risk allele carriers

Author(s): Karine Chemin, Daniel Ramsköld, Lina-Marcela Diaz-Gallo, Jessica Herrath, Miranda Houtman, Karolina Tandre, Lars Rönnblom, Anca Catrina, Vivianne Malmström
Published in: European Journal of Immunology, Issue 48/4, 2018, Page(s) 655-669, ISSN 0014-2980
DOI: 10.1002/eji.201747296

Anticitrullinated protein antibodies facilitate migration of synovial tissue-derived fibroblasts

Author(s): Meng Sun, Bence Rethi, Akilan Krishnamurthy, Vijay Joshua, Alexandra Circiumaru, Aase Haj Hensvold, Elena Ossipova, Caroline Grönwall, Yanying Liu, Marianne Engstrom, Sergiu Bogdan Catrina, Johanna Steen, Vivianne Malmstrom, Lars Klareskog, Camilla Svensson, Caroline Ospelt, Heidi Wähämaa, Anca Irinel Catrina
Published in: Annals of the Rheumatic Diseases, Issue 78/12, 2019, Page(s) 1621-1631, ISSN 0003-4967
DOI: 10.1136/annrheumdis-2018-214967

How to communicate in science

Author(s): Lars Klareskog, Anca Irinel Catrina, Camilla Svensson, Vivianne Malmstrom
Published in: Annals of the Rheumatic Diseases, 2019, Page(s) annrheumdis-2019-216016, ISSN 0003-4967
DOI: 10.1136/annrheumdis-2019-216016

Seropositivity combined with smoking is associated with increased prevalence of periodontitis in patients with rheumatoid arthritis

Author(s): Kaja Eriksson, Lena Nise, Lars Alfredsson, Anca Irinel Catrina, Johan Askling, Karin Lundberg, Lars Klareskog, Tülay Yucel-Lindberg
Published in: Annals of the Rheumatic Diseases, 2018, Page(s) annrheumdis-2017-212091, ISSN 0003-4967
DOI: 10.1136/annrheumdis-2017-212091

T cells are influenced by a long non-coding RNA in the autoimmune associated PTPN2 locus

Author(s): Miranda Houtman, Klementy Shchetynsky, Karine Chemin, Aase Haj Hensvold, Daniel Ramsköld, Karolina Tandre, Maija-Leena Eloranta, Lars Rönnblom, Steffen Uebe, Anca Irinel Catrina, Vivianne Malmström, Leonid Padyukov
Published in: Journal of Autoimmunity, Issue 90, 2018, Page(s) 28-38, ISSN 0896-8411
DOI: 10.1016/j.jaut.2018.01.003

Exploring inflammatory signatures in arthritic joint biopsies with Spatial Transcriptomics

Author(s): Konstantin Carlberg, Marina Korotkova, Ludvig Larsson, Anca I. Catrina, Patrik L. Ståhl, Vivianne Malmström
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-55441-y

Programmed death ligand 2 – A link between inflammation and bone loss in rheumatoid arthritis

Author(s): Stinne R. Greisen, Tue W. Kragstrup, Jesper Skovhus Thomsen, Aida Solhøj Hansen, Akilan Krishnamurthy, Kim Hørslev-Petersen, Merete Lund Hetland, Kristian Stengaard-Pedersen, Mikkel Østergaard, Lykke Midtbøll Ørnbjerg, Peter Junker, Arlene H. Sharpe, Gordon J. Freeman, Lakshmanan Annamalai, Malene Hvid, Søren K. Moestrup, Ellen-Margrethe Hauge, Anca Irinel Catrina, Bent Deleuran
Published in: Journal of Translational Autoimmunity, Issue 3, 2020, Page(s) 100028, ISSN 2589-9090
DOI: 10.1016/j.jtauto.2019.100028

Treatment of rheumatic immune-related adverse events due to cancer immunotherapy with immune checkpoint inhibitors—is it time for a paradigm shift?

Author(s): Katerina Chatzidionysiou, Matina Liapi, Georgios Tsakonas, Iva Gunnarsson, Anca Catrina
Published in: Clinical Rheumatology, 2020, ISSN 0770-3198
DOI: 10.1007/s10067-020-05420-w

Validation of new classification criteria of rheumatoid arthritis in an international multicentre study

Author(s): Ru Li , Xing Sun , Hua Ye, Jiajia Liu, Jinxia Zhao, Xiangyuan Liu, Yifang Mei, Zhiyi Zhang, Jialong Guo , Liqi Bi , Xia Liu , Guochun Wang , Jinjing Liu, Xiaomei Leng , Fei Gu , Lingyun Sun , Qinghua Zou , Yongfei Fang, Quan Jiang, Katerina Chatzidionysiou, Sangeetha Priya, Ramya Janardana, Aswin Nair , Anca Irinel Catrina, Debashish Danda, Zhan Guo Li
Published in: Clin Exp Rheumatol, 2020, ISSN 0392-856X

Toward Earlier Diagnosis Using Combined eHealth Tools in Rheumatology: The Joint Pain Assessment Scoring Tool (JPAST) Project

Author(s): Johannes Knitza, Rachel Knevel, Karim Raza, Tor Bruce, Ekaterina Eimer, Isabel Gehring, Linda Mathsson-Alm, Maryam Poorafshar, Axel J Hueber, Georg Schett, Martina Johannesson, Anca Catrina, Lars Klareskog
Published in: JMIR mHealth and uHealth, Issue 8/5, 2020, Page(s) e17507, ISSN 2291-5222
DOI: 10.2196/17507

DEVELOPMENT OF ULTRASOUND DETECTABLE ARTHRITIS AMONG ACPA POSITIVE SUBJECTS WITH MUSCULOSKELETAL SYMPTOMS: THE RISK RA PROSPECTIVE STUDY

Author(s): Aase Hensvold, Yogan Kisten, Alexandra Circiumaru, Monika Hansson, Meng Sun, Guozhong Fei, Nancy Vivar, Erik Af Klint, Hamed Rezaei, Lars Klareskog, Aleksandra Antovic, Anca Catrina
Published in: Ann Rheum Dis, 2019

Metabolic Changes Induced by Anti-Malondialdehyde Antibodies Promote Osteoclast Development

Author(s): Sakurabas K, Krishnamurthy A, Xu C, Amara K, Malmström V, Catrina S, Grönwall C, Rethi B, Catrina A.
Published in: Arthritis Rheumatol, 2019

IDENTIFICATION OF CELLULAR TARGETS FOR ANTI-CITRULLINATED PROTEIN ANTIBODIES (ACPAS)

Author(s): Bence Réthi, Meng Sun, Alexandra Circiumaru, Akilan Krishnamurthy, Heidi Wähämaa, Jimmy Ytterberg, Vivianne Malmström, Lars Klareskog, Anca Catrina
Published in: Ann Rheum Dis, 2019

Mechanisms of bone erosion and pain triggered by antibodies targeting post-translational protein modifications in rheumatoid arthritis

Author(s): A Krishnamurthy, K Sandor, A Jurczak, MJ Andrade, J Steen, C Grönwall, G Wigerblad, P Titcombe, H Wähämaa, B Rethi, C Svennson, A Catrina
Published in: Ann Rheum Dis, 2018

PRIMARY LYMPHOID TISSUE FROM RHEUMATOID ARTHRITIS PATIENTS HARBOUR CITRULLINE SPECIFIC PLASMA CELLS

Author(s): Radha Thyagarajan, Aase Hensvold, Lena Israelsson, Johanna Steen, Heidi Wähämaa, Annika van Vollenhoven, Khaled Amara, Anca Catrina, Vivianne Malmström, Caroline Grönwall
Published in: Ann Rheum Dis, 2019

Tenosynovitis and HLA-SE predict arthritis onset in ACPA-positive individuals at risk of developing rheumatoid arthritis

Author(s): AH Hensvold, Y Kisten, M Hansson, A Cîrciumaru, M Sun, G Fei, E af Klint, H Rezaei, A Antovic, AI Catrina
Published in: Ann Rheum Dis, 2019

CITRULLINE REACTIVE B CELLS ARE PRESENT IN THE LUNGS OF EARLY UNTREATED RA

Author(s): Vijay Joshua, Malena Loberg-Haarhaus, Heidi Wähämaa, Aase Hensvold, Magnus Sköld, Johan Grunewald, Lars Klareskog, Vivianne Malmström, Anca Catrina
Published in: Arthritis Rheumatol, 2019

CITRULLINE-REACTIVE B CELLS ARE PRESENT IN INFLAMED GINGIVAL TISSUE AND DISPLAY CROSS-REACTIVITY BETWEEN BACTERIAL AND HUMAN ANTIGENS

Author(s): Natalia Sherina, Vijay Joshua, Radha Thyagarajan, Natalie Sippl, Lena Israelsson, Heidi Wähämaa, Ragnhild Stålesen, Kaja Eriksson, Tülay Yucel-Lindberg, Aase Hensvold, Caroline Grönwall, Anca Catrina, Vivianne Malmström, Antonio Lanzavecchia, Luca Piccoli, Khaled Amara, Karin Lundberg
Published in: Ann Rheum Dis, 2019

INVESTIGATING MECHANISMS OF AUTOANTIBODY INDUCED PAIN, BONE LOSS AND ARTHRITIS DEVELOPMENT

Author(s): Akilan Krishnamurthy, Yogan Kisten, Katalin Sandor, Alexandra Circiumaru, Gustaf Wigerblad, Peter Damberg, Koji Sakurabas, Heidi Wähämaa, Patrik Jarvolli, Juan Jimenez Jimenez Andrade, Vivianne Malmström, Lars Klareskog, Camilla Svensson, Bence Réthi, Anca Catrina
Published in: Ann Rheum Dis, 2019

Datasets

Increased citrullination and expression of peptidylarginine deiminases independently of P. gingivalis and A. actinomycetemcomitans in gingival tissue of patients with periodontitis

Author(s): Engström, Marianne; Eriksson, Kaja; Linkiat Lee; Hermansson, Monika; Johansson, Anders; Nicholas, Anthony; Gerasimcik, Natalija; Lundberg, Karin; Klareskog, Lars; Catrina, Anca; Yucel-Lindberg, Tülay
Published in: figshare Academic Research System

MOESM2 of Increased citrullination and expression of peptidylarginine deiminases independently of P. gingivalis and A. actinomycetemcomitans in gingival tissue of patients with periodontitis

Author(s): Engström, Marianne; Eriksson, Kaja; Linkiat Lee; Hermansson, Monika; Johansson, Anders; Nicholas, Anthony; Gerasimcik, Natalija; Lundberg, Karin; Klareskog, Lars; Catrina, Anca; Yucel-Lindberg, Tülay
Published in: figshare

MOESM1 of Increased citrullination and expression of peptidylarginine deiminases independently of P. gingivalis and A. actinomycetemcomitans in gingival tissue of patients with periodontitis

Author(s): EngstrĂśm, Marianne; Eriksson, Kaja; Linkiat Lee; Hermansson, Monika; Johansson, Anders; Nicholas, Anthony; Gerasimcik, Natalija; Lundberg, Karin; Klareskog, Lars; Catrina, Anca; TĂźlay Yucel-Lindberg
Published in: figshare