Dare to Approach: A Neurocognitive Approach to Alleviating Persistent Avoidance in Anxiety Disorders

Project Information

DARE2APPROACH

Grant agreement ID: 772337

DOI

10.3030/772337

Project closed

EC signature date 3 May 2018

Start date 1 January 2019

End date 30 November 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

STICHTING RADBOUD UNIVERSITEIT
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

The Data Management Plan describes the data management life cycle for all data sets that will be collected, processed or generated by the action. It is a document describing what data will be collected, processed or generated and following what methodology and standards, whether and how this data will be shared and/or made open, and how it will be curated and preserved.

Publications

Peer reviewed articles (36)

Frontal Control Over Automatic Emotional Action Tendencies Predicts Acute Stress Responsivity

Author(s): Reinoud Kaldewaij, Saskia B.J. Koch, Wei Zhang, Mahur M. Hashemi, Floris Klumpers, Karin Roelofs
Published in: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Issue 4/11, 2019, Page(s) 975-983, ISSN 2451-9022
Publisher: Elsevier
DOI: 10.1016/j.bpsc.2019.06.011

Acute-stress induced change in salience network coupling prospectively predicts post-trauma symptom-development

Author(s): Wei Zhang, Reinoud Kaldewaij, Mahur M. Hashemi, Saskia B.J. Koch, Annika Smit, Vanessa van Ast, Christian F. Beckmann, Floris Klumpers, Karin Roelofs
Published in: Translational Psychiatry, Issue 12, 2022, Page(s) 63, ISSN 2158-3188
Publisher: Nature Publishing Group
DOI: 10.1101/2021.07.03.21259969

The neurocomputational link between defensive cardiac states and approach-avoidance arbitration under threat

Author(s): Felix H. Klaassen, Lycia D. de Voogd, Anneloes M. Hulsman, Jill X. O’Reilly, Floris Klumpers, Bernd Figner, Karin Roelofs
Published in: Communications Biology, Issue 7, 2023, Page(s) 576, ISSN 2399-3642
Publisher: Nature Portfolio
DOI: 10.1101/2023.11.10.566569

Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group

Author(s): Nynke A. Groenewold, Janna Marie Bas-Hoogendam, Alyssa R. Amod, Max A. Laansma, Laura S. Van Velzen, Moji Aghajani, Kevin Hilbert, Hyuntaek Oh, Ramiro Salas, Andrea P. Jackowski, Pedro M. Pan, Giovanni A. Salum, James R. Blair, Karina S. Blair, Joy Hirsch, Spiro P. Pantazatos, Franklin R. Schneier, Ardesheer Talati, Karin Roelofs, Inge Volman, Laura Blanco-Hinojo, Narcís Cardoner, Jesus Pujol, Ka
Published in: Molecular Psychiatry, Issue 28, 2023, Page(s) 1079-1089, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-022-01933-9

Individual differences in costly fearful avoidance and the relation to psychophysiology

Author(s): Anneloes M. Hulsman, Reinoud Kaldewaij, Mahur M. Hashemi, Wei Zhang, Saskia B.J. Koch, Bernd Figner, Karin Roelofs, Floris Klumpers
Published in: Behaviour Research and Therapy, Issue 137, 2021, Page(s) 103788, ISSN 0005-7967
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.brat.2020.103788

Behavioral inhibition, negative parenting, and social withdrawal: Longitudinal associations with loneliness during early, middle, and late adolescence

Author(s): Maaike Verhagen, Mare Derks, Karin Roelofs, Dominique Maciejewski
Published in: Child Development, Issue 94, 2023, Page(s) 512-528, ISSN 0009-3920
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/cdev.13874

Improving emotional-action control by targeting long-range phase-amplitude neuronal coupling

Author(s): Bob Bramson, Hanneke EM den Ouden, Ivan Toni, Karin Roelofs
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.59600

Human defensive freezing: Associations with hair cortisol and trait anxiety

Author(s): Mahur M. Hashemi, Wei Zhang, Reinoud Kaldewaij, Saskia B.J. Koch, Annika Smit, Bernd Figner, Rosa Jonker, Floris Klumpers, Karin Roelofs
Published in: Psychoneuroendocrinology, Issue 133, 2021, Page(s) 105417, ISSN 0306-4530
Publisher: Pergamon Press
DOI: 10.1016/j.psyneuen.2021.105417

Human Lateral Frontal Pole Contributes to Control over Emotional Approach–Avoidance Actions

Author(s): Bob Bramson, Davide Folloni, Lennart Verhagen, Bart Hartogsveld, Rogier B. Mars, Ivan Toni, Karin Roelofs
Published in: The Journal of Neuroscience, Issue 40/14, 2020, Page(s) 2925-2934, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.2048-19.2020

The enhancing effects of testosterone in exposure treatment for social anxiety disorder: a randomized proof-of-concept trial

Author(s): Moniek H. M. Hutschemaekers, Rianne A. de Kleine, Gert-Jan Hendriks, Mirjam Kampman, Karin Roelofs
Published in: Translational Psychiatry, Issue 11/1, 2021, ISSN 2158-3188
Publisher: Nature Publishing Group
DOI: 10.1038/s41398-021-01556-8

Emerging Adults’ Mental Health During the COVID-19 Pandemic: A Prospective Longitudinal Study on the Importance of Social Support

Author(s): Yvonne H. M. van den Berg, William J. Burk, Antonius H. N. Cillessen, Karin Roelofs
Published in: Emerging Adulthood, Issue 9, 2021, Page(s) 618-630, ISSN 2167-6968
Publisher: SAGE Publications Ltd
DOI: 10.1177/21676968211039979

A neurocognitive theory of flexible emotion control: The role of the lateral frontal pole in emotion regulation

Author(s): Karin Roelofs, Bob Bramson, Ivan Toni
Published in: Annals of the New York Academy of Sciences, Issue 1525, 2023, Page(s) 28-40, ISSN 0077-8923
Publisher: New York Academy of Sciences
DOI: 10.1111/nyas.15003

Trauma-induced human glucocorticoid receptor expression increases predict subsequent HPA-axis blunting in a prospective longitudinal design

Author(s): Lycia D. de Voogd, Rosalie Anne Kampen, Reinoud Kaldewaij, Wei Zhang, Mahur Melina Hashemi, Saskia B.J. Koch, Floris Klumpers, Jeffrey C. Glennon, Karin Roelofs
Published in: Psychoneuroendocrinology, Issue 146, 2023, Page(s) 105909, ISSN 0306-4530
Publisher: Pergamon Press
DOI: 10.1016/j.psyneuen.2022.105909

Freezing revisited: coordinated autonomic and central optimization of threat coping

Author(s): Karin Roelofs, Peter Dayan
Published in: Nature Reviews Neuroscience, Issue 23, 2023, Page(s) 568-580, ISSN 1471-003X
Publisher: Nature Publishing Group
DOI: 10.1038/s41583-022-00608-2

No evidence for disruption of reconsolidation of conditioned threat memories with a cognitively demanding intervention

Author(s): Lars Jaswetz, Lycia D. de Voogd, Eni S. Becker, Karin Roelofs
Published in: Scientific Reports, Issue 12, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-10184-1

Reply to ‘Post-encounter freezing during approach–avoidance conflict: the role of the hippocampus’

Author(s): Karin Roelofs, Felix H. Klaassen, Peter Dayan
Published in: Nature Reviews Neuroscience, Issue 24, 2023, Page(s) 453-454, ISSN 1471-003X
Publisher: Nature Publishing Group
DOI: 10.1038/s41583-023-00704-x

Anxious individuals shift emotion control from lateral frontal pole to dorsolateral prefrontal cortex

Author(s): Bob Bramson, Sjoerd Meijer, Annelies van Nuland, Ivan Toni, Karin Roelofs
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-40666-3

The gene environment aetiology of freezing and its relationship with internalizing symptoms during adolescence

Author(s): Leslie K. Held, Jacqueline M. Vink, Frank Vitaro, Mara Brendgen, Ginette Dionne, Lysandre Provost, Michel Boivin, Isabelle Ouellet-Morin, Karin Roelofs
Published in: eBioMedicine, Issue 81, 2022, Page(s) 104094, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2022.104094

Social avoidance and testosterone enhanced exposure efficacy in women with social anxiety disorder: A pilot investigation

Author(s): Moniek H.M. Hutschemaekers, Rianne A. de Kleine, Mirjam Kampman, Jasper A.J. Smits, Karin Roelofs
Published in: Psychoneuroendocrinology, Issue 158, 2023, Page(s) 106372, ISSN 0306-4530
Publisher: Pergamon Press
DOI: 10.1016/j.psyneuen.2023.106372

Context and trade-offs characterize real-world threat detection systems: A review and comprehensive framework to improve research practice and resolve the translational crisis

Author(s): Markus Fendt, Michael H. Parsons, Raimund Apfelbach, Alexandra J.R. Carthey, Chris R. Dickman, Thomas Endres, Anke S.K. Frank, Daniel E. Heinz, Menna E. Jones, Yasushi Kiyokawa, Judith C. Kreutzmann, Karin Roelofs, Miriam Schneider, Julia Sulger, Carsten T. Wotjak, Daniel T. Blumstein
Published in: Neuroscience & Biobehavioral Reviews, Issue 115, 2020, Page(s) 25-33, ISSN 0149-7634
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2020.05.002

Emotion regulation from an action-control perspective

Author(s): Bob Bramson, Ivan Toni, Karin Roelofs
Published in: Neuroscience & Biobehavioral Reviews, 2023, ISSN 1873-7528
Publisher: Elsevier
DOI: 10.31234/osf.io/tr5um

Approach-Avoidance Decisions Under Threat: The Role of Autonomic Psychophysiological States

Author(s): James J. A. Livermore, Felix H. Klaassen, Bob Bramson, Anneloes M. Hulsman, Sjoerd W. Meijer, Leslie Held, Floris Klumpers, Lycia D. de Voogd, Karin Roelofs
Published in: Frontiers in Neuroscience, Issue 15, 2021, ISSN 1662-453X
Publisher: Frontiers Media SA
DOI: 10.3389/fnins.2021.621517

Defensive freezing and its relation to approach–avoidance decision-making under threat

Author(s): Felix H. Klaassen, Leslie Held, Bernd Figner, Jill X. O’Reilly, Floris Klumpers, Lycia D. de Voogd, Karin Roelofs
Published in: Scientific Reports, Issue 11/1, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-90968-z

The functional role of cardiac activity in perception and action

Author(s): L.I. Skora, J.J.A. Livermore, K. Roelofs
Published in: Neuroscience & Biobehavioral Reviews, Issue 137, 2023, Page(s) 104655, ISSN 0149-7634
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2022.104655

Age differences in intertemporal choice among children, adolescents, and adults

Author(s): Iris Ikink, Anna C.K. van Duijvenvoorde, Hilde Huizenga, Karin Roelofs, Bernd Figner
Published in: Journal of Experimental Child Psychology, Issue 233, 2024, Page(s) 105691, ISSN 0022-0965
Publisher: Academic Press
DOI: 10.1016/j.jecp.2023.105691

Postural freezing relates to startle potentiation in a human fear‐conditioning paradigm

Author(s): Vanessa A. van Ast, Floris Klumpers, Raoul P. P. P. Grasman, Angelos‐Miltiadis Krypotos, Karin Roelofs
Published in: Psychophysiology, Issue 59, 2023, ISSN 0048-5772
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/psyp.13983

Behavioral inhibition as an early life predictor of callous-unemotional traits

Author(s): Anna L. Dapprich, Anna Tyborowska, Hannah C. M. Niermann, Eni S. Becker, Antonius H. N. Cillessen, Karin Roelofs
Published in: International Journal of Behavioral Development, Issue 46, 2023, Page(s) 333-345, ISSN 0165-0254
Publisher: SAGE Publications
DOI: 10.1177/01650254221100245

Discriminating stress from rest based on resting‐state connectivity of the human brain: A supervised machine learning study

Author(s): Wei Zhang, Alberto Llera, Mahur M. Hashemi, Reinoud Kaldewaij, Saskia B. J. Koch, Christian F. Beckmann, Floris Klumpers, Karin Roelofs
Published in: Human Brain Mapping, Issue 41/11, 2020, Page(s) 3089-3099, ISSN 1065-9471
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hbm.25000

Endogenous testosterone levels are predictive of symptom reduction with exposure therapy in social anxiety disorder

Author(s): M.H.M. Hutschemaekers, R.A. de Kleine, M.L. Davis, M. Kampman, J.A.J. Smits, K. Roelofs
Published in: Psychoneuroendocrinology, Issue 115, 2020, Page(s) 104612, ISSN 0306-4530
Publisher: Pergamon Press
DOI: 10.1016/j.psyneuen.2020.104612

Patients with Ventromedial Prefrontal Lesions Show an Implicit Approach Bias to Angry Faces

Author(s): Macià Buades-Rotger, Anne-Kristin Solbakk, Matthias Liebrand, Tor Endestad, Ingrid Funderud, Paul Siegwardt, Dorien Enter, Karin Roelofs, Ulrike M. Krämer
Published in: Journal of Cognitive Neuroscience, Issue 33, 2021, Page(s) 1069-1081, ISSN 0898-929X
Publisher: Cambridge Center for Behavioral Studies
DOI: 10.1162/jocn_a_01706

Pavlovian-to-instrumental transfer in intertemporal choice

Author(s): Floor Burghoorn, Vivian R. Heuvelmans, Anouk Scheres, Karin Roelofs, Bernd Figner
Published in: Judgment and Decision Making, Issue 19, 2024, Page(s) 1–34, ISSN 1930-2975
Publisher: Society for Judgment and Decision Making
DOI: 10.1017/jdm.2023.42

The association between serotonin transporter availability and the neural correlates of fear bradycardia

Author(s): Pieter Schipper, Marlies Hiemstra, Kari Bosch, Desiree Nieuwenhuis, Annalisa Adinolfi, Sabine Glotzbach, Bart Borghans, Dora Lopresto, Guillén Fernández, Floris Klumpers, Erno J. Hermans, Karin Roelofs, Marloes J. A. G. Henckens, Judith R. Homberg
Published in: Proceedings of the National Academy of Sciences, Issue 116/51, 2019, Page(s) 25941-25947, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1904843116

Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-analysis

Author(s): Janna Marie Bas-Hoogendam, Rachel Bernstein, Brenda E. Benson, Kristin A. Buss, Kelley E. Gunther, Koraly Pérez-Edgar, Giovanni A. Salum, Andrea P. Jackowski, Rodrigo A. Bressan, André Zugman, Kathryn A. Degnan, Courtney A. Filippi, Nathan A. Fox, Heather A. Henderson, Alva Tang, Selin Zeytinoglu, Anita Harrewijn, Manon H.J. Hillegers, Tonya White, Marinus H. van IJzendoorn, Carl E. Schwartz, Ju
Published in: Journal of the American Academy of Child & Adolescent Psychiatry, Issue 61, 2022, Page(s) 1182-1188, ISSN 0890-8567
Publisher: Elsevier BV
DOI: 10.1016/j.jaac.2022.04.023

Perceptual control or action-selection? Comment on: a perceptual control theory of emotional action

Author(s): Bob Bramson, Karin Roelofs
Published in: Cognition and Emotion, Issue 37, 2023, Page(s) 1193-1198, ISSN 0269-9931
Publisher: Psychology Press
DOI: 10.1080/02699931.2023.2269830

Acute threat enhances perceptual sensitivity without affecting the decision criterion

Author(s): Lycia D. de Voogd, Eline Hagenberg, Ying Joey Zhou, Floris P. de Lange, Karin Roelofs
Published in: Scientific Reports, Issue 12, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-11664-0

Neural patterns of threat response in adolescents predict vulnerability for and resilience against internalizing symptoms during COVID-19 waves

Author(s): Anna Tyborowska, Yvonne van den Berg, Mahur M. Hashemi, Hannah C.M. Niermann, Antonius H.N. Cillessen, Ivan Toni, Karin Roelofs
Published in: Neuroimage: Reports, Issue 3, 2023, Page(s) 100177, ISSN 2666-9560
Publisher: Elsevier
DOI: 10.1016/j.ynirp.2023.100177

Thesis and dissertations (1)

Rhythmic control: Prefrontal cortical mechanisms of emotional-action control

Author(s): Bramson, B.P.
Published in: Rhythmic control: Prefrontal cortical mechanisms of emotional-action control, Issue 3, 2021, Page(s) 1-169, ISBN 9789464162233
Publisher: S.l. : s.n.