In vivo drug discovery for cellular reprogramming to β-cells – towards a future regenerative therapy for diabetes

Project Information

Reprogram-Diabetes

Grant agreement ID: 772365

DOI

10.3030/772365

Project closed

EC signature date 14 March 2018

Start date 1 July 2018

End date 30 September 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 968,00

EU contribution

€ 1 999 968,00

Coordinated by

UPPSALA UNIVERSITET
Sweden

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (6)

Efficient knock-in method enabling lineage tracing in zebrafish

Author(s): Jiarui Mi, Olov Andersson
Published in: Life Science Alliance, 2024, ISSN 2575-1077
Publisher: Life Science Alliance LLC
DOI: 10.1101/2022.07.15.500272

Adjudin improves beta cell maturation, hepatic glucose uptake and glucose homeostasis

Author(s): Lipeng Ren, Jérémie Charbord, Lianhe Chu, Aurino M. Kemas, Maria Bertuzzi, Jiarui Mi, Chen Xing, Volker M. Lauschke, Olov Andersson
Published in: Diabetologia, Issue 67, 2023, Page(s) 137-155, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-023-06020-4

Decoding pancreatic endocrine cell differentiation and β cell regeneration in zebrafish

Author(s): Jiarui Mi, Ka-Cheuk Liu, Olov Andersson
Published in: Science Advances, Issue 9, 2024, ISSN 2375-2548
Publisher: American Association for the Advancement of Science’s (AAAS)
DOI: 10.1126/sciadv.adf5142

MNK2 deficiency potentiates β-cell regeneration via translational regulation

Author(s): Christos Karampelias, Kathleen Watt, Charlotte L Mattsson, Ángel Fernández Ruiz, Habib Rezanejad, Jiarui Mi, Xiaojing Liu, Lianhe Chu, Jason W Locasale, Gregory S Korbutt, Meritxell Rovira, Ola Larsson, Olov Andersson
Published in: Nature Chemical Biology, 2022, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-022-01047-x

Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation

Author(s): Christos Karampelias, Habib Rezanejad, Mandy Rosko, Likun Duan, Jing Lu, Laura Pazzagli, Philippe Bertolino, Carolyn E. Cesta, Xiaojing Liu, Gregory S. Korbutt, Olov Andersson
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-23673-0

Insulin-producing b-cells regenerate ectopically from a mesodermal origin under the perturbation of hemato-endothelial specification

Author(s): Ka-Cheuk Liu, Alethia Villasenor, Maria Bertuzzi, Nicole Schmitner, Niki Radros, Linn Rautio, Kenny Mattonet, Ryota L Matsuoka, Sven Reischauer, Didier YR Stainier, Olov Andersson
Published in: eLife, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.65758