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The Tumour Stroma as a Driver of Clonal Selection


Topological features of integrin adhesion complexes revealed by multiplexed proximity biotinylation

Author(s): Megan R. Chastney, Craig Lawless, Jonathan D. Humphries, Stacey Warwood, Matthew C. Jones, David Knight, Claus Jorgensen, Martin J. Humphries
Published in: Journal of Cell Biology, Issue 219/8, 2020, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202003038

A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids.

Author(s): Below CR, Kelly J, Brown A, Humphries JD, Hutton C, Xu J, Lee BY, Cintas C, Zhang X, Hernandez-Gordillo V, Stockdale L, Goldsworthy MA, Geraghty J, Foster L, O'Reilly DA, Schedding B, Askari J, Burns J, Hodson N, Smith DL, Lally C, Ashton G, Knight D, Mironov A, Banyard A, Eble JA, Morton JP, Humphries MJ, Griffith LG, Jørgensen C.
Published in: Nature Materials, 2022, ISSN 1476-4660
Publisher: Nature Publishing Group
DOI: 10.1038/s41563-021-01085-1

Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1

Author(s): Rosemarie E. Gough, Matthew C. Jones, Thomas Zacharchenko, Shimin Le, Miao Yu, Guillaume Jacquemet, Ste P. Muench, Jie Yan, Jonathan D. Humphries, Claus Jørgensen, Martin J. Humphries, Benjamin T. Goult
Published in: Journal of Biological Chemistry, Issue 297/1, 2021, Page(s) 100837, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100837

A framework for advancing our understanding of cancer-associated fibroblasts

Author(s): Erik Sahai, Igor Astsaturov, Edna Cukierman, David G. DeNardo, Mikala Egeblad, Ronald M. Evans, Douglas Fearon, Florian R. Greten, Sunil R. Hingorani, Tony Hunter, Richard O. Hynes, Rakesh K. Jain, Tobias Janowitz, Claus Jorgensen, Alec C. Kimmelman, Mikhail G. Kolonin, Robert G. Maki, R. Scott Powers, Ellen Puré, Daniel C. Ramirez, Ruth Scherz-Shouval, Mara H. Sherman, Sheila Stewart, Thea D. Tl
Published in: Nature reviews Cancer, 2020, ISSN 1474-1768
Publisher: Nature Springer
DOI: 10.1038/s41568-019-0238-1

Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells.

Author(s): Halbrook CJ, Thurston G, Boyer S, Anaraki C, Jiménez JA, McCarthy A, Steele NG, Kerk SA, Hong HS, Lin L, Law FV, Felton C, Scipioni L, Sajjakulnukit P, Andren A, Beutel AK, Singh R, Nelson BS, Van Den Bergh F, Krall AS, Mullen PJ, Zhang L, Batra S, Morton JP, Stanger BZ, Christofk HR, Digman MA, Beard DA, Viale A, Zhang J, Crawford HC, Pasca di Magliano M, Jorgensen C, Lyssiotis CA.
Published in: Nature Cancer, 2022, ISSN 2662-1347
Publisher: Nature Publishing Group
DOI: 10.1038/s43018-022-00463-1

Anti-inflammatory drugs remodel the tumor immune environment to enhance immune checkpoint blockade efficacy

Author(s): Victoria S Pelly, Agrin Moeini, Lisanne M Roelofsen, Eduardo Bonavita, Charlotte R Bell, Colin Hutton, Adrian Blanco-Gomez, Antonia Banyard, Christian P Bromley, Eimear Flanagan, Shih-Chieh Chiang, Claus Jorgensen, Ton N Schumacher, Daniela S Thommen, Santiago Zelenay
Published in: Cancer Discovery, 2021, Page(s) candisc.1815.2020, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/

Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity.

Author(s): Hutton C, Heider F, Blanco-Gomez A, Banyard A, Kononov A, Zhang X, Karim S, Paulus-Hock V, Watt D, Steele N, Kemp S, Hogg EKJ, Kelly J, Jackstadt RF, Lopes F, Menotti M, Chisholm L, Lamarca A, Valle J, Sansom OJ, Springer C, Malliri A, Marais R, Pasca di Magliano M, Zelenay S, Morton JP, Jørgensen C.
Published in: Cancer Cell, 2021, ISSN 1878-3686
Publisher: Elsevier
DOI: 10.1016/j.ccell.2021.06.017

Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis

Author(s): Lee BY, Hogg EKJ, Below CR, Kononov A, Blanco-Gomez A, Heider F, Xu J, Hutton C, Zhang X, Scheidt T, Beattie K, Lamarca A, McNamara M, Valle JW, Jørgensen C.
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-27607-8

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