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The Tumour Stroma as a Driver of Clonal Selection

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Publications

Topological features of integrin adhesion complexes revealed by multiplexed proximity biotinylation

Author(s): Megan R. Chastney, Craig Lawless, Jonathan D. Humphries, Stacey Warwood, Matthew C. Jones, David Knight, Claus Jorgensen, Martin J. Humphries
Published in: Journal of Cell Biology, 219/8, 2020, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202003038

Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1

Author(s): Rosemarie E. Gough, Matthew C. Jones, Thomas Zacharchenko, Shimin Le, Miao Yu, Guillaume Jacquemet, Ste P. Muench, Jie Yan, Jonathan D. Humphries, Claus Jørgensen, Martin J. Humphries, Benjamin T. Goult
Published in: Journal of Biological Chemistry, 297/1, 2021, Page(s) 100837, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100837

A framework for advancing our understanding of cancer-associated fibroblasts

Author(s): Erik Sahai, Igor Astsaturov, Edna Cukierman, David G. DeNardo, Mikala Egeblad, Ronald M. Evans, Douglas Fearon, Florian R. Greten, Sunil R. Hingorani, Tony Hunter, Richard O. Hynes, Rakesh K. Jain, Tobias Janowitz, Claus Jorgensen, Alec C. Kimmelman, Mikhail G. Kolonin, Robert G. Maki, R. Scott Powers, Ellen Puré, Daniel C. Ramirez, Ruth Scherz-Shouval, Mara H. Sherman, Sheila Stewart, Thea D. Tl
Published in: Nature reviews Cancer, 2020, ISSN 1474-1768
Publisher: Nature Springer
DOI: 10.1038/s41568-019-0238-1

Anti-inflammatory drugs remodel the tumor immune environment to enhance immune checkpoint blockade efficacy

Author(s): Victoria S Pelly, Agrin Moeini, Lisanne M Roelofsen, Eduardo Bonavita, Charlotte R Bell, Colin Hutton, Adrian Blanco-Gomez, Antonia Banyard, Christian P Bromley, Eimear Flanagan, Shih-Chieh Chiang, Claus Jorgensen, Ton N Schumacher, Daniela S Thommen, Santiago Zelenay
Published in: Cancer Discovery, 2021, Page(s) candisc.1815.2020, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-1815