The Tumour Stroma as a Driver of Clonal Selection

Informazioni relative al progetto

DiSect

ID dell’accordo di sovvenzione: 772577

DOI

10.3030/772577

Progetto chiuso

Data della firma CE 22 Gennaio 2018

Data di avvio 1 Giugno 2018

Data di completamento 31 Maggio 2024

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 969 768,00

Contributo UE

€ 1 969 768,00

Coordinato da

THE UNIVERSITY OF MANCHESTER
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (9)

Topological features of integrin adhesion complexes revealed by multiplexed proximity biotinylation

Autori: Megan R. Chastney, Craig Lawless, Jonathan D. Humphries, Stacey Warwood, Matthew C. Jones, David Knight, Claus Jorgensen, Martin J. Humphries
Pubblicato in: Journal of Cell Biology, Numero 219/8, 2020, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.202003038

A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids.

Autori: Below CR, Kelly J, Brown A, Humphries JD, Hutton C, Xu J, Lee BY, Cintas C, Zhang X, Hernandez-Gordillo V, Stockdale L, Goldsworthy MA, Geraghty J, Foster L, O'Reilly DA, Schedding B, Askari J, Burns J, Hodson N, Smith DL, Lally C, Ashton G, Knight D, Mironov A, Banyard A, Eble JA, Morton JP, Humphries MJ, Griffith LG, Jørgensen C.
Pubblicato in: Nature Materials, 2022, ISSN 1476-4660
Editore: Nature Publishing Group
DOI: 10.1038/s41563-021-01085-1

Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1

Autori: Rosemarie E. Gough, Matthew C. Jones, Thomas Zacharchenko, Shimin Le, Miao Yu, Guillaume Jacquemet, Ste P. Muench, Jie Yan, Jonathan D. Humphries, Claus Jørgensen, Martin J. Humphries, Benjamin T. Goult
Pubblicato in: Journal of Biological Chemistry, Numero 297/1, 2021, Pagina/e 100837, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100837

A framework for advancing our understanding of cancer-associated fibroblasts

Autori: Erik Sahai, Igor Astsaturov, Edna Cukierman, David G. DeNardo, Mikala Egeblad, Ronald M. Evans, Douglas Fearon, Florian R. Greten, Sunil R. Hingorani, Tony Hunter, Richard O. Hynes, Rakesh K. Jain, Tobias Janowitz, Claus Jorgensen, Alec C. Kimmelman, Mikhail G. Kolonin, Robert G. Maki, R. Scott Powers, Ellen Puré, Daniel C. Ramirez, Ruth Scherz-Shouval, Mara H. Sherman, Sheila Stewart, Thea D. Tl
Pubblicato in: Nature reviews Cancer, 2020, ISSN 1474-1768
Editore: Nature Springer
DOI: 10.1038/s41568-019-0238-1

Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells.

Autori: Halbrook CJ, Thurston G, Boyer S, Anaraki C, Jiménez JA, McCarthy A, Steele NG, Kerk SA, Hong HS, Lin L, Law FV, Felton C, Scipioni L, Sajjakulnukit P, Andren A, Beutel AK, Singh R, Nelson BS, Van Den Bergh F, Krall AS, Mullen PJ, Zhang L, Batra S, Morton JP, Stanger BZ, Christofk HR, Digman MA, Beard DA, Viale A, Zhang J, Crawford HC, Pasca di Magliano M, Jorgensen C, Lyssiotis CA.
Pubblicato in: Nature Cancer, 2022, ISSN 2662-1347
Editore: Nature Publishing Group
DOI: 10.1038/s43018-022-00463-1

Anti-inflammatory drugs remodel the tumor immune environment to enhance immune checkpoint blockade efficacy

Autori: Victoria S Pelly, Agrin Moeini, Lisanne M Roelofsen, Eduardo Bonavita, Charlotte R Bell, Colin Hutton, Adrian Blanco-Gomez, Antonia Banyard, Christian P Bromley, Eimear Flanagan, Shih-Chieh Chiang, Claus Jorgensen, Ton N Schumacher, Daniela S Thommen, Santiago Zelenay
Pubblicato in: Cancer Discovery, 2021, Pagina/e candisc.1815.2020, ISSN 2159-8274
Editore: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-1815

Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity.

Autori: Hutton C, Heider F, Blanco-Gomez A, Banyard A, Kononov A, Zhang X, Karim S, Paulus-Hock V, Watt D, Steele N, Kemp S, Hogg EKJ, Kelly J, Jackstadt RF, Lopes F, Menotti M, Chisholm L, Lamarca A, Valle J, Sansom OJ, Springer C, Malliri A, Marais R, Pasca di Magliano M, Zelenay S, Morton JP, Jørgensen C.
Pubblicato in: Cancer Cell, 2021, ISSN 1878-3686
Editore: Elsevier
DOI: 10.1016/j.ccell.2021.06.017

Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis

Autori: Lee BY, Hogg EKJ, Below CR, Kononov A, Blanco-Gomez A, Heider F, Xu J, Hutton C, Zhang X, Scheidt T, Beattie K, Lamarca A, McNamara M, Valle JW, Jørgensen C.
Pubblicato in: Nature Communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-27607-8

Pancreatic ductal adenocarcinoma cells employ integrin α6β4 to form hemidesmosomes and regulate cell proliferation

Autori: Jonathan D. Humphries, Junzhe Zha, Jessica Burns, Janet A. Askari, Christopher R. Below, Megan R. Chastney, Matthew C. Jones, Aleksandr Mironov, David Knight, Derek A. O'Reilly, Mark J. Dunne, David R. Garrod, Claus Jorgensen, Martin J. Humphries
Pubblicato in: Matrix Biology, Numero 110, 2024, Pagina/e 16-39, ISSN 0945-053X
Editore: Elsevier BV
DOI: 10.1016/j.matbio.2022.03.010

Non-peer reviewed articles (1)

Untangling the tumorigenic role of homotrimeric collagen I

Autori: Claus Jørgensen
Pubblicato in: Cancer Cell, Numero 40, 2024, Pagina/e 802-804, ISSN 1535-6108
Editore: Cell Press
DOI: 10.1016/j.ccell.2022.07.007