Objective
Plant receptor kinases are major pattern recognition receptors (PRRs) that function as part of dynamic multimeric complexes to perceive pathogen-associated molecular patterns or host-derived damage-associated molecular patterns at the plasma membrane (PM). Our long-term objective is to decipher the molecular basis of plant innate immunity and to understand how plant receptor kinases work.
Our recent findings point to an important role of endogenous peptides in the regulation of plant innate immune signaling. The main aim of this proposal is to understand how these endogenous peptides and their corresponding receptors regulate plant innate immune signaling. The central hypotheses of this research are that: (i) a subset of plant endogenous peptides are perceived by receptor kinases to fine-tune dynamically plant innate immune signaling, and thus act as ‘phytocytokines’; (ii) these phytocytokines and their receptors regulate the formation of active immune-signaling nanoclusters at the PM; and (iii) phytocytokine receptors participate in the sensory continuum represented by the plant PM and the cell wall to respond dynamically to environmental challenges.
We will pursue the following specific objectives:
(1) decipher the regulation, function, and perception of RALF peptides by malectin-like receptor kinases during immunity;
(2) elucidate the formation, composition, and function of PM immune receptor nanoclusters;
(3) reveal the function of the receptor kinase MIK2 and its ligand(s) in immunity.
Through a balanced combination of straight-forward and high risk/high gain biochemical, biophysical, bioimaging, and genetics approaches, this project will provide groundbreaking insights into the molecular mechanisms underlying the establishment and regulation of plant innate immune signaling, but also into the general mechanisms that control plant receptor kinase functions and by which the myriad endogenous peptides encoded by plant genomes control environmental sensing.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules
- natural sciences computer and information sciences artificial intelligence pattern recognition
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-COG - Consolidator Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2017-COG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
8006 Zurich
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.