Morecognition is reinventing the rehabilitation process, starting from upper motor neuron lesion as the result of pathologies such as stroke, multiple sclerosis, traumatic brain injury and cerebral palsy. Rehabilitation actually starts in the hospital and should be continued as necessary after release from the hospital; up to now services are costly and highly dependent on human resources. Mo.Re. SME 1 Project stemmed in this context, matching demand and supply to find new technological solutions for the most important problem in healthcare systems: the necessity of a continuous, personalized and effective home rehabilitation program. Thanks to an innovative motor-cognitive rehabilitation program (clinical trial in progress), the Morecognition system enables patients to improve their recovery, both by accelerating the recovery time span and by achieving higher functional outcomes. The technological framework, based on a wearable device and a cloud service, allows to evaluate the effectiveness of the patient’s home therapy, thus reducing the home-based interventions.