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Rheuma Tolerance for Cure

Objective

In line with IMI2 goals for improved therapies and precision medicine, the aim of this proposal is to prevent and treat RA or its progression by inhibiting maturation/expansion of pathogenic autoimmune responses through immune tolerising treatments of subjects not only in early
stages of joint inflammation (undifferentiated arthritis and early RA) but also in even earlier defined stages i.e. before onset of joint inflammation, when patients have arthralgia and/or bone loss, or sub-clinical stages of joint inflammation.

Today, no drugs are approved for these early phases of RA development, where symptoms such as pain and fatigue cause major loss of life quality and where successful interference would prevent onset of disease. Thus, an important part of our work will be to achieve a better understanding of this as yet unexplored phase of disease. In the proposed project we will develop and validate new methods to identify individuals at high risk for RA, tools to monitor disease progress and expand and further develop cohorts suitable for these purposes.
Furthermore we will validate and standardise methods to monitor immune tolerance to be used in clinical trials for tolerising therapies for RA.
The aim is thus to interfere with the specific immune reactions that contribute to RA symptoms in such a way that a specific and long-lasting therapeutic effect (ultimately a cure) is accomplished for a major proportion of RA patients and prevention of diseases is accomplished in individuals at high risk for RA.

Investigator-initiated as well as company-sponsored clinical trials in well stratified patient groups will be performed in collaboration with SMEs and/or contributing pharma companies and their immune effects studied using the same panel of biomarkers allowing for standardisation across protocols. Our ambition is also to disseminate our experiences from RA to other rheumatic and other immune-mediated diseases.

Coordinator

KAROLINSKA INSTITUTET
Net EU contribution
€ 1 136 196,31
Address
Nobels Vag 5
17177 Stockholm
Sweden

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 384 714,00

Participants (19)

Deutsches Rheuma-Forschungszentrum Berlin
Germany
Net EU contribution
€ 453 450,00
Address
Chariteplatz 1
10117 Berlin

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Region
Berlin Berlin Berlin
Activity type
Research Organisations
Non-EU contribution
€ 0,00
MEDIZINISCHE UNIVERSITAET WIEN
Austria
Net EU contribution
€ 448 725,00
Address
Spitalgasse 23
1090 Wien

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Region
Wien Wien
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 340 000,00
KING'S COLLEGE LONDON
United Kingdom
Net EU contribution
€ 454 165,38
Address
Strand
WC2R 2LS London

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 419 358,00
THE UNIVERSITY OF BIRMINGHAM
United Kingdom
Net EU contribution
€ 448 075,00
Address
Edgbaston
B15 2TT Birmingham

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Region
West Midlands (England) West Midlands Birmingham
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITATSKLINIKUM ERLANGEN
Germany
Net EU contribution
€ 449 729,85
Address
Maximiliansplatz 2
91054 Erlangen

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Region
Bayern Mittelfranken Erlangen, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 200 000,00
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
Net EU contribution
€ 449 358,46
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne

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Region
North East (England) Northumberland and Tyne and Wear Tyneside
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 11,20
UNIVERSITY OF GLASGOW
United Kingdom
Net EU contribution
€ 448 725,00
Address
University Avenue
G12 8QQ Glasgow

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Region
West Central Scotland Glasgow City
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 200 000,00
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
Net EU contribution
€ 575 175,00
Address
Albinusdreef 2
2333 ZA Leiden

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Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 624 191,20
THE UNIVERSITY OF QUEENSLAND
Australia
Net EU contribution
€ 300 000,00
Non-EU contribution
€ 100 000,00
SEMMELWEIS EGYETEM
Hungary
Net EU contribution
€ 173 700,00
Address
Ulloi Utca 26
1085 Budapest

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Region
Közép-Magyarország Budapest Budapest
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 51 300,00
APITOPE INTERNATIONAL NV
Belgium
Net EU contribution
€ 240 000,00
Address
Agoralaan A Bis
3590 Diepenbeek

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Vlaams Gewest Prov. Limburg (BE) Arr. Hasselt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
ANOCCA AB
Sweden
Net EU contribution
€ 240 000,00
Address
Forskargatan 20c
151 36 Sodertalje

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Östra Sverige Stockholm Stockholms län
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
FONDAZIONE PER L'ISTITUTO DI RICERCA IN BIOMEDICINA
Switzerland
Net EU contribution
€ 182 700,00
Address
Via Francesco Chiesa 5
6500 Bellinzona

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Region
Schweiz/Suisse/Svizzera Ticino Ticino
Activity type
Research Organisations
Non-EU contribution
€ 198 550,00
JANSSEN PHARMACEUTICA NV
Belgium
Net EU contribution
€ 0,00
Address
Turnhoutseweg 30
2340 Beerse

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Region
Vlaams Gewest Prov. Antwerpen Arr. Turnhout
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 025 000,00
UCB BIOPHARMA
Belgium
Net EU contribution
€ 0,00
Address
Allee De La Recherche 60
1070 Bruxelles

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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 868 000,00
GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.
United Kingdom
Net EU contribution
€ 0,00
Address
Great West Road 980
TW89GS Brentford

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Region
London Outer London — West and North West Hounslow and Richmond upon Thames
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 820 000,00
SANOFI-AVENTIS DEUTSCHLAND GMBH
Germany
Net EU contribution
€ 0,00
Address
Bruningstrasse 50
65929 Frankfurt Am Main

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 345 665,00
BRISTOL-MYERS SQUIBB COMPANY CORP
United States
Net EU contribution
€ 0,00
Address
Park Avenue 345
10154 New York

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 113 940,00
PFIZER LIMITED
United Kingdom
Net EU contribution
€ 0,00
Address
Ramsgate Road
CT13 9NJ Sandwich

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Region
South East (England) Kent East Kent
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 820 986,00