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Rheuma Tolerance for Cure

Deliverables

Identification of auto-antigens associated with pathogenesis of RA

Report on the identification of auto-antigens associated with pathogenesis of RA

Suitable strategy for testing of multiple tolerogenic therapies

Agreement on a suitable strategy for testing of multiple tolerogenic therapies (UNEW, UCB)

Report on the core data set for characterisation of individuals at-risk for developing RA

Report on the core data set for characterisation of individuals at-risk for developing rheumatoid arthritis. In this part of WP2 the existing cohorts of individuals at-risk for development of RA from the RTCure partners will be analyzed and compared for their type of data acquisition in order to define an essential core data set for describing the “at-risk” state. This approach will comprise clinical parameters (such for instance the documentation of inflammatory arthralgia), laboratory parameters (such as ultrasensitive C-reactive protein and autoantibody titers against various autoantigens and peptides thereof, citrullinated proteins and other relevant antigenic protein modifications), and other relevant biomarkers (such as autoantibody profiles, protein biomarkers, RNA expression profiles, epigenetic profiles) as well as imaging parameters (such as subclinical synovitis, osteitis or tenosynovitis). Core parameters will be identified, which allow a comprehensive but also feasible description of the nature of the at-risk state in these individuals. In addition, novel more experimental parameters, in particular approaches coming from the immune-phenotyping of T and B cell populations done in WP3 and WP4 will be added to this parameter set, if shown to be relevant for a better characterization of the at-risk state. Importantly, the agreed key parameters will allow for harmonization of patient criteria that can be applied across clinical sites so as to ensure data comparability.

Comparison of serologic features of at-risk individuals and recent onset arthritis patients

Compare at-risk individuals with recent-onset/early arthritis patients RTCure partners have already established well characterized cohorts of recent onset/early arthritis patients such as the TACERA, the Leiden Early Arthritis and the Scottish Early RA (SERA) cohorts, which provide an excellent possibility to compare the clinical, serologic and cellular features of patients who have recently moved into the inflammatory phase of the disease with those of imminent risk of developing the disease. Additional biobanks of recent onset/early arthritis patients from other RTCure partners (MUW, KI) provide valuable information of the serologic features of recent onset/early arthritis patients.

Screening and analysis of biological and clinical datasets

Screening and analysis of biological and clinical datasets generated within the project. Responsible partners LUMC and Pfizer.

Algorithm for predicting the development of arthritis

Establishment of an algorithm for predicting the development of arthritis. The aim of this part is to develop a risk prediction model for development of RA, which is based on the parameters collected in the at-risk cohorts of the RTCure partners. Many of these cohorts contain longitudinal follow-ups, which allow to evaluate which of the at-risk individuals developed RA and which one remained in the at-risk stage. A particular focus will be drawn on parameters which predict progression to RA in several different cohorts. In addition, additive risk prediction by using several different parameters such as combination of clinical, laboratory and imaging parameters will be addressed.

ARIAA Midterm recruitment report

Clinical trial ARIAA Midterm recruitment report (UKER, BMS)

Key risk predictors for the transition from the at-risk status to clinical arthritis

Establishment of key risk predictors for the transition from the at-risk status to clinical arthritis (UA or RA). Core data sets extracted from existing cohorts in the first part of WP2 will be evaluated for their role in predicting the risk to progress from the at-risk state to the clinical state of arthritis (either undifferentiated arthritis or rheumatoid arthritis).

Optimal participant population(s) for clinical studies of tolerogenic interventions

Definition of the optimal participant population(s) for clinical studies of tolerogenic interventions (UKER and UQ). The target population is critical for testing tolerogenic therapies and will be a topic for ongoing debate among WP6 members, with input from WPs 1 and 2 in particular.

Status on ongoing clinical trials in RTCure

Status on ongoing clinical trials in RTCure. Including: First study subject approvals package (ASCARA, ICosRA, APPIPRA), All approval package (ICosRA and APIPPRA), Midterm recruitment report (ICosRA, APIPPRA)

Compendium on current researches for inducing clinical therapeutic tolerance (4 papers published in Lancet Rheumatology)

Compendium on current researches for inducing clinical therapeutic tolerancea previous and current attempts to induce clinical therapeutic tolerance with a focus on RA but including other autoimmune allergic and transplant settingsb postulated autoantigens and supporting data in RA c information on the preRA state including data on B and T cell epitope spreading involving key autoantigens illustrating how tolerance is lost over timed potential biomarkers of the tolerant stateThis will be published reviews in a per reviewed journal

Set up internal and external website with a RTCure logo

Set up external website with a RTCure logo and an internal communication platform where partners can store and share data and information and communicate about publications.

Build a multidisciplinary task force

Build a multidisciplinary task force with expertise on biology, statistics, database management, including clinicians and ethicists.

Arrange thematic workshops in collaboration with the other WPs

Arrange thematic workshops in collaboration with the other WPs. Approximately one every year.

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Publications

Designing custom CRISPR libraries for hypothesis-driven drug target discovery

Author(s): Vaishnavi Srinivasan Iyer, Long Jiang, Yunbing Shen, Sanjaykumar V. Boddul, Sudeepta Kumar Panda, Zsolt Kasza, Bernhard Schmierer, Fredrik Wermeling
Published in: Computational and Structural Biotechnology Journal, 18, 2020, Page(s) 2237-2246, ISSN 2001-0370
Publisher: Elsevier
DOI: 10.1016/j.csbj.2020.08.009

Distinct HLA Associations with Rheumatoid Arthritis Subsets Defined by Serological Subphenotype

Author(s): Chikashi Terao, Boel Brynedal, Zuomei Chen, Xia Jiang, Helga Westerlind, Monika Hansson, Per-Johan Jakobsson, Karin Lundberg, Karl Skriner, Guy Serre, Johan Rönnelid, Linda Mathsson-Alm, Mikael Brink, Solbritt Rantapää Dahlqvist, Leonid Padyukov, Peter K. Gregersen, Anne Barton, Lars Alfredsson, Lars Klareskog, Soumya Raychaudhuri
Published in: The American Journal of Human Genetics, 105/4, 2019, Page(s) 880, ISSN 0002-9297
Publisher: University of Chicago Press
DOI: 10.1016/j.ajhg.2019.09.018

Effector Functions of CD4+ T Cells at the Site of Local Autoimmune Inflammation—Lessons From Rheumatoid Arthritis

Author(s): Karine Chemin, Christina Gerstner, Vivianne Malmström
Published in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2019.00353

Autoantibodies in Rheumatoid Arthritis: Historical Background and Novel Findings

Author(s): Maria V. Sokolova, Georg Schett, Ulrike Steffen
Published in: Clinical Reviews in Allergy & Immunology, 2021, ISSN 1080-0549
Publisher: Humana Press, Inc.
DOI: 10.1007/s12016-021-08890-1

Checkpoints controlling the induction of B cell mediated autoimmunity in human autoimmune diseases

Author(s): S. Reijm,T. Kissel,R.E.M. Toes
Published in: European Journal of Immunology, Volume 50, issue 12, 2020, Page(s) 1885-1894, ISSN 1521-4141
Publisher: Wiley
DOI: 10.1002/eji.202048820

Metabolic reprogramming of osteoclasts represents a therapeutic target during the treatment of osteoporosis

Author(s): Jule Taubmann, Brenda Krishnacoumar, Christina Böhm, Maria Faas, Dorothea I. H. Müller, Susanne Adam, Cornelia Stoll, Martin Böttcher, Dimitrios Mougiakakos, Uwe Sonnewald, Jörg Hofmann, Georg Schett, Gerhard Krönke, Carina Scholtysek
Published in: Scientific Reports, 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-77892-4

Antigen‐driven PD‐1 + TOX + BHLHE40 + and PD‐1 + TOX + EOMES + T lymphocytes regulate juvenile idiopathic arthritis in situ

Author(s): Patrick Maschmeyer, Gitta Anne Heinz, Christopher Mark Skopnik, Lisanne Lutter, Alessio Mazzoni, Frederik Heinrich, Sae Lim Stuckrad, Lorenz Elias Wirth, Cam Loan Tran, René Riedel, Katrin Lehmann, Imme Sakwa, Rolando Cimaz, Francesco Giudici, Marcus Alexander Mall, Philipp Enghard, Bas Vastert, Hyun‐Dong Chang, Pawel Durek, Francesco Annunziato, Femke Wijk, Andreas Radbruch, Tilmann Kallinich,
Published in: European Journal of Immunology, 51/4, 2021, Page(s) 915-929, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202048797

Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis.

Author(s): Vugar Azizov, Katharina Dietel, Franziska Steffen, Kerstin Dürholz, Julia Meidenbauer, Sébastien Lucas, Michael Frech, Yasunori Omata, Narges Tajik, Lisa Knipfer, Anne Kolenbrander, Silvia Seubert, Dennis Lapuente, Maria V. Sokolova, Jörg Hofmann, Matthias Tenbusch, Andreas Ramming, Ulrike Steffen, Falk Nimmerjahn, Ralf Linker, Stefan Wirtz, Martin Herrmann, Vladimir Temchura, Kerstin Sarter, G
Published in: Nature communications, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-15855-z

The citrullinated/native index of autoantibodies against hnRNP-DL predicts an individual “window of treatment success” in RA patients.

Author(s): Bianka Marklein, Madeleine Jenning, Zoltán Konthur, Thomas Häupl, Franziska Welzel, Ute Nonhoff, Sylvia Krobitsch, Debbie M. Mulder, Marije I. Koenders, Vijay Joshua, Andrew P. Cope, Mark J. Shlomchik, Hans-Joachim Anders, Gerd R. Burmester, Aase Hensvold, Anca I. Catrina, Johan Rönnelid, Günter Steiner & Karl Skriner
Published in: Arthritis Research & Therapy, 23, Article number: 239 (2021), 2021, ISSN 1478-6354
Publisher: BioMed Central
DOI: 10.1186/s13075-021-02603-x

Brief Report: Humoral and cellular immune responses to SARS‐CoV‐2 infection and vaccination in B cell depleted autoimmune patients

Author(s): David Simon, Koray Tascilar, Katja Schmidt, Bernhard Manger, Leonie Weckwerth, Maria Sokolova, Laura Bucci, Filippo Fagni, Karin Manger, Florian Schuch, Monika Ronneberger, Axel Hueber, Ulrike Steffen, Dirk Mielenz, Martin Herrmann, Thomas Harrer, Arnd Kleyer, Gerhard Krönke, Georg Schett
Published in: Arthritis & Rheumatology, 2021, ISSN 2326-5191
Publisher: Wiley
DOI: 10.1002/art.41914

Tolerance-inducing medicines in autoimmunity: rheumatology and beyond

Author(s): James A Stanway, John D Isaacs
Published in: The Lancet Rheumatology, 2/9, 2020, Page(s) e565-e575, ISSN 2665-9913
Publisher: Elsevier
DOI: 10.1016/s2665-9913(20)30100-4

Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis

Author(s): HENDY KRISTYANTO HTTPS://ORCID.ORG/0000-0002-8022-6637NIENKE J. BLOMBERGLINDA M. SLOTELLEN I. H. VAN DER VOORTPRISCILLA F. KERKMAN HTTPS://ORCID.ORG/0000-0002-6212-002XALEIDA BAKKERLEONIE E. BURGERSROBIN M. TEN BRINCK HTTPS://ORCID.ORG/0000-0002-6128-6888ANNETTE H. M. VAN DER HELM-VAN MILHERGEN SPITS HTTPS://ORCID.ORG/0000-0003-3269-8338DOMINIQUE L. BAETENTOM W. J. HUIZINGA HTTPS://ORCID.ORG/0000-
Published in: SCIENCE TRANSLATIONAL MEDICINE, VOL. 12, NO. 570, 2020, Page(s) 570, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aaz5327

Autoantigens in rheumatoid arthritis and the potential for antigen-specific tolerising immunotherapy

Author(s): Hendrik J Nel, Vivianne Malmström, David C Wraith, Ranjeny Thomas
Published in: The Lancet Rheumatology, 2/11, 2020, Page(s) e712-e723, ISSN 2665-9913
Publisher: Elsevier
DOI: 10.1016/s2665-9913(20)30344-1

Deep Phenotyping of Urinary Leukocytes by Mass Cytometry Reveals a Leukocyte Signature for Early and Non-Invasive Prediction of Response to Treatment in Active Lupus Nephritis

Author(s): Martina Bertolo, Sabine Baumgart, Pawel Durek, Anette Peddinghaus, Henrik Mei, Thomas Rose, Philipp Enghard, Andreas Grützkau
Published in: Frontiers in Immunology, 11, 2020, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2020.00256

Genetic predisposition (HLA-SE) is associated with ACPA-IgG variable domain glycosylation in the predisease phase of RA

Author(s): "Theresa Kissel # 1, Tineke J van Wesemael # 2, Anders Lundquist 3, Heidi Kokkonen 4, Atsushi Kawakami 5, Mami Tamai 6, Dirkjan van Schaardenburg 7 8, Manfred Wuhrer 9, Tom Wj Huizinga 2, Hans Ulrich Scherer 2, Diane van der Woude 2, Solbritt Rantapää-Dahlqvist 4, René E M Toes 2"
Published in: Ann Rheum Dis ., Jan;81(1), 2021, Page(s) 141-143, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-220841

Why remission is not enough: underlying disease mechanisms in RA that prevent cure

Author(s): Georg Schett, Yoshiya Tanaka, John D. Isaacs
Published in: Nature Reviews Rheumatology, 17/3, 2021, Page(s) 135-144, ISSN 1759-4790
Publisher: Nature Publishing Group
DOI: 10.1038/s41584-020-00543-5

IgA2 Antibodies against SARS-CoV-2 Correlate with NET Formation and Fatal Outcome in Severely Diseased COVID-19 Patients

Author(s): Léonie A. N. Staats, Hella Pfeiffer, Jasmin Knopf, Aylin Lindemann, Julia Fürst, Andreas E. Kremer, Holger Hackstein, Markus F. Neurath, Luis E. Muñoz, Susanne Achenbach, Moritz Leppkes, Martin Herrmann, Georg Schett, Ulrike Steffen
Published in: Cells, 9/12, 2020, Page(s) 2676, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9122676

Lack of association between clinical and ultrasound measures of disease activity in rheumatoid arthritis remission

Author(s): Kenneth F. Baker, Ben Thompson, Dennis W. Lendrem, Adam Scadeng, Arthur G. Pratt, John D. Isaacs
Published in: Therapeutic Advances in Musculoskeletal Disease, 12, 2020, Page(s) 1759720X2091532, ISSN 1759-720X
Publisher: SAGE Publications Inc.
DOI: 10.1177/1759720x20915322

Rheumatoid arthritis patients display B-cell dysregulation already in the naïve repertoire consistent with defects in B-cell tolerance

Author(s): Yan Wang, Katy A. Lloyd, Ioannis Melas, Diana Zhou, Radha Thyagarajan, Joakim Lindqvist, Monika Hansson, Anna Svärd, Linda Mathsson-Alm, Alf Kastbom, Karin Lundberg, Lars Klareskog, Anca I. Catrina, Stephen Rapecki, Vivianne Malmström, Caroline Grönwall
Published in: Scientific Reports, 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-56279-0

Similar Impact of Psoriatic Arthritis and Rheumatoid Arthritis on Objective and Subjective Parameters of Hand Function

Author(s): Anna‐Maria Liphardt, Eva Manger, Sonja Liehr, Lisa Bieniek, Arnd Kleyer, David Simon, Koray Tascilar, Michael Sticherling, Jürgen Rech, Georg Schett, Axel J. Hueber
Published in: ACR Open Rheumatology, 2/12, 2020, Page(s) 734-740, ISSN 2578-5745
Publisher: Wiley
DOI: 10.1002/acr2.11196

Association between number and type of different ACPA fine specificities with lung abnormalities in early, untreated rheumatoid arthritis

Author(s): Vijay Joshua, Aase Haj Hensvold, Gudrun Reynisdottir, Monica Hansson, Martin Cornillet, Leonor Nogueira, Guy Serre, Sven Nyren, Reza Karimi, Anders Eklund, Magnus Sköld, Johan Grunewald, Katerina Chatzidionysiou, Anca Catrina
Published in: RMD Open, 6/2, 2020, Page(s) e001278, ISSN 2056-5933
Publisher: BMJ Publishing Group
DOI: 10.1136/rmdopen-2020-001278

MiR-146a controls age related bone loss

Author(s): Victoria Saferding; Melanie Hofmann; Julia S. Brunner; Birgit Niederreiter; Melanie Timmen; Nathaniel Magilnick; Silvia Hayer; Gerwin Heller; Guenter Steiner; Richard Stange; Mark Boldin; Gernot Schabbauer; Moritz Weigl; Matthias Hackl; Johannes Grillari; Josef S Smolen; S Blueml
Published in: Aging Cell, 18, 2020, ISSN 1474-9726
Publisher: Wiley
DOI: 10.1101/2020.03.20.000174

Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications.

Author(s): Kissel T, Reijm S, Slot LM, Cavallari M, Wortel CM, Vergroesen RD, Stoeken-Rijsbergen G, Kwekkeboom JC, Kampstra A, Levarht E, Drijfhout JW, Bang H, Bonger KM, Janssen G, van Veelen PA, Huizinga T, Scherer HU, Reth M, Toes R.
Published in: Annals of the rheumatic disease, Volume 79, Issue 4, 2020, Page(s) 472-480, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2019-216499

Key opinion leaders — a critical perspective

Author(s): Jose U. Scher, Georg Schett
Published in: Nature Reviews Rheumatology, 17/2, 2021, Page(s) 119-124, ISSN 1759-4790
Publisher: Nature Publishing Group
DOI: 10.1038/s41584-020-00539-1

Biomarkers of tolerance in immune-mediated inflammatory diseases: a new era in clinical management?

Author(s): Kenneth F Baker, Jasmine P X Sim, John D Isaacs
Published in: The Lancet Rheumatology, 3/5, 2021, Page(s) e371-e382, ISSN 2665-9913
Publisher: Elsevier
DOI: 10.1016/s2665-9913(21)00069-2

Preclinical models of arthritis for studying immunotherapy and immune tolerance

Author(s): Gavin R Meehan, Ranjeny Thomas, Shaima Al Khabouri, Pascale Wehr, Catharien MU Hilkens, David C Wraith, Daniela Sieghart, Michael Bonelli, György Nagy, Paul Garside, David F Tough, Huw D Lewis, James M Brewer
Published in: Annals of the Rheumatic Diseases, 80/10, 2021, Page(s) 1268-1277, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-220043

Immunological memory in rheumatic inflammation — a roadblock to tolerance induction

Author(s): Patrick Maschmeyer, Hyun-Dong Chang, Qingyu Cheng, Mir-Farzin Mashreghi, Falk Hiepe, Tobias Alexander, Andreas Radbruch
Published in: Nature Reviews Rheumatology, 17/5, 2021, Page(s) 291-305, ISSN 1759-4790
Publisher: Nature Publishing Group
DOI: 10.1038/s41584-021-00601-6

COVID-19 and immune-mediated inflammatory diseases: effect of disease and treatment on COVID-19 outcomes and vaccine responses

Author(s): Filippo Fagni, David Simon, Koray Tascilar, Verena Schoenau, Michael Sticherling, Markus F Neurath, Georg Schett
Published in: The Lancet Rheumatology, 3/10, 2021, Page(s) e724-e736, ISSN 2665-9913
Publisher: Elsevier
DOI: 10.1016/s2665-9913(21)00247-2

I Would Never Take Preventive Medication! Perspectives and Information Needs of People Who Underwent Predictive Tests for Rheumatoid Arthritis

Author(s): Erika Mosor, Michaela Stoffer‐Marx, Günter Steiner, Karim Raza, Rebecca J. Stack, Gwenda Simons, Marie Falahee, Diana Skingle, Mircia Dobrin, Georg Schett, Matthias Englbrecht, Josef S. Smolen, Ingvild Kjeken, Axel J. Hueber, Tanja A. Stamm
Published in: Arthritis Care & Research, 72/3, 2020, Page(s) 360-368, ISSN 2151-464X
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/acr.23841

Biased TCR gene usage in citrullinated Tenascin C specific T-cells in rheumatoid arthritis

Author(s): Sharma RK, Boddul SV, Yoosuf N, Turcinov S, Dubnovitsky A, Kozhukh G, Wermeling F, Kwok WW, Klareskog L, Malmström V
Published in: Scientific Reports, 31 Dec 2021, 11(1):24512, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-04291-8

A Virtual Reality–Based App to Educate Health Care Professionals and Medical Students About Inflammatory Arthritis: Feasibility Study

Author(s): Philipp Klemm, Arnd Kleyer, Koray Tascilar, Louis Schuster, Timo Meinderink, Florian Steiger, Uwe Lange, Ulf Müller-Ladner, Johannes Knitza, Philipp Sewerin, Johanna Mucke, Alexander Pfeil, Georg Schett, Fabian Hartmann, Axel J Hueber, David Simon
Published in: JMIR Serious Games, 9/2, 2021, Page(s) e23835, ISSN 2291-9279
Publisher: JMIR Publications
DOI: 10.2196/23835

IL-4 controls activated neutrophil FcγR2b expression and migration into inflamed joints

Author(s): Sudeepta Kumar Panda, Gustaf Wigerblad, Long Jiang, Yanek Jiménez-Andrade, Vaishnavi Srinivasan Iyer, Yunbing Shen, Sanjaykumar V. Boddul, André Ortlieb Guerreiro-Cacais, Bruno Raposo, Zsolt Kasza, Fredrik Wermeling
Published in: Proceedings of the National Academy of Sciences, 117/6, 2020, Page(s) 3103-3113, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1914186117

Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load

Author(s): Sanne Reijm, Theresa Kissel, Gerrie Stoeken-Rijsbergen, Linda M. Slot, Corrie M. Wortel, Hugo J. van Dooren, Nivine E. W. Levarht, Arieke S. B. Kampstra, Veerle F. A. M. Derksen, Pleuni Ooijevaar-de Heer, Holger Bang, Jan W. Drijfhout, Leendert A. Trouw, Tom W. J. Huizinga, Theo Rispens, Hans U. Scherer & René E. M. Toes
Published in: Arthritis Research & Therapy, Arthritis Research & Therapy volume 23, Article number: 230 (2021), 2021, ISSN 1478-6354
Publisher: BioMed Central
DOI: 10.1186/s13075-021-02609-5

A Detailed Analysis of the Association between Urate Deposition and Erosions and Osteophytes in Gout

Author(s): Caroline Pecherstorfer, David Simon, Sara Unbehend, Hanna Ellmann, Matthias Englbrecht, Fabian Hartmann, Camille Figueiredo, Axel Hueber, Judith Haschka, Roland Kocijan, Arnd Kleyer, Georg Schett, Jürgen Rech, Sara Bayat
Published in: ACR Open Rheumatology, 2/10, 2020, Page(s) 565-572, ISSN 2578-5745
Publisher: Wiley
DOI: 10.1002/acr2.11172

Presence of autoantibodies in “seronegative” rheumatoid arthritis associates with classical risk factors and high disease activity

Author(s): Evan Reed, Anna Karin Hedström, Monika Hansson, Linda Mathsson-Alm, Boel Brynedal, Saedis Saevarsdottir, Martin Cornillet, Per-Johan Jakobsson, Rikard Holmdahl, Karl Skriner, Guy Serre, Lars Alfredsson, Johan Rönnelid, Karin Lundberg
Published in: Arthritis Research & Therapy, 22/1, 2020, ISSN 1478-6362
Publisher: BMC
DOI: 10.1186/s13075-020-02191-2

In vitro and ex vitro functional characterization of human HLA-DRB1∗04 restricted T cell receptors

Author(s): Sanjaykumar V. Boddul, Ravi Kumar Sharma, Anatoly Dubnovitsky, Bruno Raposo, Christina Gerstner, Yunbing Shen, Vaishnavi Srinivasan Iyer, Zsolt Kasza, William W. Kwok, Aaron R. Winkler, Lars Klareskog, Vivianne Malmström, Maria Bettini, Fredrik Wermeling
Published in: Journal of Translational Autoimmunity, 4, 2021, Page(s) 100087, ISSN 2589-9090
Publisher: Elsevier
DOI: 10.1016/j.jtauto.2021.100087

Neutrophils as emerging therapeutic targets

Author(s): Tamás Németh, Markus Sperandio, Attila Mócsai
Published in: Nature Reviews Drug Discovery, 19/4, 2020, Page(s) 253-275, ISSN 1474-1776
Publisher: Nature Publishing Group
DOI: 10.1038/s41573-019-0054-z

Osmium-Labeled Microspheres for Bead-Based Assays in Mass Cytometry

Author(s): Lisa Budzinski, Axel R. Schulz, Sabine Baumgart, Tyler Burns, Thomas Rose, Heike Hirseland, Henrik E. Mei
Published in: The Journal of Immunology, 202/10, 2019, Page(s) 3103-3112, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1801640

The autoimmune response as a potential target for tolerance induction before the development of rheumatoid arthritis

Author(s): Rene EM Toes, Karim Raza
Published in: The Lancet Rheumatology, 3/3, 2021, Page(s) e214-e223, ISSN 2665-9913
Publisher: Elsevier
DOI: 10.1016/s2665-9913(20)30445-8

A Comprehensive Evaluation of the Relationship Between Different IgG and IgA Anti-Modified Protein Autoantibodies in Rheumatoid Arthritis

Author(s): Caroline Grönwall, Lisa Liljefors, Holger Bang, Aase H. Hensvold, Monika Hansson, Linda Mathsson-Alm, Lena Israelsson, Vijay Joshua, Anna Svärd, Ragnhild Stålesen, Philip J. Titcombe, Johanna Steen, Luca Piccoli, Natalia Sherina, Cyril Clavel, Elisabet Svenungsson, Iva Gunnarsson, Saedis Saevarsdottir, Alf Kastbom, Guy Serre, Lars Alfredsson, Vivianne Malmström, Johan Rönnelid, Anca I. Catrin
Published in: Frontiers in Immunology, 12, 2021, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2021.627986

IgA subclasses have different effector functions associated with distinct glycosylation profiles

Author(s): Ulrike Steffen, Carolien A. Koeleman, Maria V. Sokolova, Holger Bang, Arnd Kleyer, Jürgen Rech, Harald Unterweger, Martin Schicht, Fabian Garreis, Jonas Hahn, Fabian T. Andes, Fabian Hartmann, Madelaine Hahn, Aparna Mahajan, Friedrich Paulsen, Markus Hoffmann, Günter Lochnit, Luis E. Muñoz, Manfred Wuhrer, David Falck, Martin Herrmann, Georg Schett
Published in: Nature Communications, 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-13992-8

Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women

Author(s): Cecilia Engdahl, Albert Bondt, Ulrike Harre, Jasmin Raufer, René Pfeifle, Alessandro Camponeschi, Manfred Wuhrer, Michaela Seeling, Inga-Lill Mårtensson, Falk Nimmerjahn, Gerhard Krönke, Hans U. Scherer, Helena Forsblad-d’Elia, Georg Schett
Published in: Arthritis Research & Therapy, 20/1, 2018, ISSN 1478-6362
Publisher: Springer Nature
DOI: 10.1186/s13075-018-1586-z

Biomechanical properties of bone are impaired in patients with ACPA-positive rheumatoid arthritis and associated with the occurrence of fractures

Author(s): Fabian Stemmler, David Simon, Anna-Maria Liphardt, Matthias Englbrecht, Juergen Rech, Axel J Hueber, Klaus Engelke, Georg Schett, Arnd Kleyer
Published in: Annals of the Rheumatic Diseases, 77/7, 2018, Page(s) 973-980, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2017-212404

Abatacept blocks anti-citrullinated protein antibody and rheumatoid factor mediated cytokine production in human macrophages in IDO-dependent manner

Author(s): Aline Bozec, Yubin Luo, Cecilia Engdahl, Camille Figueiredo, Holger Bang, Georg Schett
Published in: Arthritis Research & Therapy, 20/1, 2018, ISSN 1478-6362
Publisher: Springer Nature
DOI: 10.1186/s13075-018-1527-x

Determination of Autoantibody Isotypes Increases the Sensitivity of Serodiagnostics in Rheumatoid Arthritis

Author(s): Daniela Sieghart, Alexander Platzer, Paul Studenic, Farideh Alasti, Maresa Grundhuber, Sascha Swiniarski, Thomas Horn, Helmuth Haslacher, Stephan Blüml, Josef Smolen, Günter Steiner
Published in: Frontiers in Immunology, 9, 2018, ISSN 1664-3224
Publisher: Frontiers in immunology
DOI: 10.3389/fimmu.2018.00876

Proteasome inhibition with bortezomib induces a therapeutically relevant depletion of plasma cells in SLE but does not target their precursors

Author(s): Tobias Alexander, Qingyu Cheng, Jens Klotsche, Laleh Khodadadi, Aderajew Waka, Robert Biesen, Bimba F. Hoyer, Gerd R. Burmester, Andreas Radbruch, Falk Hiepe
Published in: European Journal of Immunology, 48/9, 2018, Page(s) 1573-1579, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201847492

Emerging therapies for pre-RA

Author(s): Andrew P. Cope
Published in: Best Practice & Research Clinical Rheumatology, 31/1, 2017, Page(s) 99-111, ISSN 1521-6942
Publisher: Bailliere Tindall And Cassell
DOI: 10.1016/j.berh.2017.08.005

The involvement of Toll-like receptor 9 in the pathogenesis of erosive autoimmune arthritis

Author(s): Anita Fischer, Shahla Abdollahi-Roodsaz, Christina Böhm, Birgit Niederreiter, Brigitte Meyer, Anthony C. Y. Yau, Erik Lönnblom, Leo A. B. Joosten, Marije Koenders, Christian H. K. Lehmann, Diana Dudziak, Gerhard Krönke, Rikard Holmdahl, Günter Steiner
Published in: Journal of Cellular and Molecular Medicine, 22/9, 2018, Page(s) 4399-4409, ISSN 1582-1838
Publisher: Wiley-Blackwell
DOI: 10.1111/jcmm.13735

PU.1 controls fibroblast polarization and tissue fibrosis

Author(s): Thomas Wohlfahrt, Simon Rauber, Steffen Uebe, Markus Luber, Alina Soare, Arif Ekici, Stefanie Weber, Alexandru-Emil Matei, Chih-Wei Chen, Christiane Maier, Emmanuel Karouzakis, Hans P. Kiener, Elena Pachera, Clara Dees, Christian Beyer, Christoph Daniel, Kolja Gelse, Andreas E. Kremer, Elisabeth Naschberger, Michael Stürzl, Falk Butter, Michael Sticherling, Susetta Finotto, Alexander Kreuter, Mar
Published in: Nature, 566/7744, 2019, Page(s) 344-349, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-0896-x

Regulation of Fatty Acid Oxidation by Twist 1 in the Metabolic Adaptation of T Helper Lymphocytes to Chronic Inflammation

Author(s): Kristyna Hradilkova, Patrick Maschmeyer, Kerstin Westendorf, Heidi Schliemann, Olena Husak, Anne Sae Lim Stuckrad, Tilmann Kallinich, Kirsten Minden, Pawel Durek, Joachim R. Grün, Hyun‐Dong Chang, Andreas Radbruch
Published in: Arthritis & Rheumatology, 2019, ISSN 2326-5191
Publisher: Wiley
DOI: 10.1002/art.40939

Generation and Analysis of Human and Murine Osteoclasts

Author(s): Ulrike Steffen, Fabian T. Andes, Georg Schett
Published in: Current Protocols in Immunology, 125/1, 2019, Page(s) e74, ISSN 1934-3671
Publisher: Greene Pub. Associates
DOI: 10.1002/cpim.74

Sequential Prodrug Strategy To Target and Eliminate ACPA-Selective Autoreactive B Cells

Author(s): Lianne P. W. M. Lelieveldt, Hendy Kristyanto, Ger J. M. Pruijn, Hans Ulrich Scherer, René E. M. Toes, Kimberly M. Bonger
Published in: Molecular Pharmaceutics, 15/12, 2018, Page(s) 5565-5573, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.8b00741

Simultaneous quantification of bone erosions and enthesiophytes in the joints of patients with psoriasis or psoriatic arthritis - effects of age and disease duration

Author(s): David Simon, Arnd Kleyer, Francesca Faustini, Matthias Englbrecht, Judith Haschka, Andreas Berlin, Sebastian Kraus, Axel J. Hueber, Roland Kocijan, Michael Sticherling, Juergen Rech, Georg Schett
Published in: Arthritis Research & Therapy, 20/1, 2018, ISSN 1478-6362
Publisher: Springer Nature
DOI: 10.1186/s13075-018-1691-z

Disease interception with interleukin-17 inhibition in high-risk psoriasis patients with subclinical joint inflammation—data from the prospective IVEPSA study

Author(s): Eleni Kampylafka, David Simon, Isabelle d’Oliveira, Christina Linz, Veronika Lerchen, Matthias Englbrecht, Juergen Rech, Arnd Kleyer, Michael Sticherling, Georg Schett, Axel J. Hueber
Published in: Arthritis Research & Therapy, 21/1, 2019, ISSN 1478-6362
Publisher: Springer Nature
DOI: 10.1186/s13075-019-1957-0

Cortical bone loss is an early feature of nonradiographic axial spondyloarthritis

Author(s): Anna Neumann, Judith Haschka, Arnd Kleyer, Louis Schuster, Matthias Englbrecht, Andreas Berlin, Camille P. Figueiredo, David Simon, Christian Muschitz, Roland Kocijan, Heinrich Resch, Jürgen Rech, Georg Schett
Published in: Arthritis Research & Therapy, 20/1, 2018, ISSN 1478-6362
Publisher: Springer Nature
DOI: 10.1186/s13075-018-1620-1

Effect of disease-modifying anti-rheumatic drugs on bone structure and strength in psoriatic arthritis patients

Author(s): David Simon, Arnd Kleyer, Sara Bayat, Koray Tascilar, Eleni Kampylafka, Timo Meinderink, Louis Schuster, Ramona Petrov, Anna-Maria Liphardt, Juergen Rech, Georg Schett, Axel J. Hueber
Published in: Arthritis Research & Therapy, 21/1, 2019, ISSN 1478-6362
Publisher: Springer Nature
DOI: 10.1186/s13075-019-1938-3

Different classes of anti-modified protein antibodies are induced on exposure to antigens expressing only one type of modification

Author(s): Arieke Suzanna Berendina Kampstra, Jacqueline Stephanie Dekkers, Mikhail Volkov, Annemarie L Dorjée, Lise Hafkenscheid, Ayla C Kempers, Myrthe van Delft, Theresa Kissel, Sanne Reijm, George M C Janssen, Peter A van Veelen, Holger Bang, Tom W J Huizinga, Leendert A Trouw, Diane van der Woude, René E M Toes
Published in: Annals of the Rheumatic Diseases, 78/7, 2019, Page(s) 908-916, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2018-214950

On the presence of HLA-SE alleles and ACPA-IgG variable domain glycosylation in the phase preceding the development of rheumatoid arthritis

Author(s): Theresa Kissel, Karin Anna van Schie, Lise Hafkenscheid, Anders Lundquist, Heidi Kokkonen, Manfred Wuhrer, Tom WJ Huizinga, Hans Ulrich Scherer, René Toes, Solbritt Rantapää-Dahlqvist
Published in: Annals of the Rheumatic Diseases, 2019, Page(s) annrheumdis-2019-215698, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2019-215698

N ‐Linked Glycans in the Variable Domain of IgG Anti–Citrullinated Protein Antibodies Predict the Development of Rheumatoid Arthritis

Author(s): Lise Hafkenscheid, Emma Moel, Irene Smolik, Stacey Tanner, Xiaobo Meng, Bas C. Jansen, Albert Bondt, Manfred Wuhrer, Tom W. J. Huizinga, Rene E. M. Toes, Hani El‐Gabalawy, Hans U. Scherer
Published in: Arthritis & Rheumatology, 71/10, 2019, Page(s) 1626-1633, ISSN 2326-5191
Publisher: Springer nature
DOI: 10.1002/art.40920

The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells

Author(s): Esperanza Perucha, Rossella Melchiotti, Jack A Bibby, Wing Wu, Klaus Stensgaard Frederiksen, Ceri A. Roberts, Zoe Hall, Gaelle LeFriec, Kevin A. Robertson, Paul Lavender, Jens Gammeltoft Gerwien, Leonie S. Taams, Julian L. Griffin, Emanuele de Rinaldis, Lisa G. M. van Baarsen, Claudia Kemper, Peter Ghazal, Andrew P. Cope
Published in: Nature Communications, 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-08332-9

The involvement of Toll‐like receptor 9 in the pathogenesis of erosive autoimmune arthritis

Author(s): Anita Fischer, Shahla Abdollahi‐Roodsaz, Christina Böhm, Birgit Niederreiter, Brigitte Meyer, Anthony C. Y. Yau, Erik Lönnblom, Leo A. B. Joosten, Marije Koenders, Christian H. K. Lehmann, Diana Dudziak, Gerhard Krönke, Rikard Holmdahl, Günter Steiner
Published in: Journal of Cellular and Molecular Medicine, 22/9, 2018, Page(s) 4399-4409, ISSN 1582-1838
Publisher: Wiley-Blackwell
DOI: 10.1111/jcmm.13735

MicroRNA-155 Controls T Helper Cell Activation During Viral Infection

Author(s): Eliana Goncalves-Alves, Victoria Saferding, Christopher Schliehe, Robert Benson, Mariola Kurowska-Stolarska, Julia Stefanie Brunner, Antonia Puchner, Bruno K. Podesser, Josef S. Smolen, Kurt Redlich, Michael Bonelli, James Brewer, Andreas Bergthaler, Günter Steiner, Stephan Blüml
Published in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2019.01367

Myeloid-Specific Deletion of Mcl-1 Yields Severely Neutropenic Mice That Survive and Breed in Homozygous Form

Author(s): Janka Zsófia Csepregi, Anita Orosz, Erik Zajta, Orsolya Kása, Tamás Németh, Edina Simon, Szabina Fodor, Katalin Csonka, Balázs L. Barátki, Dorottya Kövesdi, You-Wen He, Attila Gácser, Attila Mócsai
Published in: The Journal of Immunology, 201/12, 2018, Page(s) 3793-3803, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1701803

N-Glycosylation Site Analysis of Citrullinated Antigen-Specific B-Cell Receptors Indicates Alternative Selection Pathways During Autoreactive B-Cell Development

Author(s): Rochelle D. Vergroesen, Linda M. Slot, Barbera D. C. van Schaik, Marvyn T. Koning, Theo Rispens, Antoine H. C. van Kampen, René E. M. Toes, Hans U. Scherer
Published in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2019.02092

IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes

Author(s): Michael Bonelli, Karolina Dalwigk, Alexander Platzer, Isabel Olmos Calvo, Silvia Hayer, Birgit Niederreiter, Johannes Holinka, Florian Sevelda, Thomas Pap, Günter Steiner, Giulio Superti-Furga, Josef S. Smolen, Hans P. Kiener, Thomas Karonitsch
Published in: Experimental & Molecular Medicine, 51/7, 2019, ISSN 1226-3613
Publisher: Korean Society of Medical Biochemistry and Molecular Biology
DOI: 10.1038/s12276-019-0267-6

Importance of Fc Receptor γ-Chain ITAM Tyrosines in Neutrophil Activation and in vivo Autoimmune Arthritis

Author(s): Tamás Németh, Krisztina Futosi, Marcell Szabó, Petra Aradi, Takashi Saito, Attila Mócsai, Zoltán Jakus
Published in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Publisher: frontiers
DOI: 10.3389/fimmu.2019.00252

Dendritic cells, T cells and their interaction in rheumatoid arthritis

Author(s): P. Wehr, H. Purvis, S.‐C. Law, R. Thomas
Published in: Clinical & Experimental Immunology, 196/1, 2019, Page(s) 12-27, ISSN 0009-9104
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/cei.13256

Anticitrullinated protein antibodies facilitate migration of synovial tissue-derived fibroblasts

Author(s): Meng Sun, Bence Rethi, Akilan Krishnamurthy, Vijay Joshua, Alexandra Circiumaru, Aase Haj Hensvold, Elena Ossipova, Caroline Grönwall, Yanying Liu, Marianne Engstrom, Sergiu Bogdan Catrina, Johanna Steen, Vivianne Malmstrom, Lars Klareskog, Camilla Svensson, Caroline Ospelt, Heidi Wähämaa, Anca Irinel Catrina
Published in: Annals of the Rheumatic Diseases, 2019, Page(s) annrheumdis-2018-214967, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2018-214967

Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis

Author(s): Kaja Eriksson, Guozhong Fei, Anna Lundmark, Daniel Benchimol, Linkiat Lee, Yue O. O. Hu, Anna Kats, Saedis Saevarsdottir, Anca Irinel Catrina, Björn Klinge, Anders F. Andersson, Lars Klareskog, Karin Lundberg, Leif Jansson, Tülay Yucel-Lindberg
Published in: Journal of Clinical Medicine, 8/5, 2019, Page(s) 630, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm8050630

Secretory anti-citrullinated protein antibodies in serum associate with lung involvement in early rheumatoid arthritis

Author(s): Karin Roos Ljungberg, Vijay Joshua, Thomas Skogh, Anders Eklund, C Magnus Sköld, Reza Karimi, Sven Nyrén, Anna Svärd, Anca I Catrina, Alf Kastbom
Published in: Rheumatology, 2019, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/kez377

Considerations for Optimal Trial Design for Rheumatoid Arthritis Prevention Studies

Author(s): Andrew P. Cope
Published in: Clinical Therapeutics, 41/7, 2019, Page(s) 1299-1311, ISSN 0149-2918
Publisher: Excerpta Medica, Inc.
DOI: 10.1016/j.clinthera.2019.04.014

Targeting of tolerogenic dendritic cells to heat-shock proteins in inflammatory arthritis

Author(s): Rachel Spiering, Manon A. A. Jansen, Matthew J. Wood, Anshorulloh A. Fath, Oliver Eltherington, Amy E. Anderson, Arthur G. Pratt, Willem van Eden, John D. Isaacs, Femke Broere, Catharien M. U. Hilkens
Published in: Journal of Translational Medicine, 17/1, 2019, ISSN 1479-5876
Publisher: BioMed Central
DOI: 10.1186/s12967-019-2128-4

Different hierarchies of anti‐modified protein autoantibody reactivities in rheumatoid arthritis

Author(s): Peter Sahlström, Monika Hansson, Johanna Steen, Khaled Amara, Philip J Titcombe, Björn Forsström, Ragnhild Stålesen, Lena Israelsson, Luca Piccoli, Karin Lundberg, Lars Klareskog, Daniel L. Mueller, Anca I Catrina, Karl Skriner, Vivianne Malmström, Caroline Grönwall
Published in: Arthritis & Rheumatology, 72/10, 2020, Page(s) 1643-1657, ISSN 2326-5191
Publisher: Wiley
DOI: 10.1002/art.41385

BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (the BIO-FLARE study): protocol for a non-randomised longitudinal cohort study

Author(s): Fiona Rayner, Amy E. Anderson, Kenneth F. Baker, Christopher D. Buckley, Bernard Dyke, Sally Fenton, Andrew Filer, Carl S. Goodyear, Catharien M. U. Hilkens, Shaun Hiu, Sean Kerrigan, Mariola Kurowska-Stolarska, Fiona Matthews, Iain McInnes, Wan-Fai Ng, Arthur G. Pratt, Jonathan Prichard, Karim Raza, Stefan Siebert, Deborah Stocken, M. Dawn Teare, Stephen Young, John D. Isaacs
Published in: BMC Rheumatology, 5/1, 2021, ISSN 2520-1026
Publisher: BioMed Central Springer nature
DOI: 10.1186/s41927-021-00194-3

Mobile Health Usage, Preferences, Barriers, and eHealth Literacy in Rheumatology: Patient Survey Study

Author(s): Johannes Knitza, David Simon, Antonia Lambrecht, Christina Raab, Koray Tascilar, Melanie Hagen, Arnd Kleyer, Sara Bayat, Adrian Derungs, Oliver Amft, Georg Schett, Axel J Hueber
Published in: JMIR mHealth and uHealth, 8/8, 2020, Page(s) e19661, ISSN 2291-5222
Publisher: JMIR Publications
DOI: 10.2196/19661

Biomechanical stress in the context of competitive sports training triggers enthesitis

Author(s): David Simon, Arnd Kleyer, Sara Bayat, Johannes Knitza, Larissa Valor-Mendez, Marina Schweiger, Georg Schett, Koray Tascilar, Axel J. Hueber
Published in: Arthritis Research & Therapy, 23/1, 2021, ISSN 1478-6362
Publisher: Biomed Central
DOI: 10.1186/s13075-021-02530-x

SARS-CoV-2 vaccination responses in untreated, conventionally treated and anticytokine-treated patients with immune-mediated inflammatory diseases

Author(s): David Simon, Koray Tascilar, Filippo Fagni, Gerhard Krönke, Arnd Kleyer, Christine Meder, Raja Atreya, Moritz Leppkes, Andreas E Kremer, Andreas Ramming, Milena L Pachowsky, Florian Schuch, Monika Ronneberger, Stefan Kleinert, Axel J Hueber, Karin Manger, Bernhard Manger, Carola Berking, Michael Sticherling, Markus F Neurath, Georg Schett
Published in: Annals of the Rheumatic Diseases, 80/10, 2021, Page(s) 1312-1316, ISSN 0003-4967
Publisher: BMJ Publishing Group
DOI: 10.1136/annrheumdis-2021-220461

The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts

Author(s): Jasna Friščić, Martin Böttcher, Christiane Reinwald, Heiko Bruns, Benjamin Wirth, Samantha-Josefine Popp, Kellie Irene Walker, Jochen A. Ackermann, Xi Chen, Jason Turner, Honglin Zhu, Lisa Seyler, Maximilien Euler, Philipp Kirchner, René Krüger, Arif B. Ekici, Triin Major, Oliver Aust, Daniela Weidner, Anita Fischer, Fabian T. Andes, Zeljka Stanojevic, Vladimir Trajkovic, Martin Herrmann, Ad
Published in: Immunity, 54/5, 2021, Page(s) 1002-1021.e10, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2021.03.003

CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus

Author(s): Dimitrios Mougiakakos, Gerhard Krönke, Simon Völkl, Sascha Kretschmann, Michael Aigner, Soraya Kharboutli, Sebastian Böltz, Bernhard Manger, Andreas Mackensen, Georg Schett
Published in: New England Journal of Medicine, 385/6, 2021, Page(s) 567-569, ISSN 0028-4793
Publisher: Massachusetts Medical Society
DOI: 10.1056/nejmc2107725

Performance of a Handheld Ultrasound Device to Assess Articular and Periarticular Pathologies in Patients with Inflammatory Arthritis

Author(s): Giulia Corte, Sara Bayat, Koray Tascilar, Larissa Valor-Mendez, Louis Schuster, Johannes Knitza, Filippo Fagni, Georg Schett, Arnd Kleyer, David Simon
Published in: Diagnostics, 11/7, 2021, Page(s) 1139, ISSN 2075-4418
Publisher: MDPI Journals
DOI: 10.3390/diagnostics11071139

Secukinumab leads to shifts from stage-based towards response-based disease clusters—comparative data from very early and established psoriatic arthritis

Author(s): Eleni Kampylafka, Koray Tascilar, Veronika Lerchen, Christina Linz, Maria Sokolova, Ana Zekovic, Arnd Kleyer, David Simon, Jürgen Rech, Michael Sticherling, Georg Schett, Axel J. Hueber
Published in: Arthritis Research & Therapy, 22/1, 2020, ISSN 1478-6362
Publisher: Springer Nature
DOI: 10.1186/s13075-020-02268-y

Light chain skewing in autoantibodies and B-cell receptors of the citrullinated antigen-binding B-cell response in rheumatoid arthritis

Author(s): Linda M. Slot ,Rochelle D. Vergroesen ,Priscilla F. Kerkman,Ellen Staudinger,Sanne Reijm,Hugo J. van Dooren,Ellen I. H. van der Voort,Tom W. J. Huizinga,René E. M. Toes,Hans U. Scherer
Published in: PLoS One, Mar 30;16(3):e0247847, 2021, ISSN 1544-9173
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0247847

Phospholipase Cγ2 is essential for experimental models of epidermolysis bullosa acquisita

Author(s): Kata P. Szilveszter, Simon Vikár, Ádám I. Horváth, Zsuzsanna Helyes, Miklós Sárdy, Attila Mócsai
Published in: Journal of Investigative Dermatology, 2021, ISSN 0022-202X
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2021.09.019

Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis

Author(s): Christina Gerstner, Sara Turcinov, Aase H. Hensvold, Karine Chemin, Hannes Uchtenhagen, Tamara H. Ramwadhdoebe, Anatoly Dubnovitsky, Genadiy Kozhukh, Lars Rönnblom, William W. Kwok, Adnane Achour, Anca I. Catrina, Lisa G. M. van Baarsen, Vivianne Malmström
Published in: BMC Immunology, 21/1, 2020, ISSN 1471-2172
Publisher: BioMed Central
DOI: 10.1186/s12865-020-00357-w

Current view on the pathogenic role of anti-citrullinated protein antibodies in rheumatoid arthritis

Author(s): Anca Catrina, Akilan Krishnamurthy, Bence Rethi
Published in: RMD Open, 7/1, 2021, Page(s) e001228, ISSN 2056-5933
Publisher: BMJ Publishing group
DOI: 10.1136/rmdopen-2020-001228

Towards prevention of autoimmune diseases: The example of rheumatoid arthritis

Author(s): Aase Hensvold, Lars Klareskog
Published in: European Journal of Immunology, 51/8, 2021, Page(s) 1921-1933, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202048952

Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate

Author(s): Jack A. Bibby, Harriet A. Purvis, Thomas Hayday, Anita Chandra, Klaus Okkenhaug, Sofia Rosenzweig, Ivona Aksentijevich, Michael Wood, Helen J. Lachmann, Claudia Kemper, Andrew P. Cope, Esperanza Perucha
Published in: Nature Communications, 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17179-4

Does methotrexate influence COVID-19 infection? Case series and mechanistic data

Author(s): Fabian Schälter, Kerstin Dürholz, Laura Bucci, Gerd Burmester, Roberto Caporali, Camille Figuereido, Jaime Fogagnolo Cobra, Bernhard Manger, Mario M. Zaiss, Georg Schett
Published in: Arthritis Research & Therapy, 23/1, 2021, ISSN 1478-6362
Publisher: Biomed Central
DOI: 10.1186/s13075-021-02464-4

Stromal Cell-Contact Dependent PI3K and APRIL Induced NF-κB Signaling Prevent Mitochondrial- and ER Stress Induced Death of Memory Plasma Cells

Author(s): Rebecca Cornelis, Stefanie Hahne, Adriano Taddeo, Georg Petkau, Darya Malko, Pawel Durek, Manja Thiem, Lukas Heiberger, Lena Peter, Elodie Mohr, Cora Klaeden, Koji Tokoyoda, Francesco Siracusa, Bimba Franziska Hoyer, Falk Hiepe, Mir-Farzin Mashreghi, Fritz Melchers, Hyun-Dong Chang, Andreas Radbruch
Published in: Cell Reports, 32/5, 2020, Page(s) 107982, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107982

Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis

Author(s): Narges Tajik, Michael Frech, Oscar Schulz, Fabian Schälter, Sébastien Lucas, Vugar Azizov, Kerstin Dürholz, Franziska Steffen, Yasunori Omata, Andreas Rings, Marko Bertog, Aroldo Rizzo, Aida Iljazovic, Marijana Basic, Arnd Kleyer, Stephan Culemann, Gerhard Krönke, Yubin Luo, Klaus Überla, Udo S. Gaipl, Benjamin Frey, Till Strowig, Kerstin Sarter, Stephan C. Bischoff, Stefan Wirtz, Juan D. Ca
Published in: Nature Communications, 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-15831-7

Stabilizing Antibody Cocktails for Mass Cytometry

Author(s): Axel R. Schulz, Sabine Baumgart, Julia Schulze, Marie Urbicht, Andreas Grützkau, Henrik E. Mei
Published in: Cytometry Part A, 2019, ISSN 1552-4922
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cyto.a.23781

IgA anti-citrullinated protein antibodies   are associated with flares during DMARD tapering in rheumatoid arthritis

Author(s): Maria V Sokolova, Melanie Hagen, Holger Bang, Georg Schett, Juergen Rech, Ulrike Steffen
Published in: Rheumatology, 2021, ISSN 1462-0324
Publisher: Oxford University Press
DOI: 10.1093/rheumatology/keab585

Dysregulated CD38 Expression on Peripheral Blood Immune Cell Subsets in SLE

Author(s): Marie Burns, Lennard Ostendorf, Robert Biesen, Andreas Grützkau, Falk Hiepe, Henrik E. Mei, Tobias Alexander
Published in: International Journal of Molecular Sciences, 22/5, 2021, Page(s) 2424, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22052424

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Author(s): Andrea Cossarizza, Hyun‐Dong Chang, Andreas Radbruch, Andreas Acs, Dieter Adam, Sabine Adam‐Klages, William W. Agace, Nima Aghaeepour, Mübeccel Akdis, Matthieu Allez, Larissa Nogueira Almeida, Giorgia Alvisi, Graham Anderson, Immanuel Andrä, Francesco Annunziato, Achille Anselmo, Petra Bacher, Cosima T. Baldari, Sudipto Bari, Vincenzo Barnaba, Joana Barros‐Martins, Luca Battistini, Wolfgan
Published in: European Journal of Immunology, 49/10, 2019, Page(s) 1457-1973, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.201970107

Advanced machine learning for predicting individual risk of flares in rheumatoid arthritis patients tapering biologic drugs

Author(s): Asmir Vodencarevic, Koray Tascilar, Fabian Hartmann, Michaela Reiser, Axel J. Hueber, Judith Haschka, Sara Bayat, Timo Meinderink, Johannes Knitza, Larissa Mendez, Melanie Hagen, Gerhard Krönke, Jürgen Rech, Bernhard Manger, Arnd Kleyer, Marcus Zimmermann-Rittereiser, Georg Schett, David Simon
Published in: Arthritis Research & Therapy, 23/1, 2021, ISSN 1478-6362
Publisher: BioMed Central
DOI: 10.1186/s13075-021-02439-5

GENETIC SUSCEPTIBILITY VARIANTS FOR RHEUMATOID ARTHRITIS ARE NOT ASSOCIATED WITH EARLY REMISSION; A MULTI-COHORT STUDY

Author(s): Zapata SJ, Maurits M, Abraham Y, Van den Akker E, Barton A, Brown P, Cope A, González-Álvaro I, Goodyear C, van der Helm-van Mil A, Hu X
Published in: Annals of the Rheumatic Diseases, 2021;80, 2021, Page(s) 403-404, ISSN 0003-4967
Publisher: BMJ Publishing group