Deliverables Documents, reports (18) ARIAA Report on status of posting results Clinical trial ARIAA Report on status of posting results UKER BMS Report on progress of the prospective at-risk RTCure cohort Establish an RTCure prospective cohort of atrisk individualsWhile the analysis of already existing cohorts will allow us to obtain valuable information on the potential parameters which predict progression to RA the establishment of a new prospective cohort of atrisk individuals with contribution from all partners and with a harmonized mode of data acquisition will be an important step further which will allow i study of larger sample size of atrisk individuals with ii a higher possibility to better compare data based on standardized protocols of data acquisition and iii to provide a basis for future clinical trials see also WP6 For establishing this cohort the use of methods such as Multiple Randomised Controlled Trial MRCT design will be considered The plan is that each academic partner contributes at least 50 atrisk individuals to this joint RTCure cohort allowing a total number of at least 600 atrisk individuals with identical data collection to be studied by the RTCure consortium Immunomonitoring techniques applied and developed in WP3 and WP4 will also feed into this cohort Identification of auto-antigens associated with pathogenesis of RA Report on the identification of auto-antigens associated with pathogenesis of RA Standard operating procedures for the application of immune profiling D43 Standard operating procedures for the application of immune profiling Type R Dissemination level PU Delivery Date Month 42 Responsible partner KCL and DRFZ Report on the validation of immune tolerance signatures in relevant experimental medicine studies Report on the validation of immune tolerance signatures in relevant experimental medicine studies Type R Dissemination level PU Delivery Date Month 60 Responsible partners KCL LUMC KI Suitable strategy for testing of multiple tolerogenic therapies Agreement on a suitable strategy for testing of multiple tolerogenic therapies (UNEW, UCB) Report on the core data set for characterisation of individuals at-risk for developing RA Report on the core data set for characterisation of individuals at-risk for developing rheumatoid arthritis. In this part of WP2 the existing cohorts of individuals at-risk for development of RA from the RTCure partners will be analyzed and compared for their type of data acquisition in order to define an essential core data set for describing the “at-risk” state. This approach will comprise clinical parameters (such for instance the documentation of inflammatory arthralgia), laboratory parameters (such as ultrasensitive C-reactive protein and autoantibody titers against various autoantigens and peptides thereof, citrullinated proteins and other relevant antigenic protein modifications), and other relevant biomarkers (such as autoantibody profiles, protein biomarkers, RNA expression profiles, epigenetic profiles) as well as imaging parameters (such as subclinical synovitis, osteitis or tenosynovitis). Core parameters will be identified, which allow a comprehensive but also feasible description of the nature of the at-risk state in these individuals. In addition, novel more experimental parameters, in particular approaches coming from the immune-phenotyping of T and B cell populations done in WP3 and WP4 will be added to this parameter set, if shown to be relevant for a better characterization of the at-risk state. Importantly, the agreed key parameters will allow for harmonization of patient criteria that can be applied across clinical sites so as to ensure data comparability. Characterisation of pathogenic T- and B- cell receptors and antibodies Report on the characterisation of pathogenic T cell receptors B cell receptors and antibodies Comparison of serologic features of at-risk individuals and recent onset arthritis patients Compare at-risk individuals with recent-onset/early arthritis patients RTCure partners have already established well characterized cohorts of recent onset/early arthritis patients such as the TACERA, the Leiden Early Arthritis and the Scottish Early RA (SERA) cohorts, which provide an excellent possibility to compare the clinical, serologic and cellular features of patients who have recently moved into the inflammatory phase of the disease with those of imminent risk of developing the disease. Additional biobanks of recent onset/early arthritis patients from other RTCure partners (MUW, KI) provide valuable information of the serologic features of recent onset/early arthritis patients. Screening and analysis of biological and clinical datasets Screening and analysis of biological and clinical datasets generated within the project. Responsible partners LUMC and Pfizer. Algorithm for predicting the development of arthritis Establishment of an algorithm for predicting the development of arthritis. The aim of this part is to develop a risk prediction model for development of RA, which is based on the parameters collected in the at-risk cohorts of the RTCure partners. Many of these cohorts contain longitudinal follow-ups, which allow to evaluate which of the at-risk individuals developed RA and which one remained in the at-risk stage. A particular focus will be drawn on parameters which predict progression to RA in several different cohorts. In addition, additive risk prediction by using several different parameters such as combination of clinical, laboratory and imaging parameters will be addressed. ARIAA Midterm recruitment report Clinical trial ARIAA Midterm recruitment report (UKER, BMS) Key risk predictors for the transition from the at-risk status to clinical arthritis Establishment of key risk predictors for the transition from the at-risk status to clinical arthritis (UA or RA). Core data sets extracted from existing cohorts in the first part of WP2 will be evaluated for their role in predicting the risk to progress from the at-risk state to the clinical state of arthritis (either undifferentiated arthritis or rheumatoid arthritis). Regulatory briefing doc Regulatory briefing doc to be used in interactions with regulatory agencies Report on the development of strategies for the depletion of pathogenic cells refractory to tolerance induction Report on the development of strategies for the depletion of pathogenic cells refractory to tolerance induction Optimal participant population(s) for clinical studies of tolerogenic interventions Definition of the optimal participant population(s) for clinical studies of tolerogenic interventions (UKER and UQ). The target population is critical for testing tolerogenic therapies and will be a topic for ongoing debate among WP6 members, with input from WPs 1 and 2 in particular. Status on ongoing clinical trials in RTCure Status on ongoing clinical trials in RTCure. Including: First study subject approvals package (ASCARA, ICosRA, APPIPRA), All approval package (ICosRA and APIPPRA), Midterm recruitment report (ICosRA, APIPPRA) Compendium on current researches for inducing clinical therapeutic tolerance (4 papers published in Lancet Rheumatology) Compendium on current researches for inducing clinical therapeutic tolerancea previous and current attempts to induce clinical therapeutic tolerance with a focus on RA but including other autoimmune allergic and transplant settingsb postulated autoantigens and supporting data in RA c information on the preRA state including data on B and T cell epitope spreading involving key autoantigens illustrating how tolerance is lost over timed potential biomarkers of the tolerant stateThis will be published reviews in a per reviewed journal Websites, patent fillings, videos etc. (2) Set up internal and external website with a RTCure logo Set up external website with a RTCure logo and an internal communication platform where partners can store and share data and information and communicate about publications. Build a multidisciplinary task force Build a multidisciplinary task force with expertise on biology, statistics, database management, including clinicians and ethicists. Other (1) Arrange thematic workshops in collaboration with the other WPs Arrange thematic workshops in collaboration with the other WPs. Approximately one every year. Publications Peer reviewed articles (136) Autoreactive B cells in rheumatoid arthritis consist of activated CXCR3+ memory B cells and plasmablasts Author(s): Sanne Reijm, Joanneke C. Kwekkeboom, Nienke J. Blomberg, Jolien Suurmond, Diane van der Woude, Rene E.M. Toes, Hans U. Scherer Published in: JCI insight, 2023, ISSN 2379-3708 Publisher: American Society for Clinical Investigation DOI: 10.1172/jci.insight.172006 IgG Fab Glycans Hinder FcRn-Mediated Placental Transport Author(s): Volkov, Mikhail; Brinkhaus, Maximilian; van Schie, Karin A; Bondt, Albert; Kissel, Theresa; van der Kooi, Elvera J; Bentlage, Arthur E H; Koeleman, Carolien A M; de Taeye, Steven W; Derksen, Ninotska I; Dolhain, Radboud J E M; Braig-Scherer, Ute; Huizinga, Tom W J; Wuhrer, Manfred; Toes, René E M; Vidarsson, Gestur; van der Woude, Diane; Sub Biomol.Mass Spectrometry & Proteom.; Afd Biomol.Mass Sp Published in: Journal of Immunology, 210(2), 158. American Association of Immunologists, Issue 8, 2023, ISSN 0022-1767 Publisher: American Association of Immunologists DOI: 10.4049/jimmunol.2200438 Absence of Epstein-Barr virus DNA in anti-citrullinated protein antibody-expressing B cells of patients with rheumatoid arthritis Author(s): Kroos, S., Kampstra, A.S.B., Toes, R.E.M. et al Published in: Arthritis Res Ther, 2022, ISSN 1478-6362 Publisher: BioMed Central DOI: 10.1186/s13075-022-02919-2 Designing custom CRISPR libraries for hypothesis-driven drug target discovery Author(s): Vaishnavi Srinivasan Iyer, Long Jiang, Yunbing Shen, Sanjaykumar V. Boddul, Sudeepta Kumar Panda, Zsolt Kasza, Bernhard Schmierer, Fredrik Wermeling Published in: Computational and Structural Biotechnology Journal, Issue 18, 2020, Page(s) 2237-2246, ISSN 2001-0370 Publisher: Elsevier DOI: 10.1016/j.csbj.2020.08.009 Distinct HLA Associations with Rheumatoid Arthritis Subsets Defined by Serological Subphenotype Author(s): Chikashi Terao, Boel Brynedal, Zuomei Chen, Xia Jiang, Helga Westerlind, Monika Hansson, Per-Johan Jakobsson, Karin Lundberg, Karl Skriner, Guy Serre, Johan Rönnelid, Linda Mathsson-Alm, Mikael Brink, Solbritt Rantapää Dahlqvist, Leonid Padyukov, Peter K. Gregersen, Anne Barton, Lars Alfredsson, Lars Klareskog, Soumya Raychaudhuri Published in: The American Journal of Human Genetics, Issue 105/4, 2019, Page(s) 880, ISSN 0002-9297 Publisher: University of Chicago Press DOI: 10.1016/j.ajhg.2019.09.018 Effector Functions of CD4+ T Cells at the Site of Local Autoimmune Inflammation—Lessons From Rheumatoid Arthritis Author(s): Karine Chemin, Christina Gerstner, Vivianne Malmström Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224 Publisher: Frontiers DOI: 10.3389/fimmu.2019.00353 Autoantibodies in Rheumatoid Arthritis: Historical Background and Novel Findings Author(s): Maria V. Sokolova, Georg Schett, Ulrike Steffen Published in: Clinical Reviews in Allergy & Immunology, 2021, ISSN 1080-0549 Publisher: Humana Press, Inc. DOI: 10.1007/s12016-021-08890-1 Patient and public involvement in an international rheumatology translational research project – an evaluation. Author(s): Savia de Souza, Eva C Johansson, Susanne Karlfeldt, Karim Raza, Ruth Williams Published in: BMC Rheumatology, 2022, ISSN 2520-1026 Publisher: BioMed Central DOI: 10.1186/s41927-022-00311-w Rheumatoid Arthritis-Specific Autoimmunity in the Lung Before and at the Onset of Disease. Author(s): Joshua V, Loberg Haarhaus M, Hensvold A, Wähämaa H, Gerstner C, Hansson M, Israelsson L, Stålesen R, Sköld M, Grunewald J, Klareskog L, Grönwall C, Réthi B, Catrina A, Malmström V. Published in: Arthritis Rheumatol., 2023, ISSN 2326-5205 Publisher: Wiley, Hoboken DOI: 10.1002/art.42549 Rheumatoid Factor and Anti-Modified Protein Antibody Reactivities Converge on IgG Epitopes Author(s): Aisha M Mergaert, Zihao Zheng, Michael F Denny, Maya F Amjadi, S Janna Bashar, Michael A Newton, Vivianne Malmström, Caroline Grönwall, Sara S McCoy, Miriam A Shelef Published in: Arthritis & rheumatology, 2022, ISSN 2326-5191 Publisher: Malden, MA : Wiley, [2014]- DOI: 10.1002/art.42064 Checkpoints controlling the induction of B cell mediated autoimmunity in human autoimmune diseases Author(s): S. Reijm,T. Kissel,R.E.M. Toes Published in: European Journal of Immunology, Issue Volume 50, issue 12, 2020, Page(s) 1885-1894, ISSN 1521-4141 Publisher: Wiley DOI: 10.1002/eji.202048820 Prospective Studies on the Risk of Rheumatoid Arthritis: The European Risk RA Registry Author(s): Paul Studenic, Aase Hensvold, Arnd Kleyer, Annette van der Helm-van Mil, Arthur G. Pratt, Daniela Sieghart, Gerhard Krönke, Ruth Williams, Savia de Souza, Susanne Karlfeldt, Martina Johannesson, Niels Steen Krogh, Lars Klareskog and Anca I. Catrina Published in: Frontiers in Medicine, Issue 2296858X, 2022, ISSN 2296-858X Publisher: Frontiers Media S.A DOI: 10.3389/fmed.2022.824501 Metabolic reprogramming of osteoclasts represents a therapeutic target during the treatment of osteoporosis Author(s): Jule Taubmann, Brenda Krishnacoumar, Christina Böhm, Maria Faas, Dorothea I. H. Müller, Susanne Adam, Cornelia Stoll, Martin Böttcher, Dimitrios Mougiakakos, Uwe Sonnewald, Jörg Hofmann, Georg Schett, Gerhard Krönke, Carina Scholtysek Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-020-77892-4 Towards preventive treatment of rheumatoid arthritis. Author(s): Rech J, Schett G Published in: Lancet, 2022, ISSN 0140-6736 Publisher: The Lancet Publishing Group DOI: 10.1016/s0140-6736(22)01327-7 Antigen‐driven PD‐1 + TOX + BHLHE40 + and PD‐1 + TOX + EOMES + T lymphocytes regulate juvenile idiopathic arthritis in situ Author(s): Patrick Maschmeyer, Gitta Anne Heinz, Christopher Mark Skopnik, Lisanne Lutter, Alessio Mazzoni, Frederik Heinrich, Sae Lim Stuckrad, Lorenz Elias Wirth, Cam Loan Tran, René Riedel, Katrin Lehmann, Imme Sakwa, Rolando Cimaz, Francesco Giudici, Marcus Alexander Mall, Philipp Enghard, Bas Vastert, Hyun‐Dong Chang, Pawel Durek, Francesco Annunziato, Femke Wijk, Andreas Radbruch, Tilmann Kallinich, Published in: European Journal of Immunology, Issue 51/4, 2021, Page(s) 915-929, ISSN 0014-2980 Publisher: John Wiley & Sons Ltd. DOI: 10.1002/eji.202048797 Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis. Author(s): Vugar Azizov, Katharina Dietel, Franziska Steffen, Kerstin Dürholz, Julia Meidenbauer, Sébastien Lucas, Michael Frech, Yasunori Omata, Narges Tajik, Lisa Knipfer, Anne Kolenbrander, Silvia Seubert, Dennis Lapuente, Maria V. Sokolova, Jörg Hofmann, Matthias Tenbusch, Andreas Ramming, Ulrike Steffen, Falk Nimmerjahn, Ralf Linker, Stefan Wirtz, Martin Herrmann, Vladimir Temchura, Kerstin Sarter, G Published in: Nature communications, 2020, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-020-15855-z IgG Anti-Citrullinated Protein Antibody Variable Domain Glycosylation Increases Before the Onset of Rheumatoid Arthritis and Stabilizes Thereafter: A Cross-Sectional Study Encompassing ~1,500 Samples. Author(s): Theresa Kissel,Lise Hafkenscheid,Tineke J. Wesemael,Mami Tamai,Shin-ya Kawashiri,Atsushi Kawakami,Hani S. El-Gabalawy,Dirkjan van Schaardenburg,Solbritt Rantapää-Dahlqvist,Manfred Wuhrer,Annette H. M. van der Helm-van Mil,Cornelia F. Allaart,Diane van der Woude,Hans U. Scherer,Rene E. M. Toes,Tom W. J. Huizinga Published in: Arthritis & Rheumatology (Hoboken, N.J.), 2022, ISSN 2326-5205 Publisher: Wiley DOI: 10.1002/art.42098 Histone deacetylase 1 (HDAC1): A key player of T cell-mediated arthritis. Author(s): Göschl L, Preglej T, Boucheron N, Saferding V, Müller L, Platzer A, Hirahara K, Shih HY, Backlund J, Matthias P, Niederreiter B, Hladik A, Kugler M, Gualdoni GA, Scheinecker C, Knapp S, Seiser C, Holmdahl R, Tillmann K, Plasenzotti R, Podesser B, Aletaha D, Smolen JS, Karonitsch T, Steiner G, Ellmeier W, Bonelli M. Published in: J Autoimmun, 2020, ISSN 0896-8411 Publisher: Academic Press DOI: 10.1016/j.jaut.2019.102379 The citrullinated/native index of autoantibodies against hnRNP-DL predicts an individual “window of treatment success” in RA patients. Author(s): Bianka Marklein, Madeleine Jenning, Zoltán Konthur, Thomas Häupl, Franziska Welzel, Ute Nonhoff, Sylvia Krobitsch, Debbie M. Mulder, Marije I. Koenders, Vijay Joshua, Andrew P. Cope, Mark J. Shlomchik, Hans-Joachim Anders, Gerd R. Burmester, Aase Hensvold, Anca I. Catrina, Johan Rönnelid, Günter Steiner & Karl Skriner Published in: Arthritis Research & Therapy, Issue 23, Article number: 239 (2021), 2021, ISSN 1478-6354 Publisher: BioMed Central DOI: 10.1186/s13075-021-02603-x Antibody-induced pain-like behavior and bone erosion: links to subclinical inflammation, osteoclast activity, and acid-sensing ion channel 3-dependent sensitization Author(s): Jurczak A, Delay L, Barbier J, Simon N, Krock E, Sandor K, Agalave NM, Rudjito R, Wigerblad G, Rogóż K, Briat A, Miot-Noirault E, Martinez-Martinez A, Brömme D, Grönwall C, Malmström V, Klareskog L, Khoury S, Ferreira T, Labrum B, Deval E, Jiménez-Andrade JM, Marchand F, Svensson CI. Published in: Pain, 2022, ISSN 0304-3959 Publisher: Elsevier BV DOI: 10.1097/j.pain.0000000000002543 Brief Report: Humoral and cellular immune responses to SARS‐CoV‐2 infection and vaccination in B cell depleted autoimmune patients Author(s): David Simon, Koray Tascilar, Katja Schmidt, Bernhard Manger, Leonie Weckwerth, Maria Sokolova, Laura Bucci, Filippo Fagni, Karin Manger, Florian Schuch, Monika Ronneberger, Axel Hueber, Ulrike Steffen, Dirk Mielenz, Martin Herrmann, Thomas Harrer, Arnd Kleyer, Gerhard Krönke, Georg Schett Published in: Arthritis & Rheumatology, 2021, ISSN 2326-5191 Publisher: Wiley DOI: 10.1002/art.41914 Tolerance-inducing medicines in autoimmunity: rheumatology and beyond Author(s): James A Stanway, John D Isaacs Published in: The Lancet Rheumatology, Issue 2/9, 2020, Page(s) e565-e575, ISSN 2665-9913 Publisher: Elsevier DOI: 10.1016/s2665-9913(20)30100-4 Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis Author(s): HENDY KRISTYANTO HTTPS://ORCID.ORG/0000-0002-8022-6637NIENKE J. BLOMBERGLINDA M. SLOTELLEN I. H. VAN DER VOORTPRISCILLA F. KERKMAN HTTPS://ORCID.ORG/0000-0002-6212-002XALEIDA BAKKERLEONIE E. BURGERSROBIN M. TEN BRINCK HTTPS://ORCID.ORG/0000-0002-6128-6888ANNETTE H. M. VAN DER HELM-VAN MILHERGEN SPITS HTTPS://ORCID.ORG/0000-0003-3269-8338DOMINIQUE L. BAETENTOM W. J. HUIZINGA HTTPS://ORCID.ORG/0000- Published in: SCIENCE TRANSLATIONAL MEDICINE, Issue VOL. 12, NO. 570, 2020, Page(s) 570, ISSN 1946-6234 Publisher: American Association for the Advancement of Science DOI: 10.1126/scitranslmed.aaz5327 Data-Driven Mathematical Model of Apoptosis Regulation in Memory Plasma Cells Author(s): Burt P, Cornelis R, Geißler G, Hahne S, Radbruch A, Chang HD, Thurley K Published in: Cells, 2022, ISSN 2073-4409 Publisher: MDPI DOI: 10.3390/cells11091547 Autoantigens in rheumatoid arthritis and the potential for antigen-specific tolerising immunotherapy Author(s): Hendrik J Nel, Vivianne Malmström, David C Wraith, Ranjeny Thomas Published in: The Lancet Rheumatology, Issue 2/11, 2020, Page(s) e712-e723, ISSN 2665-9913 Publisher: Elsevier DOI: 10.1016/s2665-9913(20)30344-1 Deep Phenotyping of Urinary Leukocytes by Mass Cytometry Reveals a Leukocyte Signature for Early and Non-Invasive Prediction of Response to Treatment in Active Lupus Nephritis Author(s): Martina Bertolo, Sabine Baumgart, Pawel Durek, Anette Peddinghaus, Henrik Mei, Thomas Rose, Philipp Enghard, Andreas Grützkau Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224 Publisher: Frontiers DOI: 10.3389/fimmu.2020.00256 Genetic predisposition (HLA-SE) is associated with ACPA-IgG variable domain glycosylation in the predisease phase of RA Author(s): "Theresa Kissel # 1, Tineke J van Wesemael # 2, Anders Lundquist 3, Heidi Kokkonen 4, Atsushi Kawakami 5, Mami Tamai 6, Dirkjan van Schaardenburg 7 8, Manfred Wuhrer 9, Tom Wj Huizinga 2, Hans Ulrich Scherer 2, Diane van der Woude 2, Solbritt Rantapää-Dahlqvist 4, René E M Toes 2" Published in: Ann Rheum Dis ., Issue Jan;81(1), 2021, Page(s) 141-143, ISSN 0003-4967 Publisher: BMJ Publishing Group DOI: 10.1136/annrheumdis-2021-220841 Benchmarking computational methods for B-cell receptor reconstruction from single cell RNA-seq data Author(s): Andreani T, Slot LM, Gabillard S, Strübing C, Reimertz C, Yaligara V, Bakker AM, Olfati-Saber R, Toes REM, Scherer HU , Augé F, Šimaitė D Published in: NAR Genomics and Bioinformatics, 2022, ISSN 2631-9268 Publisher: Oxford University Press DOI: 10.1093/nargab/lqac049 Why remission is not enough: underlying disease mechanisms in RA that prevent cure Author(s): Georg Schett, Yoshiya Tanaka, John D. Isaacs Published in: Nature Reviews Rheumatology, Issue 17/3, 2021, Page(s) 135-144, ISSN 1759-4790 Publisher: Nature Publishing Group DOI: 10.1038/s41584-020-00543-5 Functional Analysis of Autoantibody Signatures in Rheumatoid Arthritis. Author(s): Milchram L, Fischer A, Huber J, Soldo R, Sieghart D, Vierlinger K, Blüml S, Steiner G, Weinhäusel A. Published in: Molecules, Issue 14203049, 2022, ISSN 1420-3049 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/molecules27041452 Rheumatic?-A Digital Diagnostic Decision Support Tool for Individuals Suspecting Rheumatic Diseases: A Multicenter Pilot Validation Study Author(s): Rachel Knevel, Johannes Knitza, Aase Hensvold, Alexandra Circiumaru, Tor Bruce, Sebastian Evans, Tjardo Maarseveen, Marc Maurits, Liesbeth Beaart-van de Voorde, David Simon, Arnd Kleyer, Martina Johannesson, Georg Schett, Tom Huizinga, Sofia Svanteson, Alexandra Lindfors, Lars Klareskog, Anca Catrina Published in: Frontiers in Medicine, 2022, ISSN 2296-858X Publisher: Frontiers Media S.A. DOI: 10.3389/fmed.2022.774945 Characterisation of age-associated B cells in early drug-naïve rheumatoid arthritis patients Author(s): Vidal-Pedrola, Gemma; Naamane, Najib; Cameron, James A.; Pratt, Arthur G.; Mellor, Andrew; Isaacs, John; Scheel-Toellner, D; Anderson, Amy E. Published in: Immunology, 2022, ISSN 1365-2567 Publisher: Wiley DOI: 10.1111/imm.13598 IgA2 Antibodies against SARS-CoV-2 Correlate with NET Formation and Fatal Outcome in Severely Diseased COVID-19 Patients Author(s): Léonie A. N. Staats, Hella Pfeiffer, Jasmin Knopf, Aylin Lindemann, Julia Fürst, Andreas E. Kremer, Holger Hackstein, Markus F. Neurath, Luis E. Muñoz, Susanne Achenbach, Moritz Leppkes, Martin Herrmann, Georg Schett, Ulrike Steffen Published in: Cells, Issue 9/12, 2020, Page(s) 2676, ISSN 2073-4409 Publisher: MDPI DOI: 10.3390/cells9122676 Divergent and dominant anti-inflammatory effects of patient-derived anticitrullinated protein antibodies (ACPA) in arthritis development Author(s): Bruno Raposo, Marcelo Afonso, Lena Israelsson, Heidi Wähämaa, Ragnhild Stålesen, Fredrik Wermeling, Aase Hensvold, Caroline Grönwall, Bence Rethi, Lars Klareskog and Vivianne Malmström Published in: Annals of the Rheumatic Diseases, 2023, ISSN 1468-2060 Publisher: BMJ publishing group DOI: 10.1136/ard-2022-223417 Lack of association between clinical and ultrasound measures of disease activity in rheumatoid arthritis remission Author(s): Kenneth F. Baker, Ben Thompson, Dennis W. Lendrem, Adam Scadeng, Arthur G. Pratt, John D. Isaacs Published in: Therapeutic Advances in Musculoskeletal Disease, Issue 12, 2020, Page(s) 1759720X2091532, ISSN 1759-720X Publisher: SAGE Publications Inc. DOI: 10.1177/1759720x20915322 Rheumatoid arthritis patients display B-cell dysregulation already in the naïve repertoire consistent with defects in B-cell tolerance Author(s): Yan Wang, Katy A. Lloyd, Ioannis Melas, Diana Zhou, Radha Thyagarajan, Joakim Lindqvist, Monika Hansson, Anna Svärd, Linda Mathsson-Alm, Alf Kastbom, Karin Lundberg, Lars Klareskog, Anca I. Catrina, Stephen Rapecki, Vivianne Malmström, Caroline Grönwall Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-019-56279-0 Similar Impact of Psoriatic Arthritis and Rheumatoid Arthritis on Objective and Subjective Parameters of Hand Function Author(s): Anna‐Maria Liphardt, Eva Manger, Sonja Liehr, Lisa Bieniek, Arnd Kleyer, David Simon, Koray Tascilar, Michael Sticherling, Jürgen Rech, Georg Schett, Axel J. Hueber Published in: ACR Open Rheumatology, Issue 2/12, 2020, Page(s) 734-740, ISSN 2578-5745 Publisher: Wiley DOI: 10.1002/acr2.11196 Association between number and type of different ACPA fine specificities with lung abnormalities in early, untreated rheumatoid arthritis Author(s): Vijay Joshua, Aase Haj Hensvold, Gudrun Reynisdottir, Monica Hansson, Martin Cornillet, Leonor Nogueira, Guy Serre, Sven Nyren, Reza Karimi, Anders Eklund, Magnus Sköld, Johan Grunewald, Katerina Chatzidionysiou, Anca Catrina Published in: RMD Open, Issue 6/2, 2020, Page(s) e001278, ISSN 2056-5933 Publisher: BMJ Publishing Group DOI: 10.1136/rmdopen-2020-001278 MiR-146a controls age related bone loss Author(s): Victoria Saferding; Melanie Hofmann; Julia S. Brunner; Birgit Niederreiter; Melanie Timmen; Nathaniel Magilnick; Silvia Hayer; Gerwin Heller; Guenter Steiner; Richard Stange; Mark Boldin; Gernot Schabbauer; Moritz Weigl; Matthias Hackl; Johannes Grillari; Josef S Smolen; S Blueml Published in: Aging Cell, Issue 18, 2020, ISSN 1474-9726 Publisher: Wiley DOI: 10.1101/2020.03.20.000174 Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications. Author(s): Kissel T, Reijm S, Slot LM, Cavallari M, Wortel CM, Vergroesen RD, Stoeken-Rijsbergen G, Kwekkeboom JC, Kampstra A, Levarht E, Drijfhout JW, Bang H, Bonger KM, Janssen G, van Veelen PA, Huizinga T, Scherer HU, Reth M, Toes R. Published in: Annals of the rheumatic disease, Issue Volume 79, Issue 4, 2020, Page(s) 472-480, ISSN 0003-4967 Publisher: BMJ Publishing Group DOI: 10.1136/annrheumdis-2019-216499 Key opinion leaders — a critical perspective Author(s): Jose U. Scher, Georg Schett Published in: Nature Reviews Rheumatology, Issue 17/2, 2021, Page(s) 119-124, ISSN 1759-4790 Publisher: Nature Publishing Group DOI: 10.1038/s41584-020-00539-1 Fluorine labelling of therapeutic human tolerogenic dendritic cells for 19F-magnetic resonance imaging Author(s): Cooke F, Neal M , Wood MJ , de Vries IJM, Anderson AE, Diboll J, Pratt AG, Stanway J, Nicorescu I, Moyse N, Hiles D, Caulfield D, Dickinson AM, Blamire AM, Thelwall P, Isaacs JD, Hilkens CMU Published in: Frontiers in Immunology,, 2022, ISSN 1664-3224 Publisher: Frontiers Media DOI: 10.3389/fimmu.2022.988667 Biomarkers of tolerance in immune-mediated inflammatory diseases: a new era in clinical management? Author(s): Kenneth F Baker, Jasmine P X Sim, John D Isaacs Published in: The Lancet Rheumatology, Issue 3/5, 2021, Page(s) e371-e382, ISSN 2665-9913 Publisher: Elsevier DOI: 10.1016/s2665-9913(21)00069-2 Randomized phase-1 trial of antigen-specific tolerizing immunotherapy with peptide/calcitriol liposomes in ACPA+ rheumatoid arthritis. Author(s): Sonigra A*, Nel H*, Wehr P*, Ramnoruth N, Patel S, van Schie K, Bladen M, Mehdi AM, Tesiram J, Talekar M, Rossjohn J, Reid H, Stuurman FE, Roberts H, Vecchio P, Gourley I, Rigby M, Becart S, Toes REM, Scherer HU, Le Cao KA, Campbell K and R Thomas. Published in: JCI Insight, 2022, ISSN 2379-3708 Publisher: American Society for Clinical Investigation DOI: 10.1172/jci.insight.160964 Preclinical models of arthritis for studying immunotherapy and immune tolerance Author(s): Gavin R Meehan, Ranjeny Thomas, Shaima Al Khabouri, Pascale Wehr, Catharien MU Hilkens, David C Wraith, Daniela Sieghart, Michael Bonelli, György Nagy, Paul Garside, David F Tough, Huw D Lewis, James M Brewer Published in: Annals of the Rheumatic Diseases, Issue 80/10, 2021, Page(s) 1268-1277, ISSN 0003-4967 Publisher: BMJ Publishing Group DOI: 10.1136/annrheumdis-2021-220043 Single cell sequencing identifies clonally expanded synovial CD4+ TPH cells expressing GPR56 in rheumatoid arthritis Author(s): Argyriou A, Wadsworth MH 2nd, Lendvai A, Christensen SM, Hensvold AH, Gerstner C, van Vollenhoven A, Kravarik K, Winkler A, Malmström V, Chemin K. 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DOI: 10.1016/j.clinthera.2019.04.014 Targeting of tolerogenic dendritic cells to heat-shock proteins in inflammatory arthritis Author(s): Rachel Spiering, Manon A. A. Jansen, Matthew J. Wood, Anshorulloh A. Fath, Oliver Eltherington, Amy E. Anderson, Arthur G. Pratt, Willem van Eden, John D. Isaacs, Femke Broere, Catharien M. U. Hilkens Published in: Journal of Translational Medicine, Issue 17/1, 2019, ISSN 1479-5876 Publisher: BioMed Central DOI: 10.1186/s12967-019-2128-4 IgA Complexes Induce Neutrophil Extracellular Trap Formation More Potently Than IgG Complexes Author(s): Anna-Katharina Gimpel, Antonio Maccataio, Harald Unterweger, Maria V Sokolova, Georg Schett, Ulrike Steffen Published in: Frontiers in immunology, 2022, ISSN 1664-3224 Publisher: Frontiers Media S.A. DOI: 10.3389/fimmu.2021.761816 Different hierarchies of anti‐modified protein autoantibody reactivities in rheumatoid arthritis Author(s): Peter Sahlström, Monika Hansson, Johanna Steen, Khaled Amara, Philip J Titcombe, Björn Forsström, Ragnhild Stålesen, Lena Israelsson, Luca Piccoli, Karin Lundberg, Lars Klareskog, Daniel L. Mueller, Anca I Catrina, Karl Skriner, Vivianne Malmström, Caroline Grönwall Published in: Arthritis & Rheumatology, Issue 72/10, 2020, Page(s) 1643-1657, ISSN 2326-5191 Publisher: Wiley DOI: 10.1002/art.41385 BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (the BIO-FLARE study): protocol for a non-randomised longitudinal cohort study Author(s): Fiona Rayner, Amy E. Anderson, Kenneth F. Baker, Christopher D. Buckley, Bernard Dyke, Sally Fenton, Andrew Filer, Carl S. Goodyear, Catharien M. U. Hilkens, Shaun Hiu, Sean Kerrigan, Mariola Kurowska-Stolarska, Fiona Matthews, Iain McInnes, Wan-Fai Ng, Arthur G. 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Isaacs Published in: BMC Rheumatology, Issue 5/1, 2021, ISSN 2520-1026 Publisher: BioMed Central Springer nature DOI: 10.1186/s41927-021-00194-3 Mobile Health Usage, Preferences, Barriers, and eHealth Literacy in Rheumatology: Patient Survey Study Author(s): Johannes Knitza, David Simon, Antonia Lambrecht, Christina Raab, Koray Tascilar, Melanie Hagen, Arnd Kleyer, Sara Bayat, Adrian Derungs, Oliver Amft, Georg Schett, Axel J Hueber Published in: JMIR mHealth and uHealth, Issue 8/8, 2020, Page(s) e19661, ISSN 2291-5222 Publisher: JMIR Publications DOI: 10.2196/19661 Diversity and Clonality of T Cell Receptor Repertoire and Antigen Specificities in Small Joints of Early Rheumatoid Arthritis Author(s): Turcinov S, Af Klint E, Van Schoubroeck B, Kouwenhoven A, Mia S, Chemin K, Wils H, Van Hove C, De Bondt A, Keustermans K, Van Houdt J, Reumers J, Felix N, Rao NL, Peeters P, Stevenaert F, Klareskog L, McKinnon M, Baker D, Suri A, Malmström V. Published in: Arthritis & Rheumatology, 2023, ISSN 2326-5205 Publisher: Wiley Periodicals LLC on behalf of American College of Rheumatology. DOI: 10.1002/art.42407 Biomechanical stress in the context of competitive sports training triggers enthesitis Author(s): David Simon, Arnd Kleyer, Sara Bayat, Johannes Knitza, Larissa Valor-Mendez, Marina Schweiger, Georg Schett, Koray Tascilar, Axel J. Hueber Published in: Arthritis Research & Therapy, Issue 23/1, 2021, ISSN 1478-6362 Publisher: Biomed Central DOI: 10.1186/s13075-021-02530-x SARS-CoV-2 vaccination responses in untreated, conventionally treated and anticytokine-treated patients with immune-mediated inflammatory diseases Author(s): David Simon, Koray Tascilar, Filippo Fagni, Gerhard Krönke, Arnd Kleyer, Christine Meder, Raja Atreya, Moritz Leppkes, Andreas E Kremer, Andreas Ramming, Milena L Pachowsky, Florian Schuch, Monika Ronneberger, Stefan Kleinert, Axel J Hueber, Karin Manger, Bernhard Manger, Carola Berking, Michael Sticherling, Markus F Neurath, Georg Schett Published in: Annals of the Rheumatic Diseases, Issue 80/10, 2021, Page(s) 1312-1316, ISSN 0003-4967 Publisher: BMJ Publishing Group DOI: 10.1136/annrheumdis-2021-220461 Rheumatoid arthritis prevention in arthralgia: fantasy or reality? Author(s): van Steenbergen HW, Cope AP, van der Helm-van Mil AHM. Published in: nature reviews rheumatology, 2023, ISSN 1759-4804 Publisher: Springer Nature DOI: 10.1038/s41584-023-01035-y The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts Author(s): Jasna Friščić, Martin Böttcher, Christiane Reinwald, Heiko Bruns, Benjamin Wirth, Samantha-Josefine Popp, Kellie Irene Walker, Jochen A. Ackermann, Xi Chen, Jason Turner, Honglin Zhu, Lisa Seyler, Maximilien Euler, Philipp Kirchner, René Krüger, Arif B. Ekici, Triin Major, Oliver Aust, Daniela Weidner, Anita Fischer, Fabian T. Andes, Zeljka Stanojevic, Vladimir Trajkovic, Martin Herrmann, Ad Published in: Immunity, Issue 54/5, 2021, Page(s) 1002-1021.e10, ISSN 1074-7613 Publisher: Cell Press DOI: 10.1016/j.immuni.2021.03.003 Antibodies against citrullinated proteins of IgA isotype are associated with progression to rheumatoid arthritis in individuals at-risk Author(s): Sokolova MV, Hartmann F, Sieghart D, et al Published in: RMD Open, 2023, ISSN 2056-5933 Publisher: BMJ Publishing Group Ltd DOI: 10.1136/rmdopen-2022-002705 IgM antibodies against acetylated proteins as a possible starting point of the anti-modified protein antibody response in rheumatoid arthritis. Author(s): van Wesemael TJ, Reijm S, Kawakami A, et al Published in: Annals of the Rheumatic Diseases, 2023, ISSN 0003-4967 Publisher: BMJ Publishing Group CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus Author(s): Dimitrios Mougiakakos, Gerhard Krönke, Simon Völkl, Sascha Kretschmann, Michael Aigner, Soraya Kharboutli, Sebastian Böltz, Bernhard Manger, Andreas Mackensen, Georg Schett Published in: New England Journal of Medicine, Issue 385/6, 2021, Page(s) 567-569, ISSN 0028-4793 Publisher: Massachusetts Medical Society DOI: 10.1056/nejmc2107725 Performance of a Handheld Ultrasound Device to Assess Articular and Periarticular Pathologies in Patients with Inflammatory Arthritis Author(s): Giulia Corte, Sara Bayat, Koray Tascilar, Larissa Valor-Mendez, Louis Schuster, Johannes Knitza, Filippo Fagni, Georg Schett, Arnd Kleyer, David Simon Published in: Diagnostics, Issue 11/7, 2021, Page(s) 1139, ISSN 2075-4418 Publisher: MDPI Journals DOI: 10.3390/diagnostics11071139 Intensity and longevity of SARS-CoV-2 vaccination response in patients with immune-mediated inflammatory disease: a prospective cohort study Author(s): David Simon, Koray Tascilar, Filippo Fagni, Arnd Kleyer, Gerhard Krönke, Christine Meder, Peter Dietrich, Till Orlemann, Johanna Mößner, Jule Taubmann, Melek Yalcin Mutlu, Johannes Knitza, Stephan Kemenes, Anna-Maria Liphardt, Verena Schönau, Daniela Bohr, Louis Schuster, Fabian Hartmann, Ioanna Minopoulou, Moritz Leppkes, Andreas Ramming, Milena Pachowsky, Florian Schuch, Monika Ronneberger, Published in: The Lancet. Rheumatology, 2022, ISSN 2665-9913 Publisher: Elsevier DOI: 10.1016/s2665-9913(22)00191-6 Evolution of anti-modified protein antibody responses can be driven by consecutive exposure to different post-translational modifications Author(s): M. Volkov; A. S. B. Kampstra; K. A. van Schie; A. Kawakami; M. Tamai; S. Kawashiri; T. Maeda; T. W. J. Huizinga; R. E. M. Toes; D. van der Woude Published in: Arthritis Research & Therapy, 2021, ISSN 1478-6362 Publisher: BioMed Central DOI: 10.1186/s13075-021-02687-5 Secukinumab leads to shifts from stage-based towards response-based disease clusters—comparative data from very early and established psoriatic arthritis Author(s): Eleni Kampylafka, Koray Tascilar, Veronika Lerchen, Christina Linz, Maria Sokolova, Ana Zekovic, Arnd Kleyer, David Simon, Jürgen Rech, Michael Sticherling, Georg Schett, Axel J. Hueber Published in: Arthritis Research & Therapy, Issue 22/1, 2020, ISSN 1478-6362 Publisher: Springer Nature DOI: 10.1186/s13075-020-02268-y Impact of Medium-Sized Extracellular Vesicles on the Transduction Efficiency of Adeno-Associated Viruses in Neuronal and Primary Astrocyte Cell Cultures. Author(s): Orsolya Tünde Kovács; Eszter Soltész-Katona; Nikolett Marton; Eszter Baricza; László Hunyady; Gábor Turu; György Nagy Published in: International Journal of Molecular Sciences, Issue 3, 2021, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms22084221 Light chain skewing in autoantibodies and B-cell receptors of the citrullinated antigen-binding B-cell response in rheumatoid arthritis Author(s): Linda M. Slot ,Rochelle D. Vergroesen ,Priscilla F. Kerkman,Ellen Staudinger,Sanne Reijm,Hugo J. van Dooren,Ellen I. H. van der Voort,Tom W. J. Huizinga,René E. M. Toes,Hans U. Scherer Published in: PLoS One, Issue Mar 30;16(3):e0247847, 2021, ISSN 1544-9173 Publisher: Public Library of Science DOI: 10.1371/journal.pone.0247847 Phospholipase Cγ2 is essential for experimental models of epidermolysis bullosa acquisita Author(s): Kata P. Szilveszter, Simon Vikár, Ádám I. Horváth, Zsuzsanna Helyes, Miklós Sárdy, Attila Mócsai Published in: Journal of Investigative Dermatology, 2021, ISSN 0022-202X Publisher: Blackwell Publishing Inc. DOI: 10.1016/j.jid.2021.09.019 Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis Author(s): Christina Gerstner, Sara Turcinov, Aase H. Hensvold, Karine Chemin, Hannes Uchtenhagen, Tamara H. Ramwadhdoebe, Anatoly Dubnovitsky, Genadiy Kozhukh, Lars Rönnblom, William W. Kwok, Adnane Achour, Anca I. Catrina, Lisa G. M. van Baarsen, Vivianne Malmström Published in: BMC Immunology, Issue 21/1, 2020, ISSN 1471-2172 Publisher: BioMed Central DOI: 10.1186/s12865-020-00357-w Antibodies to a Citrullinated Porphyromonas gingivalis Epitope Are Increased in Early Rheumatoid Arthritis, and Can Be Produced by Gingival Tissue B Cells: Implications for a Bacterial Origin in RA Etiology. Author(s): Sherina N, de Vries C, Kharlamova N, Sippl N, Jiang X, Brynedal B, Kindstedt E, Hansson M, Mathsson-Alm L, Israelsson L, Stålesen R, Saevarsdottir S, Holmdahl R, Hensvold A, Johannsen G, Eriksson K, Sallusto F, Catrina AI, Rönnelid J, Grönwall C, Yucel-Lindberg T, Alfredsson L, Klareskog L, Piccoli L, Malmström V, Amara K, Lundberg K. Published in: Frontiers in Immunology, 2022, ISSN 1664-3224 Publisher: Frontiers Research Foundation DOI: 10.3389/fimmu.2022.804822 The diagnostic and prognostic value of IgG and IgA anti-citrullinated protein antibodies in patients with early rheumatoid arthritis Author(s): Sieghart D, Konrad C, Swiniarski S, Haslacher H, Aletaha D, Steiner G. Published in: Frontiers in Immunology, 2023, ISSN 1664-3224 Publisher: Frontiers DOI: 10.3389/fimmu.2022.1096866 Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming Author(s): Cooles FAH, Tarn J, Lendrem DW, Naamane N, Lin CM, Millar B, Maney NJ, Anderson AE, Thalayasingam N, Diboll J, Bondet V, Duffy D, Barnes MR, Smith GR, Ng S, Watson D, Henkin R, Cope AP, Reynard LN, Pratt AG Published in: Ann Rheum Dis, Issue 00034967, 2022, ISSN 0003-4967 Publisher: BMJ Publishing Group DOI: 10.1136/annrheumdis-2022-222370 Current view on the pathogenic role of anti-citrullinated protein antibodies in rheumatoid arthritis Author(s): Anca Catrina, Akilan Krishnamurthy, Bence Rethi Published in: RMD Open, Issue 7/1, 2021, Page(s) e001228, ISSN 2056-5933 Publisher: BMJ Publishing group DOI: 10.1136/rmdopen-2020-001228 Towards prevention of autoimmune diseases: The example of rheumatoid arthritis Author(s): Aase Hensvold, Lars Klareskog Published in: European Journal of Immunology, Issue 51/8, 2021, Page(s) 1921-1933, ISSN 0014-2980 Publisher: John Wiley & Sons Ltd. DOI: 10.1002/eji.202048952 Anti-Citrullinated Protein Antibody Reactivity towards Neutrophil-Derived Antigens: Clonal Diversity and Inter-Individual Variation. Author(s): Cîrciumaru A, Afonso MG, Wähämaa H, Krishnamurthy A, Hansson M, Mathsson-Alm L, Keszei M, Stålesen R, Ottosson L, de Vries C, Shelef MA, Malmström V, Klareskog L, Catrina AI, Grönwall C, Hensvold A, Réthi B. Published in: Biomolecules, 2023, ISSN 2218-273X Publisher: MDPI AG DOI: 10.3390/biom13040630 Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate Author(s): Jack A. Bibby, Harriet A. Purvis, Thomas Hayday, Anita Chandra, Klaus Okkenhaug, Sofia Rosenzweig, Ivona Aksentijevich, Michael Wood, Helen J. Lachmann, Claudia Kemper, Andrew P. Cope, Esperanza Perucha Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-020-17179-4 Immune tolerance therapies for autoimmune diseases: Shifting the goalpost to cure Author(s): Ranjeny Thomas; Patrick Sharkey Published in: Curr Opin Pharmacol, Issue 14714892, 2022, ISSN 1471-4892 Publisher: Elsevier BV DOI: 10.1016/j.coph.2022.102242 Does methotrexate influence COVID-19 infection? Case series and mechanistic data Author(s): Fabian Schälter, Kerstin Dürholz, Laura Bucci, Gerd Burmester, Roberto Caporali, Camille Figuereido, Jaime Fogagnolo Cobra, Bernhard Manger, Mario M. Zaiss, Georg Schett Published in: Arthritis Research & Therapy, Issue 23/1, 2021, ISSN 1478-6362 Publisher: Biomed Central DOI: 10.1186/s13075-021-02464-4 Stromal Cell-Contact Dependent PI3K and APRIL Induced NF-κB Signaling Prevent Mitochondrial- and ER Stress Induced Death of Memory Plasma Cells Author(s): Rebecca Cornelis, Stefanie Hahne, Adriano Taddeo, Georg Petkau, Darya Malko, Pawel Durek, Manja Thiem, Lukas Heiberger, Lena Peter, Elodie Mohr, Cora Klaeden, Koji Tokoyoda, Francesco Siracusa, Bimba Franziska Hoyer, Falk Hiepe, Mir-Farzin Mashreghi, Fritz Melchers, Hyun-Dong Chang, Andreas Radbruch Published in: Cell Reports, Issue 32/5, 2020, Page(s) 107982, ISSN 2211-1247 Publisher: Cell Press DOI: 10.1016/j.celrep.2020.107982 Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis Author(s): Narges Tajik, Michael Frech, Oscar Schulz, Fabian Schälter, Sébastien Lucas, Vugar Azizov, Kerstin Dürholz, Franziska Steffen, Yasunori Omata, Andreas Rings, Marko Bertog, Aroldo Rizzo, Aida Iljazovic, Marijana Basic, Arnd Kleyer, Stephan Culemann, Gerhard Krönke, Yubin Luo, Klaus Überla, Udo S. Gaipl, Benjamin Frey, Till Strowig, Kerstin Sarter, Stephan C. Bischoff, Stefan Wirtz, Juan D. Ca Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-020-15831-7 Efficacy and safety of SARS-CoV-2 revaccination in non-responders with immune-mediated inflammatory disease Author(s): David Simon, Koray Tascilar, Filippo Fagni, Katja Schmidt, Gerhard Krönke, Arnd Kleyer, Andreas Ramming, Verena Schoenau, Daniela Bohr, Johannes Knitza, Thomas Harrer, Karin Manger, Bernhard Manger, Georg Schett Published in: Annals of the Rheumatic Diseases,, 2021, ISSN 1468-2060 Publisher: BMJ DOI: 10.1136/annrheumdis-2021-221554 Stabilizing Antibody Cocktails for Mass Cytometry Author(s): Axel R. Schulz, Sabine Baumgart, Julia Schulze, Marie Urbicht, Andreas Grützkau, Henrik E. Mei Published in: Cytometry Part A, 2019, ISSN 1552-4922 Publisher: John Wiley & Sons Ltd. DOI: 10.1002/cyto.a.23781 IgA anti-citrullinated protein antibodies are associated with flares during DMARD tapering in rheumatoid arthritis Author(s): Maria V Sokolova, Melanie Hagen, Holger Bang, Georg Schett, Juergen Rech, Ulrike Steffen Published in: Rheumatology, 2021, ISSN 1462-0324 Publisher: Oxford University Press DOI: 10.1093/rheumatology/keab585 Dysregulated CD38 Expression on Peripheral Blood Immune Cell Subsets in SLE Author(s): Marie Burns, Lennard Ostendorf, Robert Biesen, Andreas Grützkau, Falk Hiepe, Henrik E. Mei, Tobias Alexander Published in: International Journal of Molecular Sciences, Issue 22/5, 2021, Page(s) 2424, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms22052424 Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) Author(s): Andrea Cossarizza, Hyun‐Dong Chang, Andreas Radbruch, Andreas Acs, Dieter Adam, Sabine Adam‐Klages, William W. Agace, Nima Aghaeepour, Mübeccel Akdis, Matthieu Allez, Larissa Nogueira Almeida, Giorgia Alvisi, Graham Anderson, Immanuel Andrä, Francesco Annunziato, Achille Anselmo, Petra Bacher, Cosima T. Baldari, Sudipto Bari, Vincenzo Barnaba, Joana Barros‐Martins, Luca Battistini, Wolfgan Published in: European Journal of Immunology, Issue 49/10, 2019, Page(s) 1457-1973, ISSN 0014-2980 Publisher: John Wiley & Sons Ltd. DOI: 10.1002/eji.201970107 Advanced machine learning for predicting individual risk of flares in rheumatoid arthritis patients tapering biologic drugs Author(s): Asmir Vodencarevic, Koray Tascilar, Fabian Hartmann, Michaela Reiser, Axel J. Hueber, Judith Haschka, Sara Bayat, Timo Meinderink, Johannes Knitza, Larissa Mendez, Melanie Hagen, Gerhard Krönke, Jürgen Rech, Bernhard Manger, Arnd Kleyer, Marcus Zimmermann-Rittereiser, Georg Schett, David Simon Published in: Arthritis Research & Therapy, Issue 23/1, 2021, ISSN 1478-6362 Publisher: BioMed Central DOI: 10.1186/s13075-021-02439-5 Conference proceedings (8) OP0074 DISTINCT CIRCULATING LYMPHOCYTE SUBSETS DISTINGUISH FLARE FROM DRUG-FREE REMISSION IN RHEUMATOID ARTHRITIS Author(s): KF Baker, F Rayner, H Lemos, D McDonald, G Hulme, R. Hussain, J. Coxhead, A. Pratt, A. E. Anderson, A. Filby, J. Isaacs Published in: Annals of the Rheumatic Diseases, 2022 Publisher: BMJ GENETIC SUSCEPTIBILITY VARIANTS FOR RHEUMATOID ARTHRITIS ARE NOT ASSOCIATED WITH EARLY REMISSION; A MULTI-COHORT STUDY Author(s): Zapata SJ, Maurits M, Abraham Y, Van den Akker E, Barton A, Brown P, Cope A, González-Álvaro I, Goodyear C, van der Helm-van Mil A, Hu X Published in: Annals of the Rheumatic Diseases, Issue 2021;80, 2021, Page(s) 403-404, ISSN 0003-4967 Publisher: BMJ Publishing group POS0534 TRAJECTORY ANALYSIS OF RHEUMATOID ARTHRITIS PROGRESSION USING CLINICAL DATA Author(s): D Van der Bijl, T Maarseveen, A Cope, A Yann, R Knevel Published in: Annals of the Rheumatic Diseases, Scientific Abstracts, 2022, Page(s) POSTERS onlyRheumatoid arthritis - prognosis, predictors and outcome Publisher: BMJ OP0016 Abatacept To Silence Anti-Citrullinated Protein Antibody-Expressing B Cells In Rheumatoid Arthritis: Author(s): Blomberg N, Kwekkeboom J, Böhringer S, et al Published in: Annals of the Rheumatic Diseases, 2023 Publisher: BMJ POS0531 ABATACEPT DELAYS THE DEVELOPMENT OF RA– CLINICAL RESULTS AFTER 18 MONTHS FROM THE RANDOMIZED, PLACEBO-CONTROLLED ARIAA STUDY IN RA-AT RISK PATIENTS Author(s): Rech J, Kleyer A, Østergaard M, et al Published in: Annals of the Rheumatic Diseases, 2022, ISSN 0003-4967 Publisher: BMJ group OP0075 FIBROBLAST/MACROPHAGE CROSSTALK VIA LACTATE: NEW THERAPEUTIC TARGET IN RHEUMATOID ARTHRITIS Author(s): V Pucino, M Nefla, V Gauthier, SA Clayton, A Filer, A. R. Clark, K. Raza, C. D. Buckley Published in: Annals of the Rheumatic Diseases, 2022 Publisher: BMJ OP0190 COMPREHENSIVE GENETIC AND FUNCTIONAL ANALYSES OF Fc GAMMA RECEPTORS EXPLAIN RESPONSE TO RITUXIMAB THERAPY FOR AUTOIMMUNE RHEUMATIC DISEASES Author(s): MYMD Yusof, J Robinson, V Davies, D Wild, M Morgan et al. Published in: Annals of the Rheumatic Diseases, 2022 Publisher: BMJ GWAS Identified New Genes in Synovial Fibroblasts Linked to Early Remission in RA Author(s): Maurits M, Abasolo Alcazar l, van den Akker E, Askling J, Barton A, Blüml S, Böhringer S, Cope A, Emery P, Eyre S, Gaddi P, Gonzalez I, Goodyear C, van der Helm-van Mil A, Hu X, Huizinga T, Isaacs J, Jelinsky S, Johannesson M, Jurado Zapata S, Ke C, Klareskog L, Lendrem D, Lewis M, Liu M, Martin P, McInnes I, Micheroli R, Morgan A, Morton F, Naamane N, Orozco G, Ospelt C, Padyukov L, Paterson C, Published in: Arthritis & Rheumatology (Hoboken, N.J.), 2022, ISSN 2326-5191 Publisher: Wiley Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
