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Autism Innovative Medicine Studies – 2 – Trials

Objective

Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental condition affecting over five million people in the European Union. The combination of core symptoms (deficits in social-communication and repetitive and restricted behaviours and interests) and common comorbidities (e.g. epilepsy and depression) significantly reduces the quality of life and life-span of affected individuals. Currently there are no effective drug treatments for the core symptoms. Key factors that have hampered progress include; 1) limited understanding of the underlying pathophysiolog(ies); 2) lack of successful translation from animal models to humans; 3) testing of drugs with specific actions in biologically heterogeneous populations; 4) limited expertise of many European ASD centres in running large-scale clinical trials; and 5) trial designs (e.g. placebo effects).

Our vision, therefore, is to apply a precision medicine approach to ASD and improve patient outcomes by tailoring treatments to a patient’s biological profile. Our efforts will build on the achievements of 5 other IMI initiatives, 4 Horizon 2020 networks, and 6 SMEs for the first time to; 1) align global resources to validate and qualify stratification biomarkers from infancy to adulthood; 2) develop objective outcome measures that can be used in trials; 3) create a European-wide clinical trials network that reliably carries out studies able to support filings to the EMA/FDA; 4) carry out better targeted clinical trials linked to other international efforts – including quick wins or “fast fails” of ineffective agents; 5) translate molecular mechanisms and drug effects between preclinical models and particular subtypes of ASD.

Together we will bring Europe to the forefront of clinical research in ASD. Also we will provide a sustainable legacy that is accessible by others across the world, attracts industry into ASD, and helps transform healthcare.

Call for proposal

H2020-JTI-IMI2-2016-10-two-stage
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Coordinator

KING'S COLLEGE LONDON
Address
Strand
WC2R 2LS London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 20 141 917,04

Participants (47)

F. HOFFMANN-LA ROCHE AG
Switzerland
EU contribution
€ 0
Address
Grenzacherstrasse 124
4070 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 2 797 032,50
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
STICHTING RADBOUD UNIVERSITEIT
Netherlands
EU contribution
€ 4 268 059,35
Address
Houtlaan 4
6525 XZ Nijmegen
Activity type
Higher or Secondary Education Establishments
SERVICIO MADRILENO DE SALUD
Spain
EU contribution
€ 5 542 309,11
Address
Plaza Carlos Trias Bertran 7
28020 Madrid
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
INSTITUT PASTEUR
France
EU contribution
€ 2 661 580,75
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
UNIVERSITAT BASEL
Switzerland
EU contribution
€ 1 199 928,75
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments
ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT
Germany
EU contribution
€ 920 245
Address
Square J 5
68159 Mannheim
Activity type
Higher or Secondary Education Establishments
BIOSCI CONSULTING BVBA
Belgium
EU contribution
€ 192 343,75
Address
Weg Naar Geneuth 95
3631 Maasmechelen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
RIJKSUNIVERSITEIT GRONINGEN
Netherlands
EU contribution
€ 833 975
Address
Broerstraat 5
9712CP Groningen
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 751 011,25
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 847 916,25
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 37 124,92
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
EU contribution
€ 997 102,33
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland
EU contribution
€ 390 695
Address
College Green
2 Dublin
Activity type
Higher or Secondary Education Establishments
BIRKBECK COLLEGE - UNIVERSITY OF LONDON
United Kingdom
EU contribution
€ 3 039 130,90
Address
Malet Street
WC1E 7HX London
Activity type
Higher or Secondary Education Establishments
STICHTING BURO ECNP
Netherlands
EU contribution
€ 187 498,75
Address
Daltonlaan 400
3584 BK Utrecht
Activity type
Other
NOLDUS INFORMATION TECHNOLOGY BV
Netherlands
EU contribution
€ 271 352,50
Address
Nieuwe Kanaal 5
6709 PA Wageningen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ARTTIC
France
EU contribution
€ 560 015,35
Address
Rue Du Dessous Des Berges 58A
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DEMCON ADVANCED MECHATRONICS ENSCHEDE B.V.
Netherlands
EU contribution
€ 480 468,75
Address
Institutenweg 25
7521 PH Enschede
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 1 199 067,35
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
Germany
EU contribution
€ 780 202,50
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Activity type
Higher or Secondary Education Establishments
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 1 059 870
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT GENT
Belgium
EU contribution
€ 954 428,60
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
EU contribution
€ 183 968,75
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET ULM
Germany
EU contribution
€ 802 187,50
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURS
France
EU contribution
€ 24 125
Address
Boulevard Tonelle 2
37044 Tours Cedex 9
Activity type
Higher or Secondary Education Establishments
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Germany
EU contribution
€ 208 750
Address
Ismaninger Strasse 22
81675 Muenchen
Activity type
Higher or Secondary Education Establishments
Fondazione Stella Maris
Italy
EU contribution
€ 68 125
Address
Viale Del Tirreno 331
56118 Pisa
Activity type
Research Organisations
UNIVERSIDAD DE SALAMANCA
Spain
EU contribution
€ 234 231,25
Address
Calle Patio De Escuelas 1
37008 Salamanca
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF GLASGOW
United Kingdom
EU contribution
€ 183 968,75
Address
University Avenue
G12 8QQ Glasgow
Activity type
Higher or Secondary Education Establishments
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 1 056 713,75
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
Germany
EU contribution
€ 68 125
Address
Robert-koch-strasse 40
37075 Goettingen
Activity type
Higher or Secondary Education Establishments
STELLENBOSCH UNIVERSITY
South Africa
EU contribution
€ 417 777,50
Address
Victoria Street Administration B Building
7600 Stellenbosch
Activity type
Higher or Secondary Education Establishments
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 149 995
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
UNIVERSIDADE DE COIMBRA
Portugal
EU contribution
€ 777 016,05
Address
Paco Das Escolas
3004-531 Coimbra
Activity type
Higher or Secondary Education Establishments
FUNDAZIOA POLICLINICA GIPUZKOA FUNDACION
Spain
EU contribution
€ 68 125
Address
Paseo Miramon 174
20014 San Sebastian
Activity type
Other
FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA
Spain
EU contribution
€ 201 832,50
Address
Carrer Rossello 149
08036 Barcelona
Activity type
Research Organisations
JANSSEN PHARMACEUTICA NV
Belgium
EU contribution
€ 0
Address
Turnhoutseweg 30
2340 Beerse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NOVARTIS PHARMA AG
Switzerland
EU contribution
€ 0
Address
Lichtstrasse 35
4056 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UCB BIOPHARMA
Belgium
EU contribution
€ 0
Address
Allee De La Recherche 60
1070 Bruxelles
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TEVA PHARMACEUTICAL INDUSTRIES LIMITED
Israel
EU contribution
€ 0
Address
5 Basel St
49131 Petach Tivka
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
AUTISM SPEAKS INC. NON PROFIT CORPORATION
United States
EU contribution
€ 0
Address
State Road Floor 2 1060
08540 Princeton Nj
Activity type
Other
THE SIMONS FOUNDATION, INC
United States
EU contribution
€ 0
Address
160 Fifth Avenue, 7Th Floor
10010 New York
Activity type
Research Organisations
AUTISTICA
United Kingdom
EU contribution
€ 0
Address
St Saviour's House 39-41 Union Street
SE1 1SD London
Activity type
Other
AUTISME-EUROPE AISBL
Belgium
EU contribution
€ 267 469,50
Address
Rue Montoyer 39
1000 Bruxelles
Activity type
Other
UNIVERSITY OF BRISTOL
United Kingdom
EU contribution
€ 51 812,50
Address
Beacon House Queens Road
BS8 1QU Bristol
Activity type
Higher or Secondary Education Establishments
STARLAB BARCELONA SL
Spain
EU contribution
€ 122 500
Address
Avenida Tibidabo 47 Bis
08035 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)