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Prostate Cancer DIagnOsis and TreatmeNt Enhancement through the Power of Big Data in EuRope

Objective

Prostate Cancer (PCa) is the second leading cause of cancer, among men in Europe. There are currently major unmet needs in this field, such as insufficient knowledge on risk factors that contribute to PCa and on patient characteristics (including genetic profiles) that could facilitate patient stratification. Finally, there is lack of meaningful engagement of all key stakeholders, while the knowledge currently gained from clinical practice and real life data is not being fed back into PCa patients’ care pathways. There is thus a need for better definition of PCa across all stages, improved patient’s stratification at diagnosis, and standardisation of PCa-related outcomes based on real life data.

PIONEER’s unique dual approach is to first identify critical evidence gaps in PCa by respected Key Opinion Leaders, and then embark on a research priority setting exercise that reflects the needs of all key stakeholders in PCa management. To achieve this, PIONEER has brought together comprehensive datasets that consists of the most relevant prostate clinical trials and registries, large epidemiological cohorts, electronic heath records, and real-life data from different European (and non-European) patient populations. These unique data sets will be integrated, standardised, harmonised and analysed using approaches that are built on our experience of similar previous IMI projects i.e EMIF, and eTRIKS, and analysed using a unique set of methodologies and advanced analytics methods (OMOP, eHS). PIONEER has already performed a first PCa research priority setting survey, where major stakeholders were asked to identify the current unmet needs in PCa. The five most important open questions will be used as pilot studies to verify PIONEER’s research framework. As such, PIONEER’s deliverables will be outcome-driven, value-based and patient-centric, and relevant to all key stakeholders, as they would have been meaningfully involved from the inception of the project.

Coordinator

STICHTING EUROPEAN UROLOGICAL FOUNDATION
Net EU contribution
€ 738 343,25
Address
Mr. E.n. Van Kleffenstraat 5
6842 CV Arnhem
Netherlands

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Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Other
Non-EU contribution
€ 795 000,00

Participants (37)

LUNDS UNIVERSITET
Sweden
Net EU contribution
€ 185 761,25
Address
Paradisgatan 5c
22100 Lund

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Region
Södra Sverige Sydsverige Skåne län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITA VITA-SALUTE SAN RAFFAELE
Italy
Net EU contribution
€ 312 500,00
Address
Via Olgettina 58
20132 Milano

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Region
Nord-Ovest Lombardia Milano
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
Net EU contribution
€ 415 348,75
Address
Dr Molewaterplein 40
3015 GD Rotterdam

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Region
West-Nederland Zuid-Holland Groot-Rijnmond
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany
Net EU contribution
€ 150 000,00
Address
Martinistrasse 52
20251 Hamburg

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
TAMPEREEN KORKEAKOULUSAATIO SR
Finland
Net EU contribution
€ 387 500,00
Address
Kalevantie 4
33100 Tampere

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Region
Manner-Suomi Länsi-Suomi Pirkanmaa
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
KING'S COLLEGE LONDON
United Kingdom
Net EU contribution
€ 359 000,00
Address
Strand
WC2R 2LS London

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 60 000,00
EUROPEAN ORGANISATION FOR RESEARCH AND TREATMENT OF CANCER AISBL
Belgium
Net EU contribution
€ 16 000,00
Address
Avenue E. Mounier 83
1200 Brussels

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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Research Organisations
Non-EU contribution
€ 0,00
TTOPSTART BV
Netherlands
Net EU contribution
€ 237 500,00
Address
Laan Van Zuid Hoorn 15
2289 DC Rijswijk

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Region
West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
INTERNATIONAL CONSORTIUM FOR HEALTHOUTCOMES MEASUREMENT LTD
United Kingdom
Net EU contribution
€ 31 250,00
Address
1 Eversholt Street
NW1 2DN London

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
London Inner London — West Camden and City of London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
EUROPEAN CANCER PATIENT COALITION
Belgium
Net EU contribution
€ 79 993,75
Address
Avenue Des Arts 6
1210 Bruxelles

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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Other
Non-EU contribution
€ 0,00
ASSOCIATION EISBM
France
Net EU contribution
€ 700 000,00
Address
7 Parc Des Cedres 11 Rue Jean Marie Chevalier
69390 Vourles

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Region
Auvergne-Rhône-Alpes Rhône-Alpes Rhône
Activity type
Research Organisations
Non-EU contribution
€ 0,00
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
Net EU contribution
€ 200 000,00
Address
South Kensington Campus Exhibition Road
SW7 2AZ London

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
THE HYVE BV
Netherlands
Net EU contribution
€ 400 000,00
Address
Arthur Van Schendelstraat 650
3511 MJ Utrecht

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
West-Nederland Utrecht Utrecht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
European Alliance for Personalised Medicine
Slovenia
Net EU contribution
€ 180 000,00
Address
Ulica Heroja Tomšiča,
2000 Maribor

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Region
Slovenija Vzhodna Slovenija Podravska
Activity type
Other
Non-EU contribution
€ 0,00
PINSENT MASONS LLP
United Kingdom
Net EU contribution
€ 150 000,00
Address
Earl Street 30 Crown Place
EC2A 4ES London

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Region
London Inner London — East Hackney and Newham
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
CANCER INTELLIGENCE LIMITED

Participation ended

United Kingdom
Net EU contribution
€ 12 121,34
Address
11 Alma Vale Rd
BS8 2HL Bristol

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Region
South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
WEIZMANN INSTITUTE OF SCIENCE
Israel
Net EU contribution
€ 200 000,00
Address
Herzl Street 234
7610001 Rehovot

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITY OF ABERDEEN
United Kingdom
Net EU contribution
€ 409 303,00
Address
King's College Regent Walk
AB24 3FX Aberdeen

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Region
North Eastern Scotland Aberdeen City and Aberdeenshire
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
TECHNISCHE UNIVERSITAET DRESDEN
Germany
Net EU contribution
€ 125 000,00
Address
Helmholtzstrasse 10
01069 Dresden

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Region
Sachsen Dresden Dresden, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany
Net EU contribution
€ 125 000,00
Address
Hansastrasse 27c
80686 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Non-EU contribution
€ 0,00
GOETEBORGS UNIVERSITET
Sweden
Net EU contribution
€ 150 000,00
Address
Vasaparken
405 30 Goeteborg

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Region
Södra Sverige Västsverige Västra Götalands län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
STICHTING RADBOUD UNIVERSITEIT

Participation ended

Netherlands
Net EU contribution
€ 25 077,81
Address
Houtlaan 4
6525 XZ Nijmegen

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Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
IHE, INSTITUTET FOR HALSO- OCH SJUKVARDSEKONOMI AKTIEBOLAG
Sweden
Net EU contribution
€ 175 000,00
Address
Rabygatan 2, 3tr
223 61 Lund

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Södra Sverige Sydsverige Skåne län
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 20 000,00
BAYER AKTIENGESELLSCHAFT
Germany
Net EU contribution
€ 0,00
Address
Kaiser-wilhelm-allee 1
51373 Leverkusen

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Region
Nordrhein-Westfalen Köln Leverkusen, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 2 260 000,00
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
France
Net EU contribution
€ 0,00
Address
Pierre Brossolette 1
91380 Chilly Mazarin

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Region
Ile-de-France Ile-de-France Essonne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 400 000,00
VARIAN MEDICAL SYSTEM DEUTSCHLAND GMBH

Participation ended

Germany
Net EU contribution
€ 0,00
Address
Alsfelder Strasse 6
64289 Darmstadt

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Region
Darmstadt Darmstadt, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
ASTELLAS PHARMA EUROPE BV
Netherlands
Net EU contribution
€ 0,00
Address
Sylviusweg 84
2333 BE Leiden

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Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 532 500,00
NV SAS INSTITUTE SA
Belgium
Net EU contribution
€ 0,00
Address
Hertenbergstraat 6
3080 Tervuren

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Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 694 000,00
JANSSEN PHARMACEUTICA NV
Belgium
Net EU contribution
€ 0,00
Address
Turnhoutseweg 30
2340 Beerse

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Region
Vlaams Gewest Prov. Antwerpen Arr. Turnhout
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 250 000,00
LABCORP EARLY DEVELOPMENT LABORATORIES LIMITED
United Kingdom
Net EU contribution
€ 0,00
Address
Otley Road
HG3 IPY Harrogate

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Region
Yorkshire and the Humber North Yorkshire North Yorkshire CC
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 177 000,00
ORION OYJ
Finland
Net EU contribution
€ 0,00
Address
Orionintie 1
02200 Espoo

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Region
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 200 000,00
IMS INFORMATION SOLUTIONS MEDICAL RESEARCH LIMITED
United Kingdom
Net EU contribution
€ 0,00
Address
Pentonville Road 210
NI 9JY London

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Region
London Inner London — West Camden and City of London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 550 000,00
THE ECANCER GLOBAL FOUNDATION
United Kingdom
Net EU contribution
€ 47 878,66
Address
13 King Square Avenue
BS2 8HU Bristol

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of
Activity type
Other
Non-EU contribution
€ 0,00
JULIUS CLINICAL RESEARCH BV

Participation ended

Netherlands
Net EU contribution
€ 0,00
Address
Broederplein 41-43
3703 CD Zeist

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Region
West-Nederland Utrecht Utrecht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 11 531,25
ASTRAZENECA AB
Sweden
Net EU contribution
€ 0,00
Address
Vastra Maelarhamnen
151 85 Sodertaelje

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 257 500,00
HELMHOLTZ-ZENTRUM DRESDEN-ROSSENDORF EV
Germany
Net EU contribution
€ 62 500,00
Address
Bautzner Landstrasse 400
01328 Dresden

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Region
Sachsen Dresden Dresden, Kreisfreie Stadt
Activity type
Research Organisations
Non-EU contribution
€ 0,00
STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands
Net EU contribution
€ 124 922,19
Address
Geert Grooteplein 10 Zuid
6525 GA Nijmegen

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Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 13 628,64