Periodic Reporting for period 3 - ENTRANCE (Developing the iTOP kit: Empowering scientists with efficient intracellular delivery of biologicals in hard-to-manipulate cell types)
Período documentado: 2019-07-01 hasta 2019-10-31
The ENTRANCE project has allowed NTrans to market the iTOP technology as a tool for researchers to introduce a spectrum of biomolecules into primary and stem cells. iTOP technology also has important therapeutic applications, as it can be used to safely and efficiently deliver the CRISPR/Cas9 gene editing system into clinically relevant cells and repair gene mutations that are causative of disease. NTrans is collaborating with several gene-editing companies, the largest cluster of which worldwide is housed in Boston/Cambridge, Massachusetts area. These companies are essential business partners of NTrans in the development of new therapies for genetic diseases and cancer. After presenting the iTOP technology at the CRISPR meeting in Boston in February 2017 (http://crispr-congress.com/presentations-2017/) and in May 2018, NTrans has established collaborations with US-based pharmaceutical companies and other research institutions to use the iTOP technology as their delivery method of choice. These companies are developing therapeutics and CRISPR gene-editing technologies for application in genetic diseases and cancer. The next step after evaluation studies will be to set-up US collaborations for product development and marketing based on iTOP-technology licenses and/or joint development programs. Researchers have tested our technology. We are further testing the iTOP Technology on a small scale through marketing of our first product via the “Divvly” community platform. In a next phase of the company, we will try to find CRISPR-tool suppliers that would like to in-license the iTOP Technology® developed within this project for marketing purposes.
Our goal is to further support distribution and commercialization of the iTOP technology for the research community, however, we have realised that we do not have the sales and marketing team to do this on or own, and we are therefore looking for a CRISPR supplier. The knowledge developed within this H2020-project, has allowed us to develop the iTOP Technology® in other projects for therapeutic application within ophthalmology, immune-oncology and muscular dystrophies (Duchenne Muscular Dystrophy). The mission of NTrans is to translate the unique iTOP technology into new revolutionary therapies for the treatment of genetic diseases and cancer.
For more information on NTrans Technologies please visit our website: http://www.ntranstechnologies.com/
Our goal is to further support distribution and commercialization of the iTOP technology for the research community, and to develop a therapeutic platform for iTOP-based delivery of bioactive molecules. The mission of NTrans is to translate the unique iTOP technology into new revolutionary therapies for the treatment of genetic diseases and cancer.
For more information on NTrans Technologies please visit our website: http://www.ntranstechnologies.com/