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Nanostructural surface development for dental implant manufacturing

Periodic Reporting for period 1 - NanoSurf (Nanostructural surface development for dental implant manufacturing)

Reporting period: 2018-01-01 to 2019-12-31

The NanoSurf project research and innovation goals are targeted to to develop a new class of dental implants with advanced mechanical properties and improved surfaces, treated with nanotechnological methods which will demonstrate high biocompatibility, antibacterial properties and integration with a patient’s bone. The developed devices will simplify dental surgery and avoid bacterial inflammatory complications after the implant surgery. This can provide better dental services and improve health of EU society. The project is targeted to strengthen international and intersectoral collaboration, sharing new ideas, knowledge transfer from research to market, and vice versa in the field of nanostructured metal oxide optical biosensors for cancer cell detection.

The project NanoSurf is targeted to strengthen international and intersectoral collaboration in dental implant research, sharing new ideas and knowledge transfer from research to market and vice versa. We will investigate nanostructured metal oxide coatings, 3D scaffolds, obtained by electrospinning deposition of organic nanofibers and lazer patterning of the implant surface using biotechnology, cell engineering and nanotechnology. The provided research and management training to experienced researchers and early stage researchers will be quite beneficial. It will strengthen their personal skills and CVs via the new scientific papers and conference theses and strengthen a development of EU research human resources. We foresee a long lasting collaboration between the partners, based on co-supervising students and the preparation of novel collaborative project proposals. Also foreseen is a dissemination of the project results to the scientific society and wide auditories.
- Developed and investigated Ti-Zr alloy for dental implant production;
- Investigated chemical structure and composition of Ti-Zr alloys and compered with conventional metals such as CTZ and Grade-5 Ti alloy;
- Production of samples for mechanical and biological evaluation of TiZr alloys;
- Deposition of Ca-P, HA and nanoparticles (Ag, ZnO, Cu) on Ti-Zr, Ti and Mg alloys surface using plasma electro oxidation method (Published and partiallyready for publishing);
- Investigation modified surfaces using SEM, EDX, XRD, XPS, FTIR, optical properties, contact angle measurement:
The surface characterization of selected surface is shown in Figure 1.
- Preliminary investigation using osteoblast and fibroblast cell lines performed for selected surfaces.
Scheme and results of preliminary investigation is shown in Figure 2.

The project partners have been providing trainings in following disciplines:
Riga team: mechanical engineering, surface treatment, optical characterization.
Osteoplant team: dental implant production, electrochemistry, contact angle measurement, SEM.
Sumy team: cell biology, cell culture, biomedical testing.
Sheffield team: cell culture, sample preparation for biocompatibility study.
Reggio team: laser texturing, sample preparation for laser treatment
Progress beyond the state of the art
Novel TiZr alloy was produced and deposition of Ca-P, HA and nanoparticles (Ag, ZnO, Cu) on Ti-Zr, Ti and Mg alloys surface using plasma electro oxidation method provided. We have obtain mesoporous structures with both micro- and nano-pores. Structural and chemical parameters of obtained surface are much better than other materials, reported in literature. Fundamental properties of these surfaces have been investigated.

Expected results until the end of the project
- Fabrication of 3D sturctural topographies on the dental implant surface by Laser and electrospinning methods;
- Modification of abutment surface using LIPSS and electrospinning methods for improvement connective of tissue growth and antibacterial properties;
- Investigation toxicity, biocompatibility, bone cells and fibroblast response to modified and nonmodified surfaces;
- Provide assessment of antimicrobial properties of the novel implants before and after surface treatment;
- Provide in vivo tests on laboratory animals for assessment of early peri-implant tissue reaction, osseointegration and long-term bone quality after application of developed implants.

Potential impacts
The project makes following impacts:
1.Socio-economic impacts. The project will develop novel approach for dental and orthopedics implant surface modification that can decrease postoperative complications what makes impact to health care of EU citizens. Development of novel type of implant surface will make impact to EU industry. New results will stimulate development of EU research in fields of nano-, biotechnology and medicine.
2.Carrier development and strengthening of research potential. New skills will be transferred to ESRs what improve their competitiveness. Effective knowledge transfer increases scientific potential of participating countries. New proposed projects stimulate staff exchange, new papers and applications.