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Placenta-expanded adherent stromal cells (PLX-PAD) as an innovative therapy for improving recovery and survival following hip fracture arthroplasty – HIPGEN, a multicenter phase III trial

Deliverables

Publications

Editorial: Mesenchymal Stromal Cell Therapy for Regenerative Medicine

Author(s): Vivian Capilla-González, Vicente Herranz-Pérez, Rachel Sarabia-Estrada, Nadir Kadri, and Guido Moll
Published in: Front. Cell. Neurosci., 2022, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2022.932281

Impact of Cryopreservation and Freeze‑Thawing on Therapeutic Properties of Mesenchymal Stromal/Stem Cells and Other Common Cellular Therapeutics

Author(s): Chasen Cottle, Amanda Paige Porter, Ariel Lipat, Caitlin Turner-Lyles, Jimmy Nguyen, Guido Moll, Raghavan Chinnadurai
Published in: Current Stem Cell Reports, 2022, ISSN 2198-7866
Publisher: Springer
DOI: 10.1007/s40778-022-00212-1

Perinatal derivatives: How to best validate their immunomodulatory functions

Author(s): Andrea Papait, Antonietta Silini, Maria Gazouli, Ricardo Malvicini, Maurizio Muraca, Lorraine O’Driscoll, Natalia Pacienza, Wei Seong Toh, Gustavo Yannarelli, Peter Ponsaerts, Ornella Pa-rolini, Günther Eissner, Michela Pozzobon, Sai Kiang Lim and Bernd Giebel
Published in: Front Bioeng Biotechnol, 22964185, 2022, ISSN 2296-4185
Publisher: Frontiers Media S.A.
DOI: 10.3389/fbioe.2022.981061

Angiogenic Role of Mesothelium-Derived Chemokine CXCL1 during Unfavourable Peritoneal Tissue Remodelling in Patients Receiving Peritoneal Dialysis as Renal Replacement Therapy

Author(s): Rusan Catar and Guido Moll et al
Published in: Frontiers in Immunology, 2021, ISSN 1664-3224
Publisher: Frontiers media
DOI: 10.3389/fimmu.2022.821681

Expanded Hemodialysis Therapy Ameliorates Uremia-Induced Systemic Microinflammation and Endothelial Dysfunction by Modulating VEGF, TNF-α and AP-1 Signaling

Author(s): Rusan Catar and Guido Moll et al
Published in: Frontiers in Immunology, 2021, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2021.774052

Ground reaction forces and external hip joint moments predict in vivo hip con-tact forces during gait

Author(s): Sónia A. Alves, Jörg Polzehl, Nicholas M. Brisson, alwina Bender, Alison N. Agres, Philipp Damm, Georg N. Duda
Published in: Journal of Biomechanics, 18732380, 2022, ISSN 1873-2380
Publisher: Elsevier
DOI: 10.1016/j.jbiomech.2022.111037

Diagnosis of Metal Hypersensitivity in Total Knee Arthroplasty: A Case Report

Author(s): Janosch Schoon, Melanie J. Ort, Katrin Huesker, Sven Geissler, Anastasia Rakow
Published in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2019.02758

Mesenchymal Stem/Stromal Cells as a Therapeutic Tool in Cell-Based Therapy and Regenerative Medicine: An Introduction Expertise to the Topical Collection

Author(s): Chasen Cottle, Amanda Paige Porter, Ariel Lipat, Caitlin Turner-Lyles, Jimmy Nguyen, Guido Moll, Raghavan Chinnadurai
Published in: Cells, 2022, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11193158

Perinatal Mesenchymal Stromal Cells and Their Possible Contribution to Fetal-Maternal Tolerance

Author(s): Marta Magatti, Francesca Romana Stefani, Andrea Papait, Anna Cargnoni, Alice Masserdotti, Antonietta Rosa Silini, Ornella Parolini
Published in: Cells, 8/11, 2019, Page(s) 1401, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells8111401

Mesenchymal stromal cell and bone marrow concentrate therapies for musculoskeletal indications: a concise review of current literature

Author(s): Christian Eder, Katharina Schmidt-Bleek, Sven Geissler, F. Andrea Sass, Tazio Maleitzke, Matthias Pumberger, Carsten Perka, Georg N. Duda, Tobias Winkler
Published in: Molecular Biology Reports, 47/6, 2020, Page(s) 4789-4814, ISSN 0301-4851
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s11033-020-05428-0

Preclinical Toxicity Evaluation of Clinical Grade Placenta-Derived Decidua Stromal Cells

Author(s): Behnam Sadeghi, Gianluca Moretti, Fabian Arnberg, Erik Samén, Bita Kohein, Rusan Catar, Julian Kamhieh-Milz, Sven Geissler, Guido Moll, Staffan Holmin, Olle Ringdén
Published in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2019.02685

Mesenchymal Stromal Cells from Fetal and Maternal Placenta Possess Key Similarities and Differences: Potential Implications for Their Applications in Regenerative Medicine

Author(s): Andrea Papait, Elsa Vertua, Marta Magatti, Sabrina Ceccariglia, Silvia De Munari, Antonietta Rosa Silini, Michal Sheleg, Racheli Ofir, Ornella Parolini
Published in: Cells, 9/1, 2020, Page(s) 127, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9010127

MSCs in Space: Mesenchymal Stromal Cell Therapeutics as Enabling Technology for Long-Distance Manned Space Travel

Author(s): Jayeeta Giri and Guido Moll
Published in: Current Stem Cell Reports, 2022, ISSN 2198-7866
Publisher: cell press
DOI: 10.1007/s40778-022-00207-y

The Recovery of Weight-Bearing Symmetry After Total Hip Arthroplasty Is Activ-ity-Dependent

Author(s): Sónia A. Alves, Marco Preuße, Hagen Hommel, Georg N. Duda, Alison N. Agres
Published in: Front Bioeng Biotechnol, 22964185, 2022, ISSN 2296-4185
Publisher: Frontiers Media S.A.
DOI: 10.3389/fbioe.2022.813345

RESTORE Survey on the Public Perception of Advanced Therapies and ATMPs in Europe—Why the European Union Should Invest More!

Author(s): Gady Goldsobel, Christoph von Herrath, Stephan Schlickeiser, Nicola Brindle, Frauke Stähler, Petra Reinke, Zami Aberman, Racheli Ofir, Gabriella Dessole, Stefano Benvenuti, Nuno M. Neves, Rui L. Reis, Guido Moll, and Hans-Dieter Volk
Published in: Frontiers in Medicine, 2021, ISSN 2296-858X
Publisher: Springer
DOI: 10.3389/fmed.2021.739987

Shaping the Future of Perinatal Cells: Lessons From the Past and Interpretations of the Present

Author(s): Antonietta R. Silini, Alice Masserdotti, Andrea Papait, Ornella Parolini
Published in: Frontiers in Bioengineering and Biotechnology, 7, 2019, Page(s) 1-7, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2019.00075

Intravascular Mesenchymal Stromal/Stem Cell Therapy Product Diversification: Time for New Clinical Guidelines

Author(s): Guido Moll, James A. Ankrum, Julian Kamhieh-Milz, Karen Bieback, Olle Ringdén, Hans-Dieter Volk, Sven Geissler, Petra Reinke
Published in: Trends in Molecular Medicine, 25/2, 2019, Page(s) 149-163, ISSN 1471-4914
Publisher: Elsevier BV
DOI: 10.1016/j.molmed.2018.12.006

Cell therapy to improve regeneration of skeletal muscle injuries

Author(s): Taimoor H. Qazi, Georg N. Duda, Melanie J. Ort, Carsten Perka, Sven Geissler, Tobias Winkler
Published in: Journal of Cachexia, Sarcopenia and Muscle, 10/3, 2019, Page(s) 501-516, ISSN 2190-5991
Publisher: Springer Verlag
DOI: 10.1002/jcsm.12416

Immunomodulatory placental-expanded, mesenchymal stromal cells improve muscle function following hip arthroplasty

Author(s): Tobias Winkler, Carsten Perka, Philipp von Roth, Alison N. Agres, Henning Plage, Bernd Preininger, Matthias Pumberger, Sven Geissler, Esther Lukasiewicz Hagai, Racheli Ofir, Lena Pinzur, Eli Eyal, Gisela Stoltenburg-Didinger, Christian Meisel, Christine Consentius, Mathias Streitz, Petra Reinke, Georg N. Duda, Hans-Dieter Volk
Published in: Journal of Cachexia, Sarcopenia and Muscle, 9/5, 2018, Page(s) 880-897, ISSN 2190-5991
Publisher: Springer Verlag
DOI: 10.1002/jcsm.12316

Unraveling local tissue changes within severely injured skeletal muscles in response to MSC-based intervention using MALDI Imaging mass spectrometry

Author(s): Oliver Klein, Kristin Strohschein, Grit Nebrich, Michael Fuchs, Herbert Thiele, Patrick Giavalisco, Georg N. Duda, Tobias Winkler, Jan Hendrik Kobarg, Dennis Trede, Sven Geissler
Published in: Scientific Reports, 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-30990-w

Editorial comment: variables affecting the presence of mesenchymal stromal cells in the peripheral blood and their relationship with apheresis product

Author(s): Guido Moll, Norman Drzeniek, Julian Kamhieh‐Milz, Sven Geissler, Petra Reinke
Published in: British Journal of Haematology, 189/4, 2020, Page(s) 593-596, ISSN 0007-1048
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/bjh.16389

Improved MSC Minimal Criteria to Maximize Patient Safety: A Call to Embrace Tissue Factor and Hemocompatibility Assessment of MSC Products

Author(s): Guido Moll, James A. Ankrum, Scott D. Olson, Jan A. Nolta
Published in: Stem Cells Translational Medicine, 2022, ISSN 2157-6564
Publisher: AlphaMed Press
DOI: 10.1093/stcltm/szab005

Mesenchymal stromal cell and bone marrow concentrate therapies for musculoskeletal indications: a concise review of current literature

Author(s): Christian Eder, Katharina Schmidt-Bleek , Sven Geissler , F Andrea Sass , Tazio Maleitzke, Matthias Pumberger, Carsten Perka, Georg N Duda , Tobias Winkler
Published in: Molecular Biological Report, 2020, Page(s) 4789-4814, ISSN 0301-4851
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s11033-020-05428-0

MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Delivery for Treatment Safety and Efficacy

Author(s): Guido Moll, Norman Drzeniek, Julian Kamhieh-Milz, Sven Geissler, Hans-Dieter Volk, Petra Reinke
Published in: Frontiers in Immunology, 11, 2020, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2020.01091

Transcriptional Regulation of Thrombin-Induced Endothelial VEGF Induction and Proangiogenic Response.

Author(s): Rusan Catar; Guido Moll; Guido Moll; Isa Hosp; Michèle Simon; Christian Luecht; Hongfan Zhao; Dashan Wu; Lei Chen; Julian Kamhieh-Milz; Katarzyna Korybalska; Daniel Zickler; Janusz Witowski; Janusz Witowski
Published in: Cells, Vol 10, Iss 910, p 910 (2021), 6, 2021, ISSN 2073-4409
Publisher: mdpi
DOI: 10.3390/cells10040910

Batch Effects during Human Bone Marrow Stromal Cell Propagation Prevail Donor Variation and Culture Duration: Impact on Genotype, Phenotype and Function.

Author(s): Gabriele Brachtl ,Rodolphe Poupardin,Sarah Hochmann, Anna Raninge, Karsten Jürchott, Mathias Streitz, Stephan Schlickeiser,Michaela Oeller,Martin Wolf,Katharina Schallmoser,Hans-Dieter Volk , Sven Geissler and Dirk Strunk.
Published in: Cells, 2022, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11060946

Multi-Parameter Analysis of Biobanked Human Bone Marrow Stromal Cells Shows Little Influence for Donor Age and Mild Comorbidities on Phenotypic and Functional Properties

Author(s): Anastazja Andrzejewska, Rusan Catar, Janosch Schoon, Taimoor Hasan Qazi, Frauke Andrea Sass, Dorit Jacobi, Antje Blankenstein, Simon Reinke, David Krüger, Mathias Streitz, Stephan Schlickeiser, Sarina Richter, Naima Souidi, Christien Beez, Julian Kamhieh-Milz, Ulrike Krüger, Tomasz Zemojtel, Karsten Jürchott, Dirk Strunk, Petra Reinke, Georg Duda, Guido Moll, Sven Geissler
Published in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2019.02474

Quantifying Asymmetry in Gait: The Weighted Universal Symmetry Index to Evaluate 3D Ground Reaction Forces

Author(s): Sónia A. Alves, Rainald M. Ehrig, Peter C. Raffalt, Alwina Bender, Georg N. Duda, Alison N. Agres
Published in: Frontiers in Bioengineering and Biotechnology, 8, 2020, ISSN 2296-4185
Publisher: Frontiers Media S.A.
DOI: 10.3389/fbioe.2020.579511

Bio-instructive hydrogel expands the paracrine potency of mesenchymal stem cells

Author(s): Drzeniek NM, Mazzocchi A, Schlickeiser S, Forsythe SD, Moll G, Geißler S, Reinke P, Gossen M, Gorantla VS, Volk HD, Soker S.
Published in: Biofabrication, 2021, ISSN 1758-5082
Publisher: IOS Press
DOI: 10.1088/1758-5090/ac0a32

The Allergic Bone Marrow? The Immuno-Capacity of the Human Bone Marrow in Context of Metal-Associated Hypersensitivity Reactions

Author(s): Melanie J. Ort, Sven Geissler, Anastasia Rakow, Janosch Schoon
Published in: Frontiers in Immunology, 10, 2019, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2019.02232

H3F3A-mutated giant cell tumour of bone without giant cells—clinical presentation, radiology and histology of three cases

Author(s): Benedikt Leinauer, […],Sven Geißler,[…],Gernot Jundt
Published in: Histopathology, 2022, ISSN 1365-2559
Publisher: Wiley
DOI: 10.1111/his.14401