Placenta-expanded adherent stromal cells (PLX-PAD) as an innovative therapy for improving recovery and survival following hip fracture arthroplasty – HIPGEN, a multicenter phase III trial

Información del proyecto

HIPGEN

Identificador del acuerdo de subvención: 779293

DOI

10.3030/779293

Proyecto cerrado

Fecha de la firma de la CE 21 Noviembre 2017

Fecha de inicio 1 Enero 2018

Fecha de finalización 30 Septiembre 2022

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 7 437 127,50

Aportación de la UE

€ 7 437 127,50

Coordinado por

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (5)

Publications and material for communication (flyers, press release, videos, seminars, publications)-1st year

Communication material

Project visual identity

project logo and set up of documents

Project web site

web site

Publications and material for communication (flyers, press release, videos, seminars, publications) 4th year

communication material

Publications and material for communication (flyers, press release, videos, seminars, publications) 3rd year

communication material

Documents, reports (2)

Report on dissemination activities

report

Initial dissemination plan

document

Publicaciones

Peer reviewed articles (29)

Editorial: Mesenchymal Stromal Cell Therapy for Regenerative Medicine

Autores: Vivian Capilla-González, Vicente Herranz-Pérez, Rachel Sarabia-Estrada, Nadir Kadri, and Guido Moll
Publicado en: Front. Cell. Neurosci., 2022, ISSN 1662-5102
Editor: Frontiers Research Foundation
DOI: 10.3389/fncel.2022.932281

Impact of Cryopreservation and Freeze‑Thawing on Therapeutic Properties of Mesenchymal Stromal/Stem Cells and Other Common Cellular Therapeutics

Autores: Chasen Cottle, Amanda Paige Porter, Ariel Lipat, Caitlin Turner-Lyles, Jimmy Nguyen, Guido Moll, Raghavan Chinnadurai
Publicado en: Current Stem Cell Reports, 2022, ISSN 2198-7866
Editor: Springer
DOI: 10.1007/s40778-022-00212-1

Perinatal derivatives: How to best validate their immunomodulatory functions

Autores: Andrea Papait, Antonietta Silini, Maria Gazouli, Ricardo Malvicini, Maurizio Muraca, Lorraine O’Driscoll, Natalia Pacienza, Wei Seong Toh, Gustavo Yannarelli, Peter Ponsaerts, Ornella Pa-rolini, Günther Eissner, Michela Pozzobon, Sai Kiang Lim and Bernd Giebel
Publicado en: Front Bioeng Biotechnol, 2022, ISSN 2296-4185
Editor: Frontiers Media S.A.
DOI: 10.3389/fbioe.2022.981061

Angiogenic Role of Mesothelium-Derived Chemokine CXCL1 during Unfavourable Peritoneal Tissue Remodelling in Patients Receiving Peritoneal Dialysis as Renal Replacement Therapy

Autores: Rusan Catar and Guido Moll et al
Publicado en: Frontiers in Immunology, 2021, ISSN 1664-3224
Editor: Frontiers media
DOI: 10.3389/fimmu.2022.821681

Expanded Hemodialysis Therapy Ameliorates Uremia-Induced Systemic Microinflammation and Endothelial Dysfunction by Modulating VEGF, TNF-α and AP-1 Signaling

Autores: Rusan Catar and Guido Moll et al
Publicado en: Frontiers in Immunology, 2021, ISSN 1664-3224
Editor: Frontiers Media
DOI: 10.3389/fimmu.2021.774052

Ground reaction forces and external hip joint moments predict in vivo hip con-tact forces during gait

Autores: Sónia A. Alves, Jörg Polzehl, Nicholas M. Brisson, alwina Bender, Alison N. Agres, Philipp Damm, Georg N. Duda
Publicado en: Journal of Biomechanics, 2022, ISSN 1873-2380
Editor: Elsevier
DOI: 10.1016/j.jbiomech.2022.111037

Diagnosis of Metal Hypersensitivity in Total Knee Arthroplasty: A Case Report

Autores: Janosch Schoon, Melanie J. Ort, Katrin Huesker, Sven Geissler, Anastasia Rakow
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2019.02758

Mesenchymal Stem/Stromal Cells as a Therapeutic Tool in Cell-Based Therapy and Regenerative Medicine: An Introduction Expertise to the Topical Collection

Autores: Chasen Cottle, Amanda Paige Porter, Ariel Lipat, Caitlin Turner-Lyles, Jimmy Nguyen, Guido Moll, Raghavan Chinnadurai
Publicado en: Cells, 2022, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells11193158

Perinatal Mesenchymal Stromal Cells and Their Possible Contribution to Fetal-Maternal Tolerance

Autores: Marta Magatti, Francesca Romana Stefani, Andrea Papait, Anna Cargnoni, Alice Masserdotti, Antonietta Rosa Silini, Ornella Parolini
Publicado en: Cells, Edición 8/11, 2019, Página(s) 1401, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells8111401

Preclinical Toxicity Evaluation of Clinical Grade Placenta-Derived Decidua Stromal Cells

Autores: Behnam Sadeghi, Gianluca Moretti, Fabian Arnberg, Erik Samén, Bita Kohein, Rusan Catar, Julian Kamhieh-Milz, Sven Geissler, Guido Moll, Staffan Holmin, Olle Ringdén
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2019.02685

Mesenchymal Stromal Cells from Fetal and Maternal Placenta Possess Key Similarities and Differences: Potential Implications for Their Applications in Regenerative Medicine

Autores: Andrea Papait, Elsa Vertua, Marta Magatti, Sabrina Ceccariglia, Silvia De Munari, Antonietta Rosa Silini, Michal Sheleg, Racheli Ofir, Ornella Parolini
Publicado en: Cells, Edición 9/1, 2020, Página(s) 127, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells9010127

MSCs in Space: Mesenchymal Stromal Cell Therapeutics as Enabling Technology for Long-Distance Manned Space Travel

Autores: Jayeeta Giri and Guido Moll
Publicado en: Current Stem Cell Reports, 2022, ISSN 2198-7866
Editor: cell press
DOI: 10.1007/s40778-022-00207-y

The Recovery of Weight-Bearing Symmetry After Total Hip Arthroplasty Is Activ-ity-Dependent

Autores: Sónia A. Alves, Marco Preuße, Hagen Hommel, Georg N. Duda, Alison N. Agres
Publicado en: Front Bioeng Biotechnol, 2022, ISSN 2296-4185
Editor: Frontiers Media S.A.
DOI: 10.3389/fbioe.2022.813345

RESTORE Survey on the Public Perception of Advanced Therapies and ATMPs in Europe—Why the European Union Should Invest More!

Autores: Gady Goldsobel, Christoph von Herrath, Stephan Schlickeiser, Nicola Brindle, Frauke Stähler, Petra Reinke, Zami Aberman, Racheli Ofir, Gabriella Dessole, Stefano Benvenuti, Nuno M. Neves, Rui L. Reis, Guido Moll, and Hans-Dieter Volk
Publicado en: Frontiers in Medicine, 2021, ISSN 2296-858X
Editor: Springer
DOI: 10.3389/fmed.2021.739987

Shaping the Future of Perinatal Cells: Lessons From the Past and Interpretations of the Present

Autores: Antonietta R. Silini, Alice Masserdotti, Andrea Papait, Ornella Parolini
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 7, 2019, Página(s) 1-7, ISSN 2296-4185
Editor: Frontiers
DOI: 10.3389/fbioe.2019.00075

Intravascular Mesenchymal Stromal/Stem Cell Therapy Product Diversification: Time for New Clinical Guidelines

Autores: Guido Moll, James A. Ankrum, Julian Kamhieh-Milz, Karen Bieback, Olle Ringdén, Hans-Dieter Volk, Sven Geissler, Petra Reinke
Publicado en: Trends in Molecular Medicine, Edición 25/2, 2019, Página(s) 149-163, ISSN 1471-4914
Editor: Elsevier BV
DOI: 10.1016/j.molmed.2018.12.006

Cell therapy to improve regeneration of skeletal muscle injuries

Autores: Taimoor H. Qazi, Georg N. Duda, Melanie J. Ort, Carsten Perka, Sven Geissler, Tobias Winkler
Publicado en: Journal of Cachexia, Sarcopenia and Muscle, Edición 10/3, 2019, Página(s) 501-516, ISSN 2190-5991
Editor: Springer Verlag
DOI: 10.1002/jcsm.12416

Immunomodulatory placental-expanded, mesenchymal stromal cells improve muscle function following hip arthroplasty

Autores: Tobias Winkler, Carsten Perka, Philipp von Roth, Alison N. Agres, Henning Plage, Bernd Preininger, Matthias Pumberger, Sven Geissler, Esther Lukasiewicz Hagai, Racheli Ofir, Lena Pinzur, Eli Eyal, Gisela Stoltenburg-Didinger, Christian Meisel, Christine Consentius, Mathias Streitz, Petra Reinke, Georg N. Duda, Hans-Dieter Volk
Publicado en: Journal of Cachexia, Sarcopenia and Muscle, Edición 9/5, 2018, Página(s) 880-897, ISSN 2190-5991
Editor: Springer Verlag
DOI: 10.1002/jcsm.12316

Editorial comment: variables affecting the presence of mesenchymal stromal cells in the peripheral blood and their relationship with apheresis product

Autores: Guido Moll, Norman Drzeniek, Julian Kamhieh‐Milz, Sven Geissler, Petra Reinke
Publicado en: British Journal of Haematology, Edición 189/4, 2020, Página(s) 593-596, ISSN 0007-1048
Editor: Blackwell Publishing Inc.
DOI: 10.1111/bjh.16389

Improved MSC Minimal Criteria to Maximize Patient Safety: A Call to Embrace Tissue Factor and Hemocompatibility Assessment of MSC Products

Autores: Guido Moll, James A. Ankrum, Scott D. Olson, Jan A. Nolta
Publicado en: Stem Cells Translational Medicine, 2022, ISSN 2157-6564
Editor: AlphaMed Press
DOI: 10.1093/stcltm/szab005

Mesenchymal stromal cell and bone marrow concentrate therapies for musculoskeletal indications: a concise review of current literature

Autores: Christian Eder, Katharina Schmidt-Bleek , Sven Geissler , F Andrea Sass , Tazio Maleitzke, Matthias Pumberger, Carsten Perka, Georg N Duda , Tobias Winkler
Publicado en: Molecular Biological Report, 2020, Página(s) 4789-4814, ISSN 0301-4851
Editor: Kluwer Academic Publishers
DOI: 10.1007/s11033-020-05428-0

MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Delivery for Treatment Safety and Efficacy

Autores: Guido Moll, Norman Drzeniek, Julian Kamhieh-Milz, Sven Geissler, Hans-Dieter Volk, Petra Reinke
Publicado en: Frontiers in Immunology, Edición 11, 2020, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2020.01091

Transcriptional Regulation of Thrombin-Induced Endothelial VEGF Induction and Proangiogenic Response.

Autores: Rusan Catar; Guido Moll; Guido Moll; Isa Hosp; Michèle Simon; Christian Luecht; Hongfan Zhao; Dashan Wu; Lei Chen; Julian Kamhieh-Milz; Katarzyna Korybalska; Daniel Zickler; Janusz Witowski; Janusz Witowski
Publicado en: Cells, Vol 10, Iss 910, p 910 (2021), Edición 6, 2021, ISSN 2073-4409
Editor: mdpi
DOI: 10.3390/cells10040910

Batch Effects during Human Bone Marrow Stromal Cell Propagation Prevail Donor Variation and Culture Duration: Impact on Genotype, Phenotype and Function.

Autores: Gabriele Brachtl ,Rodolphe Poupardin,Sarah Hochmann, Anna Raninge, Karsten Jürchott, Mathias Streitz, Stephan Schlickeiser,Michaela Oeller,Martin Wolf,Katharina Schallmoser,Hans-Dieter Volk , Sven Geissler and Dirk Strunk.
Publicado en: Cells, 2022, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells11060946

Multi-Parameter Analysis of Biobanked Human Bone Marrow Stromal Cells Shows Little Influence for Donor Age and Mild Comorbidities on Phenotypic and Functional Properties

Autores: Anastazja Andrzejewska, Rusan Catar, Janosch Schoon, Taimoor Hasan Qazi, Frauke Andrea Sass, Dorit Jacobi, Antje Blankenstein, Simon Reinke, David Krüger, Mathias Streitz, Stephan Schlickeiser, Sarina Richter, Naima Souidi, Christien Beez, Julian Kamhieh-Milz, Ulrike Krüger, Tomasz Zemojtel, Karsten Jürchott, Dirk Strunk, Petra Reinke, Georg Duda, Guido Moll, Sven Geissler
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2019.02474

Quantifying Asymmetry in Gait: The Weighted Universal Symmetry Index to Evaluate 3D Ground Reaction Forces

Autores: Sónia A. Alves, Rainald M. Ehrig, Peter C. Raffalt, Alwina Bender, Georg N. Duda, Alison N. Agres
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 8, 2020, ISSN 2296-4185
Editor: Frontiers Media S.A.
DOI: 10.3389/fbioe.2020.579511

Bio-instructive hydrogel expands the paracrine potency of mesenchymal stem cells

Autores: Drzeniek NM, Mazzocchi A, Schlickeiser S, Forsythe SD, Moll G, Geißler S, Reinke P, Gossen M, Gorantla VS, Volk HD, Soker S.
Publicado en: Biofabrication, 2021, ISSN 1758-5082
Editor: IOS Press
DOI: 10.1088/1758-5090/ac0a32

The Allergic Bone Marrow? The Immuno-Capacity of the Human Bone Marrow in Context of Metal-Associated Hypersensitivity Reactions

Autores: Melanie J. Ort, Sven Geissler, Anastasia Rakow, Janosch Schoon
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2019.02232

H3F3A-mutated giant cell tumour of bone without giant cells—clinical presentation, radiology and histology of three cases

Autores: Benedikt Leinauer, […],Sven Geißler,[…],Gernot Jundt
Publicado en: Histopathology, 2022, ISSN 1365-2559
Editor: Wiley
DOI: 10.1111/his.14401