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Bidirectional Hyper-Connected Neural System

Deliverables

Report on networking activities

This document will report on cooperation sessions cluster meetings and synergistic collaborations with relevant national and European projects on WR during the project lifecycle Preliminary reporting at M36 and final report at M48

Report on the engagement of civil society

This report will elaborate on the conclusion of activities in WP44 and the impact on public awareness

Model-based control of muscle electrical stimulators and powered exoskeletons

Demonstration of online EMGdriven modelling and proof of functionality of model predictions for control of electrical stimulation and exoskeletons for functional support

Documentation for human feasibility experiments

Report on the results from in vitro and in vivo testing demonstrating the safety of the whole system for human experiments

Neural-based models of ET and PD and SCI patients

Description of design development and testing of offline subjectspecific EMGdriven models intramuscular signals of tremor and SCI patients

Preliminary BHNS for ET and PD management and SCI rehabilitation

Report on preliminary experimentation of BHNS

Implant materials and fabrication

Report on the materials and fabrication techniques to be used for the injectable implants

Neural-based models of healthy individuals

Description of design development and testing of offline subjectspecific EMGdriven models based on EMG recordings from intramuscular electrodes

Plan for Exploitation and Dissemination of Results (PEDR) and Plan for Communication (PfC)

Documents addressing an analysis of patent situation IPR policy and coordinated activities in the area of standardisation It will also contain a section on future exploitation venues that can result from the technological development of EXTEND as well as the updated plan for dissemination and communication Preliminary reports will be ready at M6 M18 M30 while the final report will be delivered at M42

Patients management and recruitment plan

A detailed plan describing all protocols for patient management during experiments and how they will be recruited Preliminary reports are foreseen at M1 M17 and the final deliverable at M30

Project and risk management plan

The first draft of this document will be delivered at month 1 A second updated draft will be delivered at month 30

Report on non-technological roadblocks for BHNS

This deliverable includes the different ethical and legal aspects of connected neural interfaces.

Final BHNS for ET and PD management and SCI rehabilitation

Final Report on feasibility experimentation of BHNS

Ethical and legal management reports

A report on the management of the ethical and legal issues related to the project experimental activities on humans and animals including and ethical and regulatory framework It will be preliminarily reported at M24 and then the final version will be ready at M48

Report on risks management for BHNS

This report shall include multiple disciplinary perspectives on technological and legal risks of connected neural interfaces

EXTEND technological specifications

A document containing all the technological specifications that are needed for EXTEND The report will be preliminary released at M6 and then updated in a final version at M30

NeuroInterface Hub web page, related social media

The web page httpwwwneurointerfacehuborg will be ready and continuously updated with information about topics related to implanted neural interfaces from around the world Accounts in Twitter LinkedIn Facebook and YouTube will be created and constantly updated to promote the content of the website

External systems for human feasibility trials

The demonstrator will consist of 3 desktop units and 3 portable units M24

Pre-ASIC implant circuits with EMG capabilities

The demonstrator will consist of 100 units of implant circuits with EMG capabilities (M12).

Injectable implants pre-ASIC and external systems for animal experimentation

The demonstrator will consist of 30 units of injectable implants and 4 external systems M18

Sterilized implants for human feasibility trials

The demonstrator will consist of 30 sterilized units ready for human proofofconcept trials M30

Workshop on ethics, law and policy on human enhancement technologies

A workshop will be organised to discuss on the results obtained from the multidisciplinary analyses on human enhancement technologies First workshop at M24 and a second workshop at M36

Project web page, related social media

The web page (http://www.extendproject.eu) will be ready, and continuously updated with information about project objectives, dissemination activities scientific publications. Accounts in Twitter, LinkedIn, Facebook and YouTube will be created and constantly updated to promote the content of the website.

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Publications

Energetic Passivity Decoding of Human Hip Joint for Physical Human-Robot Interaction

Author(s): S. Farokh Atashzar, Hsien-Yung Huang, Fulvia Del Duca, Etienne Burdet, Dario Farina
Published in: IEEE Robotics and Automation Letters, 5/4, 2020, Page(s) 5953-5960, ISSN 2377-3766
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/lra.2020.3010459

Non-invasive electrical stimulation of peripheral nerves for the management of tremor

Author(s): Alejandro Pascual-Valdunciel; Apoorva Rajagopal; Jose L. Pons; Scott Delp
Published in: Journal of the Neurological Sciences, 120195., 0022510X, 2022, ISSN 0022-510X
Publisher: Elsevier BV
DOI: 10.1016/j.jns.2022.120195

Voluntary and tremorogenic inputs to motor neuron pools of agonist/antagonist muscles in essential tremor patients

Author(s): Gonthicha Puttaraksa, Silvia Muceli, Juan Álvaro Gallego, Ales Holobar, Steven K. Charles, Jose L. Pons, Dario Farina
Published in: Journal of Neurophysiology, 122/5, 2019, Page(s) 2043-2053, ISSN 0022-3077
Publisher: American Physiological Society
DOI: 10.1152/jn.00407.2019

Powering electronic implants by high frequency volume conduction: in human validation

Author(s): Jesus Minguillon, Marc Tudela Pi, Laura Becerra Fajardo, Enric Perera Bel, Antonio J. del Ama, Ángel Gil Agudo, Álvaro Megía García, Aracelys García Moreno, Antoni Ivorra
Published in: bioRxiv, p. 2021.03.15.435404, 26928205, 2021, ISSN 2692-8205
Publisher: bioRxiv
DOI: 10.1101/2021.03.15.435404

Intramuscular EMG-driven Musculoskeletal Modelling: Towards Implanted Muscle Interfacing in Spinal Cord Injury Patients.

Author(s): Moonki Jung; Silvia Muceli; Camila Rodrigues; Alvaro Megia-Garcia; Alejandro Pascual Valdunciel; A. J. del-Ama; Ángel Gil-Agudo; Juan Moreno; Filipe O. Barroso; Jose L Pons; Dario Farina
Published in: IEEE Transactions on Biomedical Engineering, 69(1)., 00189294, 2021, Page(s) 63-74, ISSN 0018-9294
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tbme.2021.3087137

Floating EMG sensors and stimulators wirelessly powered and operated by volume conduction for networked neuroprosthetics

Author(s): Laura Becerra-Fajardo; Marc Oliver Krob; Jesus Minguillon; Camila Rodrigues; Christine Welsch; Marc Tudela-Pi; Albert Comerma; Filipe Oliveira Barroso; Andreas Schneider; Antoni Ivorra
Published in: Journal of NeuroEngineering and Rehabilitation. 19(1), 1-19, 17430003, 2022, ISSN 1743-0003
Publisher: BioMed Central
DOI: 10.1101/2022.03.09.483628

The Natural-Artificial Distinction and the Technologization of Sport

Author(s): Aníbal Monasterio Astobiza
Published in: Philosophies, 5/4, 2020, Page(s) 28, ISSN 2409-9287
Publisher: MDPI
DOI: 10.3390/philosophies5040028

Additional file 1 of Peripheral electrical stimulation to reduce pathological tremor: a review

Author(s): Pascual-Valdunciel, Alejandro; Hoo, Grace W.; Avrillon, Simon; Barroso, Filipe Oliveira; Goldman, Jennifer G.; Hernandez-Pavon, Julio C.; Pons, José L.
Published in: Journal of neuroengineering and rehabilitation. 18(1), 1-19, 17430003, 2021, ISSN 1743-0003
Publisher: BioMed Central
DOI: 10.6084/m9.figshare.14037710.v1

Peripheral electrical stimulation to reduce pathological tremor: a review

Author(s): Alejandro Pascual-Valdunciel, Grace W. Hoo, Simon Avrillon, Filipe Oliveira Barroso, Jennifer G. Goldman, Julio C. Hernandez-Pavon & José L. Pons
Published in: Journal of NeuroEngineering and Rehabilitation, 2021, Page(s) J NeuroEngineering Rehabil 18, 33, ISSN 1743-0003
Publisher: BioMed Central
DOI: 10.1186/s12984-021-00811-9

Decoding motor neuron activity from epimysial thin-film electrode recordings following targeted muscle reinnervation

Author(s): Silvia Muceli, Konstantin D Bergmeister, Klaus-Peter Hoffmann, Martin Aman, Ivan Vukajlija, Oskar C Aszmann, Dario Farina
Published in: Journal of Neural Engineering, 16/1, 2019, Page(s) 016010, ISSN 1741-2560
Publisher: Institute of Physics Publishing
DOI: 10.1088/1741-2552/aaed85

A thin-film multichannel electrode for muscle recording and stimulation in neuroprosthetics applications

Author(s): Silvia Muceli, Wigand Poppendieck, Klaus-Peter Hoffmann, Strahinja Dosen, Julián Benito-León, Filipe Oliveira Barroso, José Luis Pons, Dario Farina
Published in: Journal of Neural Engineering, 16/2, 2019, Page(s) 026035, ISSN 1741-2560
Publisher: Institute of Physics Publishing
DOI: 10.1088/1741-2552/ab047a

Traducir el pensamiento en acción: Interfaces cerebro-máquina y el problema ético de la agencia.

Author(s): Aníbal Monasterio Astobiza, Txetxu Ausín, Mario Toboso, Ricardo Morte, Manuel Aparicio, Daniel López
Published in: Revista de Bioética y Derecho, 2019, 2019, ISSN 1886-5887
Publisher: Observatorio de Bioética y Derecho (OBD)
DOI: 10.1344/rbd2019.0.26862

Un marco ético-político para la robótica asistencial

Author(s): Manuel APARICIO PAYÁ, Mario TOBOSO MARTÍN, Txetxu AUSÍN DÍEZ, Anibal MONASTERIO ASTOBIZA, Ricardo MORTE FERRER, Daniel LÓPEZ CASTRO
Published in: ArtefaCToS. Revista de estudios sobre la ciencia y la tecnología, 8/1, 2019, Page(s) 97, ISSN 1989-3612
Publisher: Ediciones Universidad de Salamanca
DOI: 10.14201/art20198197117

Machine Ethics: Similarities and Differences between Artificial Morality and Human Morality

Author(s): Aníbal Monasterio Astobiza
Published in: International Journal of Applied Ethics, Number 30, 2019, Page(s) 129-147, ISSN 1989-7022
Publisher: ILEMATA

Effects of gravity and kinematic constraints on muscle synergies in arm cycling.

Author(s): Lilla Botzheim; Jozsef Laczko; Jozsef Laczko; Diego Torricelli; Mariann Mravcsik; Jose L Pons; Filipe O. Barroso
Published in: Journal of Neurophysiology. 125(4), 00223077, 2021, Page(s) 1367-1381, ISSN 0022-3077
Publisher: American Physiological Society
DOI: 10.1152/jn.00415.2020

Attitudes about Brain–Computer Interface (BCI) technology among Spanish rehabilitation professionals

Author(s): Aníbal Monasterio Astobiza; Aníbal Monasterio Astobiza; David Rodriguez Arias-Vailhen; Txetxu Ausín; Mario Toboso; Manuel Aparicio; Daniel López
Published in: AI & SOCIETY, 2021, ISSN 1435-5655
Publisher: Springer
DOI: 10.1007/s00146-021-01292-z

Intramuscular stimulation of muscle afferents attains prolonged tremor reduction in essential tremor patients

Author(s): Alejandro Pascual Valdunciel, Miguel Gonzalez-Sanchez, Silvia Muceli, Beatriz Adan-Barrientos, Viviana Escobar-Segura, Javier Ricardo Perez-Sanchez, Moon Ki Jung, Andreas Schneider, Klaus-Peter Hoffmann, Juan C. Moreno, Francisco Grandas, Dario Farina, Pons Jose, Filipe Barroso
Published in: IEEE Transactions on Biomedical Engineering, 2020, Page(s) 1-1, ISSN 0018-9294
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tbme.2020.3015572

Robotics as an Instrument for Social Mediation

Author(s): Mario Toboso, Ricardo Morte, Aníbal Monasterio, Txetxu Ausín, Manuel Aparicio, Daniel López
Published in: Inclusive Robotics for a Better Society - Selected Papers from INBOTS Conference 2018, 16-18 October, 2018, Pisa, Italy, 25, 2020, Page(s) 51-58, ISBN 978-3-030-24073-8
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-24074-5_11

Discursive Frameworks for the Development of Inclusive Robotics

Author(s): Manuel Aparicio, Mario Toboso, Txetxu Ausín, Daniel López, Ricardo Morte, Aníbal Monasterio
Published in: Inclusive Robotics for a Better Society - Selected Papers from INBOTS Conference 2018, 16-18 October, 2018, Pisa, Italy, 25, 2020, Page(s) 74-80, ISBN 978-3-030-24073-8
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-24074-5_14

Conceptual Analysis: Technology, Machine and Robot

Author(s): Aníbal Monasterio, Daniel López, Manuel Aparicio, Ricardo Morte, Txetxu Ausín, Mario Toboso
Published in: Inclusive Robotics for a Better Society - Selected Papers from INBOTS Conference 2018, 16-18 October, 2018, Pisa, Italy, 25, 2020, Page(s) 66-73, ISBN 978-3-030-24073-8
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-24074-5_13

Cartography of the Values Involved in Robotics

Author(s): Daniel López, Aníbal Monasterio, Mario Toboso, Manuel Aparicio, Txetxu Ausín, Ricardo Morte
Published in: Inclusive Robotics for a Better Society - Selected Papers from INBOTS Conference 2018, 16-18 October, 2018, Pisa, Italy, 25, 2020, Page(s) 98-104, ISBN 978-3-030-24073-8
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-24074-5_18

Noninvasive Modalities Used in Spinal Cord Injury Rehabilitation

Author(s): Filipe O. Barroso, Alejandro Pascual-Valdunciel, Diego Torricelli, Juan C. Moreno, Antonio Del Ama-Espinosa, Jozsef Laczko, José L. Pons
Published in: Spinal Cord Injury Therapy [Working Title], 2019
Publisher: IntechOpen
DOI: 10.5772/intechopen.83654

Review on Tremor Suppression Using Afferent Electrical Stimulation

Author(s): Filipe O. Barroso, Alejandro Pascual-Valdunciel, José L. Pons
Published in: Converging Clinical and Engineering Research on Neurorehabilitation III - Proceedings of the 4th International Conference on NeuroRehabilitation (ICNR2018), October 16-20, 2018, Pisa, Italy, 21, 2019, Page(s) 1092-1096, ISBN 978-3-030-01844-3
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-01845-0_218

The Ethics of BCI

Author(s): Monasterio, A.
Published in: Artificial Intelligence: a Multidisciplinary Perspective, 2018
Publisher: Vernon Press

Aging between Participation and Simulation - Ethical Dimensions of Socially Assistive Technologies in Elderly Care

Author(s): Ricardo Morte, Mario Toboso, Manuel Aparicio, Txetxu Ausín, Aníbal Monasterio, Daniel López
Published in: Aging between Participation and Simulation, Personal autonomy in elderly and disabled: How assistive technologies impact on it, 2020, Page(s) 185-198, ISBN 9783110677485
Publisher: Walter de Gruyter
DOI: 10.1515/9783110677485

Modulation of reciprocal inhibition at the wrist as a neurophysiological correlate of tremor suppression: a pilot healthy subject study

Author(s): Pascual-Valdunciel A, Barroso FO, Muceli S, Taylor J, Farina D, Pons JL
Published in: EMBC’19 – 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 2019., 2019
Publisher: EMBC2019