Mid-infrared arthroscopy innovative imaging system for real-time clinical in depth examination and diagnosis of degenerative joint diseases

Livrables

Set of communication tools and materials ready and delivered to all partners

Miracle dedicated website designed and published

Report describing the installation at hardware level and architecture used to develop the software

Report on the standardization landscape and applicable standards

This report will include the identification of the existing and on-going standards that are relevant for the project as well as the relevant standardization technical committees. The fields to be considered and the extent of the searches will be decided together with the project coordinator and relevant partners.

GCSS User Manual

Report analysing the overall functionalities of the software Platform capabilities buttons user interfaces

Report on the contribution to standardization

This report will include the actions taken and their results regarding the consideration of the project outcomes and approach in future standardization works with the aim of facilitating their market acceptance This comprises the interaction with the relevant standardization committees and the progress intended and achieved in the contribution to standards in the field

Public final report

Final report with public information of the project outcomes

Publications

Preprocessing strategies for infrared spectral data with limited numbers of spectral channels

Auteurs: Lintvedt, Tiril Aurora
Publié dans: Master thesis, 2019, Page(s) 91
Éditeur: Norwegian University of Life Sciences

Advanced waveguide technologies for enhancing the performance of infrared chemo/bio sensors

Auteurs: Haas, Julian
Publié dans: 2020
Éditeur: Ulm University
DOI: 10.18725/oparu-31169

Pre-processing strategies for sparse infrared spectroscopy: a case study on cartilage diagnostics

Auteurs: Tafintseva V., Lintvedt T.A., Solheim J., Zimmermann B., Rehman H.U., Virtanen V., Shaikh R., Nippolainen E., Afara I., Saarakkala S, Rieppo L., Krebs P., Fomina P., Mizaikoff B., Kohler A.
Publié dans: Molecules, Numéro 27(3), 2022, Page(s) 873, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27030873

Structural, compositional, and functional effects of blunt and sharp cartilage damage on the joint: A 9-month equine groove model study

Auteurs: Nikae C. R. te Moller, Ali Mohammadi,Saskia Plomp, Filipe M. Serra Bragança, Martijn Beukers, Behdad Pouran, Isaac O. Afara, Ervin Nippolainen, Janne T. A. Mäkelä, Rami K. Korhonen, Juha Töyräs, Harold Brommer, P. René van Weeren
Publié dans: Journal of Orhopedic research, Numéro 39(11), 2020, Page(s) 13, ISSN 0736-0266
Éditeur: Elsevier BV
DOI: 10.1002/jor.24971

Near Infrared Spectroscopy Enables Differentiation of Mechanically and Enzymatically Induced Cartilage Injuries

Auteurs: Ervin Nippolainen, Rubina Shaikh, Vesa Virtanen, Lassi Rieppo, Simo Saarakkala, Juha Töyräs & Isaac O. Afara
Publié dans: Annals of Biomedical Engineering, Numéro 48, 2020, Page(s) 11, ISSN 0090-6964
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10439-020-02506-z

Tissue optical properties combined with machine learning enables estimation of articular cartilage composition and functional integrity

Auteurs: Iman Kafian-Attari, Ervin Nippolainen, Dmitry Semenov, Markku Hauta-Kasari, Juha Töyräs, and Isaac O. Afara
Publié dans: Biomedical Optics Express, Numéro 11(11), 2020, Page(s) 15, ISSN 2156-7085
Éditeur: The Optical Society
DOI: 10.1364/boe.402929

Infrared Fiber-Optic Spectroscopy Detects Bovine Articular Cartilage Degeneration

Auteurs: Vesa Virtanen, Ervin Nippolainen, Rubina Shaikh, Isaac O. Afara, Juha Töyräs, Johanne Solheim, Valeria Tafintseva, Boris Zimmermann, Achim Kohler, Simo Saarakkala, Lassi Rieppo
Publié dans: Cartilage, Numéro 13(2), 2021, ISSN 1947-6035
Éditeur: SAGE Publications Inc.
DOI: 10.1177/1947603521993221

Infrared spectroscopy is suitable for objective assessment of articular cartilage health

Auteurs: V.Virtanena, V.Tafintsevab, R.Shaikhc, E.Nippolainenc., J.Haasde, I.O.Afaracf, J.Töyräscg, H.Krögerh, J.Solheimb, B.Zimmermann, A.Kohlerb, B.Mizaikoff, M.Finnilä, L.Rieppoa, S.Saarakkalaa
Publié dans: Osteoarthritis and Cartilage Open, Numéro 4(2), 2022, ISSN 2665-9131
Éditeur: ELSEVIER
DOI: 10.1016/j.ocarto.2022.100250

Preclassification of Broadband and Sparse Infrared Data by Multiplicative Signal Correction Approach

Auteurs: Rehman H.U., Tafintseva V., Zimmermann B., Solheim J., Virtanen V., Shaikh R., Nippolainen E., Afara I., Saarakkala S, Rieppo L., Krebs P., Fomina P., Mizaikoff B., Kohler A.
Publié dans: Molecules, Numéro 27(7), 2022, Page(s) 2298, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27072298

Raman Spectroscopy is Sensitive to Biochemical Changes Related to Various Cartilage Injuries

Auteurs: Rubina Shaikh; Ervin Nippolainen; Vesa Virtanen; Jari Torniainen; Lassi Rieppo; Simo Saarakkala; Isaac O. Afara; Juha Töyräs
Publié dans: Journal of Raman spectroscopy, Numéro 52(4), 2021, Page(s) 9, ISSN 1097-4555
Éditeur: John Wiley & Sons Ltd
DOI: 10.2139/ssrn.3606831

Analytical performance of μ-groove silicon attenuated total reflection waveguides

Auteurs: Julian Haas, Anja Müller, Lorenz Sykora, Boris Mizaikoff
Publié dans: The Analyst, Numéro 144/10, 2019, Page(s) 3398-3404, ISSN 0003-2654
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c9an00417c

Surface analysis of sheep menisci after meniscectomy via infrared attenuated total reflection spectroscopy

Auteurs: Ángela I. López‐Lorente, Pei Wang, Svenja Stein, Jonas Balko, Rui Lu, Lutz Dürselen, Boris Mizaikoff
Publié dans: Journal of Biophotonics, 2019, Page(s) e201800429, ISSN 1864-063X
Éditeur: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201800429

Analysis of human menisci degeneration via infrared attenuated total reflection spectroscopy

Auteurs: Pei Wang, Jonas Balko, Rui Lu, Ángela I. López-Lorente, Lutz Dürselen, Boris Mizaikoff
Publié dans: The Analyst, Numéro 143/20, 2018, Page(s) 5023-5029, ISSN 0003-2654
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c8an00924d

Mid-infrared GaAs/AlGaAs micro-ring resonators characterized via thermal tuning

Auteurs: Julian Haas, Philipp Artmann, Boris Mizaikoff
Publié dans: RSC Advances, Numéro 9/15, 2019, Page(s) 8594-8599, ISSN 2046-2069
Éditeur: Royal Society of Chemistry
DOI: 10.1039/c8ra10395j

iBEAM: substrate-integrated hollow waveguides for efficient laser beam combining

Auteurs: Julian Haas, Michael Pleyer, Josephine Nauschütz, Johannes Koeth, Markus Nägele, Olga Bibikova, Tatiana Sakharova, Viacheslav Artyushenko, Boris Mizaikoff
Publié dans: Optics Express, Numéro 27/16, 2019, Page(s) 23059, ISSN 1094-4087
Éditeur: Optical Society of America
DOI: 10.1364/oe.27.023059

Articular cartilage optical properties in the near-infrared (NIR) spectral range vary with depth and tissue integrity

Auteurs: Bilour Khan, Iman Kafian-Attari, Ervin Nippolainen, Rubina Shaikh, Dmitry Semenov, Markku Hauta-Kasari, Juha Töyräs, and Isaac O. Afara
Publié dans: Biomedical Optics Express, Numéro 12(10), 2021, Page(s) 15, ISSN 2156-7085
Éditeur: The Optical Society
DOI: 10.1364/boe.430053

Quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health

Auteurs: Paakkari, Petri; Inkinen, Satu I.; Honkanen, Miitu K. M.; Prakash, Mithilesh; Shaikh, Rubina; Nieminen, Miika T.; Grinstaff, Mark W.; Mäkelä, Janne T. A.; Töyräs, Juha; Honkanen, Juuso T. J.
Publié dans: Scientific Reports, Numéro 11(4), 2021, Page(s) 11, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-021-84800-x

Characterization of connective tissues using near-infrared spectroscopy and imaging.

Auteurs: Isaac O. Afara; Isaac O. Afara; Rubina Shaikh; Ervin Nippolainen; William Querido; Jari Torniainen; Jaakko K. Sarin; Shital Kandel; Nancy Pleshko; Juha Töyräs; Juha Töyräs
Publié dans: Nature Protocols, Numéro Volume 16, 2021, Page(s) 33, ISSN 1754-2189
Éditeur: Nature Publishing Group
DOI: 10.1038/s41596-020-00468-z

Machine learning augmented near-infrared spectroscopy: In vivo follow-up of cartilage defects

Auteurs: J.K. Sarin, N.C.R. te Moller, A. Mohammadi, M. Prakash, J. Torniainen, H. Brommer, E. Nippolainen, R. Shaikh, J.T.A. Mäkelä, R.K. Korhonen, P.R. van Weeren, I.O. Afara, J. Töyräs
Publié dans: Osteoarthritis and Cartilage, 2020, ISSN 1063-4584
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.joca.2020.12.007

Nanotechnological Strategies for Osteoarthritis Diagnosis, Monitoring, Clinical Management, and Regenerative Medicine: Recent Advances and Future Opportunities

Auteurs: Reza Mohammadinejad, Milad Ashrafizadeh, Abbas Pardakhty, Ilona Uzieliene, Jaroslav Denkovskij, Eiva Bernotiene, Lauriane Janssen, Gabriela S. Lorite, Simo Saarakkala, Ali Mobasheri
Publié dans: Current Rheumatology Reports, Numéro 22/4, 2020, ISSN 1523-3774
Éditeur: Current Science Inc.
DOI: 10.1007/s11926-020-0884-z

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