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CalScreener® – an innovative device for Bacterial Analysis and Diagnostics through Growth and Energy-release in Real-time

Project description

Microcalorimetry tool for antimicrobial susceptibility testing

As the global concern over antimicrobial resistance (AMR) and antibiotic misuse intensifies, the need for reliable and rapid diagnostic tests has never been more critical. Current solutions fall short, leading to inappropriate prescribing and antibiotic overuse. Symcel has developed the calScreenerTM, a ground-breaking multichannel calorimetric system designed for cell-based assays in pharmaceutical research. Building upon this innovation, the EU-funded BADGER project will commercialise an in vitro diagnostic tool based on isothermal microcalorimetry. It will accurately determine the minimum inhibitory concentration for antimicrobial susceptibility testing (AST) of hetero-resistant sepsis-causing strains. By delivering easy, precise, and timely diagnoses, the BADGER project will elevate AST to new levels of accuracy and speed, combating AMR effectively.

Objective

SymCel provides a novel cell-based assay tool for real-time cellular bioenergetics measurements. Our key product, the calScreenerTM, is the first multichannel calorimetric system specifically developed for cell-based assays, which to date has been sold to the pharmaceutical research segment only. Even though calorimetry is a highly advanced research tool, it is considered not suitable for broad scale uptake into daily clinical practice. Through the BADGER project we intend to break this paradigm by validating and commercializing an in vitro diagnostic tool, that is based on isothermal micro calorimetry, for determining MIC for antimicrobial susceptibility testing (AST) of hetero-resistant sepsis causing strains. By providing a tool for the easy, correct and timely diagnoses of hetero-resistant and extensively resistant infections, we will redefine the commercial application segment for calorimetry systems (from pure research settings -> near patient diagnostics) and take AST to a new level of accuracy and speed.
The clinical importance of AST is increasing in line with the growing concerns over antimicrobial-resistance (AMR) and the misuse of antibiotics. Lack of a rapid, low-cost and readily available solution contributes to the inappropriate prescribing and overuse of antibiotics. Clinicians are in need of an accurate and rapid diagnostic test to increase antibiotic stewardship, introduce combination treatment for critically ill patients and help combat AMR.
The calScreenerTM will meet the users’ needs by providing a reliable diagnostic tool with high speed, specificity, and sensitivity in a smartly designed and packaged device with the tools available to perform testing in a near-patient setting.
In all, the Phase 2 project will lay the foundation to clinically validate the calScreenerTM which will improve diagnostic decisions, provide a higher service level for patients, combat AMR and allow for more personalized and cost-efficient approaches to healthcare.

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Topic(s)

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SME-2 - SME instrument phase 2

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Call for proposal

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(opens in new window) H2020-SMEInst-2016-2017

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Coordinator

SYMCEL AB
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 3 572 567,50
Address
DOMNARVSGATAN 4
163 53 SPANGA
Sweden

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Östra Sverige Stockholm Stockholms län
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 3 572 567,50
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