Discovering microbiome-based disease risk factors

Publications

Peer reviewed articles (20)

Cross-reactive antibodies against human coronaviruses and the animal coronavirome suggest diagnostics for future zoonotic spillovers

Author(s): Shelley Klompus, Sigal Leviatan, Thomas Vogl, Roei D. Mazor, Iris N. Kalka, Liat Stoler-Barak, Nachum Nathan, Ayelet Peres, Lihee Moss, Anastasia Godneva, Sharon Kagan Ben Tikva, Eilat Shinar, Hadas Cohen-Dvashi, Ronen Gabizon, Nir London, Ron Diskin, Gur Yaari, Adina Weinberger, Ziv Shulman, Eran Segal
Published in: Science Immunology, 6/61, 2021, ISSN 2470-9468
Publisher: Science
DOI: 10.1126/sciimmunol.abe9950

Population-wide diversity and stability of serum antibody epitope repertoires against human microbiota

Author(s): Thomas Vogl, Shelley Klompus, Sigal Leviatan, Iris N. Kalka, Adina Weinberger, Cisca Wijmenga, Jingyuan Fu, Alexandra Zhernakova, Rinse K. Weersma, Eran Segal
Published in: Nature Medicine, 27/8, 2021, Page(s) 1442-1450, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-021-01409-3

Structural variation in the gut microbiome associates with host health

Author(s): David Zeevi, Tal Korem, Anastasia Godneva, Noam Bar, Alexander Kurilshikov, Maya Lotan-Pompan, Adina Weinberger, Jingyuan Fu, Cisca Wijmenga, Alexandra Zhernakova, Eran Segal
Published in: Nature, 568/7750, 2019, Page(s) 43-48, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1065-y

A reference map of potential determinants for the human serum metabolome

Author(s): Noam Bar, Tal Korem, Omer Weissbrod, David Zeevi, Daphna Rothschild, Sigal Leviatan, Noa Kosower, Maya Lotan-Pompan, Adina Weinberger, Caroline I. Le Roy, Cristina Menni, Alessia Visconti, Mario Falchi, Tim D. Spector, Jerzy Adamski, Paul W. Franks, Oluf Pedersen, Eran Segal
Published in: Nature, 588/7836, 2020, Page(s) 135-140, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2896-2

The road ahead in genetics and genomics

Author(s): Amy L. McGuire, Stacey Gabriel, Sarah A. Tishkoff, Ambroise Wonkam, Aravinda Chakravarti, Eileen E. M. Furlong, Barbara Treutlein, Alexander Meissner, Howard Y. Chang, Núria López-Bigas, Eran Segal, Jin-Soo Kim
Published in: Nature Reviews Genetics, 21/10, 2020, Page(s) 581-596, ISSN 1471-0056
Publisher: Nature Publishing Group
DOI: 10.1038/s41576-020-0272-6

Large-scale association analyses identify host factors influencing human gut microbiome composition

Author(s): Alexander Kurilshikov, Carolina Medina-Gomez, Rodrigo Bacigalupe, Djawad Radjabzadeh, Jun Wang, Ayse Demirkan, Caroline I. Le Roy, Juan Antonio Raygoza Garay, Casey T. Finnicum, Xingrong Liu, Daria V. Zhernakova, Marc Jan Bonder, Tue H. Hansen, Fabian Frost, Malte C. Rühlemann, Williams Turpin, Jee-Young Moon, Han-Na Kim, Kreete Lüll, Elad Barkan, Shiraz A. Shah, Myriam Fornage, Joanna Szopinska
Published in: Nature Genetics, 53/2, 2021, Page(s) 156-165, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-020-00763-1

The rationale and design of the personal diet study, a randomized clinical trial evaluating a personalized approach to weight loss in individuals with pre-diabetes and early-stage type 2 diabetes

Author(s): Collin J. Popp, David E. St-Jules, Lu Hu, Lisa Ganguzza, Paige Illiano, Margaret Curran, Huilin Li, Antoinette Schoenthaler, Michael Bergman, Ann Marie Schmidt, Eran Segal, Anastasia Godneva, Mary Ann Sevick
Published in: Contemporary Clinical Trials, 79, 2019, Page(s) 80-88, ISSN 1551-7144
Publisher: Elsevier BV
DOI: 10.1016/j.cct.2019.03.001

SARS-CoV-2 antibody testing for estimating COVID-19 prevalence in the population

Author(s): Thomas Vogl, Sigal Leviatan, Eran Segal
Published in: Cell Reports Medicine, 2/2, 2021, Page(s) 100191, ISSN 2666-3791
Publisher: Cell
DOI: 10.1016/j.xcrm.2021.100191

Clinically Accurate Prediction of Glucose Levels in Patients with Type 1 Diabetes

Author(s): Yotam Amar, Smadar Shilo, Tal Oron, Eran Amar, Moshe Phillip, Eran Segal
Published in: Diabetes Technology & Therapeutics, 22/8, 2020, Page(s) 562-569, ISSN 1520-9156
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/dia.2019.0435

Prediction of gestational diabetes based on nationwide electronic health records

Author(s): Nitzan Shalom Artzi, Smadar Shilo, Eran Hadar, Hagai Rossman, Shiri Barbash-Hazan, Avi Ben-Haroush, Ran D. Balicer, Becca Feldman, Arnon Wiznitzer, Eran Segal
Published in: Nature Medicine, 26/1, 2020, Page(s) 71-76, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-019-0724-8

Axes of a revolution: challenges and promises of big data in healthcare

Author(s): Smadar Shilo, Hagai Rossman, Eran Segal
Published in: Nature Medicine, 26/1, 2020, Page(s) 29-38, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-019-0727-5

The pros, cons, and many unknowns of probiotics

Author(s): Jotham Suez, Niv Zmora, Eran Segal, Eran Elinav
Published in: Nature Medicine, 25/5, 2019, Page(s) 716-729, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-019-0439-x

The Gut Microbiome and Individual-Specific Responses to Diet

Author(s): Avner Leshem, Eran Segal, Eran Elinav
Published in: mSystems, 5/5, 2020, ISSN 2379-5077
Publisher: American Society for Microbiology
DOI: 10.1128/msystems.00665-20

Potential roles of gut microbiome and metabolites in modulating ALS in mice

Author(s): Eran Blacher, Stavros Bashiardes, Hagit Shapiro, Daphna Rothschild, Uria Mor, Mally Dori-Bachash, Christian Kleimeyer, Claudia Moresi, Yotam Harnik, Maya Zur, Michal Zabari, Rotem Ben-Zeev Brik, Denise Kviatcovsky, Niv Zmora, Yotam Cohen, Noam Bar, Izhak Levi, Nira Amar, Tevie Mehlman, Alexander Brandis, Inbal Biton, Yael Kuperman, Michael Tsoory, Leenor Alfahel, Alon Harmelin, Michal Schwartz, Ad
Published in: Nature, 572/7770, 2019, Page(s) 474-480, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1443-5

Rich data sets could end costly drug discovery

Author(s): Eran Segal
Published in: Nature, 577/7792, 2020, Page(s) S19-S19, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/d41586-020-00200-7

Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome

Author(s): Ruben A.T. Mars, Yi Yang, Tonya Ward, Mo Houtti, Sambhawa Priya, Heather R. Lekatz, Xiaojia Tang, Zhifu Sun, Krishna R. Kalari, Tal Korem, Yogesh Bhattarai, Tenghao Zheng, Noam Bar, Gary Frost, Abigail J. Johnson, Will van Treuren, Shuo Han, Tamas Ordog, Madhusudan Grover, Justin Sonnenburg, Mauro D’Amato, Michael Camilleri, Eran Elinav, Eran Segal, Ran Blekhman, Gianrico Farrugia, Jonathan R. S
Published in: Cell, 182/6, 2020, Page(s) 1460-1473.e17, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.08.007

Potential role of indolelactate and butyrate in multiple sclerosis revealed by integrated microbiome-metabolome analysis

Author(s): Izhak Levi, Michael Gurevich, Gal Perlman, David Magalashvili, Shay Menascu, Noam Bar, Anastasia Godneva, Liron Zahavi, Danyel Chermon, Noa Kosower, Bat Chen Wolf, Gal Malka, Maya Lotan-Pompan, Adina Weinberger, Erez Yirmiya, Daphna Rothschild, Sigal Leviatan, Avishag Tsur, Maria Didkin, Sapir Dreyer, Hen Eizikovitz, Yamit Titngi, Sue Mayost, Polina Sonis, Mark Dolev, Yael Stern, Anat Achiron, Era
Published in: Cell Reports Medicine, 2/4, 2021, Page(s) 100246, ISSN 2666-3791
Publisher: Elsevier B.V.
DOI: 10.1016/j.xcrm.2021.100246

Identifying gut microbes that affect human health

Author(s): Sigal Leviatan, Eran Segal
Published in: Nature, 587/7834, 2020, Page(s) 373-374, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/d41586-020-03069-8

The human tumor microbiome is composed of tumor type–specific intracellular bacteria

Author(s): Deborah Nejman, Ilana Livyatan, Garold Fuks, Nancy Gavert, Yaara Zwang, Leore T. Geller, Aviva Rotter-Maskowitz, Roi Weiser, Giuseppe Mallel, Elinor Gigi, Arnon Meltser, Gavin M. Douglas, Iris Kamer, Vancheswaran Gopalakrishnan, Tali Dadosh, Smadar Levin-Zaidman, Sofia Avnet, Tehila Atlan, Zachary A. Cooper, Reetakshi Arora, Alexandria P. Cogdill, Md Abdul Wadud Khan, Gabriel Ologun, Yuval Bussi,
Published in: Science, 368/6494, 2020, Page(s) 973-980, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aay9189

The gut microbiome: a key player in the complexity of amyotrophic lateral sclerosis (ALS)

Author(s): Sarah L. Boddy, Ilaria Giovannelli, Matilde Sassani, Johnathan Cooper-Knock, Michael P. Snyder, Eran Segal, Eran Elinav, Lynne A. Barker, Pamela J. Shaw, Christopher J. McDermott
Published in: BMC Medicine, 19/1, 2021, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-020-01885-3

Non-peer reviewed articles (1)

A Significant Expansion of Our Understanding of the Composition of the Human Microbiome

Author(s): Sigal Leviatan, Eran Segal
Published in: mSystems, 4/1, 2019, Page(s) e00010-19, ISSN 2379-5077
Publisher: American Society of Microbiology
DOI: 10.1128/msystems.00010-19