Blocking the prion-like disease propagation in Parkinson’s disease and related disorders – model development and identification of cell-autonomous and cell non-autonomous factors.

Project Information

Alpha-Synuclein

Grant agreement ID: 786433

DOI

10.3030/786433

Project closed

EC signature date 26 February 2018

Start date 1 September 2019

End date 31 August 2021

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 200 194,80

EU contribution

€ 200 194,80

Coordinated by

AARHUS UNIVERSITET
Denmark

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (5)

Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain

Author(s): Nelson Ferreira, Nádia Pereira Gonçalves, Asad Jan, Nanna Møller Jensen, Amelia van der Laan, Simin Mohseni, Christian Bjerggaard Vægter, Poul Henning Jensen
Published in: Acta Neuropathologica Communications, Issue 9/1, 2021, ISSN 2051-5960
Publisher: BioMed Central
DOI: 10.1186/s40478-021-01131-8

The Prion-Like Spreading of Alpha-Synuclein in Parkinson’s Disease: Update on Models and Hypotheses

Author(s): Asad Jan, Nádia Pereira Gonçalves, Christian Bjerggaard Vaegter, Poul Henning Jensen, Nelson Ferreira
Published in: International Journal of Molecular Sciences, Issue 22/15, 2021, Page(s) 8338, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22158338

α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response

Author(s): Alberto Delaidelli, Mette Richner, Lixiang Jiang, Amelia van der Laan, Ida Bergholdt Jul Christiansen, Nelson Ferreira, Jens R. Nyengaard, Christian B. Vægter, Poul H. Jensen, Ian R. Mackenzie, Poul H. Sorensen, Asad Jan
Published in: Acta Neuropathologica Communications, Issue 9/1, 2021, ISSN 2051-5960
Publisher: BioMed Central
DOI: 10.1186/s40478-021-01209-3

Gene Transfer in Rodent Nervous Tissue Following Hindlimb Intramuscular Delivery of Recombinant Adeno-Associated Virus Serotypes AAV2/6, AAV2/8, and AAV2/9

Author(s): Asad Jan, Mette Richner, Christian B Vægter, Jens R Nyengaard, Poul H Jensen
Published in: Neuroscience Insights, Issue 14, 2019, Page(s) 117906951988902, ISSN 2633-1055
Publisher: SAGE
DOI: 10.1177/1179069519889022

Prodromal neuroinvasion of pathological Α-synuclein in brainstem reticular nuclei and white matter lesions in a model of Α-synucleinopathy

Author(s): Nelson Ferreira, Mette Richner, Amelia van der Laan, Ida Bergholdt Jul Christiansen, Christian B Vægter, Jens R Nyengaard, Glenda M Halliday, Joachim Weiss, Benoit I Giasson, Ian R Mackenzie, Poul H Jensen, Asad Jan
Published in: Brain Communications, 2021, ISSN 2632-1297
Publisher: Oxford University Press
DOI: 10.1093/braincomms/fcab104