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Host Protective Engineering of Cancer Immunity by Targeting the Intracellular Immune Checkpoint NR2F6

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Publications

Chemically modified mRNA nucleofection of primary human T cells

Author(s): Nikolaus Thuille, Tajana Sajinovic, Kerstin Siegmund, Gottfried Baier
Published in: Journal of Immunological Methods, 487, 2020, Page(s) 112878, ISSN 0022-1759
Publisher: Elsevier BV
DOI: 10.1016/j.jim.2020.112878

Emerging Next-Generation Target for Cancer Immunotherapy Research: The Orphan Nuclear Receptor NR2F6

Author(s): Victoria Klepsch, Kerstin Siegmund, Gottfried Baier
Published in: Cancers, 13/11, 2021, Page(s) 2600, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13112600

Tumor rejection in Cblb-/- mice depends on IL-9 and Th9 cells

Author(s): Schanz O, Cornez I, Yajnanarayana SP, David FS, Peer S, Gruber T, Krawitz P, Brossart P, Heine A, Landsberg J, Baier G, Wolf D
Published in: J Immunother Cancer, 2021 Jul;9(7), 2021, Page(s) e002889, ISSN 2051-1426
Publisher: BMJ Publishing Group Ltd.
DOI: 10.1136/jitc-2021-002889

Novel mutant mouse line emphasizes the importance of protein kinase C theta for CD4+ T lymphocyte activation

Author(s): Kerstin Siegmund, Nikolaus Thuille, Nina Posch, Friedrich Fresser, Michael Leitges, Gottfried Baier
Published in: Cell Communication and Signaling, 17/1, 2019, ISSN 1478-811X
Publisher: BioMed Central
DOI: 10.1186/s12964-019-0364-0

Loss-of-function phenotype of a PKCθT219A knockin mouse strain

Author(s): Nikolaus Thuille, Kerstin Siegmund, Victoria Klepsch, Jacqueline Schörgenhuber, Sarah Danklmaier, Michael Leitges, Gottfried Baier
Published in: Cell Communication and Signaling, 17/1, 2019, ISSN 1478-811X
Publisher: BioMed Central
DOI: 10.1186/s12964-019-0466-8

Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation through Regulation of IL-21

Author(s): William J. Olson, Bojana Jakic, Verena Labi, Katia Schoeler, Michaela Kind, Victoria Klepsch, Gottfried Baier, Natascha Hermann-Kleiter
Published in: Cell Reports, 28/11, 2019, Page(s) 2878-2891.e5, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.08.024

Targeting the orphan nuclear receptor NR2F6 in T cells primes tumors for immune checkpoint therapy

Author(s): Victoria Klepsch, Maria Pommermayr, Dominik Humer, Natascha Brigo, Natascha Hermann-Kleiter, Gottfried Baier
Published in: Cell Communication and Signaling, 18/1, 2020, ISSN 1478-811X
Publisher: BioMed Central
DOI: 10.1186/s12964-019-0454-z

Loss of the orphan nuclear receptor NR2F6 enhances CD8+ T-cell memory via IFN-γ

Author(s): Bojana Jakic, William J. Olson, Kerstin Siegmund, Victoria Klepsch, Janine Kimpel, Verena Labi, Dietmar Zehn, Gottfried Baier, Natascha Hermann-Kleiter
Published in: Cell Death & Disease, 12/2, 2021, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-021-03470-9