Host Protective Engineering of Cancer Immunity by Targeting the Intracellular Immune Checkpoint NR2F6

Project Information

HOPE

Grant agreement ID: 786462

DOI

10.3030/786462

Project closed

EC signature date 18 July 2018

Start date 1 October 2018

End date 30 September 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 484 325,00

EU contribution

€ 2 484 325,00

Coordinated by

MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (17)

T cell-intrinsic protein kinase D3 is dispensable for the cells' activation

Author(s): Jiří Koutník 1 , Michael Leitges 2 , Kerstin Siegmund 1
Published in: Front Immunol, 2022, ISSN 1664-3224
Publisher: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.1049033

A MLR-Based Approach to Analyze Regulators of T Lymphocyte Activation In Vivo

Author(s): Koutník, Jiˇrí; Klepsch, Victoria; Pommermayr, Maria; Thuille, Nikolaus; Baier, Gottfried; Siegmund, Kerstin
Published in: International Journal of Molecular Sciences, Vol 23, Iss 10, p 5337 (2022), Issue 2, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23105337

Melanoma-intrinsic NR2F6 activity regulates antitumor immunity

Author(s): Hyungsoo Kim 1 , Yongmei Feng 1 , Rabi Murad 1 , Joanna Pozniak 2 , Carl Pelz 3 , Yeqing Chen 4 Bhavik Dalal 5 , Rosalie Sears 3 , Eduard Sergienko 1 , Michael Jackson 1 , Eytan Ruppin 6 , Meenhard Herlyn 4 , Curtis Harris 5 , Jean-Christophe Marine 2 , Victoria Klepsch 7 , Gottfried Baier 7 , Ze'ev A Ronai 1
Published in: Science Advances, 2023, ISSN 2375-2548
Publisher: AAAS

Chemically modified mRNA nucleofection of primary human T cells

Author(s): Nikolaus Thuille, Tajana Sajinovic, Kerstin Siegmund, Gottfried Baier
Published in: Journal of Immunological Methods, Issue 487, 2020, Page(s) 112878, ISSN 0022-1759
Publisher: Elsevier BV
DOI: 10.1016/j.jim.2020.112878

Emerging Next-Generation Target for Cancer Immunotherapy Research: The Orphan Nuclear Receptor NR2F6

Author(s): Victoria Klepsch, Kerstin Siegmund, Gottfried Baier
Published in: Cancers, Issue 13/11, 2021, Page(s) 2600, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13112600

Additional file 2 of Addressing the role of PKD3 in the T cell compartment with knockout mice

Author(s): Koutník, Jiří; Neururer, Verena; Gruber, Thomas; Peer, Sebastian; Hermann-Kleiter, Natascha; Olson, William J.; Labi, Verena; Leitges, Michael; Baier, Gottfried; Siegmund, Kerstin
Published in: Cell Commun Signal, Issue 54-60, 2022, ISSN 1478-811X
Publisher: BioMed Central
DOI: 10.6084/m9.figshare.19619514

Tumor rejection in Cblb-/- mice depends on IL-9 and Th9 cells

Author(s): Schanz O, Cornez I, Yajnanarayana SP, David FS, Peer S, Gruber T, Krawitz P, Brossart P, Heine A, Landsberg J, Baier G, Wolf D
Published in: J Immunother Cancer, Issue 2021 Jul;9(7), 2021, Page(s) e002889, ISSN 2051-1426
Publisher: BMJ Publishing Group Ltd.
DOI: 10.1136/jitc-2021-002889

Novel mutant mouse line emphasizes the importance of protein kinase C theta for CD4+ T lymphocyte activation

Author(s): Kerstin Siegmund, Nikolaus Thuille, Nina Posch, Friedrich Fresser, Michael Leitges, Gottfried Baier
Published in: Cell Communication and Signaling, Issue 17/1, 2019, ISSN 1478-811X
Publisher: BioMed Central
DOI: 10.1186/s12964-019-0364-0

Loss-of-function phenotype of a PKCθT219A knockin mouse strain

Author(s): Nikolaus Thuille, Kerstin Siegmund, Victoria Klepsch, Jacqueline Schörgenhuber, Sarah Danklmaier, Michael Leitges, Gottfried Baier
Published in: Cell Communication and Signaling, Issue 17/1, 2019, ISSN 1478-811X
Publisher: BioMed Central
DOI: 10.1186/s12964-019-0466-8

A role for the nuclear receptor NR2F6 in peritoneal B cell homeostasis

Author(s): William J Olson 1 2 , Bojana Jakic 1 , Verena Labi 3 , Johannes Woelk 1 , Emmanuel Derudder 2 , Gottfried Baier 1 , Natascha Hermann-Kleiter 1
Published in: Front Immunol, 2022, ISSN 1664-3224
Publisher: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.845235

Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation through Regulation of IL-21

Author(s): William J. Olson, Bojana Jakic, Verena Labi, Katia Schoeler, Michaela Kind, Victoria Klepsch, Gottfried Baier, Natascha Hermann-Kleiter
Published in: Cell Reports, Issue 28/11, 2019, Page(s) 2878-2891.e5, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.08.024

A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection

Author(s): Miriam Bosch; Nina Kallin; Sainitin Donakonda; Jitao David Zhang; Hannah Wintersteller; Silke Hegenbarth; Kathrin Heim; Carlos Ramirez; Anna Fürst; Elias Isaac Lattouf; Martin Feuerherd; Sutirtha Chattopadhyay; Nadine Kumpesa; Vera Griesser; Jean-Christophe Hoflack; Juliane Siebourg-Polster; Carolin Mogler; Leo Swadling; Laura J. Pallett; Philippa Meiser; Katrin Manske; Gustavo P. de Almeida; Ann
Published in: Nature, Issue Jul;631(8022), 2024, Page(s) 867-875, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-07630-7

Targeting the orphan nuclear receptor NR2F6 in T cells primes tumors for immune checkpoint therapy

Author(s): Victoria Klepsch, Maria Pommermayr, Dominik Humer, Natascha Brigo, Natascha Hermann-Kleiter, Gottfried Baier
Published in: Cell Communication and Signaling, Issue 18/1, 2020, ISSN 1478-811X
Publisher: BioMed Central
DOI: 10.1186/s12964-019-0454-z

Loss of the orphan nuclear receptor NR2F6 enhances CD8+ T-cell memory via IFN-γ

Author(s): Bojana Jakic, William J. Olson, Kerstin Siegmund, Victoria Klepsch, Janine Kimpel, Verena Labi, Dietmar Zehn, Gottfried Baier, Natascha Hermann-Kleiter
Published in: Cell Death & Disease, Issue 12/2, 2021, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-021-03470-9

New Insights into the Diverse Functions of the NR2F Nuclear Orphan Receptor Family

Author(s): Tajana Sajinovic, Gottfried Baier
Published in: 2768-6701, 2023, ISSN 2768-6701
Publisher: IMR PRESS
DOI: 10.31083/j.fbl2801013.

Protein kinase N1 deficiency results in upregulation of cerebral energy metabolism and is highly protective in in vivo and in vitro stroke models

Author(s): Zur Nedden S, Safari MS, Weber D, Kuenkel L, Garmsiri C, Lang L, Orset C, Freret T, Haelewyn B, Hotze M, Kwiatkowski M, Sarg B, Faserl K, Savic D, Skvortsova II, Krogsdam A, Carollo S, Trajanoski Z, Oberacher H, Zlotek D, Ostermaier F, Cameron A, Baier G, Baier Bitterlich G.
Published in: Metabolism, 2024, ISSN 0026-0495
Publisher: Elsevier BV
DOI: 10.1016/j.metabol.2024

Kim H, Feng Y, Murad R, Pozniak J, Pelz C, Chen Y, Dalal B, Sears R, Sergienko E, Jackson M, Ruppin E, Herlyn M, Harris C, Marine JC, Klepsch V, Baier G, Ronai ZA

Author(s): Melanoma-intrinsic NR2F6 activity regulates antitumor immunity
Published in: Sci Adv, Issue 6621, 2023, ISSN 2375-2548
Publisher: AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.adf6621